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Journal of Cell Communication and Signaling

Sheng-Jun Liao, Jing Luo, Dong Li, Yuan-Hong Zhou, Bin Yan, Jing-Jing Wei, Jian-Cheng Tu, Yi-Rong Li, Gui-Mei Zhang, Zuo-Hua Feng
TGF-β1 is a main inducer of epithelial to mesenchymal transition (EMT). However, many breast cancer cells are not sensitive to the EMT induction by TGF-β1 alone. So far, the mechanisms underlying the induction of TGF-β1-insensitive breast cancer cells remains unclear. Here we report that TNF-α can induce EMT and invasiveness of breast cancer cells which are insensitive to TGF-β1. Intriguingly, TGF-β1 could cooperate with TNF-α to promote the EMT and invasiveness of breast cancer cells. The prolonged co-stimulation with TGF-β1 and TNF-α could enhance the sustained activation of Smad2/3, p38 MAPK, ERK, JNK and NF-κB pathways by enhancing the activation of TAK1, which was mediated by the gradually up-regulated TβRs...
February 9, 2019: Journal of Cell Communication and Signaling
Abhishek Mohanty, Rashmi Tiwari-Pandey, Nihar R Pandey
Mitochondria, the dynamic organelles and power house of eukaryotic cells function as metabolic hubs of cells undergoing continuous cycles of fusion and fission. Recent findings have made it increasingly apparent that mitochondria essentially involved in energy production have evolved as principal intracellular signaling platforms regulating not only innate immunity but also inflammatory responses. Perturbations in mitochondrial dynamics, including fusion/fission, electron transport chain (ETC) architecture and cristae organization have now been actively correlated to modulate metabolic activity and immune function of innate and adaptive immune cells...
February 4, 2019: Journal of Cell Communication and Signaling
Bernard Perbal
No abstract text is available yet for this article.
January 31, 2019: Journal of Cell Communication and Signaling
Piyush Chaudhary, Gosipatala Sunil Babu, Ranbir Chander Sobti, Satish Kumar Gupta
Hepatocyte growth factor (HGF) is reported to be down-regulated in pregnancy complications like intrauterine growth retardation and preeclampsia, which are associated with abnormal trophoblast migration/invasion. In this study, role of HGF and associated signaling pathways has been investigated in HTR-8/SVneo trophoblastic cells migration/invasion under normoxia (20% O2 ) and hypoxia (2% O2 ). HTR-8/SVneo cells exposed to hypoxia showed increase in migration and invasion as compared to cells incubated under normoxic conditions...
January 26, 2019: Journal of Cell Communication and Signaling
Yong-Chul Kim, Reyda Gonzalez-Nieves, Mary L Cutler
The Rsu1 protein contributes to cell adhesion and migration via its association with the adaptor complex of Integrin linked kinase (ILK), PINCH, and Parvin (IPP), which binds to the cytoplasmic domain of β1 integrins joining integrins to the actin cytoskeleton. Rsu1 binding to PINCH in the IPP complex is required for EGF-induced adhesion, spreading and migration in MCF10A mammary epithelial cells. In addition, Rsu1 expression inhibits Jun kinase but is necessary for the activation of MKK4 and p38 Map kinase signaling essential for migration in MCF10A cells...
January 25, 2019: Journal of Cell Communication and Signaling
Tejaswini Subbannayya, Pamela Leal-Rojas, Alex Zhavoronkov, Ivan V Ozerov, Mikhail Korzinkin, Niraj Babu, Aneesha Radhakrishnan, Sandip Chavan, Remya Raja, Sneha M Pinto, Arun H Patil, Mustafa A Barbhuiya, Prashant Kumar, Rafael Guerrero-Preston, Sanjay Navani, Pramod K Tiwari, Rekha Vijay Kumar, T S Keshava Prasad, Juan Carlos Roa, Akhilesh Pandey, David Sidransky, Harsha Gowda, Evgeny Izumchenko, Aditi Chatterjee
Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late presentation of the disease, lack of early diagnostic markers and limited efficacy of therapeutic interventions. Elucidation of molecular events in GBC can contribute to better management of the disease by aiding in the identification of therapeutic targets. To identify aberrantly activated signaling events in GBC, tandem mass tag-based quantitative phosphoproteomic analysis of five GBC cell lines was carried out...
January 21, 2019: Journal of Cell Communication and Signaling
Jaganmay Sarkar, Tapati Chakraborti, Animesh Chowdhury, Rajabrata Bhuyan, Sajal Chakraborti
The signalling pathway involving MMP-2 and sphingosine-1-phosphate (S1P) in endothelin-1 (ET-1) induced pulmonary artery smooth muscle cell (PASMC) proliferation is not clearly known. We, therefore, investigated the role of NADPH oxidase derived O2 .- -mediated modulation of MMP2-sphingomyeline-ceramide-S1P signalling axis in ET-1 induced increase in proliferation of PASMCs. Additionally, protective role of the tea cathechin, epigallocatechin-3-gallate (EGCG), if any, in this scenario has also been explored...
