#21
JOURNAL ARTICLE
Qun Zhang, Pan Wang, Menghuan Shen, Chun Shan
OBJECTIVE: To investigate the clinical characteristics and prognostic risk factors for Klebsiella pneumoniae bloodstream infections in immunocompetent patients. METHODS: The study included patients with K. pneumoniae bloodstream infection treated in Zhongda Hospital from June 2016 to June 2021. Clinical data and antibiotic susceptibility test results were retrospectively collected and analyzed. Independent risk factors for mortality were screened using the chi-square test and multivariate logistic regression...
February 29, 2024: Journal of Infection in Developing Countries
#22
JOURNAL ARTICLE
Ifeoluwa O Bejide, Tolulope A Kayode, Angel E Ebagua, Oghenetega D Obayendo, Divine O Mere, Abasianam B Newman, Amarachukwu M Obi-Odunukwe, Ademola K Fadare, Muhammad I Ahmed, Temitope M Adeyemi-Kayode, Onikepe A Folarin
INTRODUCTION: Hepatitis B virus and human immunodeficiency virus (HBV/HIV) co-infection is a global health concern due to its significant impact on morbidity and mortality. Reports of HBV/HIV co-infections are increasing in Nigeria, but information on the disease burden in pregnant women and its implications on the fetus is scarce. This study aimed to determine the prevalence of HBV/HIV co-infection in pregnant women. In addition, the study identified the risk factors for the disease in pregnant women attending antenatal clinics in Osun State, Nigeria...
January 31, 2024: Journal of Infection in Developing Countries
#23
JOURNAL ARTICLE
Radka Komitova, Ani Kevorkyan, Elitsa Golkocheva-Markova, Mariya Atanasova, Vanya Rangelova, Ralitsa Raycheva, Chyidem Ismailova, Asya Stoyanova, Tencho Tenev
INTRODUCTION: Acute hepatitis E virus (HEV) infection is recognized as a zoonosis in several European countries. We describe the characteristics and outcomes of locally acquired acute HEV hepatitis. METHODOLOGY: A prospective study was conducted among adult patients with acute HEV hepatitis at the University Hospital in Plovdiv, South Bulgaria between January 2020 and May 2022. An acute HEV infection case was a patient with acute hepatitis and laboratory-confirmed anti-HEV IgM antibodies and/or HEV RNA in serum...
January 31, 2024: Journal of Infection in Developing Countries
#24
JOURNAL ARTICLE
Bülent Dabanlıoğlu, Aysun Yılmaz, Sümeyye Akyüz, Barış Gülhan
INTRODUCTION: The measurement of hepatitis C virus (HCV) RNA is a test that requires high cost, advanced technique, and qualified personnel. Diagnosis and treatment of patients may be delayed due to the high rate of false-positive results. This study aims to predict true antibody positivity and viremia by determining the most appropriate anti-HCV signal-to-cutoff (S/Co) value reflecting HCV infection. METHODOLOGY: The presence of anti-HCV antibodies and HCV RNA levels were examined in 72341 people who applied to the Mengücek Gazi Training and Research Hospital between January 2018 and December 2020...
January 31, 2024: Journal of Infection in Developing Countries
#25
JOURNAL ARTICLE
Bilal Tekin, Jehat Kiliç, Gürhan Taşkin, İhsan Solmaz, Onur Tezel, Bilgin Bahadır Başgöz
INTRODUCTION: The elderly population is unique and the prognostic scoring systems developed for the adult population need to be validated. We evaluated the predictive value of frequently used scoring systems on mortality in critically ill elderly sepsis patients. METHODOLOGY: In this single-center, observational, prospective study, critically ill elderly sepsis patients were evaluated. Sequential organ failure evaluation score (SOFA), acute physiology and chronic health evaluation score-II (APACHE-II), logistic organ dysfunction score (LODS), multiple organ dysfunction score (MODS), and simplified acute physiology score-II (SAPS-II) were calculated...
January 31, 2024: Journal of Infection in Developing Countries
#26
JOURNAL ARTICLE
Tugba Bedir Demirdag, Aslinur Ozkaya Parlakay, Fatma Aydin, Gokcen Dilsa Tugcu, Beytullah Santaflıoglu, Saliha Kanik Yuksek, Belgin Gulhan, Guzin Cinel, Banu Celikel Acar
INTRODUCTION: Biologic modifying agents are associated with an increased risk for infection with mycobacteria. The aim of this study is to document patients who received different biologic modifying therapies in our pediatric rheumatology department and the possibility of development of tuberculosis (TB). METHODOLOGY: This retrospective study was conducted in Ankara City Hospital. Pediatric patients who were treated with biologic modifying agents between 2010-2020 were documented...
