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Journal of Genetics and Genomics, Yi Chuan Xue Bao

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https://read.qxmd.com/read/30745214/defining-gene-networks-controlling-the-maintenance-and-function-of-the-differentiation-niche-by-an-in-vivo-systematic-rnai-screen
#1
Yuan Gao, Ying Mao, Rong-Gang Xu, Ruibao Zhu, Ming Zhang, Jin Sun, Da Shen, Ping Peng, Ting Xie, Jian-Quan Ni
In the Drosophila ovary, escort cells (ECs) extrinsically control germline stem cell (GSC) maintenance and progeny differentiation. However, the underlying mechanisms remain poorly understood. In this study, we identified 173 EC genes for their roles in controlling GSC maintenance and progeny differentiation by using an in vivo systematic RNAi approach. Of the identified genes, 10 and 163 are required in ECs to promote GSC maintenance and progeny differentiation, respectively. The genes required for progeny differentiation fall into different functional categories, including transcription, mRNA splicing, protein degradation, signal transduction and cytoskeleton regulation...
January 30, 2019: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30733188/generation-of-marker-free-transgenic-rice-using-crispr-cas9-system-controlled-by-floral-specific-promoters
#2
LETTER
Junjie Wang, Chun Wang, Kejian Wang
No abstract text is available yet for this article.
January 28, 2019: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30745213/whole-brain-patterns-of-the-presynaptic-inputs-and-axonal-projections-of-bdnf-neurons-in-the-paraventricular-nucleus
#3
Fang Luo, Yuling Mu, Cuicui Gao, Yan Xiao, Qian Zhou, Yiqing Yang, Xinyan Ni, Wei L Shen, Jiajun Yang
Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions...
January 26, 2019: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30737149/osspl18-controls-grain-weight-and-grain-number-in-rice
#4
Hua Yuan, Peng Qin, Li Hu, Shijie Zhan, Shifu Wang, Peng Gao, Jing Li, Mengya Jin, Zhengyan Xu, Qiang Gao, Anping Du, Bin Tu, Weilan Chen, Bingtian Ma, Yuping Wang, Shigui Li
Grain weight and grain number are two important traits directly determining grain yield in rice. To date, a lot of genes related to grain weight and grain number have been identified; however, the regulatory mechanism underlying these genes remains largely unknown. In this study, we studied the biological function of OsSPL18 during grain and panicle development in rice. Knockout (KO) mutants of OsSPL18 exhibited reduced grain width and thickness, panicle length and grain number, but increased tiller number...
January 23, 2019: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30679103/engineering-stable-heterosis
#5
LETTER
Yingxiang Wang
No abstract text is available yet for this article.
January 11, 2019: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30733189/the-histone-h4k20-methyltransferase-pr-set7-fine-tunes-the-transcriptional-activation-of-wingless-signaling-in-drosophila
#6
LETTER
Yun Yu, Long Liu, Xiaojiao Li, Xingjie Hu, Haiyun Song
No abstract text is available yet for this article.
January 8, 2019: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30606471/identification-and-characterization-of-rice-blast-resistance-gene-pid4-by-a-combination-of-transcriptomic-profiling-and-genome-analysis
#7
Zhixiong Chen, Wen Zhao, Xiaobo Zhu, Chengdong Zou, Junjie Yin, Mawsheng Chern, Xiaogang Zhou, Heng Ying, Xin Jiang, Yongzhen Li, Haicheng Liao, Mengping Cheng, Weitao Li, Min He, Jing Wang, Jichun Wang, Bingtian Ma, Jirui Wang, Shigui Li, Lihuang Zhu, Xuewei Chen
Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat (CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast...
December 31, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30594466/drosophila-homolog-of-the-intellectual-disability-related-long-chain-acyl-coa-synthetase-4-is-required-for-neuroblast-proliferation
#8
Mingyue Jia, Danqing Meng, Mo Chen, Tingting Li, Yong Q Zhang, Aiyu Yao
Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic X-linked intellectual disability (ID). However, the neural functions of ACSL4 and how loss of ACSL4 leads to ID remain largely unexplored. We report here that mutations in Acsl, the Drosophila ortholog of human ACSL3 and ACSL4, result in developmental defects of the mushroom body (MB), the center of olfactory learning and memory. Specifically, Acsl mutants show fewer MB neuroblasts (Nbs) due to reduced proliferation activity and premature differentiation...
December 26, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30595471/generating-a-reporter-mouse-line-marking-medium-spiny-neurons-in-the-developing-striatum-driven-by-arpp21-cis-regulatory-elements
#9
LETTER
Pan Chen, Xiangbin Ruan, Yongqiang Chen, Shilong Chu, Kunlun Mo, Chao Wu, Wei Liu, Bin Yin, Junjie Zhou, Liang Li, Lin Hou, Jiangang Yuan, Boqin Qiang, Jiekai Chen, Pengcheng Shu, Xiaozhong Peng
No abstract text is available yet for this article.
