journal
https://read.qxmd.com/read/36928738/top-10-significant-spindled-head-and-neck-lesions-to-scrutinze
#101
REVIEW
Aaron M Udager
BACKGROUND: Spindled lesions are a challenging area in head and neck pathology. This is particularly true in the sinonasal tract, where several uncommon entities with both unique and overlapping morphologic, immunophenotypic, and/or molecular features can occur. METHODS: Review. RESULTS: The clinicopathologic characteristics of biphenotypic sinonasal sarcoma and nine important differential diagnostic considerations with one or more overlapping feature are summarized to establish a practical framework for approaching spindled lesions of the sinonasal tract...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928737/top-10-differential-diagnoses-for-desmoplastic-melanoma
#102
REVIEW
Angel Fernandez-Flores, Rajendra Singh, David S Cassarino
BACKGROUND: Desmoplastic melanoma is a rare subtype of melanoma mainly appearing on sun-exposed skin. Clinically, it is many times non-pigmented and therefore the diagnosis is often not suspected. METHODS: Review article. RESULTS: In this paper we review the main histopathological, immunohistochemical, and molecular features of desmoplastic melanoma, as well as the top 10 morphologic differential diagnoses which should be considered in most cases...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928736/cystic-lesions-of-the-jaws-the-top-10-differential-diagnoses-to-ponder
#103
REVIEW
Anne C McLean, Pablo A Vargas
BACKGROUND: Cystic lesions of the gnathic bones present challenges in differential diagnosis. This category includes a smorgasbord of odontogenic and non-odontogenic entities that may be reactive or neoplastic in nature. While most cystic jaw lesions are benign, variability in biologic behavior makes distinction between these entities absolutely crucial. METHODS: Review. RESULTS: Two clinical cases are presented in parallel and are followed by an illustrated discussion of the ten most likely differential diagnoses that should be considered when confronted with a cystic jaw lesion...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928735/top-ten-oncocytic-head-and-neck-lesions-to-contemplate
#104
REVIEW
Martin J Bullock, Xiaoyin S Jiang
BACKGROUND: Oncocytes are a component of many metaplastic and neoplastic lesions throughout the head and neck area, primarily originating in salivary/seromucinous glands and the thyroid gland. In addition, other lesions can contain cells that mimic oncocytes (pseudo-oncocytes); these can be of epithelial or non-epithelial origin. METHODS: Review article. RESULTS: Oncocytic metaplasia is common in seromucinous glands throughout the upper aerodigestive tract, most notable in the oral cavity, nasopharynx and larynx...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928734/top-10-clear-cell-head-and-neck-lesions-to-contemplate
#105
REVIEW
Nicole A Cipriani, Aanchal Kakkar
BACKGROUND: Optically clear cytoplasm may occur in neoplastic and non-neoplastic conditions, either as a characteristic feature of a disease entity or as a morphologic rarity, potentially creating diagnostic dilemmas in various organ systems. In the head and neck, clear cell change can occur in lesions of salivary, odontogenic, thyroid, parathyroid, or sinonasal/skull base origin, as well as in metastases to these regions. METHODS: This review elaborates the top ten clear cell lesions in the head and neck, emphasizing their distinguishing histologic, immunohistochemical, and molecular attributes, and presents a rational approach to arriving at an accurate classification...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928733/top-ten-differentials-to-mull-over-for-head-and-neck-myoepithelial-neoplasms
#106
REVIEW
Lester D R Thompson, Bin Xu
BACKGROUND: Myoepithelial neoplasms of the salivary gland are benign or malignant neoplasms composed exclusively of neoplastic myoepithelial cells. These tumors, including the benign myoepithelioma and the malignant counterpart myoepithelial carcinoma, exhibit a wide range of cytomorphologic features and architectural patterns. METHODS: Review. RESULTS: Myoepithelial cells can be epithelial, plasmacytoid, clear cell, spindle cell, and/or oncocytic cell, arranging as trabeculae, solid sheets, nests, cords, and/or single cells...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928732/top-10-basaloid-neoplasms-of-the-sinonasal-tract
