journal
https://read.qxmd.com/read/38775845/acinic-cell-carcinoma-with-high-grade-squamoglandular-and-chondrosarcomatous-transformation-mimicking-carcinosarcoma-ex-pleomorphic-adenoma-a-wrinkle-in-the-proposed-nomenclature-revision-for-sarcomatoid-salivary-gland-neoplasms
#21
JOURNAL ARTICLE
Rayan Rammal, Bethany Batson, Matthew E Spector, Simion I Chiosea, Raja R Seethala
While acinic cell carcinoma (AciCC) can undergo high-grade transformation (HGT) to high-grade adenocarcinoma or poorly differentiated carcinoma, other morphologies such as spindle cell/sarcomatoid carcinoma are rare and not well-characterized. We herein report a novel case of AciCC with squamoglandular and chondrosarcomatous HGT mimicking a so-called 'carcinosarcoma ex-pleomorphic adenoma'. The patient is an 81-year-old male with a two-month history of neck swelling and referred otalgia who presented with a left parapharyngeal space mass extending into retropharyngeal space and pterygoid muscles...
May 22, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38735907/a-novel-gene-fusion-ylpm1-prkd1-identified-in-a-cribriform-subtype-of-polymorphous-adenocarcinoma
#22
JOURNAL ARTICLE
Monica Miyakawa-Liu, Michael G Ozawa, Michelle Chen, Mobeen Rahman
Cribriform adenocarcinoma of the salivary gland (CASG) is an entity that is currently classified under polymorphous adenocarcinoma (PAC), cribriform subtype per the 2022 WHO classification of head and neck tumours. There is debate about whether CASG should be considered a separate diagnostic entity, as CASG differs from conventional PAC in anatomic site, clinical behaviors, and molecular patterns. Herein we describe a challenging and unique case which shares histologic and behavioral features between CASG and conventional PAC with a YLPM1::PRKD1 rearrangement not previously reported in the literature...
May 13, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38735890/chronic-sclerosing-sialadenitis-of-the-submandibular-gland-and-its-histopathological-spectrum-in-the-igg4-related-disease-a-series-of-17-cases
#23
JOURNAL ARTICLE
Vinícius Rio Verde Melo Muniz, Albina Altemani, Valéria Souza Freitas, Bruno Cunha Pires, Dandara Andrade de Santana, Larissa Abbehusen Couto, Maria Cristina Teixeira Cangussu, Ricardo Santiago Gomez, Suzana Catanhede Orsine Machado de Souza, Pablo Augustin Vargas, Patrícia Ramos Cury, Iguaracyra Barreto de Araújo, Roberta Rayra Martins Chaves, Felipe Paiva Fonseca, Jean Nunes Dos Santos
PURPOSE: This study aimed to characterize the histopathological immunohistochemical features of chronic sclerosing sialadenitis, emphasizing the IgG4-related disease. METHODS: Seventeen cases of chronic sclerosing sialoadenitis were examined for histopathological aspects, (inflammation, fibrosis, glandular parenchyma, and lymphoid follicles) and immunohistochemistry (BCL2, CD3, CD20, CD34, CD163, p63, cyclin D1, mast cell, SMA, S100A4, IgG, and IgG4) which were scored...
May 13, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38727854/columnar-cell-thyroid-carcinoma-a-heterogeneous-entity-demonstrating-overlap-between-papillary-thyroid-carcinoma-and-follicular-neoplasms
#24
JOURNAL ARTICLE
Kathleen E Higgins, Peter M Sadow, Daniel N Johnson, Peng Wang, Pankhuri Wanjari, Nicole A Cipriani
BACKGROUND: Columnar cell papillary thyroid carcinoma (CC-PTC) is a morphologic subtype of papillary thyroid carcinoma with a variable prognosis. It is characterized by neoplastic thyroid follicular-derived cells with pseudostratified columnar morphology arranged in papillary or follicular structures with supranuclear or subnuclear vacuoles. The molecular profile of this subtype has only recently come under scrutiny, with mixed results. The aim of this study is to further explore the morphologic, immunohistochemical, and genetic profile of CC-PTC, as well as to correlate these features with clinical outcomes...
May 10, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38727841/an-update-on-the-use-of-artificial-intelligence-in-digital-pathology-for-oral-epithelial-dysplasia-research
#25
REVIEW
Shahd A Alajaji, Zaid H Khoury, Maryam Jessri, James J Sciubba, Ahmed S Sultan
INTRODUCTION: Oral epithelial dysplasia (OED) is a precancerous histopathological finding which is considered the most important prognostic indicator for determining the risk of malignant transformation into oral squamous cell carcinoma (OSCC). The gold standard for diagnosis and grading of OED is through histopathological examination, which is subject to inter- and intra-observer variability, impacting accurate diagnosis and prognosis. The aim of this review article is to examine the current advances in digital pathology for artificial intelligence (AI) applications used for OED diagnosis...
