journal
https://read.qxmd.com/read/38279742/edible-vaccines-a-patent-driven-exploration-of-immunization-technologies
#1
JOURNAL ARTICLE
Sahil Kashyap, Shikha Kamboj, Rohit Kamboj, Kumar Guarve, Sweta Kamboj
Vaccines are biological preparations that improve immunity to particular diseases. Particularly for poor developing nations, edible vaccines show significant potential as a financially advantageous, simple to administer, straightforward to store, fail-safe, and socially and culturally acceptable vaccine delivery system. A vaccine incorporates the gene-encoding bacterial or viral disease-causing agent in plants without losing its immunogenic property. Potatoes, tomatoes, rice, soybeans, and bananas are the primary plants for edible vaccines...
January 25, 2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38275072/medicinal-plants-in-the-treatment-of-respiratory-diseases-and-their-future-aspects
#2
JOURNAL ARTICLE
Aliya Firdaus, Mohd Hadi Yunus, Syed Khalida Izhar, Uzma Afaq
The utilization of medicinal plants in the treatment of respiratory diseases has a rich history dating back centuries. This study delves into the diverse range of plant species known for their therapeutic properties, with a specific focus on their applications in respiratory health. Medicinal plants have played a crucial role as a source of ingredients for medications and the synthesis of drugs. Globally, over 35,000 plant species are employed for medicinal purposes, particularly in emerging countries where traditional medicine, predominantly plant-based pharmaceuticals, serves as a primary healthcare resource...
January 24, 2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38528667/exploring-trachyspermum-ammi-and-foeniculum-vulgare-in-hydroponic-system-and-compare-its-chemical-constituents-with-soil-based-method-a-prospective-in-agriculture
#3
JOURNAL ARTICLE
Shilpa Debnath, Alok Sharma
BACKGROUND: The forthcoming problems will be of food, and soil due to environmental alteration, growing populations, pollution, and exhaustion of natural resources among other factors. Hydroponic farming has the capacity to alleviate the intimidation of these con-cerned issues in the agricultural system. Hydroponics is recommended as an alternative way to enhance product yield compared to conventional agriculture. OBJECTIVE: The present study aimed to determine the different growth parameters and constituents of soil-grown and hydroponically grown Trachyspermum ammi and Foeniculum vulgare for the first time, which could be a patentable in future...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38528666/an-outline-of-the-immunogenic-potential-of-progressing-sarscov-2-vaccine-technologies-among-children-and-adolescents
#4
JOURNAL ARTICLE
Hytham Ghanem, Shehab Ghanem, Ehsan AlMutawa
BACKGROUND: SARS-CoV-2, a highly dynamic beta-coronavirus, can afflict all age groups. Notably, over 16100 mortalities have been recorded among children as yet. In this regard, many vaccine projects are operational to assess immuno-potency among young cohorts. A bulk of reports have evidenced the efficacy of these immunization technologies in the elderly population, though the impact is yet to be determined among children. OBJECTIVES: This review is envisioned to outline the current efficacy of contributing vaccine technologies and examine the dose-dependent impact of immunization regimens in lowering the risks of SARS-CoV-2 infections among children and adolescents...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38282444/botanical-extracts-and-compounds-of-castanea-plants-and-methods-of-use-us20190125818a1-the-united-states-patent-evaluation
#5
JOURNAL ARTICLE
Tatiane Batista Dos Santos, Denilson Dos Santos Gomes, Agenor Gomes Dos Santos Neto, Lívia Maria do Amorim Costa Gaspar, Daniela Droppa-Almeida
BACKGROUND: Bacterial infections are increasingly difficult to combat, which makes them a threat to public health on a global level. Staphylococcus aureus is considered one of the main causes of infections in hospitals, as it has a variety of virulence factors, as well as is able to produce bacterial biofilms, which, consequently, bring numerous damages to public health as a result of increased resistance to conventional antibiotics and a longer hospital stay. Therefore, the use of compounds extracted from medicinal plants is a potential pharmaceutically acceptable target, as they do not have toxicity and the potential to disrupt biofilms produced by Staphylococcus aureus already evidenced, thus revealing their relevance to our study...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38282443/intellectual-property-rights-protection-of-biotechnological-inventions-in-india