#107
REVIEW
Martina Baněčková, Darren Cox
BACKGROUND: Basaloid neoplasms of the sinonasal tract represent a significant group of tumors with histological overlap but often with different etiologies (i.e., viral, genetics), clinical management, and prognostic significance. METHODS: Review. RESULTS: "Basaloid" generally refers to cells with coarse chromatin in round nuclei and sparse cytoplasm, resembling cells of epithelial basal layers or imparting an "immature" appearance. Tumors with this characteristic in the sinonasal tract are represented by a spectrum of benign to high-grade malignant neoplasms, such as adenoid cystic carcinoma, NUT carcinoma, sinonasal undifferentiated carcinoma, SWI/SNF complex-deficient carcinomas, and adamantinoma-like Ewing sarcoma...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36849672/wpoi-5-accurately-identified-at-intraoperative-consultation-and-predictive-of-occult-cervical-metastases
#108
JOURNAL ARTICLE
John E Beute, Lily A Greenberg, Lauren E Wein, Danielle A Kapustin, Jun Fan, Eric M Dowling, Shabnam Samankan, Ammar Matloob, Monica Xing, Ippolito Modica, Daniel Chung, William Carroll, Eben L Rosenthal, Mohemmed Nazir Khan, Raymond L Chai, Margaret S Brandwein-Weber, Mark L Urken
BACKGROUND: Frozen section analysis of oral cancer specimens is ideal for assessing margin distances and depth of invasion (DOI); the latter impacts intraoperative decisions regarding elective neck dissection (END). Here, we show that intraoperative determination of worst pattern of invasion (WPOI), specifically WPOI-5, has a high level of accuracy. This relates to our demonstration herein that WPOI-5 predicts occult cervical metastases (OCM) for pT1 oral squamous carcinoma (OSC). METHODS: The presence of OCM was correlated with WPOI in 228 patients with primary T1/T2/cN0 OSC undergoing resection and END...
February 28, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36849671/sinonasal-adenosquamous-carcinoma-morphology-and-genetic-drivers-including-low-and-high-risk-human-papillomavirus-mrna-dek-aff2-fusion-and-maml2-rearrangement
#109
JOURNAL ARTICLE
Dean Holliday, Mitra Mehrad, Kim A Ely, Fangjia Tong, Xiaowei Wang, Jen-Fan Hang, Ying-Ju Kuo, Jaylou M Velez-Torres, Abberly Lott-Limbach, James S Lewis
BACKGROUND: Sinonasal adenosquamous carcinoma is rare, and there are almost no studies detailing morphology or characterizing their genetic driver events. Further, many authors have termed sinonasal tumors with combined squamous carcinoma and glands as mucoepidermoid carcinoma but none have analyzed for the presence of MAML2 rearrangement. METHODS: Cases from 2014 to 2020 were collected and diagnosed using World Health Organization criteria. They were tested for p16 expression by immunohistochemistry (70% cut-off), DEK::AFF2 fusion by fluorescence in situ hybridization (FISH) and AFF2 immunohistochemistry, MAML2 rearrangement by FISH, and low- and high-risk HPV by RNA ISH and reverse transcription PCR, respectively...
February 28, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36849670/mucous-membrane-pemphigoid-following-the-administration-of-covid-19-vaccine
#110
LETTER
Dulyapong Rungraungrayabkul, Nattha Rattanasiriphan, Rachai Juengsomjit
No abstract text is available yet for this article.
February 28, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36746884/nkx3-1-expression-and-molecular-characterization-of-secretory-myoepithelial-carcinoma-smca-advancing-the-case-for-a-salivary-mucous-acinar-phenotype
#111
JOURNAL ARTICLE
Simmi Patel, Abigail I Wald, Jassem M Bastaki, Simon I Chiosea, Aatur D Singhi, Raja R Seethala
BACKGROUND: Secretory myoepithelial carcinomas (SMCA) are rare, mucinous, signet ring predominant tumors with primitive myoepithelial features. While many mucinous salivary gland tumors have now been molecularly characterized, key drivers in SMCA have yet to be elucidated. Recently, NKX3.1, a homeodomain transcription factor implicated in salivary mucous acinar development was also shown in a subset of salivary mucinous neoplasms, salivary intraductal papillary mucinous neoplasms (SG-IPMN)...
