journal
https://read.qxmd.com/read/37843734/qualitative-assessment-of-collagen-and-elastic-fibers-in-oral-submucous-fibrosis-osmf-osmf-with-dysplasia-and-oral-squamous-cell-carcinoma-arising-from-osmf-a-histochemical-study
#81
JOURNAL ARTICLE
Deepak Pandiar, E Aswani, Reshma Poothakulath Krishnan
BACKGROUND: Oral submucous fibrosis (OSMF) is a habit related potentially malignant disorder seen mainly in South Asian people. The malignancy arising from OSMF has been regarded as low grade with better outcome. The present study was orchestrated to histochemically analyze collagen and elastic fibres in OSMF without dysplasia, OSMF with dysplasia and OSMF turning malignant. MATERIALS AND METHODS: 100 cases (80 cases and 20 healthy controls) were included after obtaining clearance from ethical committee...
October 16, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37831429/salivary-duct-carcinoma-arising-in-a-warthin-tumor-of-the-parotid-gland-a-rare-case-report-with-review-of-literature-and-pd-l1-expression
#82
JOURNAL ARTICLE
Kaitlyn J Nielson, Gamaliel Lorenzo, Shweta Agarwal
Warthin's tumor is the second most common neoplasm of the parotid gland and consists of 2 components, including lymphoid stroma and glandular epithelium. Malignant transformation in this tumor is mostly seen in the lymphoid component; however, the carcinomatous transformation of the epithelial component is extremely rare. Cases of latter reported in the literature include squamous cell carcinoma, adenocarcinoma, mucoepidermoid carcinoma, oncocytic carcinoma, Merkel cell carcinoma, and undifferentiated carcinoma...
October 13, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37792236/ocular-crystal-storing-histiocytosis-with-co-existing-malt-lymphoma-a-rare-case-with-cytologic-and-heretofore-not-reported-findings-on-frozen-section
#83
JOURNAL ARTICLE
Ming Liang Oon, Bingcheng Wu, Hian Lee Esther Chan, Fredrik Petersson
BACKGROUND: Crystal-storing histiocytosis (CSH) is a rare disorder which most commonly occurs in the setting of concurrent lymphoproliferative disease. Morphologically, it consists of aggregates of histiocytes containing eosinophilic crystalline material, which in most cases is composed of aggregated abnormal light chains. METHODS: Using histomorphology, immunohistochemistry and in situ hybridization, the authors characterize a rare case of orbital CSH associated with extranodal marginal zone (MALT) lymphoma and report for the first time the frozen section features of CSH...
October 4, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37775618/macrofollicular-architecture-in-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-a-pitfall-in-thyroid-practice
#84
JOURNAL ARTICLE
Sujata Yadav, Devasenathipathy Kandasamy, Nishikant Damle, Rashi Goel, Sunil Chumber, Mehar C Sharma, Monikongkona Boruah, Shipra Agarwal
BACKGROUND: Predominantly macrofollicular architecture in invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC-MF) is rare and often a cause of misinterpretation during pre-operative work-up and histopathology evaluation. We comprehensively evaluated the radiological, cytological, gross, microscopic, molecular and follow-up characteristics of four such cases, intending to increase its recognition and add our experience to the limited literature available. METHODS: All such histopathologically-proven cases of IEFVPTC-MF were retrieved from the departmental archives...
September 29, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37735289/orofacial-manifestations-in-a-middle-aged-woman-with-cowden-syndrome-a-case-image
#85
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Clara Herrera Freire, Taísa Domingues Boehmer Leite, César Werneck Noce, Israel Leal Cavalcante, Jéssica de Oliveira Vogel, Ricardo Alves Mesquita, Jefferson R Tenório, Bruno Augusto Benevenuto de Andrade
A 56-year-old Brazilian woman sought dental care, presenting with multiple asymptomatic papillomatous lesions with a coalescent pattern and intermingled cobblestone-like clefts along the alveolar ridge and marginal and attached gingivae. Multiple whitish papules were also observed on the face, neck, and limbs. Incisional biopsies of these lesions were performed. Microscopically, the skin lesion revealed epithelial clear cells and intraepithelial keratinization with areas of orthokeratosis, while the gingival lesions showed a parakeratinized stratified squamous epithelium with collagenous connective tissue...
