Bo Yu, Alex Costa, Yang Zhao
No abstract text is available yet for this article.
February 16, 2024: Journal of Genetics and Genomics
Zhujuan Huang, Yongtai Xu, Zhongkai Qiu, Yunyun Jiang, Jiaye Wu, Qing Lin, Sicong He, Jianan Y Qu, Jiahao Chen, Jin Xu
No abstract text is available yet for this article.
February 13, 2024: Journal of Genetics and Genomics
Chaolong Wang, Xiaowen Yu, Jian Wang, Zhigang Zhao, Jianmin Wan
Heterosis, also known as hybrid vigor, is commonly observed in rice crosses. The hybridization of rice species or subspecies exhibits robust hybrid vigor, however, the direct harnessing of this vigor is hindered by reproductive isolation. Here, we review recent advances in understanding of the molecular mechanisms governing reproductive isolation in inter-subspecific and inter-specific hybrids. This review encompasses the genetic model of reproductive isolation within and among Oryza sativa species, emphasizing the essential role of mitochondria in this process...
February 5, 2024: Journal of Genetics and Genomics
Daolei Zhang, Yujun Gan, Liang Le, Li Pu
Epigenetics-mediated breeding (Epibreeding) involves engineering crop traits and stress responses through targeted manipulation of key epigenetic features to enhance agricultural productivity. While conventional breeding methods raise concerns about reduced genetic diversity, epibreeding propels crop improvement through epigenetic variations that regulate gene expression, ultimately impacting crop yield. Epigenetic regulation in crops encompasses various modes, including histone modification, DNA modification, RNA modification, non-coding RNA, and chromatin remodeling...
February 2, 2024: Journal of Genetics and Genomics
Botao Ye, Yangyang Liu, Ziying Wang, Liping Shen, Changbin Yin, Kuocheng Shen, Jiaqiang Sun, Xiaowan Xu, Mengjing Sun, Jianhui Wu, Zhonghu He, Xuchang Yu, Fei Lu, Yuanfeng Hao, Zifeng Guo
No abstract text is available yet for this article.
January 29, 2024: Journal of Genetics and Genomics
Meilin Jin, Gang Liu, Jian Lu, Zhiqiang Chen, Huihua Wang, Taotao Li, Caihong Wei
No abstract text is available yet for this article.
January 26, 2024: Journal of Genetics and Genomics
Shihui Ding, Tursunjan Aziz, Anming Meng, Shunji Jia
Clathrin-mediated endocytosis has been implicated in various physiological processes, including nutrient uptake, signal transduction, synaptic vesicle recycling, maintenance of cell polarity, and antigen presentation. Despite prior knowledge of its importance as a key regulator in promoting clathrin-mediated endocytosis, the physiological function of α- and γ-adaptin binding protein (aagab) remains elusive. In this study, we investigate the biological function of aagab during zebrafish development...
January 20, 2024: Journal of Genetics and Genomics
Ruihui Lu, Jingwen Zhu, Xin Li, Cheng Zeng, Yan Huang, Chao Peng, Yingfang Zhou, Qing Xue
Endometriosis refers to as an estrogen-dependent disease. Estrogen receptor β (ERβ), the main estrogen receptor subtype which is encoded by the estrogen receptor 2 (ESR2) gene, can mediate the action of estrogen in endometriosis. Although selective estrogen receptor modulators can target ERβ, they are not specific due to the wide distribution of ERβ. Recently, long noncoding RNAs have been implicated in endometriosis. Therefore, we aim to explore and validate the downstream regulatory mechanism of ERβ, and to investigate the potential role of long intergenic noncoding RNA 1018 (LINC01018) as a nonhormonal treatment for endometriosis...
January 13, 2024: Journal of Genetics and Genomics
Linggang Zheng, Juntao Shen, Ruiyue Chen, Yucan Hu, Wei Zhao, Elaine Lai-Han Leung, Lei Dai
The human gut microbiome, a complex ecosystem, significantly influences host health, impacting crucial aspects such as metabolism and immunity. To deepen our comprehension and control of the molecular mechanisms orchestrating the intricate interplay between gut commensal bacteria and human health, the exploration of genome engineering for gut microbes is a promising frontier. Nevertheless, the complexities and diversities inherent in the gut microbiome pose substantial challenges to the development of effective genome engineering tools for human gut microbes...
January 11, 2024: Journal of Genetics and Genomics
Danhui Ruan, Jiancheng Xu, Yang Liu, Juan Luo, Xuyang Zhao, Yuhua Li, Guangxi Wang, Jiawen Feng, Hui Liang, Yue Yin, Jianyuan Luo, Yuxin Yin
PTEN is a multifunctional gene that is involved in a variety of physiological and pathological processes. Circular RNAs (circRNAs) are generated from back-splicing events during mRNA processing and participate in cell biological processes through binding to RNAs or proteins. However, PTEN-related circRNAs are largely unknown. Here we report that circPTEN-MT (hsa_circ_0002934) is a circular RNA encoded by exons 3, 4, and 5 of PTEN and is a critical regulator of mitochondrial energy metabolism. CircPTEN-MT is localized to mitochondria and physically associated with leucine-rich pentatricopeptide repeat-containing protein (LRPPRC), which regulates posttranscriptional gene expression in mitochondria...