February 6, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723854/hamartomatous-polyp-of-the-palatine-tonsil-a-case-report-and-critical-literature-review
#112
JOURNAL ARTICLE
Gleyson Kleber do Amaral-Silva, Jhennyfer Ribeiro-Brizola, Áthilla Arcari Santos, Silvia Roberta Cieslak-Sanches, Gabriela Moura Chicrala, Ellen Cristina Gaetti-Jardim, Daniella Moraes Antunes
BACKGROUND: Hamartomatous polyp of the palatine tonsil is a rare benign tumor poorly recognized by clinicians and pathologists. We present a novel case report and provide a literature review about this diagnosis, highlighting its clinicopathological features and treatment modalities. METHODS: We herein report a case of a 22-year-old female patient who complained of a foreign body sensation in her throat. She presented with a pedunculated polyp attached to her right palatine tonsil, which was noticed 15 years ago...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723853/relationship-between-worst-pattern-of-invasion-and-extranodal-extension-in-oral-tongue-squamous-cell-carcinomas
#113
JOURNAL ARTICLE
Mayuri Yasuda, Celina Chiodo, Cullen Lilley, Swati Mehrotra, Vijayalakshmi Ananthanarayanan, Andrea Ziegler, Eric Thorpe
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy of the oral cavity with poor survival rates. The aim of this project is to investigate the relationship between certain histopathological factors such as Worst Pattern of Invasion (WPOI) and Extranodal Extension (ENE) in patients with oral tongue squamous cell carcinoma (OTSCC) who underwent surgical resection at Loyola University Medical Center. METHODS: This was a retrospective cohort study at a tertiary care academic medical center...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723851/congenital-melanotic-macule-of-the-tongue-report-of-two-cases-and-literature-review
#114
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Rosanna Gómez, Verónica Bracho, Israel Leal Cavalcante, Ricardo Pérez-Alfonzo, Mariana Villarroel-Dorrego, Bruno Augusto Benevenuto de Andrade
BACKGROUND: Congenital melanotic macule of the tongue (CMMT) has been described as a distinct entity, despite its unknown etiology. However, the diagnosis and management of affected newborns may challenge clinicians and pediatric dentists. METHODS: We document here the clinicopathological findings of two additional cases of CMMT. A literature review of CMMT reports identified across PubMed, Web of Science, Embase, and Scopus was also conducted. RESULTS: The patients, 2- and 4 month-old Venezuelan boys, respectively, presented at birth with a single or multiple dark-brown-pigmented macule exclusively on the dorsum of the tongue...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723850/prognostic-impact-of-tumor-immune-microenvironment-and-its-predictive-role-in-salivary-gland-cancer
#115
REVIEW
Maria Vittoria Veneroni, Bianca Maria Festa, Andrea Costantino, Giuseppe Spriano, Giuseppe Mercante, Armando De Virgilio, Luca Di Tommaso
BACKGROUND: Recently, many studies have investigated the role of tumor immune microenvironment (TIME) in carcinogenesis, highlighting its relation to both tumor regression and progression. In particular, the "inflammatory system", made of innate and adaptive immune cells, interacts with cancer cells and their surrounding stroma. In this setting, the aim of this review is to summarize the current literature regarding the TIME of major salivary gland carcinomas (MSGCs), with particular attention on the characteristics and prognostic role of tumor infiltrating lymphocytes (TILs), the mechanisms that lead to TILs exhaustion and the important additional immune infiltrating factors that help SGC progression or remission...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723849/the-true-history-of-cementoblastoma
#116
JOURNAL ARTICLE