September 21, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37735287/hpv-associated-squamous-cell-carcinoma-of-the-eyelid-diagnostic-utility-of-p16-immunohistochemistry-and-mrna-in-situ-hybridization
#86
JOURNAL ARTICLE
Aanchal Kakkar, Kirti Srivastava, S Deepa, Seema Kashyap, Seema Sen, Sandeep Bhoriwal, Kavneet Kaur, Suryanarayan V S Deo
BACKGROUND: High-risk (HR) Human papillomavirus (HPV) has been implicated in pathogenesis of squamous cell carcinomas (SCC) at several sites with mucocutaneous junctions, including the head and neck. SCC is the second most common eyelid malignancy. However, its association with transcriptionally active HR-HPV has not been adequately studied. METHODS: Two index cases of eyelid HPV-associated SCC are described in detail. A retrospective cohort of eyelid SCC was examined for p16 immunoexpression...
September 21, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37735286/clear-cell-squamous-cell-carcinoma-of-the-maxillary-gingiva-associated-with-pik3ca-and-hras-mutations-report-of-a-case-and-literature-review
#87
JOURNAL ARTICLE
Katsutoshi Hirose, Takumi Shibahara, Akari Teramoto, Yu Usami, Sawako Ono, Yuri Iwamoto, Shumei Murakami, Kaori Oya, Narikazu Uzawa, Daisuke Motooka, Yumiko Hori, Eiichi Morii, Satoru Toyosawa
BACKGROUND: Squamous cell carcinoma (SCC) is the most common oral malignancy, and somatic mutations in some driver genes have been implicated in SCC development. Clear cell SCC (CCSCC) is a rare histological variant of SCC, and various clear cell neoplasms must be considered in the differential diagnosis of CCSCC in the oral cavity. Based on a limited number of CCSCC cases reported in the oral cavity, CCSCC is considered an aggressive variant of SCC with a poor prognosis; however, its genetic characteristics remain unknown...
September 21, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37612573/is-viable-tumor-cell-the-most-important-prognostic-factor-in-head-and-neck-squamous-cell-carcinoma
#88
LETTER
Elaheh Sanjari, Hadi Raeisi Shahraki
No abstract text is available yet for this article.
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37594632/loss-of-bap1-protein-expression-by-immunohistochemistry-in-the-salivary-duct-carcinoma-component-of-an-intracapsular-carcinoma-ex-pleomorphic-adenoma-of-the-parotid-gland
#89
JOURNAL ARTICLE
Eleonora Fiorletta Quiroga, Patricia R Connor, Lisa Rooper, Mauricio A Moreno, J Stephen Nix
BACKGROUND: BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that is altered in a variety of neoplasms as well as in BAP1 tumor predisposition syndrome. BAP1 alterations are associated with aggressive behavior in some malignancies and may have treatment implications in future. We present the first documented case of loss of BAP1 protein expression by immunohistochemistry in the salivary duct carcinoma (SDC) component of an intracapsular carcinoma ex pleomorphic adenoma (CXPA) in the context of molecular loss of function of BAP1 in the neoplasm...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37540486/low-grade-myofibroblastic-sarcoma-of-the-oral-and-maxillofacial-region-an-international-clinicopathologic-study-of-13-cases-and-literature-review
#90
REVIEW
Daniela Giraldo-Roldan, Brendo Vinicius Rodrigues Louredo, Paulo Victor Mendes Penafort, Hélder Antônio Rebelo Pontes, Aline Pinheiro Alves, Fernando C A Lima, Thamyres Campos Fonseca, Aline Corrêa Abrahão, Mário José Romañach, Felipe Paiva Fonseca, Wilson A Delgado, Liam Robinson, Willie F P Van Heerden, Oslei Paes de Almeida, Pablo Agustin Vargas
Low-grade myofibroblastic sarcoma (LGMS) represents an atypical tumor composed of myofibroblasts with a variety of histological patterns and with a high tendency to local recurrence and a low probability of distant metastases. LGMS has predilection for the head and neck regions, especially the oral cavity. This study aimed to report 13 new cases of LGMS arising in the oral and maxillofacial region. This study included LGMS cases from five oral and maxillofacial pathology laboratories in four different countries (Brazil, Peru, Guatemala, and South Africa)...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37540485/a-systematic-review-of-adenoid-ameloblastoma-a-newly-recognized-entity