January 19, 2019: Journal of Cell Communication and Signaling
Rodolfo Daniel Cervantes-Villagrana, Víctor Manuel Color-Aparicio, Guadalupe Reyes-Cruz, José Vázquez-Prado
Reciprocal communication among cells of the tumor microenvironment contributes to cancer progression. Here, we show that a protumoral population of cultured bone marrow-derived cells (BMDC) containing Tie2+/CD45+/CD11b + cells responded to lung carcinoma cells and reciprocally stimulated them. These cells migrated via heterotrimeric G protein-dependent signaling pathways and strongly activated the PI3K/AKT, ERK and mTOR signaling cascades in response to conditioned media and chemotactic agonists. To get insight into the molecular machinery involved in BMDC migration, we revealed their repertoire of guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) and G proteins in comparison with fresh bone marrow cells, proven that these cell populations had contrasting effects on tumor growth...
January 5, 2019: Journal of Cell Communication and Signaling
Gargi Maity, Jinia Chakraborty, Arnab Ghosh, Inamul Haque, Snigdha Banerjee, Sushanta K Banerjee
Tumor neovascularization/tumor angiogenesis is a pathophysiological process in which new blood vessels are formed from existing blood vessels in the primary tumors to supply adequate oxygen and nutrition to cancer cells for their proliferation and metastatic growth to the distant organs. Therefore, controlling tumor angiogenesis is an attractive target for cancer therapy. Structural abnormalities of the vasculature (i.e., leakiness due to the abnormal lining of pericytes on the microvessels) are one of the critical features of tumor angiogenesis that sensitizes vascular cells to cytokines and helps circulating tumor cells to metastasize to distant organs...
January 4, 2019: Journal of Cell Communication and Signaling
Yousof Taghavi, Gholamhossein Hassanshahi, Nicholas G Kounis, Ioanna Koniari, Hossein Khorramdelazad
Diabetic retinopathy (DR) is considered as a diabetes-related complication that can render severe visual impairments and is also a risk factor for acquired blindness in both developed as well as developing countries. Through fibrovascular epiretinal membranes (ERMs), this condition can similarly lead to tractional retinal detachment. Laboratory efforts evaluating the DR pathogenesis can be provided by ocular vitreous fluid and ERMs resulting from vitrectomy. The clinical stages of DR are significantly associated with expression levels of certain chemokines, including monocyte chemotactic protein-1 (MCP-1) in the intraocular fluid...
January 3, 2019: Journal of Cell Communication and Signaling
Edward J Calabrese
The historical foundations of cancer risk assessment and its adoption by the US EPA in the mid 1970s were based on the discovery of X-ray-induced gene mutations by Hermann J. Muller, its transformation into the linear nonthreshold (LNT) single-hit theory and the recommendations of the model by the US National Academy of Sciences, Biological Effects of Atomic/Ionizing Radiation, Genetics Panels in 1956 and 1972. This testimony summarizes substantial recent revelations which profoundly challenge the use of LNT as a default in cancer risk assessment, showing multiple significant scientific errors and incorrect interpretations, mixed with deliberate misrepresentation of the scientific record by leading ideologically motivated radiation geneticists...
December 18, 2018: Journal of Cell Communication and Signaling
Sabra I Djomehri, Boris Burman, Maria E Gonzalez, Shuichi Takayama, Celina G Kleer
While 3D cellular models are useful to study biological processes, gel-embedded organoids have large variability. This paper describes high-yield production of large (~1 mm diameter), scaffold-free, highly-spherical organoids in a one drop-one organoid format using MCF10A cells, a non-tumorigenic breast cell line. These organoids display a hollow lumen and secondary acini, and express mammary gland-specific and progenitor markers, resembling normal human breast acini. When subjected to treatment with TGF-β, the hypoxia-mimetic reagent CoCl2 , or co-culture with mesenchymal stem/stromal cells (MSC), the organoids increase collagen I production and undergo large phenotypic and morphological changes of neoplastic progression, which were reproducible and quantifiable...
December 4, 2018: Journal of Cell Communication and Signaling
Vijayalaxmi Gupta, Sneha Bhavanasi, Mohiuddin Quadir, Kevin Singh, Gaurav Ghosh, Kritin Vasamreddy, Arnab Ghosh, Teruna J Siahaan, Snigdha Banerjee, Sushanta K Banerjee
PEGylation is a biochemical modification process of bioactive molecules with polyethylene glycol (PEG), which lends several desirable properties to proteins/peptides, antibodies, and vesicles considered to be used for therapy or genetic modification of cells. However, PEGylation of proteins is a complex process and can be carried out using more than one strategy that depends on the nature of the protein and the desired application. Proteins of interest are covalently conjugated or non-covalently complexed with inert PEG strings...
November 29, 2018: Journal of Cell Communication and Signaling
Afak Rasheed Salman Zaidi, Sadie Dresman, Charlotte Burt, Simon Rule, Lynn McCallum
Mantle cell lymphoma (MCL) is a comparatively rare non-Hodgkin's lymphoma characterised by overexpression of cyclin D1. Many patients present with or progress to advanced stage disease within 3 years. MCL is considered an incurable disease with median survival between 3 and 4 years. We have investigated the role(s) of CCN1 (CYR61) and cell cycle regulators in progressive MCL. We have used the human MCL cell lines REC1 < G519 < JVM2 as a model for disease aggression. The magnitude of CCN1 expression in human MCL cells is REC1 > G519 > JVM2 cells by RQ-PCR, depicting a decrease in CCN1 expression with disease progression...