#6
JOURNAL ARTICLE
Virendra Gomase, Kiran Kemkar, Vaishali Potnis
The current Intellectual Property Rights (IPR) framework supports the commercialization of seed improvement, monoculture, and the patent protection of novel plant varieties, microorganisms, and genetically modified animals. As a consequence, our rich biogenetic diversity is irreversibly dissipating. However, we need to figure out how to create a methodology for elective choices that will achieve harmony between the official Intellectual Property (IP) structure and maintainable biodiversity components. The majority of the biotechnology sector's programmes in India are managed by the Department of Biotechnology...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38282442/fundamental-uses-of-peptides-as-a-new-model-in-both-treatment-and-diagnosis
#7
JOURNAL ARTICLE
Hend Okasha
An amino acid short chain is known as a peptide. Peptide bonds are the connections that hold the amino acids of a peptide together in a particular order. Characteristically, the shorter length of peptides helps to identify them from proteins. Different ways are used to classify peptides, including chain length, source of peptides, or their biological functions. The fact that peptides serve several purposes suggests that there is a foundation for improvement in peptide production and structure to enhance action...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38282441/a-review-on-romiplostim-mechanism-of-action-and-the-expressive-approach-in-e-coli
#8
REVIEW
Masoud Hashemzaei, Mohammad Bagher Ghoshoon, Mehrnaz Jamshidi, Fatemeh Moradbeygi, Ahmad Hashemzehi
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder determined by immune-mediated platelet demolition and reduction of platelet production. Romiplostim is a new thrombopoiesis motivating peptibody that binds and stimulates the human thrombopoietin receptor the patent of which was registered in 2008. It is used to treat thrombocytopenia in patients with chronic immune thrombocytopenic purpura. Romiplostim is a 60 kDa peptibody designed to inhibit cross-reacting immune responses. It consists of four high-affinity TPO-receptor binding domains for the Mpl receptor and one human IgG1 Fc domain...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38205775/gonadotropic-activity-of-pituitary-extract-of-african-catfish-clarias-gariepinus-in-mammals-using-immature-wistar-rats-as-models
#9
JOURNAL ARTICLE
Simon Azubuike Ubah, Samson Eneojo Abalaka, Victory Clara Asibor, Ebenezer Kehinde Ogundana, Itodo Joy Iyojo, Oluwa Adikpe Agbonu, Philemon Kwinjoh Columbus, Kenneth Owoicho Abah, Christopher Ese Obudu, Oluwatobi Akefe Isaac, Prisca Adaoma Ezinwo
BACKGROUND: The pituitary glands normally produce and stores gonadotropic hormones (GnH) that are responsible for ovulation and spermiation in animals. However, whether fish pituitary extracts can elicit same effects in treated animals need elucidation as a prelude to their practical usage in animals. OBJECTIVES: The aim of this study was to investigate the oestrus-inducing potential of the pituitary gland extract of the Africa Catfish ( Clarias gariepinus ) in immature Wistar rats...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38205774/comparison-of-five-escherichia-coli-strains-to-achieve-the-maximum-yield-of-a-recombinant-immunotoxin-consisting-of-an-antibody-against-vegf-conjugated-with-map30-toxin-in-a-benchtop-bioreactor
#10
JOURNAL ARTICLE
Mina Zarei, Mohammad Hossein Morowvat
BACKGROUND: Cancer is among the leading causes of death worldwide, imposing high costs on the health systems of all societies. Extensive biological studies are required to discover appropriate therapies. Escherichia coli has long been regarded as one of the main biotechnological bio-factories to produce recombinant protein-based therapeutics. In the present study, five strains of E. coli were compared to achieve the maximum production of a previously designed recombinant immunotoxin-carrying MAP30 toxin against VEGF-overexpressed cancer cells in a benchtop bioreactor...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38205773/the-role-of-light-on-the-microalgae-biotechnology-fundamentals-technological-approaches-and-sustainability-issues