#91
JOURNAL ARTICLE
Hannah Gil de Farias Morais, Rani Iani Costa Gonçalo, Carla Samily de Oliveira Costa, Hévila de Figueiredo Pires, Rodrigo Porpino Mafra, Everton Freitas de Morais, Márcia Cristina da Costa Miguel, Roseana de Almeida Freitas
BACKGROUND: Recently, a new odontogenic tumor has been described, the so-called adenoid ameloblastoma (AdAM). The aim of this review was to determine the clinical and imaging features of AdAM and to describe its main histopathological findings. METHODS: The systematic review included published cases with a diagnosis of AdAM in the gnathic bones, which had sufficient clinical, imaging, and histopathological data to confirm its diagnosis. The following histopathological diagnostic criteria were adopted: presence of ameloblastoma-like components, duct-like structures, spiral cellular condensations, and a cribriform architecture...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486537/significance-of-worst-pattern-of-invasion-5-in-early-stage-oral-cavity-squamous-cell-carcinoma
#92
JOURNAL ARTICLE
Shima Mohamed, Hadeel Jawad, Ryan O' Sullivan, Deirdre Callanan, Patrick Sheahan, Linda Feeley
BACKGROUND: There is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection of patients who may benefit from adjuvant treatment. The objective of this study was to evaluate the prognostic ability of worst pattern of invasion-5 (WPOI-5) defined by the presence of satellite nodules, extratumoural perineural invasion (PNI) and/or extratumoural lymphovascular space invasion (LVI) in low-stage, node negative OCSCC...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486535/lipoblastoma-arising-in-the-head-and-neck-a-clinicopathologic-analysis-of-20-cases
#93
REVIEW
Zahra Aldawood, Alyaa Al-Ibraheemi
BACKGROUND: Lipoblastomas (LPBs) are benign adipocytic neoplasms believed to recapitulate the development of embryonal fat. METHODS: We investigated the clinicopathologic and immunohistochemical features of 20 lipoblastomas arising in the head and neck in 18 patients. RESULTS: Patients included 6 males and 12 females (1:2 ratio) with age at diagnosis ranging from 4 months to 28 years. Tumors occurred more commonly in the neck (12, 66.7%) and less commonly in the forehead, scalp, and tongue (2, 11...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37247174/adverse-reactions-associated-with-dermal-fillers-in-the-oral-and-maxillofacial-region-a-venezuelan-experience
#94
JOURNAL ARTICLE
Gabriela Rosendy, Israel Leal Cavalcante, Caio César da Silva Barros, Jeaneth López-Labady, Nieves González, Ricardo Pérez-Alfonzo, Maria Gabriela González, Clara Herrera Freire, José Alcides Almeida de Arruda, Bruno Augusto Benevenuto de Andrade, Mariana Villarroel-Dorrego
BACKGROUND: Dermal facial fillers are increasingly popular. Published reports on the clinical and histopathologic characteristics related to adverse reactions to dermal fillers in the facial region have been relatively well documented. This study adds to the literature on adverse reactions to injected filler in the oral and maxillofacial region in a South American population. METHODS: A retrospective, descriptive cross-sectional study (2019-2020) was performed. The study population was a dermatology service in Venezuela...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37227678/warthin-tumor-of-the-parotid-gland-the-history-of-an-eponym
#95
JOURNAL ARTICLE
Fumio Ide, Shinnichi Sakamoto, Yuji Miyazaki, Michiko Nishimura, Yumi Ito, Takashi Muramatsu, Kentaro Kikuchi
The eponymous history of Warthin tumor (WT) is a fascinating issue in the field of salivary gland pathology. The late decades of the nineteenth century and the turn of the century saw notable German and French contributions on WT. Especially, the seminal 1910 paper of Albrecht and Arzt of Vienna is the foundation for the current knowledge of WT. It is generally believed that prior to this pioneering study, Hildebrand of Göttingen accurately described the lesion of WT in 1895. However, the historical origins of WT appear to be unsettled, and only a few German pathologists and surgeons are aware that dating back to 1885, the first recognizable reference to WT was that by the renowned German-Swiss pathologist Zahn, whose name is eponymously associated with "Zahn infarct" and "lines of Zahn"...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37118352/differentiated-papillary-nut-carcinoma-an-unexpected-deceptively-bland-presentation-of-a-sinonasal-carcinoma
