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Dose-response: a Publication of International Hormesis Society

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https://read.qxmd.com/read/30745862/bidirectional-effects-of-pyrrolidine-dithiocarbamate-on-severe-acute-pancreatitis-in-a-rat-model
#1
Huan Yang, ShuCan Ma, Yu Guo, DongLai Cui, JinFeng Yao
Introduction: The mechanism by which intestinal mucosal barrier is damaged in severe acute pancreatitis (SAP)-associated impairment is not fully understood. Methods: We established an l-arginine-induced SAP rat model, pretreated with or without pyrrolidine dithiocarbamate (PDTC). Hematoxylin and eosin staining was performed to evaluate the pathological alterations. Western blotting was conducted to detect the expression of autophagy-related proteins. Oxidative stress was assessed by the levels of malondialdehyde and superoxide dismutase...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30733653/comparative-analysis-of-mitochondrial-proteome-reveals-the-mechanism-of-enhanced-ram-sperm-motility-induced-by-carbon-ion-radiation-after-in-vitro-liquid-storage
#2
Yuxuan He, Hongyan Li, Yong Zhang, Junjie Hu, Yulong Shen, Jin Feng, Xingxu Zhao
The aim of this study was to reveal the mechanism of enhanced ram sperm motility induced by heavy ion radiation (HIR) after in vitro liquid storage. Ram semen was stored for 24 hours at 5°C and then irradiated with 0.1 Gy carbon ion radiation (CIR). In comparison to nonirradiated (NIR) sperm, the motility, viability, and adenosine triphosphate content were all higher in CIR sperm, and the reactive oxygen species levels were lower. Moreover, 87 differential mitochondrial protein spots were detected in 2-dimensional gels between CIR and NIR sperm and were identified as 52 corresponding proteins...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30733652/ethics-of-adoption-and-use-of-the-linear-no-threshold-model
#3
Moshe Yanovskiy, Yair Y Shaki, Yehoshua Socol
The linear no-threshold (LNT) model of ionizing radiation-induced cancer assumes that every increment of radiation dose, no matter how small, constitutes an increased cancer risk for humans. Linear no-threshold is presently the most widely applied model for radiation risk assessment. As such, it imposes very heavy burden on the society in both economic and human terms. This model, which was adopted in late 1950s in the wake of massive government investments in science, is controversial and raises important ethical issues...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30733651/effects-of-60-co-%C3%AE-irradiation-on-the-reproductive-function-of-caenorhabditis-elegans
#4
Fengmei Cui, Nan Ma, Xiaojing Han, Na Chen, Yue Xi, Weiye Yuan, Yufan Xu, Jianfang Han, Xiaoyan Xu, Yu Tu
The effects of ionizing radiation on the reproductive system have always been a matter of great interest. Both artificial and naturally occurring ionizing radiation can directly or indirectly affect the reproductive system via the introduction of DNA single-strand and double-strand breaks, the excitation of water molecules, and the generation of free radicals. In order to quantitatively investigate the effects of ionizing radiation on reproductive function, 60 Co γ irradiation was applied on a model organism, Caenorhabditis elegans (C...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30728758/targeted-subcutaneous-vibration-with-single-neuron-electrophysiology-as-a-novel-method-for-understanding-the-central-effects-of-peripheral-vibrational-therapy-in-a-rodent-model
#5
Kyle B Bills, Travis Clarke, George H Major, Cecil B Jacobson, Jonathan D Blotter, Jeffrey Brent Feland, Scott C Steffensen
Very little is known about the effects of whole body vibration on the supraspinal central nervous system. Though much clinical outcome data and mechanistic data about peripheral neural and musculoskeletal mechanisms have been explored, the lack of central understanding is a barrier to evidence-based, best practice guidelines in the use of vibrational therapy. Disparate methods of administration render study to study comparisons difficult. To address this lack of uniformity, we present the use of targeted subcutaneous vibration combined with simultaneous in vivo electrophysiological recordings as a method of exploring the central effects of peripheral vibration therapy...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30718988/national-trends-of-bladder-cancer-and-trihalomethanes-in-drinking-water-a-review-and-multicountry-ecological-study
#6
REVIEW
Joseph A Cotruvo, Heather Amato
We examined trends in incidence of bladder cancer in 8 countries in the 45+ years since trihalomethanes (THMs) were detected in chlorinated drinking water. Total trihalomethanes (TTHMs) are the principal regulated disinfection by-products (DBPs) along with halogenated acetic acids (HAAs). Numerous epidemiological studies have examined exposure to TTHMs and associations with bladder cancer. Concentrations of TTHM have declined in most of the 8 countries that were studied as has smoking prevalence. Incidences of bladder cancer have usually stayed relatively flat, especially for females, with some variations...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30670940/the-disparity-of-impairment-of-neurogenesis-and-cognition-after-acute-or-fractionated-radiation-exposure-in-adolescent-balb-c-mice
#7
