Arun Everest-Dass, Stepan Nersisyan, Hanna Maar, Victor Novosad, Jennifer Schröder-Schwarz, Vera Freytag, Johanna L Stuke, Mia C Beine, Alina Schiecke, Marie-Therese Haider, Malte Kriegs, Omar Elakad, Hanibal Bohnenberger, Lena-Christin Conradi, Maria Raygorodskaya, Linda Krause, Mark von Itzstein, Alexander Tonevitsky, Udo Schumacher, Diana Maltseva, Daniel Wicklein, Tobias Lange
Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly expressed in CRC patients. CD44 isoform 4 indicated poor outcome and correlated with epithelial-mesenchymal transition (EMT) and decreased oxidative phosphorylation in patients; opposite associations were found for isoform 3. Pan-CD44 knockdown (kd) independently impaired primary tumor formation and abrogated distant metastasis in CRC xenografts...
October 18, 2023: Molecular Oncology