Yaël Glasson, Laure-Agnès Chépeaux, Anne-Sophie Dumé, Virginie Lafont, Julien Faget, Nathalie Bonnefoy, Henri-Alexandre Michaud
Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial, stromal, and immune) cell types constantly interact. Importantly, the abundance, localization, and functional orientation of each cell component within the tumor microenvironment vary significantly over time and in response to treatment. Such intratumoral heterogeneity influences the tumor course and its sensitivity to treatments. Recently, high-dimensional imaging mass cytometry (IMC) has been developed to explore the tumor ecosystem at the single-cell level...
January 4, 2023: Seminars in Immunopathology