journal
https://read.qxmd.com/read/36913073/first-reported-case-of-malignant-ectomesenchymoma-with-p-leu122arg-mutation-in-myod1-gene-extensive-intra-and-extracranial-tumor-in-a-15-year-old-female
#81
JOURNAL ARTICLE
E M Pena-Burgos, D Plaza-López De Sabando, C Utrilla, J J Pozo-Kreilinger, A Sastre, P Rubio, A Escudero, M Mendiola-Sabio, A Pérez-Martínez
BACKGROUND: Ectomesenchymomas (EMs) are extremely rare neoplasms composed of malignant mesenchymal components and neuroectodermal derivatives. They are described in a wide variety of locations, with the head and neck region being one of the most frequently involved areas. EMs are usually managed as high-risk rhabdomyosarcomas and have similar outcomes. METHODS: We present the case of a 15-year-old female with an EM that arose in the parapharyngeal space and extended into the intracranial space...
March 13, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36892803/clinicopathological-analysis-of-actinic-cheilitis-a-systematic-review-with-meta-analyses
#82
JOURNAL ARTICLE
Mailon Cury Carneiro, Milenka Gabriela Quenta-Huayhua, Mariela Peralta-Mamani, Heitor Marques Honório, Paulo Sérgio da Silva Santos, Izabel Regina Fischer Rubira-Bullen, Cássia Maria Fischer Rubira
BACKGROUND: This systematic review aimed to conduct a complete investigation of the demographic aspects, clinicopathological features, degrees of epithelial dysplasia, and malignant transformation rate of actinic cheilitis. METHODS: The study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered in the International Prospective Register of Systematic Reviews (CRD42020201254). A search without year and language restrictions was performed using PubMed/MEDLINE, Embase, Virtual Health Library, Scopus, Web of Science, and gray literature...
March 9, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36941503/top-10-histological-mimics-of-neuroendocrine-carcinoma-you-should-not-miss-in-the-head-and-neck
#83
REVIEW
C Christofer Juhlin, Munita Bal
BACKGROUND: The spectrum of neuroendocrine neoplasia (NEN) of the head and neck region is wide-ranging and diverse, including a variety of diagnoses stretching from benign and low-malignant tumor forms to highly proliferative, poor prognosis neuroendocrine carcinoma (NEC). Moreover, there are several non-neuroendocrine differential diagnoses to keep in mind as well, displaying various degree of morphological and/or immunohistochemical overlap with bona fide neuroendocrine lesions. METHODS: Review...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928740/top-10-nested-pattern-head-and-neck-lesions-to-notice
#84
REVIEW
Abberly Lott Limbach, Deborah J Chute
BACKGROUND: Nested is defined as "cellular clusters arranged in small groupings with intervening vascular or stromal networks, lacking lumens or glandular formation." Using this definition, multiple neoplastic and non-neoplastic lesions of the head and neck come into the differential. We have broadly organized the differential diagnosis of "nested" tumors into entities with neuroendocrine differentiation, squamous differentiation, thyroid follicular cell differentiation, and other lesions...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928739/top-ten-lymphoproliferative-lesions-not-to-miss-when-evaluating-oral-ulcer-biopsies
#85
REVIEW
Martin D Hyrcza, Tanya R Lindenmuth, Aaron Auerbach
BACKGROUND: Oral ulcers represent a full thickness loss of the mucosal epithelium leading to exposure of the submucosal connective tissue. These are common and usually self-limited lesions, although they may sometimes result from neoplasms, most commonly squamous cell carcinoma. Lymphoproliferative disorders may be difficult to diagnose in apthous ulcers since they mimic reactive inflammation. METHODS: This review presents ten rare oral lymphoid proliferations which should not be missed when assessing oral ulcer biopsies...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928738/top-10-significant-spindled-head-and-neck-lesions-to-scrutinze
#86
REVIEW
Aaron M Udager
BACKGROUND: Spindled lesions are a challenging area in head and neck pathology. This is particularly true in the sinonasal tract, where several uncommon entities with both unique and overlapping morphologic, immunophenotypic, and/or molecular features can occur. METHODS: Review. RESULTS: The clinicopathologic characteristics of biphenotypic sinonasal sarcoma and nine important differential diagnostic considerations with one or more overlapping feature are summarized to establish a practical framework for approaching spindled lesions of the sinonasal tract...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928737/top-10-differential-diagnoses-for-desmoplastic-melanoma