January 31, 2024: Journal of Infection in Developing Countries
#27
JOURNAL ARTICLE
Yongchun Ruan, Minghui Li, Dan Wang, Jinnan Duan, Haiwang Zhang, Yiqing Zhou
INTRODUCTION: The spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) is a substantial severe global public health burden. Non-carbapenemase-producing CRKP (non-CP-CRKP) is increasingly recognized as the source of severe infections. METHODOLOGY: We analyzed the genotypic, and phenotypic profiles of non-CP-CRKP strains with the whole-genome sequences isolated between 2017 and 2019 and the clinical characterization of non-CP-CRKP infection. RESULTS: A total of 91 CRKP strains were collected, of which 5 (5...
January 31, 2024: Journal of Infection in Developing Countries
#28
JOURNAL ARTICLE
Haval Mohammed Khalid
INTRODUCTION: Acinetobacter baumannii (A. baumannii) is an opportunistic pathogenic bacterium mainly associated with hospital acquired infections and in immunocompromised individuals who stay in hospitals for a long time. In recent years, it has become increasingly resistant to many different types of antibiotics. The production of the metallo-beta-lactamase (MBL) enzyme is one of the primary causes of this resistance. This study aimed to detect the presence of MBL genes that belong to the verona integrin metallo-β-lactamase (bla-VIM) and imipenemase (bla-IMP) groups in the isolates of Acinetobacter baumannii from burn patients...
January 31, 2024: Journal of Infection in Developing Countries
#29
JOURNAL ARTICLE
Yu Siyu, Li Shihong, Liu Yang, Jiang Yue, Cai Fengzhu, Xiao Shaotan, Hao Lipeng, He Gengsheng
INTRODUCTION: In developing and underdeveloped countries, undernutrition plays a major role in subverting the immune system, leading to an increase in TB infections; this study investigated the associations between dietary patterns and latent tuberculosis infection risk among young adults in Shanghai. METHODOLOGY: In a case-control study, 96 cases of latent tuberculosis infection and 192 healthy controls were studied among contacts of students in clusters of tuberculosis epidemics in colleges from January 2021 to March 2023...
January 31, 2024: Journal of Infection in Developing Countries
#30
JOURNAL ARTICLE
Samir Ali, Mahde Assafi
INTRODUCTION: this study aimed to isolate P. aeruginosa and S. aureus, investigate the antimicrobial resistance of collected isolates, and investigate the distribution of exoU and mecA genes in P. aeruginosa and S. aureus isolates. METHODOLOGY: Out of 150 samples, 32 isolates were identified as P. aeruginosa, 48 isolates were identified as S. aureus. All isolates were checked for AST. Then, a PCR was applied to detect exoU and mecA genes in P. aeruginosa and S. aureus...
January 31, 2024: Journal of Infection in Developing Countries
#31
JOURNAL ARTICLE
Wen Zhu, Haowei Wang, Hai Zhou, Lei Cheng, Chao Weng
INTRODUCTION: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant rapidly appeared in Shanghai, China in early March 2022. Although a few studies have analyzed the risk factors of the severe type, identifying risk factors for non-mild COVID-19 outcomes (general/severe/critical type) which occur with radiographic evidence of pneumonia is lacking. METHODOLOGY: The COVID-19 patients admitted to a district-level designated hospital from April 26 to May 21 were enrolled in this retrospective study...
January 31, 2024: Journal of Infection in Developing Countries
#32
JOURNAL ARTICLE
Xiao Ding, Jiru Ye, Yao Tang, Feng Zhu
INTRODUCTION: To explore the association between vaccination status and the days of hospitalization in non-severe adult COVID-19 patients. METHODOLOGY: We retrospectively analyzed the 368 non-severe adult COVID-19 patients which were divided into three groups according to their vaccination status. Univariate and multivariate linear regression analysis were performed to determine the correlation between vaccination and the days of hospitalization. A generalized additive model and hierarchical linear regression model were used for outcome analysis...
January 31, 2024: Journal of Infection in Developing Countries
#33
RANDOMIZED CONTROLLED TRIAL
Sohom Ghosh, Rajesh Padhi, Samir Sahu, Meghanad Meher, Parshav Jain, Sambeet Kumar Subudhi, Jonnalagadda Vihari, Archana Samal, Anita Kumari Sahu
INTRODUCTION: By administering inferior vena cava (IVC) directed fluid, it is possible to avoid the use of additional fluid and fluid overload in patients with septic shock (SS) and sepsis-induced hypoperfusion (SIH). METHODOLOGY: In patients with SIH and SS, we conducted prospective observational research on fluid therapy. A time-motion trace of the IVC diameter was created using M-mode imaging. The ability to predict fluid responsiveness was based on the IVC collapsibility index (cIVC) > 40%...