Fumio Ide, Shinnichi Sakamoto, Yuji Miyazaki, Miyako Hoshino, Michiko Nishimura, Takashi Muramatsu, Kentaro Kikuchi
Cementoblastoma (CB) is unique among odontogenic tumors because its gross pathological anatomy is pathognomonic in most cases, i.e., a rounded calcified growth that is fused to the root of a tooth and completely encapsulated by fibrous tissue. The resulting radiographic appearance is a well-defined, globular mixed radiopaque/lucent or completely radiopaque mass obliterating some details of the root, with a thin radiolucent zone surrounding the central opacity. Although hundreds of publications have covered the clinicopathologic features of CB, almost nothing is known about its true history...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36622533/respiratory-epithelial-adenomatoid-hamartoma
#117
JOURNAL ARTICLE
Ashley F Schemel, Katherine M Zamperini, Karl A Soderlund, Kevin R Torske, Gregory G Capra
BACKGROUND: Respiratory Epithelial Adenomatoid Hamartoma (REAH) is an uncommon, benign tumor of the sinonasal tract. It can, however, be confused with a sinonasal malignancy causing undo morbidity to patients. Therefore, the clinical as well as histological diagnosis is crucial in order to correctly care for patients. METHODS: This review of a patient, to include their clinical pictures, radiologic pictures, and histologic pictures, allow for the clinician to accurately evaluate and diagnose REAH...
January 9, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36586079/cancer-microenvironment-defines-tumor-infiltrating-lymphocyte-density-and-tertiary-lymphoid-structure-formation-in-laryngeal-cancer
#118
JOURNAL ARTICLE
Anastasia G Gkegka, Michael I Koukourakis, Michael Katotomichelakis, Alexandra Giatromanolaki
BACKGROUND: The presence and activity of tumor-infiltrating lymphocytes (TILs) is a key parameter related to the antitumor immune response. A large number of studies reveal TIL density as a prognostic marker and predictor of response to radiotherapy, chemotherapy, and immunotherapy. METHODS: We examined the TIL and tertiary lymphoid structure TLS density in the invading front and inner tumor stroma, in a 33 squamous cell laryngeal carcinomas (LSCC) treated with laryngectomy...
December 31, 2022: Head and Neck Pathology
https://read.qxmd.com/read/36586078/prame-staining-in-sinonasal-mucosal-melanoma-a-single-center-experience
#119
JOURNAL ARTICLE
W F Julius Scheurleer, W Weibel Braunius, Bernard M Tijink, Karijn P M Suijkerbuijk, Miranda P Dierselhuis, Ruud W J Meijers, Willeke A M Blokx, Remco de Bree, Gerben E Breimer, Johannes A Rijken
BACKGROUND: Sinonasal mucosal melanoma (MM) is a rare, aggressive melanoma subtype. Complete surgical excision, with or without adjuvant radiotherapy, remains the cornerstone of treatment and yields adequate locoregional control. Metastatic MM is managed similarly to metastatic cutaneous melanoma but with poorer survival. PReferentially expressed Antigen in MElanoma (PRAME) has been identified as a potential diagnostic marker and therapeutic target in the treatment of cutaneous melanoma...
December 31, 2022: Head and Neck Pathology
https://read.qxmd.com/read/36586077/prognostic-genomic-markers-of-pathological-stage-in-oral-squamous-cell-carcinoma
#120
JOURNAL ARTICLE
Su Kyung Kuk, Jae Il Lee, Kitae Kim
BACKGROUND: To identify the prognostic markers of oral squamous cell carcinoma (OSCC), the genetic heterogeneity of the pathological stages was investigated. METHODS: The data of 295 patients with primary OSCC obtained from the Cancer Genome Atlas were studied. The genetic prognostic landscape of the pathological stages was systematically analyzed by Cox regressions, Fisher's exact tests, and Gene Ontology (GO) enrichment. RESULTS: Stage 4 patients had a poor prognosis in univariate and multivariate Cox models...
December 31, 2022: Head and Neck Pathology
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