Brunno Santos de Freitas Silva, Renata Santos Fedato Tobias, Cecilia Raquel Guimarães de Oliveira, Fernanda Paula Yamamoto-Silva
BACKGROUND: Traumatic Ulcerative Granuloma with Stromal Eosinophilia, commonly known as Eosinophilic Ulcer, is a reactive solitary and self-limiting benign lesion. It manifests as a punched-out ulcer with a distinct surrounding indurated border, often raising concerns about malignancy. METHODS: A 44-year-old male presented with a painless, indurated tongue ulcer evolving over three months. Despite being asymptomatic, the patient underwent an incisional biopsy due to suspicions of oral squamous cell carcinoma...
February 5, 2024: Head and Neck Pathology
Diana Bell
BACKGROUND: Poorly differentiated sinonasal small round cell tumors (SRCTs) are rare and heterogeneous, posing challenges in diagnosis and treatment. METHODS: Recent advances in molecular findings and diagnostic refinement have promoted better understanding and management of these tumors. RESULTS: The newly defined and emerging sinonasal entities demonstrate diverse morphologies, specific genomic signatures, and clinical behavior from conventional counterparts...
February 5, 2024: Head and Neck Pathology
Prokopios P Argyris, Bindu Challa, Swati Satturwar, Kyle K VanKoevering, Paul E Wakely
Somatic-type malignancy (STM) can occur infrequently within a primary or metastatic testicular germ cell tumor (TGCT) and is associated with dismal prognosis and survival. STM with chondrosarcomatous features is exceedingly rare and head and neck involvement has not been previously documented. A 39-year-old white man presented with nasal obstruction and epistaxis. Imaging disclosed a 6.9-cm expansile tumor involving the nasal cavity and skull base with intraorbital and intracranial extension. The histopathologic properties of the tumor were compatible with chondrosarcoma, grade II-III...
January 18, 2024: Head and Neck Pathology
Raisa Jordana Geraldine Severino-Lazo, Marianne de Vasconcelos Carvalho, Camilla Porto Campello, Sandra Lúcia Dantas Moraes, Belmiro Cavalcanti do Egito Vasconcelos, Eduardo Piza Pellizzer
BACKGROUND: The BRAF p.V600E genetic variant facilitates the pathogenesis of various tumors by triggering tumor proliferation and progression. The aim of this study was to analyze the prevalence of BRAF p.V600E in benign mixed epithelial and mesenchymal and malignant odontogenic tumors. In addition, we discussed the different detection methods used to assess for aberrant BRAF. METHODS: This systematic review followed the PRISMA guidelines and was registered in Prospero (CRD42023445689)...
December 2023: Head and Neck Pathology
Alberto Jose Peraza Labrador, Luciano Hermios Matos Valdez, Nestor Ricardo Gonzalez Marin, Karem Annelise Rodriguez Ibazetta, Marcelo Villacis, Joan Lopez Chacon, Hebert Ochoa Huaman, Harold Cuzcano Pariahuamán, Hosting Barría Angulo, Victoria Woo
BACKGROUND: The intraosseous schwannoma (IS) is a benign peripheral nerve sheath tumor postulated to arise de novo or from nerve fibers in preexisting nutrient canals. ISs are uncommon and comprise less than 1% of neoplasms originating in bone. We herein present two cases of mandibular schwannomas-the first case was a 66-year-old female with a four-month history of pain and pressure associated with an anterior mandibular radiolucency, and the second case was an asymptomatic 12-year-old female with separate radiolucencies of her mandibular symphysis and right posterior mandible...
December 2023: Head and Neck Pathology
Aarushi Garg, Aadithya B Urs, Bidhan Chandra Koner, Jeyaseelan Augustine, Sameer Ahmad Guru
BACKGROUND: Altered levels of miRNAs might affect the pathogenesis of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). This study evaluated the diagnostic potential of salivary miRNA-21 and miRNA-184 in OSCC and OPMD. METHODS: We recruited a total of 90 subjects including OSCC, OPMD, and healthy controls. RNA was isolated from the saliva samples of the study subjects. Expression of miRNA-21 and miRNA-184 was analyzed using qRT-PCR...
December 2023: Head and Neck Pathology
Nan Xie, Zhipei Chen, Yi Liu, Jingbin Huo, Xiaohua Chen, Alfred King-Yin Lam
BACKGROUND: The study aims to analyse the non-calcifying/Langerhans cell rich (NCLC) subtype of calcifying epithelial odontogenic tumour (CEOT).  METHOD: The features of cases of the NCLC subtype of CEOT noted in the English literature by PubMed as well as 3 new cases were reviewed. RESULTS: Overall, twenty-one cases were noted. Many were women in the fourth to sixth decades (male-to-female ratio =1 to 2). Radiologically, the lesion is often unilocular with resorption of the affected teeth...
