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Recent Patents on Biotechnology

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https://read.qxmd.com/read/30747089/potential-angiotensin-converting-enzyme-inhibitors-from-moringa-oleifera
#1
Huma Khan, Varun Jaiswal, Saurabh Kulshreshtha, Azhar Khan
BACKGROUND: Hypertension is the chronic medical condition and it affect billions of people worldwide. Natural medicines are the main alternatives of treatment for a large majority of people suffering from hypertension. Niazicin-A, Niazimin-A, and Niaziminin-B compounds were reported from Moringa oleifera ethanolic leave extract having potential antihypertensive activity. OBJECTIVE: These compounds targeted with Angiotensin-converting enzyme [ACE] which is one of the main regulatory enzymes of the renin-angiotensin system...
February 10, 2019: Recent Patents on Biotechnology
https://read.qxmd.com/read/30747088/nucleic-acid-therapeutics-in-huntington-s-disease
#2
Kuljit Singh, Ipsita Roy
BACKGROUND: Protein misfolding is a critical factor in the progression of a large number of neurodegenerative diseases. The incorrectly folded protein is prone to aggregation, leading in aberrant interaction with other cellular proteins, elevated oxidative stress, impaired cellular machinery, finally resulting in cell death. Due to its monogenic origin, Huntington's disease (HD) is a poster child of protein misfolding neurodegenerative disorders. The presence of neuronal inclusions of mutant huntingtin N-terminal fragments, mainly in the cortex and striatum, is a neuropathological hallmark of HD...
February 8, 2019: Recent Patents on Biotechnology
https://read.qxmd.com/read/30714536/exploring-the-patent-landscape-of-rnai-based-innovation-for-plant-breeding
#3
Dario Gianfranco Frisio, Vera Ventura
BACKGROUND: RNA interference (RNAi) is an innovative technique for plant improvement based on naturally occurring mechanisms that shows great potential because of its high specificity and possibility to be applied through innovative methods of topical application in plants. This specific innovation sector is worth analysing from the economic perspective given the great potentiality of RNAi-based plants and product to support modern agriculture in reaching the goals for the improvement of agri-food chains global sustainability...
February 4, 2019: Recent Patents on Biotechnology
https://read.qxmd.com/read/30657052/ammonia-sensing-and-cytotoxicity-of-biosynthesized-silver-nanoparticle-by-arabic-gum-ag
#4
Nahid Jalalian Elahi, Masoud Salehmoghadam, Danial Taherzadeh, Alireza Hashemzadeh, Majid Darroudi
BACKGROUND: The green synthesizing procedure of Silver nanoparticles (AgNPs) has been performed through the usage of a natural polysaccharide; Arabic gum (AG) as a stabilizing/capping agent. For characterization of AgNPs, TEM, particle size analyzer and UV-Vis were used. METHODS: The aim of our project was to identify biosynthesized AgNPs for sensing ammonia and to explore its toxicity on Neuro-2A cells. We also reviewed the patents for biosynthesized AgNO3 and ammonia sensing...
January 18, 2019: Recent Patents on Biotechnology
https://read.qxmd.com/read/30648529/recent-patents-applications-in-red-biotechnology-a-mini-review
#5
Raíssa C D Graciano, Júlia A T Ribeiro, Anderson K S Macedo, Jose Paulo de S Lavareda, Pedro R de Oliveira, Jairo B Netto, Lais M Nogueira, Juliana M Machado, Mariana Campos-da-Paz, Rodolfo Cordeiro Giunchetti, Alexsandro S Galdino
The different fields of biotechnology can be classified by colors, as a "rainbow" methodology; In this sense, the red biotechnology, is focused on the preservation of health, has been outstanding in helping to solve this challenge through the provision of technologies, including diagnostic kits, molecular diagnostics, vaccines, innovations in cancer research, therapeutic antibodies and stem cells. In this work, we revised some patents regarding to red biotechnology as examples to covers this subject...
January 14, 2019: Recent Patents on Biotechnology
https://read.qxmd.com/read/30621572/in-silico-analysis-of-different-signal-peptides-for-secretory-production-of-arginine-deiminase-in-escherichia-coli
#6
Mahboubeh Zarei, Navid Nezafat, Mohammad Hossein Morowvat, Mohsen Ektefaie, Younes Ghasemi
BACKGROUND: Secretory production of recombinant protein in bacterial hosts fulfill several advantages. Selecting an appropriate secretory signal peptide is a critical step in secretory production of different protein. Several patents report the usage of signal peptides for secretory production of recombinant proteins in E. coli. In silico identification of suitable signal peptides is a reliable and cost-effective alternative to experimental approaches. OBJECTIVE: This study was aimed to predict best signal peptides for the secretory production of recombinant arginine deiminase in E...