#11
JOURNAL ARTICLE
Rafaela Basso Sartori, Mariany Costa Deprá, Rosangela Rodrigues Dias, Mariane Bittencourt Fagundes, Leila Queiroz Zepka, Eduardo Jacob-Lopes
Light energy directly affects microalgae growth and productivity. Microalgae in natural environments receive light through solar fluxes, and their duration and distribution are highly variable over time. Consequently, microalgae must adjust their photosynthetic processes to avoid photo limitation and photoinhibition and maximize yield. Considering these circumstances, adjusting light capture through artificial lighting in the main culture systems benefits microalgae growth and induces the production of commercially important compounds...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/38205772/nano-lipid-carriers-as-a-promising-drug-delivery-carrier-for-neurodegenerative-disorders-an-overview-of-recent-advances
#12
JOURNAL ARTICLE
Vishal Kumar, Sreeja C Nair
The last few decades have seen a rise in the number of deaths caused by neurological disorders. The blood-brain barrier (BBB), which is very complex and has multiple mechanisms, makes drug delivery to the brain challenging for many scientists. Lipid nanoparticles (LNPs) such as nanoemulsions, solid-lipid nanoparticles, liposomes, and nano lipid carriers (NLCs) exhibit enhanced bioavailability and flexibility among these nanocarriers. NLCs are found to be very effective. In the last few decades, they have been a center of attraction for controlled drug delivery...
2024: Recent Patents on Biotechnology
https://read.qxmd.com/read/37957916/innovative-nanomaterials-for-targeting-hypoxia-to-improve-treatment-for-triple-negative-breast-cancer
#13
JOURNAL ARTICLE
Suman Kumar Ray, Sukhes Mukherjee
Triple-negative breast cancer (TNBC) is an aggressive breast cancer with a high rate of metastases, a short overall survival time, and a poor response to targeted therapy. Improving tumor hypoxia by lowering the oxygen consumption rate of breast tumor cells is a powerful strategy. A viable way to address this issue is to improve therapeutic efficacy by improving the effectiveness of radiation and overcoming drug resistance in TNBC treatment by controlling hypoxia in the tumor microenvironment. The failure of radiation and chemotherapy in TNBC is frequently caused by hypoxia...
November 10, 2023: Recent Patents on Biotechnology
https://read.qxmd.com/read/37936448/human-dna-mutations-and-their-impact-on-genetic-disorders
#14
JOURNAL ARTICLE
Safia Samir
DNA is a remarkably precise medium for copying and storing biological information. It serves as a design for cellular machinery that permits cells, organs, and even whole organisms to work. The fidelity of DNA replication results from the action of hundreds of genes involved in proofreading and damage repair. All human cells can acquire genetic changes in their DNA all over life. Genetic mutations are changes to the DNA sequence that happen during cell division when the cells make copies of themselves. Mutations in the DNA can cause genetic illnesses such as cancer, or they could help humans better adapt to their environment over time...
November 3, 2023: Recent Patents on Biotechnology
https://read.qxmd.com/read/37779409/innovation-and-patenting-activities-during-covid-19-and-advancement-of-biochemical-and-molecular-diagnosis-in-the-postcovid-19-era
#15
JOURNAL ARTICLE
Suman Kumar Ray, Sukhes Mukherjee
The COVID-19 pandemic is to escalate globally and acquire new mutations quickly, so accurate diagnostic technologies play a vital role in controlling and understanding the epidemiology of the disease. A plethora of technologies acquires diagnosis of individuals and informs clinical management of COVID. Some important biochemical parameters for COVID diagnosis are the elevation of liver enzymes, creatinine, and nonspecific inflammatory markers such as C-reactive protein (CRP) and Interleukin 6 (IL-6). The main progression predictors are lymphopenia, elevated D-dimer, and hyperferritinemia, although it is also necessary to consider LDH, CPK, and troponin in the marker panel of diagnosis...