#87
REVIEW
Angel Fernandez-Flores, Rajendra Singh, David S Cassarino
BACKGROUND: Desmoplastic melanoma is a rare subtype of melanoma mainly appearing on sun-exposed skin. Clinically, it is many times non-pigmented and therefore the diagnosis is often not suspected. METHODS: Review article. RESULTS: In this paper we review the main histopathological, immunohistochemical, and molecular features of desmoplastic melanoma, as well as the top 10 morphologic differential diagnoses which should be considered in most cases...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928736/cystic-lesions-of-the-jaws-the-top-10-differential-diagnoses-to-ponder
#88
REVIEW
Anne C McLean, Pablo A Vargas
BACKGROUND: Cystic lesions of the gnathic bones present challenges in differential diagnosis. This category includes a smorgasbord of odontogenic and non-odontogenic entities that may be reactive or neoplastic in nature. While most cystic jaw lesions are benign, variability in biologic behavior makes distinction between these entities absolutely crucial. METHODS: Review. RESULTS: Two clinical cases are presented in parallel and are followed by an illustrated discussion of the ten most likely differential diagnoses that should be considered when confronted with a cystic jaw lesion...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928735/top-ten-oncocytic-head-and-neck-lesions-to-contemplate
#89
REVIEW
Martin J Bullock, Xiaoyin S Jiang
BACKGROUND: Oncocytes are a component of many metaplastic and neoplastic lesions throughout the head and neck area, primarily originating in salivary/seromucinous glands and the thyroid gland. In addition, other lesions can contain cells that mimic oncocytes (pseudo-oncocytes); these can be of epithelial or non-epithelial origin. METHODS: Review article. RESULTS: Oncocytic metaplasia is common in seromucinous glands throughout the upper aerodigestive tract, most notable in the oral cavity, nasopharynx and larynx...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928734/top-10-clear-cell-head-and-neck-lesions-to-contemplate
#90
REVIEW
Nicole A Cipriani, Aanchal Kakkar
BACKGROUND: Optically clear cytoplasm may occur in neoplastic and non-neoplastic conditions, either as a characteristic feature of a disease entity or as a morphologic rarity, potentially creating diagnostic dilemmas in various organ systems. In the head and neck, clear cell change can occur in lesions of salivary, odontogenic, thyroid, parathyroid, or sinonasal/skull base origin, as well as in metastases to these regions. METHODS: This review elaborates the top ten clear cell lesions in the head and neck, emphasizing their distinguishing histologic, immunohistochemical, and molecular attributes, and presents a rational approach to arriving at an accurate classification...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928733/top-ten-differentials-to-mull-over-for-head-and-neck-myoepithelial-neoplasms
#91
REVIEW
Lester D R Thompson, Bin Xu
BACKGROUND: Myoepithelial neoplasms of the salivary gland are benign or malignant neoplasms composed exclusively of neoplastic myoepithelial cells. These tumors, including the benign myoepithelioma and the malignant counterpart myoepithelial carcinoma, exhibit a wide range of cytomorphologic features and architectural patterns. METHODS: Review. RESULTS: Myoepithelial cells can be epithelial, plasmacytoid, clear cell, spindle cell, and/or oncocytic cell, arranging as trabeculae, solid sheets, nests, cords, and/or single cells...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36928732/top-10-basaloid-neoplasms-of-the-sinonasal-tract
#92
REVIEW
Martina Baněčková, Darren Cox
BACKGROUND: Basaloid neoplasms of the sinonasal tract represent a significant group of tumors with histological overlap but often with different etiologies (i.e., viral, genetics), clinical management, and prognostic significance. METHODS: Review. RESULTS: "Basaloid" generally refers to cells with coarse chromatin in round nuclei and sparse cytoplasm, resembling cells of epithelial basal layers or imparting an "immature" appearance. Tumors with this characteristic in the sinonasal tract are represented by a spectrum of benign to high-grade malignant neoplasms, such as adenoid cystic carcinoma, NUT carcinoma, sinonasal undifferentiated carcinoma, SWI/SNF complex-deficient carcinomas, and adamantinoma-like Ewing sarcoma...