December 31, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30569861/arginine-deiminase-current-understanding-and-applications
#7
Mahboubeh Zarei, Mohammad Reza Rahbar, Mohammad Hossein Morowvat, Navid Nezafat, Manica Negahdaripour, Aydin Berenjian, Younes Ghasemi
BACKGROUND: Arginine deiminase (ADI), an arginine catabolizing enzyme, is considered as an anti-tumor agent for the treatment of arginine auxotrophic cancers. However, some obstacles limit its clinical applications. OBJECTIVE: This review will summarize the clinical applications of ADI, from a brief history to its limitations, and will discuss the different ways to deal with the clinical limitations. METHODS: The structure analysis, cloning, expression, protein engineering and applications of arginine deiminase enzyme have been explained in this review...
December 20, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30556508/patents-on-quantitative-susceptibility-mapping-qsm-of-tissue-magnetism
#8
Feng Lin, Martin R Prince, Pascal Spincemaille, Yi Wang
BACKGROUND: Quantitative susceptibility mapping (QSM) depicts biodistributions of tissue magnetic susceptibility sources, including endogenous iron and calcifications, as well as exogenous paramagnetic contrast agents and probes. When comparing QSM with simple susceptibility weighted MRI, QSM eliminates blooming artifacts and shows reproducible tissue susceptibility maps independent of field strength and scanner manufacturer over a broad range of image acquisition parameters. For patient care, QSM promises to inform diagnosis, guide surgery, gauge medication, and monitor drug delivery...
December 16, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30514197/development-insights-of-surface-modified-lipid-nanoemulsions-of-dihydroartemisinin-for-malaria-chemotherapy-characterization-and-in-vivo-antimalarial-evaluation
#9
Chukwuebuka Emmanuel Umeyor, Onyedikachi Obachie, Rozeeta Chukwuka, Anthony Attama
BACKGROUND: The use of dihydroartemisinin (DHA) for effective malaria treatment is challenged by its poor aqueous solubility and inadequate bioavailability leading to treatment failures and emergence of resistant strains. A review of some novel drug delivery systems developed to address these challenges and their patents revealed that no study has reported the application of surface modified lipid nanoemulsions for improved antimalarial activity of DHA. OBJECTIVE: The main thrust of this study is to develop oral dihydroartemisinin formulations solubilized in surface modified lipid nanoemulsions, characterize, and evaluate their activity against murine malaria Methods: Lipid nanoemulsions containing dihydroartemisinin were formulated by high pressure homogenization using soybean oil, and polyethylene glycol 4000 was employed for surface modification...
December 3, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30479222/cryopreservation-of-orchids-a-review
#10
Saranjeet Kaur
BACKGROUND: The orchids are one of the beautiful creations of nature which stand apart from any other assemblage of flowering plants. They are highly evolutionary and ecologically significant group of plants that have effectively occupied almost every habitat on the earth. Indiscriminate collections and extermination of their natural habitats have threatened many species of orchids with extinction, resulting into severe reduction of their genetic resources in nature. It is necessary to adopt sound scientific protocols for preservation of orchid species...
November 27, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30370868/lipases-sources-production-purification-and-applications
#11
Naveen Patel, Dhananjai Rai, Soni Shivam, Shraddha Shahane, Umesh Mishra
Background and sources: Lipase enzyme is a naturally occurring enzyme found in the stomach and pancreatic juice. They function is to digests fats and lipids, helping to maintain correct gallbladder function. Lipase is the one such widely used and versatile enzyme. These enzymes are obtained from animals, plants and as well as from several microorganisms and are sufficiently stable. These are considered as nature's catalyst but commercially only microbial lipases are being used significantly. Applications: They found enormous application in the industries of fat and oil processing, oleochemical industry, food industry, detergents, pulp and paper industry, detergents, environment management, tea processing, biosensors and cosmetics and perfumery...
October 28, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30318009/isolation-purification-characterisation-and-application-of-l-asnase-l-asnase-a-review
#12
Tania Paul, Abhijit Mondal, Tarun Kanti Bandyopadhyay
BACKGROUND: L-ASNase (L-asparagine aminohydrolase EC 3.5.1.1) is used for the conversion of L-asparagine to L-aspartic acid and ammonia and also it was found as an agent of chemotherapeutic property. It is known as an anti-cancer agent and recently it has received an immense attention. The various microorganisms have ability to secrete the L-ASNase. It is famous world-wide as anti-tumour medicine for acute lymphoblastic leukemia and lymphosarcoma. L-ASNase helps in deamination of Asparagine and Glutamine...
October 12, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30246646/computational-fluid-dynamics-cfd-simulation-of-cross-flow-mode-operation-of-membrane-for-downstream-processing
#13
Anirban Banik, Tarun Kanti Bandyopadhyay, Sushant Kumar Biswal
BACKGROUND: Membrane filtration process produced good quality of permeate flux due to which it is used in different industries like dairy, pharmaceutical, sugar, starch and sweetener industry, bio separation, purification of biomedical materials, and downstream polishing etc. The cross flow mode of operation has also been used to improve the quality of the Rubber Industrial effluent of Tripura, India. METHODS: The Computational Fluid Dynamics (CFD) simulation of the cross flow membrane is done by using ANSYS Fluent 6...