Shuang Peng, Bo Yang, Meng Yun Duan, Zi Wei Liu, Wei Feng Wang, Xiang Zhi Zhang, Bo Xu Ren, Feng Ru Tang
The effect of acute X-ray irradiation with 2 Gy or fractionated exposure with 0.2 Gy continuously for 10 days (0.2 Gy × 10 = 2 Gy) was evaluated in the postnatal day 21 (P21) BALB/c mouse model. Both acute and fractionated irradiation induced impairment of cell proliferation and neurogenesis in the subgranular zone of the dentate gyrus labeled by Ki67 and doublecortin, respectively. Parvalbumin immunopositive interneurons in the subgranular zone were also reduced significantly. However, the 2 patterns of irradiation did not affect animal weight gain when measured at ages of P90 and P180 or 69 and 159 days after irradiation...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30670939/changes-of-8-ohdg-and-trxr-in-the-residents-who-bathe-in-radon-hot-springs
#8
Gao Yanxiao, Tian Mei, Gao Gang, Wang Xiaochun, Liu Jianxiang
This study explored the effects of long-term bathing in radon hot springs on oxidative damage and antioxidation function in humans. In this study, blood was collected from residents in the Pingshan radon hot spring area (RHSA), Jiangzha RHSA, and control area (CA). 8-Hydroxydeoxyguanosine (8-OHdG) and thioredoxin reductase (TrxR), representing oxidation and antioxidant levels, respectively, were analyzed as indices. Compared to the CA group, the RHSA group in the Pingshan and Jiangzha areas showed significantly decreased 8-OHdG levels ( Z = -3...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30670938/evidence-of-dose-threshold-for-radiation-induced-leukemia-absorbed-dose-and-uncertainty
#9
Jerry M Cuttler
No abstract text is available yet for this article.
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30670937/serum-8-hydroxy-2-deoxyguanosine-level-as-a-potential-biomarker-of-oxidative-dna-damage-induced-by-ionizing-radiation-in-human-peripheral-blood
#10
Yu Gao, Ping Wang, Zhaonan Wang, Lin Han, Jie Li, Chongbin Tian, Fengling Zhao, Jianpo Wang, Fang Zhao, Qiao Zhang, Yumin Lyu
In this study, the effect of ionizing radiation on 8-hydroxy-2'-deoxyguanosine (8-OHdG) in human peripheral blood was investigated. Blood samples were collected from 230 radiation workers and 8 patients who underwent radiotherapy for population study. Blood samples from 2 healthy individuals were irradiated with different X-ray doses for in vitro experiment, and levels of 8-OHdG in serum and cell culture supernatants were assessed by enzyme-linked immunosorbent assay. Observations demonstrated the positive relationships between serum 8-OHdG level and radiation dose and working period were observed, and serum 8-OHdG levels were higher among interventional radiation workers than among other hospital radiation workers...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30670936/lower-body-acceleration-and-muscular-responses-to-rotational-and-vertical-whole-body-vibration-at-different-frequencies-and-amplitudes
#11
Lisa N Zaidell, Ross D Pollock, Darren C James, Joanna L Bowtell, Di J Newham, David P Sumners, Katya N Mileva
Aim: The aim of this study was to characterize acceleration transmission and neuromuscular responses to rotational vibration (RV) and vertical vibration (VV) at different frequencies and amplitudes. Methods: Twelve healthy males completed 2 experimental trials (RV vs VV) during which vibration was delivered during either squatting (30°; RV vs VV) or standing (RV only) with 20, 25, and 30 Hz, at 1.5 and 3.0 mm peak-to-peak amplitude. Vibration-induced accelerations were assessed with triaxial accelerometers mounted on the platform and bony landmarks at ankle, knee, and lumbar spine...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30670935/natural-products-mediated-targeting-of-virally-infected-cancer
#12
REVIEW
Iram Fatima, Sobia Kanwal, Tariq Mahmood
The role of viral infection in developing cancer was determined in the start of 20th century. Until now, 8 different virus-associated cancers have been discovered and most of them progressed in immunosuppressed individuals. The aim of the present study is to look into the benefits of natural products in treating virally infected cancers. The study focuses on bioactive compounds derived from natural sources. Numerous pharmaceutical agents have been identified from plants (vincristine, vinblastine, stilbenes, combretastatin, and silymarin), marine organisms (bryostatins, cephalostatin, ecteinascidins, didemnin, and dolastatin), insects (cantharidin, mastoparan, parectadial, and cecropins), and microorganisms (vancomycin, rhizoxin, ansamitocins, mitomycin, and rapamycin)...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30627069/evidence-of-a-dose-rate-threshold-for-life-span-reduction-of-dogs-exposed-lifelong-to-%C3%AE-radiation
#13
Jerry M Cuttler, Ludwig E Feinendegen, Yehoshua Socol
Our return to a study on dogs exposed lifelong to cobalt-60 γ-radiation was prompted by a comment that data in dog studies have large statistical errors due to the small number of dogs. We located an earlier article on the same study that had a better mortality curve for the dogs in each dose-rate group. The median life span of the dogs in each group was tabulated, and the standard error of each was calculated. No statistically significant shortening of median life span was observed for the lowest dose-rate group at any reasonable significance level ( P value: ...
