John E Beute, Lily A Greenberg, Lauren E Wein, Danielle A Kapustin, Jun Fan, Eric M Dowling, Shabnam Samankan, Ammar Matloob, Monica Xing, Ippolito Modica, Daniel Chung, William Carroll, Eben L Rosenthal, Mohemmed Nazir Khan, Raymond L Chai, Margaret S Brandwein-Weber, Mark L Urken
BACKGROUND: Frozen section analysis of oral cancer specimens is ideal for assessing margin distances and depth of invasion (DOI); the latter impacts intraoperative decisions regarding elective neck dissection (END). Here, we show that intraoperative determination of worst pattern of invasion (WPOI), specifically WPOI-5, has a high level of accuracy. This relates to our demonstration herein that WPOI-5 predicts occult cervical metastases (OCM) for pT1 oral squamous carcinoma (OSC). METHODS: The presence of OCM was correlated with WPOI in 228 patients with primary T1/T2/cN0 OSC undergoing resection and END...
February 28, 2023: Head and Neck Pathology