Ruben Bill, William C Faquin, Sara I Pai
Immune checkpoint inhibitors have improved the outcome of patients diagnosed with inoperable recurrent or metastatic head and neck squamous cell carcinoma. However, as only a subset of head and neck cancer patients benefit from this treatment, biomarkers predicting treatment response help guide physicians in their clinical decision-making. PD-L1 expression assessed by immunohistochemistry is the single most clinically relevant biomarker predicting response to PD-1-blocking antibodies. Here, we discuss in which clinical context assessment of PD-L1 expression is instrumental for the choice of therapy, how pathologists score it, and how it affects the approval of anti-PD-1 antibodies...
December 2023: Head and Neck Pathology
John Lennon Silva Cunha, Bruno Augusto Benevenuto de Andrade, Israel Leal Cavalcante, Clara Herrera Freire, Nathália de Almeida Freire, Sarah Aparecida Ferreira Antero, Fábio Ramôa Pires, Mônica Simões Israel
Squamous odontogenic tumor (SOT) is a rare benign but locally infiltrative tumor often misdiagnosed as other entities, such as ameloblastoma and squamous cell carcinoma, due to overlapping morphological findings. We document here the clinicopathological and imaging findings of an aggressive intraosseous SOT in the posterior left region of the maxilla in a 25-year-old male patient. On intraoral examination, the tumor extended from the region of the left lateral incisor to the upper left premolar and was covered by reddish mucosa, with discrete areas of ulceration...
December 2023: Head and Neck Pathology
Roee Noy, Ido Livneh, Inna Naroditsky, Yona Vaisbuch
The differential diagnosis for an isolated lytic mastoid lesion is broad, encompassing various conditions requiring careful consideration. These include granulomatous disorders such as Langerhans cell histiocytosis and sarcoidosis, neoplastic processes like multiple myeloma, leukemia, lymphoma, and metastases, primary bone diseases such as Paget's disease, fibrous dysplasia, and osteitis fibrosa cystica, as well as infectious causes like osteomyelitis. In this report, we present a patient with otalgia and an isolated lytic mastoid lesion...
December 2023: Head and Neck Pathology
Raelly Katharinne Lima de Menêses, Talytha Barbosa da Rocha, John Lennon Silva Cunha, Francisco Franceschini Neto, Manuel Antonio Gordón-Nuñéz, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves
Surgical ciliated cysts, also known as implantation cysts or postoperative maxillary cysts, are uncommon cystic formations predominantly arising in the posterior maxillary region after radical maxillary sinus surgery. Herein, we present the case of a 28-year-old male patient who had previously undergone orthognathic surgery and later experienced a minor car accident without major consequences. Approximately four years after surgery, the patient sought dental care due to the presence of a painless swelling in the maxillary region...
November 27, 2023: Head and Neck Pathology
Patricia Castro, Germán Corredor, Can Koyuncu, Luke A Nordstrom, Michelle Tiji, Taylor Leavitt, James S Lewis, Anant Madabhushi, Mitchell J Frederick, Vlad C Sandulache
OBJECTIVE: Oropharyngeal squamous cell carcinoma (OPSCC) recurrence is almost universally fatal. Development of effective therapeutic options requires an improved understanding of recurrent OPSCC biology. METHODS: We analyzed paired primary-recurrent OPSCC from Veterans treated at the Michael E. DeBakey Veterans Affairs Medical Center between 2000 and 2020 who received curative intent radiation-based treatment (with or without chemotherapy). Patient tumors were analyzed using standard immunohistochemistry and automated imaging of infiltrating lymphocytes and multinucleated tumor cells coupled to machine learning algorithms...
November 23, 2023: Head and Neck Pathology
Fumio Ide, Shinnichi Sakamoto, Michiko Nishimura, Yuji Miyazaki, Kentaro Kikuchi
No abstract text is available yet for this article.
November 9, 2023: Head and Neck Pathology
Joshua J X Li, Joanna K M Ng, Amy B W Chan
DEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal malignancy defined by its unique translocation. DEK::AFF2 carcinomas may be deceptively monotonous and lack keratinization, resembling transitional epithelium. The lack of traditional cytological atypia presents diagnostic challenges. Our case describes the first report of fine-needle aspiration cytology of a lymph node involved by DEK::AFF2 carcinoma in a patient with previously resected sinonasal inverted papilloma with carcinomatous transformation six years prior to presentation...