October 2018: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30627068/acute-and-chronic-effects-of-whole-body-vibration-on-balance-postural-stability-and-mobility-in-women-with-multiple-sclerosis
#14
Eduardo D S Freitas, Christine Frederiksen, Ryan M Miller, Aaron Heishman, Mark Anderson, Gabriel Pardo, Cecilie Fjeldstad, Debra A Bemben, Michael G Bemben
The acute and chronic effects of whole-body vibration (WBV) on balance, postural stability, and mobility were evaluated in 21 women with relapsing-remitting multiple sclerosis (MS) randomly assigned to control (n = 9) or experimental (n = 12) groups. To assess acute responses, outcome variables were assessed before and immediately after a session of WBV (five 30-second bouts of vibration; frequency 30 Hz; amplitude 3 mm; 1-minute rest intervals) during their first visit (week 1) using field (Timed-Up and Go; 500-m walk; Berg Balance Scale) and laboratory tests (NeuroCom Balance Master and EquiTest System-Sensory Organization Test, Adaptation Test, Limits of Stability, Modified Clinical Test for Sensory Integration of Balance, Unilateral Stance, Tandem Walk, Step/Quick Turn)...
October 2018: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30627067/critical-analysis-of-x-ray-imaging-is-essential-for-contemporary-chiropractic-and-manual-therapy-spinal-rehabilitation-radiography-increases-benefits-and-reduces-risks-by-oakley-et-al
#15
Brian Anderson
No abstract text is available yet for this article.
October 2018: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30627066/letter-to-the-editor-re-oakley-pa-cuttler-jm-harrison-de-x-ray-imaging-is-essential-for-contemporary-chiropractic-and-manual-therapy-spinal-rehabilitation-radiography-increases-benefits-and-reduces-risks-dose-response-2018-jun-19-16-2
#16
Greg Kawchuk, Christine Goertz, Iben Axén, Martin Descarreaux, Simon French, Mitchell Haas, Jan Hartvigsen, Carolina Kolberg, Hazel Jenkins, Cynthia Peterson, John Taylor
No abstract text is available yet for this article.
October 2018: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30627065/response-to-letters-from-anderson-and-kawchuk-et-al-x-ray-imaging-is-essential-for-contemporary-chiropractic-and-manual-therapy-spinal-rehabilitation-radiography-increases-benefits-and-reduces-risks
#17
Paul A Oakley, Jerry M Cuttler, Deed E Harrison
No abstract text is available yet for this article.
October 2018: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30627064/acquired-resilience-an-evolved-system-of-tissue-protection-in-mammals
#18
REVIEW
Jonathan Stone, John Mitrofanis, Daniel M Johnstone, Benedetto Falsini, Silvia Bisti, Paul Adam, Arturo Bravo Nuevo, Mindy George-Weinstein, Rebecca Mason, Janis Eells
This review brings together observations on the stress-induced regulation of resilience mechanisms in body tissues. It is argued that the stresses that induce tissue resilience in mammals arise from everyday sources: sunlight, food, lack of food, hypoxia and physical stresses. At low levels, these stresses induce an organised protective response in probably all tissues; and, at some higher level, cause tissue destruction. This pattern of response to stress is well known to toxicologists, who have termed it hormesis...
October 2018: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30622449/prophylactic-administration-of-nanocurcumin-abates-the-incidence-of-liver-toxicity-induced-by-an-overdose-of-copper-sulfate-role-of-cyp4502e1-nf-%C3%AE%C2%BAb-and-bax-expressions
#19
Ahlam Alhusaini, Iman H Hasan, Nouf Aldowsari, Njood Alsaadan
Background: The consequences of excess copper in human tissue are the alterations in the oxidative stress markers and peroxidative damage of membrane lipids. Unselective copper binding may be the clue to damaging impact to protein construction and hence modifying their biological functions. The aim of this study is to match the hepatoprotective efficacy of curcumin (CM) or nanocurcumin (NCM) with that of desferrioxamine (DSF; standard heavy metal chelator) against toxic doses of copper sulphate (CuSO4 )...
October 2018: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30622448/late-effects-of-low-dose-radiation-on-the-bone-marrow-lung-and-testis-collected-from-the-same-exposed-balb-cj-mice
#20
Witawat Jangiam, Chatchanok Udomtanakunchai, Paiboon Reungpatthanaphong, Montree Tungjai, Louise Honikel, Chris R Gordon, Kanokporn Noy Rithidech
We used 3 biological metrics highly relevant to health risks, that is, cell death, inflammation, and global DNA methylation, to determine the late effects of low doses (0.05 or 0.1 Gy) of 137 Cs γ rays on the bone marrow, lung, and testis collected at 6 months post-irradiation from the same exposed BALB/cJ mouse. This integrative approach has not been used for such a purpose. Mice exposed to 0 or 1 Gy of radiation served as a sham or positive control group, respectively. The results could deliver information for better health risk assessment across tissues, including better scientific basis for radiation protection and clinical application...
October 2018: Dose-response: a Publication of International Hormesis Society
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