December 2023: Head and Neck Pathology
Urvashi Yadav, Ria Mahendru, Jyoti Sharma, Aanchal Kakkar
BACKGROUND: Adenoid cystic carcinoma (AdCC), associated with MYB/MYBL1 gene rearrangements, shows epithelial and basaloid myoepithelial cells arranged in tubular, cribriform and solid patterns. Variations from this classic morphology make diagnosis challenging, necessitating molecular testing. AdCC with striking tubular hypereosinophilia (AdCC-STE) is one such recently described histological subtype. METHODS: A 52-year-old female presented with a floor of mouth swelling for two months, diagnosed elsewhere as polymorphous adenocarcinoma (PAC)...
December 2023: Head and Neck Pathology
Ruben Bill, William C Faquin, Sara I Pai
Immune checkpoint inhibitors have improved the outcome of patients diagnosed with inoperable recurrent or metastatic head and neck squamous cell carcinoma. However, as only a subset of head and neck cancer patients benefit from this treatment, biomarkers predicting treatment response help guide physicians in their clinical decision-making. PD-L1 expression assessed by immunohistochemistry is the single most clinically relevant biomarker predicting response to PD-1-blocking antibodies. Here, we discuss in which clinical context assessment of PD-L1 expression is instrumental for the choice of therapy, how pathologists score it, and how it affects the approval of anti-PD-1 antibodies...
December 2023: Head and Neck Pathology
John Lennon Silva Cunha, Bruno Augusto Benevenuto de Andrade, Israel Leal Cavalcante, Clara Herrera Freire, Nathália de Almeida Freire, Sarah Aparecida Ferreira Antero, Fábio Ramôa Pires, Mônica Simões Israel
Squamous odontogenic tumor (SOT) is a rare benign but locally infiltrative tumor often misdiagnosed as other entities, such as ameloblastoma and squamous cell carcinoma, due to overlapping morphological findings. We document here the clinicopathological and imaging findings of an aggressive intraosseous SOT in the posterior left region of the maxilla in a 25-year-old male patient. On intraoral examination, the tumor extended from the region of the left lateral incisor to the upper left premolar and was covered by reddish mucosa, with discrete areas of ulceration...
December 2023: Head and Neck Pathology
Roee Noy, Ido Livneh, Inna Naroditsky, Yona Vaisbuch
The differential diagnosis for an isolated lytic mastoid lesion is broad, encompassing various conditions requiring careful consideration. These include granulomatous disorders such as Langerhans cell histiocytosis and sarcoidosis, neoplastic processes like multiple myeloma, leukemia, lymphoma, and metastases, primary bone diseases such as Paget's disease, fibrous dysplasia, and osteitis fibrosa cystica, as well as infectious causes like osteomyelitis. In this report, we present a patient with otalgia and an isolated lytic mastoid lesion...
December 2023: Head and Neck Pathology
Raelly Katharinne Lima de Menêses, Talytha Barbosa da Rocha, John Lennon Silva Cunha, Francisco Franceschini Neto, Manuel Antonio Gordón-Nuñéz, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves
Surgical ciliated cysts, also known as implantation cysts or postoperative maxillary cysts, are uncommon cystic formations predominantly arising in the posterior maxillary region after radical maxillary sinus surgery. Herein, we present the case of a 28-year-old male patient who had previously undergone orthognathic surgery and later experienced a minor car accident without major consequences. Approximately four years after surgery, the patient sought dental care due to the presence of a painless swelling in the maxillary region...
November 27, 2023: Head and Neck Pathology
Patricia Castro, Germán Corredor, Can Koyuncu, Luke A Nordstrom, Michelle Tiji, Taylor Leavitt, James S Lewis, Anant Madabhushi, Mitchell J Frederick, Vlad C Sandulache
OBJECTIVE: Oropharyngeal squamous cell carcinoma (OPSCC) recurrence is almost universally fatal. Development of effective therapeutic options requires an improved understanding of recurrent OPSCC biology. METHODS: We analyzed paired primary-recurrent OPSCC from Veterans treated at the Michael E. DeBakey Veterans Affairs Medical Center between 2000 and 2020 who received curative intent radiation-based treatment (with or without chemotherapy). Patient tumors were analyzed using standard immunohistochemistry and automated imaging of infiltrating lymphocytes and multinucleated tumor cells coupled to machine learning algorithms...
November 23, 2023: Head and Neck Pathology
Fumio Ide, Shinnichi Sakamoto, Michiko Nishimura, Yuji Miyazaki, Kentaro Kikuchi
No abstract text is available yet for this article.
November 9, 2023: Head and Neck Pathology
Joshua J X Li, Joanna K M Ng, Amy B W Chan
DEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal malignancy defined by its unique translocation. DEK::AFF2 carcinomas may be deceptively monotonous and lack keratinization, resembling transitional epithelium. The lack of traditional cytological atypia presents diagnostic challenges. Our case describes the first report of fine-needle aspiration cytology of a lymph node involved by DEK::AFF2 carcinoma in a patient with previously resected sinonasal inverted papilloma with carcinomatous transformation six years prior to presentation...