November 8, 2023: Head and Neck Pathology
Laura Borges Kirschnick, Lauren Frenzel Schuch, Rogério Gondak, Elena Riet Correa Rivero, Ana Paula Neutzling Gomes, Adriana Etges, Sandra Beatriz Chaves Tarquinio, Ricardo Alves Mesquita, Patrícia Carlos Caldeira, Adriana Aparecida Silva da Costa, Elismauro Francisco Mendonça, Jean Nunes Dos Santos, Chané Smit, Liam Robinson, Elena María José Román Tager, Adalberto Mosqueda-Taylor, Hélder Antônio Rebelo Pontes, Bruno Augusto Benevenuto de Andrade, Thamyres Campos Fonseca, Aline Corrêa Abrahão, Michelle Agostini, Mário José Romañach, Fábio Abreu Alves, Graziella Chagas Jaguar, Nathalia Félix de Mendonça, Mariana Bitu Ramos Pinto, Luan César da Silva, Márcio Ajudarte Lopes, Pablo Agustin Vargas, Willie van Heerden, Lucas Guimarães Abreu, Manoela Domingues Martins, Ana Carolina Uchoa Vasconcelos
BACKGROUND: This study aimed to investigate the clinicopathological features of metastases in the oral and maxillofacial regions. METHODS: In this retrospective study, biopsy records were obtained from referral centers for oral and maxillofacial diagnosis in Brazil, Guatemala, Mexico, and South Africa. RESULTS: A total of 120 cases were evaluated. Of these, 53.78% affected female patients, with a mean age of 57.64 years. Intraosseous lesions were more frequent, particularly in the posterior region of the mandible (49...
October 30, 2023: Head and Neck Pathology
Fumio Ide, Shinnichi Sakamoto, Yuji Miyazaki, Michiko Nishimura, Takashi Muramatsu, Kentaro Kikuchi
BACKGROUND: Practically every facet of the most common odontogenic tumor, odontoma, has been covered by an extensive volume of literature. However, uncertainty about its precise history has persisted. MATERIALS AND METHODS: The historical evolution of odontoma was traced with reference to the original illustrations that accompanied European and American reports published at the beginning of the 19th century and also at the turn of the century. RESULTS: The prevailing views regarding the first description of odontoma by Oudet of Paris in 1809 and the original designation "odontome" by Broca of Paris in 1867 are not entirely accurate...
October 19, 2023: Head and Neck Pathology
Arlind Adili, Tracy O Connor, Philipp Wales, Marcus Seemann, Sylvia Höller, Barbara Hummer, Sandra N Freiberger, Stephan Rauthe, Niels J Rupp
BACKGROUND: Lymphoepithelial carcinoma of the salivary glands (LECSG) is a rare disease in the Western hemisphere that is typically associated with an EBV infection. The molecular mechanisms of LECSG tumorigenesis are poorly understood. RESULTS: Here we report a case of EBV-associated LECSG with an unusual immunophenotype. The tumor exhibited bi-morphic histological features with a mutually exclusive expression of HER2 and p16. The p16-positive domain of the tumor immunohistochemically co-expressed late membrane protein 1 (LMP-1), while the HER2 positive domain did not...
October 17, 2023: Head and Neck Pathology
Ana Luiza Oliveira Corrêa Roza, Thamyres Campos Fonsêca, Bruno Augusto Linhares Almeida Mariz, Paulo Victor Mendes Penafort, René Martínez-Flores, Maureen Marshall-Baburizza, Sven Eric Niklander, Márcio Ajudarte Lopes, Sandra Regina Torres, Michelle Agostini, Aline Corrêa Abrahão, Oslei Paes de Almeida, Pablo Agustin Vargas, Mário José Romañach
BACKGROUND: Human papillomavirus-associated oral epithelial dysplasia (HPV-OED) is a distinct oral epithelial disorder characterized by viral cytopathic changes caused by transcriptionally active high-risk HPV. The aim of the present study was to report 5 additional cases from Latin America. METHODS: Clinical data from five patients with HPV-OED were obtained from the archives of three oral pathology services from Brazil and Chile. All cases were submitted to morphological, p16 expression and in situ hybridization (ISH) for HPV analyses...
October 16, 2023: Head and Neck Pathology
Deepak Pandiar, E Aswani, Reshma Poothakulath Krishnan
BACKGROUND: Oral submucous fibrosis (OSMF) is a habit related potentially malignant disorder seen mainly in South Asian people. The malignancy arising from OSMF has been regarded as low grade with better outcome. The present study was orchestrated to histochemically analyze collagen and elastic fibres in OSMF without dysplasia, OSMF with dysplasia and OSMF turning malignant. MATERIALS AND METHODS: 100 cases (80 cases and 20 healthy controls) were included after obtaining clearance from ethical committee...
October 16, 2023: Head and Neck Pathology
Kaitlyn J Nielson, Gamaliel Lorenzo, Shweta Agarwal
Warthin's tumor is the second most common neoplasm of the parotid gland and consists of 2 components, including lymphoid stroma and glandular epithelium. Malignant transformation in this tumor is mostly seen in the lymphoid component; however, the carcinomatous transformation of the epithelial component is extremely rare. Cases of latter reported in the literature include squamous cell carcinoma, adenocarcinoma, mucoepidermoid carcinoma, oncocytic carcinoma, Merkel cell carcinoma, and undifferentiated carcinoma...