#96
JOURNAL ARTICLE
Martin Wartenberg, Sara-Lynn Hool, Andrea Marrazzini, Roland Giger, Niels J Rupp
BACKGROUND: In recent years, the list of tumor entities in the sinonasal tract has significantly expanded, requiring advanced diagnostic testing. We report the case of a 32-year-old patient with an unusual NUT carcinoma originating in the maxillary sinus, which showed extensive well-differentiated, papillary squamous morphology, similar to the spectrum of the recently described DEK::AFF2 fusion-associated carcinoma. METHODS: We performed immunohistochemical and molecular studies including EBV- and HPV-testing, as well as DNA/RNA next generation sequencing...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37076754/intraoral-minor-salivary-gland-tumors-a-retrospective-clinicopathologic-single-center-study-of-432-cases-in-japan-and-a-comparison-with-epidemiological-data
#97
JOURNAL ARTICLE
Katsutoshi Kokubun, Takatoshi Chujo, Kei Yamamoto, Yoshihiko Akashi, Kei Nakajima, Masayuki Takano, Akira Katakura, Kenichi Matsuzaka
BACKGROUND: Intraoral minor salivary gland tumors are relatively rare lesions with histological subtypes not commonly found in major salivary glands. This study aimed to retrospectively evaluate the clinicopathologic features of intraoral minor salivary gland tumors from the Tokyo Dental College Hospital, Japan, and compare them with findings from other epidemiological studies. METHODS: We conducted a retrospective clinicopathologic evaluation of 432 cases of intraoral minor salivary gland tumors [161 male (37...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37014573/the-challenge-of-monomorphic-mucoepidermoid-carcinoma-report-of-a-rare-case-with-pure-spindle-clear-cell-morphology
#98
JOURNAL ARTICLE
Xinyi Qu, Edwin Jun Chen Chew, Sathiyamoorthy Selvarajan, Bingcheng Wu, Abbas Agaimy, Fredrik Petersson
BACKGROUND: Mucoepidermoid carcinoma is a malignant salivary gland tumor which, in most cases, is composed of variable proportions of mucous, epidermoid, and intermediate cells. METHODS: We report a case of parapharyngeal mucoepidermoid carcinoma with highly unusual ("monomorphic") light microscopic features as well as atypical immunohistochemical properties. Molecular analysis was performed using the TruSight RNA fusion panel. RESULTS: The tumor featured heretofore undescribed histopathological features: sheets and nests composed of monomorphic neoplastic (plump spindle to epithelioid) cells with no mucous, intermediate, glandular/columnar, or any other cell type identified...
September 2023: Head and Neck Pathology
https://read.qxmd.com/read/37612574/histopathological-analysis-of-nodal-disease-after-chemoradiation-reveals-viable-tumor-cells-as-the-most-important-prognostic-factor-in-head-and-neck-squamous-cell-carcinoma-doi-10-1007-s12105-023-01557-7
#99
LETTER
Grégoire B Morand, Aline Golliez, Niels J Rupp
No abstract text is available yet for this article.
August 23, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37541995/true-oncocytic-acinic-cell-carcinoma-a-case-image
#100
JOURNAL ARTICLE
Matthew G Romanish, Raja R Seethala
A 67-year-old female with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) presented with right sided otalgia and a 2-3 cm firm, tender right posterior parotid mass. Fine needle aspiration biopsy (FNAB) established a diagnosis of acinic cell carcinoma (AciCC). Further workup demonstrated lung nodules which were confirmed by FNAB to represent metastatic AciCC. A right radical parotidectomy with sacrifice of the facial nerve, segmental mandibulectomy, and selective neck dissection (levels II-IV) was performed...
August 4, 2023: Head and Neck Pathology
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