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Asian Journal of Transfusion Science

Ripal J Shah, Vishvas Amin
No abstract text is available yet for this article.
July 2018: Asian Journal of Transfusion Science
Jitendra N Patel, Ajaykumar B Donta, Arpit C Patel, Amrish N Pandya, Swati S Kulkarni
The blood specimen of a 30-year-old male donor showing a discrepancy in cell and serum grouping was targeted for detailed study at the blood bank at tertiary care hospital in South Gujarat. Forward grouping showed group as "O" RhD positive and reverse grouping as group "A." Further testing confirmed that the individual's blood group was para-Bombay A (para-AH). Family members were screened, and younger brother was also identified as para-Bombay phenotype. The para-Bombay phenotype is very rare, and only a few cases have been reported from India...
July 2018: Asian Journal of Transfusion Science
Ashish Jain, Sheetal Malhotra, Neelam Marwaha, Praveen Kumar, Ratti Ram Sharma
ABO incompatibility and other alloantibodies have emerged as a significant cause of hemolytic disease of fetus and newborn (HDFN), leading to neonatal morbidity and mortality. We report three cases of severe ABO-HDFN where blood exchange transfusions (ETs) were required in neonates with hyperbilirubinemia. Blood grouping (ABO/RhD) was performed using conventional tube technique. The antibody screen was done using commercial three-cell panel (Bio-Rad ID-Diacell-I-II-III, Switzerland) by gel technique. Direct antiglobulin test (DAT) on neonatal sample and compatibility testing were also done by gel technique...
July 2018: Asian Journal of Transfusion Science
Prashant Kumar Pandey, Nitin Agarwal, Manish Gupta
In half of the suspected autoimmune encephalitis (AIE) patients, no antibodies are identified despite extensive investigation. Therapeutic plasma exchange (TPE) is a potential first-line therapy for various subtypes of AIE. Here, we present a case of autoantibody-negative-suspected AIE, managed successfully with TPE after patient showed no response to steroids. A total of 5 sessions of TPE was done. One standard TPE procedure session was 1.2-1.5 plasma volume exchanges using 5% albumin as a replacement fluid...
July 2018: Asian Journal of Transfusion Science
Dhivya Kandasamy, Shamee Shastry, Deepika Chenna, Ganesh Mohan
Detection of nonspecific antibodies unrelated to blood group antigen that causes nuisance in pretransfusion testing is a rare event. Their interpretation is often made only after the exclusion of all possible clinically significant antibodies and results in the unnecessary expenditure of reagents and human resources. We report one such nuisance antibody detected in an antenatal female that showed pan reaction with antibody screening and identification panel red cells including auto control but was compatible with group-specific donor units...
July 2018: Asian Journal of Transfusion Science
Suchet Sachdev, Arun Kumar Sharma, Sunil Sethi, Sachin Garg, Divjot Singh Lamba, Ratti Ram Sharma, Neelam Marwaha
World Health Organization (WHO) recommends screening of syphilis in low prevalence populations of blood donors by treponemal tests like enzyme-linked immunosorbent assay (ELISA), whereas in India screening is done by rapid plasma reagin (RPR). The present pilot study evaluated the performance of ELISA compared to RPR, keeping Treponema pallidum hemagglutination assay as a reference test. ELISA was equally sensitive (100%), more specific (56.3% vs. 0%), more accurate (83.7% vs. 62.7%), had better positive predictive value (79...
July 2018: Asian Journal of Transfusion Science
Mohit Chowdhry, Raj Nath Makroo, Brinda Kakkar, Yogita Thakur, Manoj Kumar, Mandhata Singh
Transplant recipients are always at a risk of developing anti-human leukocyte antigen (HLA) antibodies due to prior sensitizing events such as blood transfusions, multiple pregnancies, or transplantation. Unexpected positive outcomes can be seen in complement dependent cytotoxicity (CDC) based assays due to underlying autoimmune disorders or pharmacological treatment (rituximab/intravenous immunoglobulin/anti-thymocyte globulin administration), therefore, limiting its value. CDC based assay results strongly depend on the vitality of the donor lymphocytes, highlighting another major limitation of this assay...