October 13, 2023: Head and Neck Pathology
Ming Liang Oon, Bingcheng Wu, Hian Lee Esther Chan, Fredrik Petersson
BACKGROUND: Crystal-storing histiocytosis (CSH) is a rare disorder which most commonly occurs in the setting of concurrent lymphoproliferative disease. Morphologically, it consists of aggregates of histiocytes containing eosinophilic crystalline material, which in most cases is composed of aggregated abnormal light chains. METHODS: Using histomorphology, immunohistochemistry and in situ hybridization, the authors characterize a rare case of orbital CSH associated with extranodal marginal zone (MALT) lymphoma and report for the first time the frozen section features of CSH...
October 4, 2023: Head and Neck Pathology
Sujata Yadav, Devasenathipathy Kandasamy, Nishikant Damle, Rashi Goel, Sunil Chumber, Mehar C Sharma, Monikongkona Boruah, Shipra Agarwal
BACKGROUND: Predominantly macrofollicular architecture in invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC-MF) is rare and often a cause of misinterpretation during pre-operative work-up and histopathology evaluation. We comprehensively evaluated the radiological, cytological, gross, microscopic, molecular and follow-up characteristics of four such cases, intending to increase its recognition and add our experience to the limited literature available. METHODS: All such histopathologically-proven cases of IEFVPTC-MF were retrieved from the departmental archives...
September 29, 2023: Head and Neck Pathology
José Alcides Almeida de Arruda, Clara Herrera Freire, Taísa Domingues Boehmer Leite, César Werneck Noce, Israel Leal Cavalcante, Jéssica de Oliveira Vogel, Ricardo Alves Mesquita, Jefferson R Tenório, Bruno Augusto Benevenuto de Andrade
A 56-year-old Brazilian woman sought dental care, presenting with multiple asymptomatic papillomatous lesions with a coalescent pattern and intermingled cobblestone-like clefts along the alveolar ridge and marginal and attached gingivae. Multiple whitish papules were also observed on the face, neck, and limbs. Incisional biopsies of these lesions were performed. Microscopically, the skin lesion revealed epithelial clear cells and intraepithelial keratinization with areas of orthokeratosis, while the gingival lesions showed a parakeratinized stratified squamous epithelium with collagenous connective tissue...
September 21, 2023: Head and Neck Pathology
Aanchal Kakkar, Kirti Srivastava, S Deepa, Seema Kashyap, Seema Sen, Sandeep Bhoriwal, Kavneet Kaur, Suryanarayan V S Deo
BACKGROUND: High-risk (HR) Human papillomavirus (HPV) has been implicated in pathogenesis of squamous cell carcinomas (SCC) at several sites with mucocutaneous junctions, including the head and neck. SCC is the second most common eyelid malignancy. However, its association with transcriptionally active HR-HPV has not been adequately studied. METHODS: Two index cases of eyelid HPV-associated SCC are described in detail. A retrospective cohort of eyelid SCC was examined for p16 immunoexpression...
September 21, 2023: Head and Neck Pathology
Katsutoshi Hirose, Takumi Shibahara, Akari Teramoto, Yu Usami, Sawako Ono, Yuri Iwamoto, Shumei Murakami, Kaori Oya, Narikazu Uzawa, Daisuke Motooka, Yumiko Hori, Eiichi Morii, Satoru Toyosawa
BACKGROUND: Squamous cell carcinoma (SCC) is the most common oral malignancy, and somatic mutations in some driver genes have been implicated in SCC development. Clear cell SCC (CCSCC) is a rare histological variant of SCC, and various clear cell neoplasms must be considered in the differential diagnosis of CCSCC in the oral cavity. Based on a limited number of CCSCC cases reported in the oral cavity, CCSCC is considered an aggressive variant of SCC with a poor prognosis; however, its genetic characteristics remain unknown...
September 21, 2023: Head and Neck Pathology
Elaheh Sanjari, Hadi Raeisi Shahraki
No abstract text is available yet for this article.
September 2023: Head and Neck Pathology
Eleonora Fiorletta Quiroga, Patricia R Connor, Lisa Rooper, Mauricio A Moreno, J Stephen Nix
BACKGROUND: BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that is altered in a variety of neoplasms as well as in BAP1 tumor predisposition syndrome. BAP1 alterations are associated with aggressive behavior in some malignancies and may have treatment implications in future. We present the first documented case of loss of BAP1 protein expression by immunohistochemistry in the salivary duct carcinoma (SDC) component of an intracapsular carcinoma ex pleomorphic adenoma (CXPA) in the context of molecular loss of function of BAP1 in the neoplasm...
September 2023: Head and Neck Pathology
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