November 21, 2018: Journal of Cell Communication and Signaling
Yusuke Kamatsuki, Eriko Aoyama, Takayuki Furumatsu, Shinichi Miyazawa, Ami Maehara, Nobuyasu Yamanaka, Takashi Nishida, Satoshi Kubota, Toshifumi Ozaki, Masaharu Takigawa
Menisci are a pair of crescent-shaped fibrocartilages, particularly of which their inner region of meniscus is an avascular tissue. It has characteristics similar to those of articular cartilage, and hence is inferior in healing. We previously reported that low-intensity pulsed ultrasound (LIPUS) treatment stimulates the production of CCN2/CTGF, a protein involved in repairing articular cartilage, and the gene expression of major cartilage matrices such as type II collagen and aggrecan in cultured chondrocytes...
November 20, 2018: Journal of Cell Communication and Signaling
Bernard Perbal, Susan Tweedie, Elspeth Bruford
An examination of the confusion generated around the use of different acronyms for CCN proteins has been performed by the editors of the HUGO Gene Nomenclature Committee upon the request of the International CCN Society Scientific Committee. After careful consideration of the various arguments, and after polling the community of researchers who have published in the field over the past ten years, the HGNC have decided to adopt and approve the CCN nomenclature for all 6 genes. Effective October 2018, the genes referred to as CYR61, CTGF, NOV and WISP1-3 will be respectively designated by the gene symbols CCN1-6 with corresponding gene names « cellular communication Q2 network factor 1-6 »...
December 2018: Journal of Cell Communication and Signaling
Mohd Younis Bhat, Hitendra S Solanki, Jayshree Advani, Aafaque Ahmad Khan, T S Keshava Prasad, Harsha Gowda, Saravanan Thiyagarajan, Aditi Chatterjee
Interferon gamma (IFN-γ), is a cytokine, which is an important regulator of host defense system by mediating both innate and adaptive immune responses. IFN-γ signaling is primarily associated with inflammation and cell-mediated immune responses. IFN-γ is also represented as antitumor cytokine which facilitates immunosurveillance in tumor cells. In addition, IFN-γ mediated signaling also elicits pro-tumorigenic transformations and promotes tumor progression. Impact of IFN-γ signaling in mammalian cells has been widely studied which indicate that IFN-γ orchestrates distinct cellular functions including immunomodulation, leukocyte trafficking, apoptosis, anti-microbial, and both anti- and pro-tumorigenic role...
December 2018: Journal of Cell Communication and Signaling
Andrzej Loesch, Michael R Dashwood
The saphenous vein (SV) is the most commonly used conduit for revascularization in patients undergoing coronary artery bypass surgery (CABG). The patency rate of this vessel is inferior to the internal thoracic artery (ITA). In the majority of CABG procedures the ITA is removed with its outer pedicle intact whereas the (human) SV (hSV) is harvested with pedicle removed. The vasa vasorum, a microvessel network providing the adventitia and media with oxygen and nutrients, is more pronounced and penetrates deeper towards the lumen in veins than in arteries...
December 2018: Journal of Cell Communication and Signaling
Apeksha Sahu, Lathika Gopalakrishnan, Nayana Gaur, Oishi Chatterjee, Praseeda Mol, Prashant Kumar Modi, Shobha Dagamajalu, Jayshree Advani, Sanjeev Jain, T S Keshava Prasad
The monoamine neurotransmitter, 5-Hydroxytryptamine or serotonin, is derived from tryptophan and synthesized both centrally and systemically. Fourteen structurally and functionally distinct receptor subtypes have been identified for serotonin, each of which mediates the neurotransmitter's effects through a range of downstream signaling molecules and effectors. Although it is most frequently described for its role in the etiology of neuropsychiatric and mood disorders, serotonin has been implicated in a slew of fundamental physiological processes, including apoptosis, mitochondrial biogenesis, cell proliferation and migration...
December 2018: Journal of Cell Communication and Signaling
Firdous A Bhat, Jayshree Advani, Aafaque Ahmad Khan, Sonali Mohan, Arnab Pal, Harsha Gowda, Prantar Chakrabarti, T S Keshava Prasad, Aditi Chatterjee
Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a cytokine involved in the production of platelets. THPO is a glycoprotein produced by liver and kidney. It regulates the production of platelets by stimulating the differentiation and maturation of megakaryocyte progenitors. It acts as a ligand for MPL receptor, a member of the hematopoietic cytokine receptor superfamily and is essential for megakaryocyte maturation. THPO binding induces homodimerization of the receptor which results in activation of JAKSTAT and MAPK signaling cascades that subsequently control cellular proliferation, differentiation and other signaling events...
December 2018: Journal of Cell Communication and Signaling
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