July 2018: Asian Journal of Transfusion Science
Ruhi A Mehra, Seema A Gupta, D B Borkar
Sickle cell-beta thalassemia is a double heterozygous state. Red cell exchange (RCE) transfusion reduces the concentration of sickle cells without increasing the hematocrit or whole-blood viscosity. It can be performed manually or by erythrocytapheresis. RCE transfusion is an effective tool for both acute and chronic complications of sickle cell disease. In patients unaffording erythrocytapheresis, even manual RCE can give favorable results. A 37-year-old male, a known case of sickle cell-beta+ thalassemia (βs β+), presented with avascular necrosis of right femur and humeral head...
July 2018: Asian Journal of Transfusion Science
Swati Pabbi Mehta, Aseem Kumar Tiwari, Rajesh Puri, Dinesh Arora, Geet Aggarwal, Ankita Ratan
Hypertriglyceridemia (HTG) is the third most significant risk factor for acute pancreatitis after gallstones and alcohol. Therapeutic plasma exchange (TPE) has been considered a possible treatment for HTG-induced pancreatitis, especially in severe and refractory cases. Here, we report one such clinical experience with a patient of severe HTG-induced pancreatitis. He was treated with TPE along with intravenous insulin, statins, and fibrates. TPE resulted in immediate relief of symptoms as well as a marked improvement in laboratory values, with 74...
July 2018: Asian Journal of Transfusion Science
Raj Nath Makroo, Raman Sardana, Leena Mediratta, Hena Butta, Uday Kumar Thakur, Soma Agrawal, Mohit Chowdhry, Satendra Kumar, Sourit Chokroborty
BACKGROUND: Blood transfusion of contaminated components is a potential source of sepsis by a wide range of known and unknown pathogens. Collection mechanism and storage conditions of platelets make them vulnerable for bacterial contamination. Several interventions aim to reduce the transfusion of contaminated platelet units; however, data suggest that contaminated platelet transfusion remains very common. AIM: A pathogen inactivation system, "INTERCEPT", to inactivate bacteria in deliberately contaminated platelet units was implemented and evaluated...
July 2018: Asian Journal of Transfusion Science
Gopal Kumar Patidar, Daljit Kaur
BACKGROUND: Auditing and education are the tools for improvement in the transfusion practices. Clinicians are not providing patient's demographic data and medical history to the blood bank that required transfusion. This missing information in blood request forms can lead to transfusion reactions to the patient. So we planned to analyse the blood request forms received at our blood bank and the impact of educational program for the clinicians. METHODS: A total of 6894 blood request forms were received from the month of July 2014 to December 2014 at a blood bank in Amritsar, India...
July 2018: Asian Journal of Transfusion Science
Ankit Mathur, Narasimha Swamy, Samrat Thapa, Santanu Chakraborthy, Latha Jagannathan
BACKGROUND: Platelet additive solutions (PAS) are crystalloid nutrient media used in place of plasma for platelet storage. They replace 60%-70% of plasma in platelet components, so the amount of storage plasma can be decreased. Platelets in PAS have lower risk for allergic transfusion reactions with equivalent clinical efficacy for controlling bleeding. AIM: The aim of this study is to evaluate the clinical and laboratory efficacy of PAS-platelets. MATERIALS AND METHODS: A total of 1674 single donor platelet (SDP) were collected in PAS in the month of June to September 2016 by different apheresis systems...
July 2018: Asian Journal of Transfusion Science
Saravanan Margabandhu, Suchitra Ranjit, Indira Jayakumar, Chitra Sundaramoorthy, Mahesh Janarthanan, Jayakumar Reddy, Meena Thiagarajan, Shyamala Jayamoorthy, Latha Vishwanathan
INTRODUCTION: Outcome data in pediatric plasma exchange, especially in nonrenal indications are scarce. We aimed to evaluate its role and outcome in our patients. SUBJECTS AND METHODS: A retrospective study of children admitted in the year 2016 to the Pediatric Intensive Care Unit requiring plasma exchange for nonrenal indications was undertaken. Plasma exchange was given as adjunctive therapy along with primary treatment for the disease concerned. Demographic and clinical data were studied, and descriptive statistical analysis was carried out...