January 4, 2024: Journal of Genetics and Genomics
Ke Wu, Fengxiao Bu, Yang Wu, Gen Zhang, Xin Wang, Shunmin He, Mo-Fang Liu, Runsheng Chen, Huijun Yuan
Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies...
January 3, 2024: Journal of Genetics and Genomics
Ting Hu, Lan Liu, He Wang, Mei Yang, Bocheng Xu, Hanbing Xie, Ziyuan Lin, Xiaolei Jin, Ping Wang, Yanyan Liu, Huaqin Sun, Shanling Liu
Noncompaction of the ventricular myocardium (NVM), the third most diagnosed cardiomyopathy, is characterized by prominent trabeculae and intratrabecular recesses. However, the genetic etiology of 40-60% of NVM cases remains unknown. We identified two infants with NVM, in a nonconsanguineous family, with a typical clinical presentation of persistent bradycardia since the prenatal period. A homozygous missense variant (R223L) of RCAN family member 3 (RCAN3) was detected in both infants using whole-exome sequencing...
January 3, 2024: Journal of Genetics and Genomics
Yan Shi, Chunyan Cao, Yiheng Zeng, Yuanliang Ding, Long Chen, Fuze Zheng, Xuejiao Chen, Fanggui Zhou, Xiefeng Yang, Jinjing Li, Liuqing Xu, Guorong Xu, Minting Lin, Hiroyuki Ishiura, Shoji Tsuji, Ning Wang, Zhiqiang Wang, Wanjin Chen, Kang Yang
CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with leukoencephalopathy. However, since only three patients from a single family were reported, it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/NUTM2B-AS1. Here, using repeat-primed PCR and long-read sequencing, we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1, typically presenting with oculopharyngodistal myopathy...
December 28, 2023: Journal of Genetics and Genomics
Chang Ye, Tian-Zi Zhang, Yan-Yu Zang, Yun Stone Shi, Guoqiang Wan
No abstract text is available yet for this article.
December 27, 2023: Journal of Genetics and Genomics
Yeming Yang, Xiaoyan Jiang, Junyao Chen, Lu Liu, Guo Liu, Kuanxiang Sun, Wenjing Liu, Xianjun Zhu, Qiuyue Guan
Inherited retinal dystrophies (IRDs) are major causes of visual impairment and irreversible blindness worldwide, while the precise molecular and genetic mechanisms are still unexclusive. N6 -methyladenosine (m6 A) modification is the most prevalent internal modification in eukaryotic mRNA. YTH domain containing 2 (YTHDC2), an m6 A reader protein, has recently been identified as a key player in germline development and human cancer. However, its contribution to retinal function remains unknown. Here, we explore the role of YTHDC2 in visual function of retinal rod photoreceptors by generating rod-specific Ythdc2 knockout mice...
December 27, 2023: Journal of Genetics and Genomics
Xiaoshu Feng, Sihan Liu, Ke Li, Fengxiao Bu, Huijun Yuan
The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. Therefore, it is urgent to improve the diagnostic yield by exploring the pathogenic mechanisms of variants in non-coding regions. However, the interpretation of non-coding variants remains a significant challenge, due to the complex functional regulatory mechanisms of non-coding regions and the current limitations of available databases and tools...
December 22, 2023: Journal of Genetics and Genomics
Jierong Wang, Yuxi Peng, Yiwen Xu, Zhiru Li, Gangming Zhan, Zhensheng Kang, Jing Zhao
No abstract text is available yet for this article.
December 19, 2023: Journal of Genetics and Genomics
Ming Jin, Jiajia Lin, Yu Zhang, Qingquan Xiao, Xiangfeng Kong, Xiumei Zhang, Zhurui Shao, Yin Wang, Yuyang Yu, Jinjing Li, Wan-Jin Chen, Guoling Li, Hui Yang, Ning Wang
No abstract text is available yet for this article.
December 14, 2023: Journal of Genetics and Genomics
Yuhong Huang, Qinghua Shi, Chen Zhou, Chunhui Wang, Yang Liu, Congyang Yi, Handong Su, Fangpu Han
No abstract text is available yet for this article.
December 7, 2023: Journal of Genetics and Genomics
Xin Li, Quan Liu, Chong Fu, Mengxun Li, Changchun Li, Xinyun Li, Shuhong Zhao, Zhuqing Zheng
Structural variants (SVs), such as deletions (DELs) and insertions (INSs), contribute substantially to pig genetic diversity and phenotypic variation. Using a library of SVs discovered from long-read (LR) primary assemblies and short-read (SR) sequenced genomes, we map pig genomic SVs with a graph-based method for re-genotyping SVs in 402 genomes. Our results demonstrate that those SVs harboring specific trait-associated genes may greatly shape pig domestication and local adaptation. Further characterization of SVs reveals that some population-stratified SVs may alter the transcription of genes by affecting regulatory elements...
December 4, 2023: Journal of Genetics and Genomics
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