September 24, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30246645/biotechnological-applications-of-serine-proteases-a-patent-review
#14
Amin Jablaoui, Aicha Kriaa, Nizar Akermi, Hela Mkaouar, Ali Gargouri, Emmanuelle Maguin, Moez Rhimi
BACKGROUND: Serine proteases have long been recognized to play key roles in various physiological processes. However, their disequilibrium can be linked to several diseases. Taking into account their wide diversity and specificity, they have been actively investigated by many industrial, academic and pharmaceutical industries. OBJECTIVE: This review aims to provide a concise analysis of the described serine proteases as well as their relevant biotechnological and therapeutic applications...
September 24, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30221606/optimization-of-process-parameters-for-production-of-pectinase-using-bacillus-subtilis-mf447840-1
#15
Ram Balak Mahto, Mukesh Yadav, Soumya Sasmal
BACKGROUND: Pectinase enzyme has immense industrial prospects in food and beverage industries. We mentioned the patents relating to pectinase used in various industries. OBJECTIVE: In this study, the optimization of the process parameters for the pectinase production was carried out from Bacillus Subtilis MF447840.1 using submerged fermentation. METHOD: 2% (OD600 nm=0.1) of seed culture was inoculated in production media. The production media components used for this study was 1 g/l of pectin, 0...
September 16, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30147019/mode-of-action-properties-production-and-application-of-laccase-a-review
#16
Naveen Patel, Shraddha Shahane, Soni Shivam, Ria Majumdar, Umesh Mishra
Background and Source: Laccase belongs to the blue multi-copper oxidases, which are widely distributed in fungi and higher plants. It is present in Ascomycetes, Deuteromycetes, and Basidiomycetes and found abundantly in white-rot fungi. APPLICATIONS: Laccase enzyme because of their potential have acquired more importance and application in the area of textile, pulp and paper, and food industry. Recently, it is being used in developing biosensors for detection and removal of toxic pollutants, designing of biofuel cells and medical diagnostics tool...
August 21, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30124162/cfd-and-optimization-study-of-frictional-pressure-drop-through-bends
#17
Suman Debnath, Anirban Banik, TarunKanti Bandyopadhyay, Apu Kumar Saha
BACKGROUND: The non-Newtonian pseudoplastic liquid flow through different types of the bend is more complicated compared to the simple straight pipe as the bends are associated with various curve geometry. Bends have wide application in bioengineering, biotechnology and biomedical such as study biofluids, blood rheology study, the design of medical equipment like equipment measuring the cholesterol etc. Methods:The papers deal with the estimation of loss coefficient and frictional pressure drop of Newtonian and non-Newtonian pseudoplastic fluid flow through the different bend of 0...
August 20, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30156167/propolis-and-its-dental-applications-a-technological-prospection
#18
Lidia Audrey Rocha Valadas Marques, Keniesd Sampaio Mendonca, Rosueti Diogenes de Oliveira Filho, Edilson Martins Rodrigues Neto, Joao Hildo de Carvalho Furtado, Marta Maria de Franca Fonteles, Leandro Maciel Uchoa Gadelha, Nicole de Mello Fiallo, Ana Cristina de Mello Fiallos
BACKGROUND: Propolis is a resinous complex produced by Apis mellifera L. bees whose variety of pharmacological properties is resulting from the complexity of its composition. In dentistry, propolis is used on the prevention of oral diseases such as dental caries and gingivitis. Prospective studies in intellectual property banks are important to increase market competitiveness and thus generate new products in the various research areas. In this way, investments in patents play an important role in the technological and economic development of a country...
August 14, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/30062978/carcinoembryonic-antigen-cea-and-hepatic-metastasis-in-colorectal-cancer-update-on-biomarker-for-clinical-and-biotechnological-approaches
#19
Mariana Campos-da-Paz, Jose Garrofe Dorea, Alexsandro Sobreira Galdino, Zulmira Guerrero Marques Lacava, Maria de Fatima Menezes Almeida Santos
Carcinoembryonic antigen (CEA) is a prognostic marker in colorectal cancer (CRC) for tumor diagnosis and monitoring response to therapy. High CEA levels are specifically associated with CRC progression and liver metastasis. Due to its differential expression between cancer and healthy tissues, and between positive and negative lymph nodes CEA has been explored for new cancer therapy and diagnosis approaches. We revised the literature on CEA role in CRC as well as the patents relating to CEA targeting for cancer management...
July 30, 2018: Recent Patents on Biotechnology
https://read.qxmd.com/read/29866025/patent-landscape-on-structured-lipids-produced-by-enzyme-technology
#20
Emilia Akil, Elisa d'Avila Costa Cavalcanti, Sabrina Dias de Oliveira, Priscilla Filomena Fonseca Amaral, Denise Maria Guimaraes Freire, Alexandre Guedes Torres
BACKGROUND: Lipid modification results in several benefits for the food industry, biotechnology advances and human health. Customizing bioactive lipids is very appealing because it improves the product's nutritional quality. Lipases are sustainable biocatalysts that can be reused, show selectivity towards substrates and reactions occur in mild conditions. OBJECTIVES: We aimed at systematically searching for patents deposited worldwide, that approached the production of structured lipids by using lipases as biocatalysts...
June 3, 2018: Recent Patents on Biotechnology
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