July 2018: Asian Journal of Transfusion Science
Ashish Jain, Nilotpal Chowdhury, Sanchit Jain
AIM: The study intended to estimate the intra- and inter-model reliability and agreement between the HemoCue Models 201+ and 301 in a blood bank donor screening setting. MATERIALS AND METHODS: Venous blood samples from 115 blood donors were analyzed by two Hemocue 201+ instruments and two HemoCue 301 instruments. The Lin's concordance correlation coefficient (CCC) as well as the Bland-Altman limits of agreement was measured. RESULTS: The 95% lower confidence interval (CI) of all the CCCs had a value >0...
July 2018: Asian Journal of Transfusion Science
Rasika Dhawan Setia, Satyam Arora, Anil Handoo, Dharma Choudhary, Sanjeev Kumar Sharma, Vipin Khandelwal, Meenu Kapoor, Shalu Bajaj, Tina Dadu, Gaurav Dhamija, Virendra Bachchas
BACKGROUND AND OBJECTIVE: Controlled-rate freezing is a complicated, expensive, and time-consuming procedure. Therefore, there is a growing interest in uncontrolled-rate freezing (UCF) with -80°C mechanical freezers for cryopreservation of hematopoietic stem cells. This is a retrospective analysis of efficiency of UCF and outcome of autologous peripheral hematopoietic stem cell (PBSC) transplants at our center from December 2011 to June 2016. MATERIALS AND METHODS: Cryoprotectant solutions used included 5% dimethyl sulfoxide and 5% albumin with 2% hydroxyethyl starch and stored at -80°C mechanical freezer till transplant...
July 2018: Asian Journal of Transfusion Science
Kallol Kumar Bhattacharyya, Aritra Biswas, Debanjali Gupta, Provash C Sadhukhan
INTRODUCTION: One of the most common blood-borne transfusion-transmitted diseases is hepatitis C. Patients with a history of multiple blood transfusions are significantly at a greater risk of infection by contaminated blood and blood products. Beta thalassemia major is one such condition where repeated blood transfusions are required for patient management. MATERIALS AND METHODS: The present study was conducted to investigate the serological prevalence of hepatitis C virus (HCV), its viremia, and genotype distribution with clinical parameters among multitransfused thalassemic individuals...
July 2018: Asian Journal of Transfusion Science
Nitesh Gonnade, Archana Bajpayee, Abhay Elhence, Vaibhav Lokhande, Neeraj Mehta, Manish Mishra, Arunpreet Kaur
BACKGROUND: Plantar fasciitis (PF) a common chronic musculoskeletal pain routinely diagnosed and treated in rehabilitation practices. When conservative management fails in this degenerative disease, local injections of corticosteroids, platelet rich plasma (PRP), botulinum toxin, extracorporeal shockwave therapy, surgical release are used. In our prospective randomized pilot study we compared the regenerative efficacy of Platelet Rich Plasma vs Kinesiotaping with phonophoresis who were resistant to conservative management of PF...
July 2018: Asian Journal of Transfusion Science
Sudipta Sekhar Das, Ritam Chakrabarty, R U Zaman
BACKGROUND AND AIM: Patients with warm autoimmune hemolytic anemia (AIHA) may carry immunoglobulin (Ig) M antibodies that react at room temperature and are nonpathological, but few may have cold agglutinins that react at or above 30°C and are referred to as "mixed" AIHA (MAIHA). Here, we present our experience on characterizing MAIHA both clinically and serologically. MATERIALS AND METHODS: Out of 134 AIHA patients, 13 diagnosed as MAIHA were subjected to detailed immunohematological characterization...
July 2018: Asian Journal of Transfusion Science
Shamee Shastry, Karishma Ashwin Doshi, Vijayram Reddy Kankula, Pruthvi Raj Guduri
No abstract text is available yet for this article.
July 2018: Asian Journal of Transfusion Science
Jayashree Sharma
No abstract text is available yet for this article.
July 2018: Asian Journal of Transfusion Science
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