September 27, 2023: Recent Patents on Biotechnology
https://read.qxmd.com/read/37605394/herbal-technological-prospects-of-morus-nigra-l-a-systematic-patent-analysis-review
#16
JOURNAL ARTICLE
Larissa Pereira Alves, Widson Michael Dos Santos, Myla Lôbo de Souza, Larissa Araújo Rolim, Pedro José Rolim-Neto
BACKGROUND: Morus nigra L. is a plant with significant potential for drug development due to the presence of numerous bioactive compounds in its various parts. OBJECTIVES: This article aims to compile the technological perspectives of Morus nigra L. towards drug development and therapeutic indications based on registered patents in databases. METHODS: The study analyzed patents published within the last five years, focusing on products derived from different parts of the Morus nigra L...
August 21, 2023: Recent Patents on Biotechnology
https://read.qxmd.com/read/37594090/potentials-of-stem-cell-therapy-in-patients-infected-with-covid19-a-systematic-review
#17
JOURNAL ARTICLE
Zahra Tamis, Fatemeh Sadeghi, Aigin Heydari, Saima Shahzad Mirza, Mohammad Hossein Morowvat
INTRODUCTION: In the present study, we have examined different aspects and potentials of stem cells for the management of patients infected with COVID-19. BACKGROUND: The novel coronavirus disease (COVID-19) has been reported in most of the countries and territories (>230) of the world with ∼686 million confirmed cases (as of Apr. 22, 2023). While the scientific community is working to develop vaccines and develop drugs against the COVID-19 pandemic, novel alternative therapies may reduce the mortality rate...
August 18, 2023: Recent Patents on Biotechnology
https://read.qxmd.com/read/37537776/role-of-algal-derived-bioactive-compounds-in-human-health
#18
JOURNAL ARTICLE
Gyanendra Tripathi, Priyanka Dubey, Suhail Ahmad, Alvina Farooqui, Vishal Mishra
Algae is emerging as a bioresource with high biological potential. Various algal strains have been used in traditional medicines and human diets worldwide. They are a rich source of bioactive compounds like ascorbic acid, riboflavin, pantothenate, biotin, folic acid, nicotinic acid, phycocyanins, gamma-linolenic acid (GLA), adrenic acid (ARA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), etc. Beta-carotene, astaxanthin, and phycobiliproteins are different classes of pigments that are found in algae...
July 19, 2023: Recent Patents on Biotechnology
https://read.qxmd.com/read/37231757/in-silico-design-and-evaluation-of-a-novel-therapeutic-agent-against-the-spike-protein-as-a-novel-treatment-strategy-for-covid-19-treatment
#19
JOURNAL ARTICLE
Soroush Sarmadi, Mohammad Reza Rahbar, Hamideh Najafi, Onyeka S Chukwudozie, Mohammad Hossein Morowvat
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a viral respiratory disease that is associated with severe damage to other human organs. It causes by a novel coronavirus, and it is spreading all over the world. To date, there is some approved vaccine or therapeutic agent which could be effective against this disease. But their effectiveness against mutated strains is not studied completely. The spike glycoprotein on the surface of the coronaviruses gives the virus the ability to bind to host cell receptors and enter cells...
May 23, 2023: Recent Patents on Biotechnology
https://read.qxmd.com/read/37138429/technology-prospection-of-ora-pro-n%C3%A3-bis-pereskia-aculeate-mill-a-non-conventional-food-plant
#20
JOURNAL ARTICLE
Kellen Miranda Sá, Igor Lima Soares, Marcos Venânces de Souza Leão, Maria Izabel Carneiro Ferreira, Patrícia Georgina Garcia do Nascimento, Claudilane Martins Pontes, Alane Maia da Hora, Lucas Pontes Leal, Maria Nilka de Oliveira, Mary Anne Medeiros Bandeira, Dorasilvia Ferreira Pontes
BACKGROUND: The ora-pro-nóbis (Pereskia aculeata Mill.) is a plant from Brazilian biodiversity used for food and medicinal purposes. It has ample technological potential, however, it is still underutilized, being classified as a Non-Conventional Food Plant (PANC). Prospective studies in intellectual property banks make it possible to expand perspectives for scientific research, enhancing the generation of new products. OBJECTIVE: Evaluate the patents of products containing Pereskia aculeata Mill...
May 2, 2023: Recent Patents on Biotechnology
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