March 2023: Head and Neck Pathology
https://read.qxmd.com/read/36849672/wpoi-5-accurately-identified-at-intraoperative-consultation-and-predictive-of-occult-cervical-metastases
#93
JOURNAL ARTICLE
John E Beute, Lily A Greenberg, Lauren E Wein, Danielle A Kapustin, Jun Fan, Eric M Dowling, Shabnam Samankan, Ammar Matloob, Monica Xing, Ippolito Modica, Daniel Chung, William Carroll, Eben L Rosenthal, Mohemmed Nazir Khan, Raymond L Chai, Margaret S Brandwein-Weber, Mark L Urken
BACKGROUND: Frozen section analysis of oral cancer specimens is ideal for assessing margin distances and depth of invasion (DOI); the latter impacts intraoperative decisions regarding elective neck dissection (END). Here, we show that intraoperative determination of worst pattern of invasion (WPOI), specifically WPOI-5, has a high level of accuracy. This relates to our demonstration herein that WPOI-5 predicts occult cervical metastases (OCM) for pT1 oral squamous carcinoma (OSC). METHODS: The presence of OCM was correlated with WPOI in 228 patients with primary T1/T2/cN0 OSC undergoing resection and END...
February 28, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36849671/sinonasal-adenosquamous-carcinoma-morphology-and-genetic-drivers-including-low-and-high-risk-human-papillomavirus-mrna-dek-aff2-fusion-and-maml2-rearrangement
#94
JOURNAL ARTICLE
Dean Holliday, Mitra Mehrad, Kim A Ely, Fangjia Tong, Xiaowei Wang, Jen-Fan Hang, Ying-Ju Kuo, Jaylou M Velez-Torres, Abberly Lott-Limbach, James S Lewis
BACKGROUND: Sinonasal adenosquamous carcinoma is rare, and there are almost no studies detailing morphology or characterizing their genetic driver events. Further, many authors have termed sinonasal tumors with combined squamous carcinoma and glands as mucoepidermoid carcinoma but none have analyzed for the presence of MAML2 rearrangement. METHODS: Cases from 2014 to 2020 were collected and diagnosed using World Health Organization criteria. They were tested for p16 expression by immunohistochemistry (70% cut-off), DEK::AFF2 fusion by fluorescence in situ hybridization (FISH) and AFF2 immunohistochemistry, MAML2 rearrangement by FISH, and low- and high-risk HPV by RNA ISH and reverse transcription PCR, respectively...
February 28, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36849670/mucous-membrane-pemphigoid-following-the-administration-of-covid-19-vaccine
#95
LETTER
Dulyapong Rungraungrayabkul, Nattha Rattanasiriphan, Rachai Juengsomjit
No abstract text is available yet for this article.
February 28, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36746884/nkx3-1-expression-and-molecular-characterization-of-secretory-myoepithelial-carcinoma-smca-advancing-the-case-for-a-salivary-mucous-acinar-phenotype
#96
JOURNAL ARTICLE
Simmi Patel, Abigail I Wald, Jassem M Bastaki, Simon I Chiosea, Aatur D Singhi, Raja R Seethala
BACKGROUND: Secretory myoepithelial carcinomas (SMCA) are rare, mucinous, signet ring predominant tumors with primitive myoepithelial features. While many mucinous salivary gland tumors have now been molecularly characterized, key drivers in SMCA have yet to be elucidated. Recently, NKX3.1, a homeodomain transcription factor implicated in salivary mucous acinar development was also shown in a subset of salivary mucinous neoplasms, salivary intraductal papillary mucinous neoplasms (SG-IPMN)...