December 10, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30595472/loss-of-mir-83-extends-lifespan-and-affects-target-gene-expression-in-an-age-dependent-manner-in-caenorhabditis-elegans
#10
Emmanuel Enoch Dzakah, Ahmed Waqas, Shuai Wei, Bin Yu, Xiaolin Wang, Tao Fu, Lei Liu, Ge Shan
MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the post-transcriptional regulation of protein-coding genes. miRNAs modulate lifespan and the aging process in a variety of organisms. In this study, we identified a role of miR-83 in regulating lifespan of Caenorhabditis elegans. mir-83 mutants exhibited extended lifespan, and the overexpression of miR-83 was sufficient to decrease the prolonged lifespan of the mutants. We observed upregulation of the expression levels of a set of miR-83 target genes in young mir-83 mutant adults; while different sets of genes were upregulated in older mir-83 mutant adults...
December 9, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30745215/homozygous-loss-of-function-mutations-in-fsip2-cause-male-infertility-with-asthenoteratospermia
#11
LETTER
Wangjie Liu, Huan Wu, Li Wang, Xiaoyu Yang, Chunyu Liu, Xiaojin He, Weiyu Li, Jiajia Wang, Yujie Chen, Hongyan Wang, Yang Gao, Shuyan Tang, Shenmin Yang, Li Jin, Feng Zhang, Yunxia Cao
No abstract text is available yet for this article.
December 6, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30594465/wdr74-functions-as-a-novel-coactivator-in-tgf-%C3%AE-signaling
#12
Jinquan Liu, Meiling Zhao, Bo Yuan, Shuchen Gu, Mingjie Zheng, Jian Zou, Jianping Jin, Ting Liu, Xin-Hua Feng
Smads are critical intracellular signal transducers for transforming growth factor-β (TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74 (WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-β signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-β-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-β-induced physiological responses...
November 27, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30683256/the-10-th-national-congress-of-genetic-society-of-china-celebrating-its-40-th-anniversary-in-nanjing
#13
LETTER
Ying Zhang, Chi Xu, Yubo Han, Xiaofang Chen, Yan Zhang, Mingjie Xiao
No abstract text is available yet for this article.
December 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30482272/an-overview-of-rice-genetics-research-in-china
#14
EDITORIAL
James A Birchler
No abstract text is available yet for this article.
November 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30482271/highlights-of-genetics-research-over-the-past-four-decades-in-china
#15
EDITORIAL
Yongbiao Xue, Yaping Zhang
No abstract text is available yet for this article.
November 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30459119/the-forty-years-of-medical-genetics-in-china
#16
REVIEW
Lei Cai, Lan Alice Zheng, Lin He
Medical genetics is the newest cutting-edge discipline that focuses on solving medical problems using genetics knowledge and methods. In China, medical genetics research activities initiated from a poor inner basis but a prosperous outer environment. During the 40 years of reform and opening-up policy, Chinese scientists contributed significantly in the field of medical genetics, garnering considerable attention worldwide. In this review, we highlight the significant findings and/or results discovered by Chinese scientists in monogenic diseases, complex diseases, cancer, genetic diagnosis, as well as gene manipulation and gene therapy...
November 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30459118/the-molecular-and-evolutionary-basis-of-reproductive-isolation-in-plants
#17
REVIEW
Yidan Ouyang, Qifa Zhang
Reproductive isolation is defined as processes that prevent individuals of different populations from mating, survival or producing fertile offspring. Reproductive isolation is critical for driving speciation and maintaining species identity, which has been a fundamental concern in evolutionary biology. In plants, reproductive isolation can be divided into prezygotic and postzygotic reproductive barriers, according to its occurrence at different developmental stages. Postzygotic reproductive isolation caused by reduced fitness in hybrids is frequently observed in plants, which hinders gene flow between divergent populations and has substantial effects on genetic differentiation and speciation, and thus is a major obstacle for utilization of heterosis in hybrid crops...
November 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30455039/conservation-genetics-and-genomics-of-threatened-vertebrates-in-china
#18
REVIEW
Huizhong Fan, Yibo Hu, Qi Wu, Yonggang Nie, Li Yan, Fuwen Wei
Conservation genetics and genomics are two independent disciplines that focus on using new techniques in genetics and genomics to solve problems in conservation biology. During the past two decades, conservation genetics and genomics have experienced rapid progress. Here, we summarize the research advances in the conservation genetics and genomics of threatened vertebrates (e.g., carnivorans, primates, ungulates, cetaceans, avians, amphibians and reptiles) in China. First, we introduce the concepts of conservation genetics and genomics and their development...
November 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30455038/a-legacy-of-the-1-program-the-chinese-chapter-of-the-human-genome-reference-sequence
#19
LETTER
Wei Dong, Xiaoling Wang, Zhi Xia, Xiuqing Zhang, Huanming Yang
No abstract text is available yet for this article.
November 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30455037/fruit-fly-research-in-china
#20
REVIEW
Ying Cheng, Dahua Chen
Served as a model organism over a century, fruit fly has significantly pushed forward the development of global scientific research, including in China. The high similarity in genomic features between fruit fly and human enables this tiny insect to benefit the biomedical studies of human diseases. In the past decades, Chinese biologists have used fruit fly to make numerous achievements on understanding the fundamental questions in many diverse areas of biology. Here, we review some of the recent fruit fly studies in China, and mainly focus on those studies in the fields of stem cell biology, cancer therapy and regeneration medicine, neurological disorders and epigenetics...
November 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
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