January 31, 2024: Journal of Infection in Developing Countries
#34
JOURNAL ARTICLE
Yiyun Ni, Bin Liu, Weizhen Zhang, Shengwen Shi, Jianchao Deng
INTRODUCTION: Hemorrhagic fever with renal syndrome (HFRS) is a globally prevalent infectious disease caused by the hantavirus in rodents. CASE STUDY: This report describes a case of a 36-year-old male presenting with elevated ferritin, vitamin B12, and folic acid deficiency during the early onset phase of HFRS. Despite normal renal function at admission, the patient exhibited persistent fever and thrombocytopenia, leading to a potential misdiagnosis of an atypical HFRS presentation...
January 31, 2024: Journal of Infection in Developing Countries
#35
JOURNAL ARTICLE
Que Yang, Baojing Wu, Wenxia Wang, Ni Tan, Huarong Huang
INTRODUCTION: Disseminated bacillus Calmette-Guérin (BCG) disease is a rare but serious BCG complication in children. Early diagnosis and timely interventions are essential to improve prognosis. However, its manifestations can closely mimic those of Langerhans cell histiocytosis (LCH), which usually leads to a high rate of misdiagnoses. Herein we report the first case of successful application of biopsy tissue metagenomic next-generation sequencing (mNGS) in the differential diagnosis of disseminated BCG disease and LCH...
January 31, 2024: Journal of Infection in Developing Countries
#36
JOURNAL ARTICLE
Varsha Choudhary, Prabhat Kiran Khatri, Palak Khinvasara, Gajender Kumar Aseri, Neelam Jain
INTRODUCTION: Coronavirus disease 2019 (COVID-19) has infected millions of people globally. Many recent studies have suggested that the ABO blood type may contribute to COVID-19 infection immunopathogenesis. We aimed to determine the proportional distribution of COVID-19 infection among ABO blood types. METHODOLOGY: This retrospective research was conducted in the city of Jodhpur (Rajasthan), India. The research involved 1140 COVID-19 patients, whose medical records were available in blood banks...
January 31, 2024: Journal of Infection in Developing Countries
#37
JOURNAL ARTICLE
Hani Nasr, Marwah Al-Zumair, Taha Al-Mahbashi, Fekri Dureab
INTRODUCTION: The emergence of cholera in 2016 in Yemen, worsened the morbidity and mortality of diarrheal diseases, particularly among children under five. Multiple outbreaks in Yemen are triggered by years of conflict and the collapse of basic infrastructure including water supply and sanitation systems. This study aims to assess factors associated with the cholera outbreak, in a cholera-prone region, in Al-Mahweet, Yemen. METHODOLOGY: We conducted a multivariate analysis of the data collected through a household survey of 384 households in Al-Mahweet, Yemen...
January 31, 2024: Journal of Infection in Developing Countries
#38
JOURNAL ARTICLE
Gholamreza Barzgar, Ehsan Ahmadpour, Mohammad Hasan Kohansal, Sirous Mehrani Moghaddam, Tohid Jafari Koshki, Aleksandra Barac, Veeranoot Nissapatorn, Alok K Paul, Jelena Micić
INTRODUCTION: Toxoplasma gondii is an obligate intracellular parasite affecting a broad range of warm-blooded animals, including humans. Infection acquired during pregnancy can be transmitted to the fetus and leading to serious problems such as spontaneous abortion, stillbirth, or severe mental and/or physical handicaps in the child. The purpose of this study was to investigate the seroprevalence of Toxoplasma infection and related risk factors in pregnant woman. METHODOLOGY: The study enrolled 1200 serum samples of pregnant women from February-November 2017...
January 31, 2024: Journal of Infection in Developing Countries
#39
JOURNAL ARTICLE
Yeliz Çiçek, Hıdır Sarı, Duygu İmre Yetkin, Mehmet Özel
INTRODUCTION: Coinfection of COVID-19 with influenza pathogens, may complicate the diagnosis, treatment, and prognosis, which is a new concern. This study aims to evaluate COVID-19 and influenza coinfected cases during the flu season, while the SARS-CoV-2 pandemic continues. METHODOLOGY: The study was conducted between November 2021 and January 2022. A total of 1987 (1752 outpatients, 235 inpatients) patients were included, and 44 simultaneous COVID-19 and influenza laboratory-confirmed diagnoses...
January 31, 2024: Journal of Infection in Developing Countries
#40
JOURNAL ARTICLE
Claudiu Nanu, Liana Adela Ciocan, Georgiana Radu, Liliana Sumedrea, Gabriel Adrian Popescu, Alina Maria Borcan
A 22-year-old male, with a history of recreational drug use, was admitted with a 24-hour history of sore throat, bilateral otalgia, fever, chills, sweats, and pain in the upper chest. The blood cultures were positive for Fusobacterium necrophorum. A thoracic and neck soft tissue computed tomography (CT) scan revealed an intratonsillar abscess and pulmonary septic emboli. Initial treatment with Piperacillin-tazobactam and Clindamycin was de-escalated after 5 days. The patient made a complete recovery after 22 days of antibiotic treatment...
January 31, 2024: Journal of Infection in Developing Countries
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