February 6, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723854/hamartomatous-polyp-of-the-palatine-tonsil-a-case-report-and-critical-literature-review
#97
JOURNAL ARTICLE
Gleyson Kleber do Amaral-Silva, Jhennyfer Ribeiro-Brizola, Áthilla Arcari Santos, Silvia Roberta Cieslak-Sanches, Gabriela Moura Chicrala, Ellen Cristina Gaetti-Jardim, Daniella Moraes Antunes
BACKGROUND: Hamartomatous polyp of the palatine tonsil is a rare benign tumor poorly recognized by clinicians and pathologists. We present a novel case report and provide a literature review about this diagnosis, highlighting its clinicopathological features and treatment modalities. METHODS: We herein report a case of a 22-year-old female patient who complained of a foreign body sensation in her throat. She presented with a pedunculated polyp attached to her right palatine tonsil, which was noticed 15 years ago...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723853/relationship-between-worst-pattern-of-invasion-and-extranodal-extension-in-oral-tongue-squamous-cell-carcinomas
#98
JOURNAL ARTICLE
Mayuri Yasuda, Celina Chiodo, Cullen Lilley, Swati Mehrotra, Vijayalakshmi Ananthanarayanan, Andrea Ziegler, Eric Thorpe
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy of the oral cavity with poor survival rates. The aim of this project is to investigate the relationship between certain histopathological factors such as Worst Pattern of Invasion (WPOI) and Extranodal Extension (ENE) in patients with oral tongue squamous cell carcinoma (OTSCC) who underwent surgical resection at Loyola University Medical Center. METHODS: This was a retrospective cohort study at a tertiary care academic medical center...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723851/congenital-melanotic-macule-of-the-tongue-report-of-two-cases-and-literature-review
#99
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Rosanna Gómez, Verónica Bracho, Israel Leal Cavalcante, Ricardo Pérez-Alfonzo, Mariana Villarroel-Dorrego, Bruno Augusto Benevenuto de Andrade
BACKGROUND: Congenital melanotic macule of the tongue (CMMT) has been described as a distinct entity, despite its unknown etiology. However, the diagnosis and management of affected newborns may challenge clinicians and pediatric dentists. METHODS: We document here the clinicopathological findings of two additional cases of CMMT. A literature review of CMMT reports identified across PubMed, Web of Science, Embase, and Scopus was also conducted. RESULTS: The patients, 2- and 4 month-old Venezuelan boys, respectively, presented at birth with a single or multiple dark-brown-pigmented macule exclusively on the dorsum of the tongue...
February 1, 2023: Head and Neck Pathology
https://read.qxmd.com/read/36723850/prognostic-impact-of-tumor-immune-microenvironment-and-its-predictive-role-in-salivary-gland-cancer
#100
REVIEW
Maria Vittoria Veneroni, Bianca Maria Festa, Andrea Costantino, Giuseppe Spriano, Giuseppe Mercante, Armando De Virgilio, Luca Di Tommaso
BACKGROUND: Recently, many studies have investigated the role of tumor immune microenvironment (TIME) in carcinogenesis, highlighting its relation to both tumor regression and progression. In particular, the "inflammatory system", made of innate and adaptive immune cells, interacts with cancer cells and their surrounding stroma. In this setting, the aim of this review is to summarize the current literature regarding the TIME of major salivary gland carcinomas (MSGCs), with particular attention on the characteristics and prognostic role of tumor infiltrating lymphocytes (TILs), the mechanisms that lead to TILs exhaustion and the important additional immune infiltrating factors that help SGC progression or remission...
February 1, 2023: Head and Neck Pathology
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