November 8, 2023: Head and Neck Pathology
Laura Borges Kirschnick, Lauren Frenzel Schuch, Rogério Gondak, Elena Riet Correa Rivero, Ana Paula Neutzling Gomes, Adriana Etges, Sandra Beatriz Chaves Tarquinio, Ricardo Alves Mesquita, Patrícia Carlos Caldeira, Adriana Aparecida Silva da Costa, Elismauro Francisco Mendonça, Jean Nunes Dos Santos, Chané Smit, Liam Robinson, Elena María José Román Tager, Adalberto Mosqueda-Taylor, Hélder Antônio Rebelo Pontes, Bruno Augusto Benevenuto de Andrade, Thamyres Campos Fonseca, Aline Corrêa Abrahão, Michelle Agostini, Mário José Romañach, Fábio Abreu Alves, Graziella Chagas Jaguar, Nathalia Félix de Mendonça, Mariana Bitu Ramos Pinto, Luan César da Silva, Márcio Ajudarte Lopes, Pablo Agustin Vargas, Willie van Heerden, Lucas Guimarães Abreu, Manoela Domingues Martins, Ana Carolina Uchoa Vasconcelos
BACKGROUND: This study aimed to investigate the clinicopathological features of metastases in the oral and maxillofacial regions. METHODS: In this retrospective study, biopsy records were obtained from referral centers for oral and maxillofacial diagnosis in Brazil, Guatemala, Mexico, and South Africa. RESULTS: A total of 120 cases were evaluated. Of these, 53.78% affected female patients, with a mean age of 57.64 years. Intraosseous lesions were more frequent, particularly in the posterior region of the mandible (49...
October 30, 2023: Head and Neck Pathology
Fumio Ide, Shinnichi Sakamoto, Yuji Miyazaki, Michiko Nishimura, Takashi Muramatsu, Kentaro Kikuchi
BACKGROUND: Practically every facet of the most common odontogenic tumor, odontoma, has been covered by an extensive volume of literature. However, uncertainty about its precise history has persisted. MATERIALS AND METHODS: The historical evolution of odontoma was traced with reference to the original illustrations that accompanied European and American reports published at the beginning of the 19th century and also at the turn of the century. RESULTS: The prevailing views regarding the first description of odontoma by Oudet of Paris in 1809 and the original designation "odontome" by Broca of Paris in 1867 are not entirely accurate...
October 19, 2023: Head and Neck Pathology
Arlind Adili, Tracy O Connor, Philipp Wales, Marcus Seemann, Sylvia Höller, Barbara Hummer, Sandra N Freiberger, Stephan Rauthe, Niels J Rupp
BACKGROUND: Lymphoepithelial carcinoma of the salivary glands (LECSG) is a rare disease in the Western hemisphere that is typically associated with an EBV infection. The molecular mechanisms of LECSG tumorigenesis are poorly understood. RESULTS: Here we report a case of EBV-associated LECSG with an unusual immunophenotype. The tumor exhibited bi-morphic histological features with a mutually exclusive expression of HER2 and p16. The p16-positive domain of the tumor immunohistochemically co-expressed late membrane protein 1 (LMP-1), while the HER2 positive domain did not...
October 17, 2023: Head and Neck Pathology
Ana Luiza Oliveira Corrêa Roza, Thamyres Campos Fonsêca, Bruno Augusto Linhares Almeida Mariz, Paulo Victor Mendes Penafort, René Martínez-Flores, Maureen Marshall-Baburizza, Sven Eric Niklander, Márcio Ajudarte Lopes, Sandra Regina Torres, Michelle Agostini, Aline Corrêa Abrahão, Oslei Paes de Almeida, Pablo Agustin Vargas, Mário José Romañach
BACKGROUND: Human papillomavirus-associated oral epithelial dysplasia (HPV-OED) is a distinct oral epithelial disorder characterized by viral cytopathic changes caused by transcriptionally active high-risk HPV. The aim of the present study was to report 5 additional cases from Latin America. METHODS: Clinical data from five patients with HPV-OED were obtained from the archives of three oral pathology services from Brazil and Chile. All cases were submitted to morphological, p16 expression and in situ hybridization (ISH) for HPV analyses...
October 16, 2023: Head and Neck Pathology
Deepak Pandiar, E Aswani, Reshma Poothakulath Krishnan
BACKGROUND: Oral submucous fibrosis (OSMF) is a habit related potentially malignant disorder seen mainly in South Asian people. The malignancy arising from OSMF has been regarded as low grade with better outcome. The present study was orchestrated to histochemically analyze collagen and elastic fibres in OSMF without dysplasia, OSMF with dysplasia and OSMF turning malignant. MATERIALS AND METHODS: 100 cases (80 cases and 20 healthy controls) were included after obtaining clearance from ethical committee...
October 16, 2023: Head and Neck Pathology
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