May 10, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38727801/the-depth-of-invasion-and-level-iv-cervical-node-metastasis-in-patients-with-clinically-n0-tongue-cancer
#26
JOURNAL ARTICLE
Imdat Yüce, Aslıhan Oflaz Çapar, Veli Çetinaslan, Kemal Deniz, Alperen Vural, Sedat Çağlı, Serap Doğan, Mete Gündoğ
BACKGROUND: The accurate indication for level IV dissection is crucial for preventing complications such as phrenic nerve damage and chylous fistulas in clinically N0 tongue cancer. Although the depth of invasion is an established independent risk factor for occult lymph node metastasis in tongue cancer, its relationship with level IV metastasis has not been evaluated. This study investigated the relationship between the depth of invasion and level IV nodal metastasis in clinically N0 tongue cancer...
May 10, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38727794/clic4-function-in-the-epithelial-mesenchymal-transition-of-epithelial-odontogenic-lesions
#27
JOURNAL ARTICLE
Mariana Carvalho Xerez, Caio César da Silva Barros, Maurília Raquel de Souto Medeiros, Rodrigo Porpino Mafra, Hévio Freitas de Lucena, Éricka Janine Dantas da Silveira, Antonio de Lisboa Lopes Costa
BACKGROUND: Odontogenic lesions constitute a heterogeneous group of lesions. CLIC4 protein regulates different cellular processes, including epithelial-mesenchymal transition and fibroblast-myofibroblast transdifferentiation. This study analyzed CLIC4, E-cadherin, Vimentin, and α-SMA immunoexpression in epithelial odontogenic lesions that exhibit different biological behavior. METHODS: It analyzed the immunoexpression of CLIC4, E-cadherin, and Vimentin in the epithelial cells, as well as CLIC4 and α-SMA in the mesenchymal cells, of ameloblastoma (AM) (n = 16), odontogenic keratocyst (OKC) (n = 20), and adenomatoid odontogenic tumor (AOT) (n = 8)...
May 10, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38710882/challenges-in-the-assessment-of-medullary-bone-invasion-in-oral-cavity-cancers-and-its-prognostic-significance
#28
JOURNAL ARTICLE
Badrinath Venkatesh, Paromita Roy, Anand Bardia, Indranil Mallick, Sanjoy Chatterjee, Pattatheyil Arun, Anisha Gehani
BACKGROUND: As per AJCC 8th edition TNM staging system, bone invasion is a poor prognostic marker that upstages oral cavity squamous carcinoma (OSCC) to pT4a. Cortical erosion alone of bone or tooth socket by a gingival primary is not sufficient to upstage a tumour. The differentiation of cortical erosion from invasion through the cortical bone into the medulla is often challenging, limiting accurate staging. This review aims to assess the difficulties in differentiating cortical erosion from medullary invasion and evaluate the prognostic significance of different patterns of bone involvement...
May 6, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38709462/an-evaluation-of-high-risk-hpv-in-squamous-cell-carcinomas-of-the-lip-in-a-south-african-cohort
#29
JOURNAL ARTICLE
Sharon N Harbor, Johann W Schneider, Nadine Solomons, Micheline Sanderson, Amir H Afrogheh
BACKGROUND: To determine the prevalence of HR-HPV in a series of lip SCC from South African patients, using currently accepted HPV-testing methodologies and to define the clinical and histomorphologic features of HPV-associated lip SCC. METHODS: Fifty SCC of lip and 50 control cases were tested for HR-HPV using p16 and HR-HPV DNA PCR. p16-equivocal/positive and HPV DNA PCR-positive SCC were further evaluated for the expression of HPV-16 and HPV-18 mRNA transcripts using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) to confirm transcriptionally active HPV...
May 6, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38687428/congenital-juvenile-xanthogranuloma-in-the-perioral-region-a-case-image
#30
JOURNAL ARTICLE
Andrea Maldonado, Rubén Muñoz, Nayari Alarcon, José Victor Lemos Ventura, Bruno Augusto Benevenuto de Andrade, Mariana Villarroel-Dorrego, José Alcides Almeida de Arruda
Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytosis in childhood. It often presents with cutaneous involvement and exhibits a predilection for the head and neck region. This article illustrates a case of congenital JXG in a 5-month-old boy, characterized by a solitary, well-circumscribed nodule above the left upper lip. Histopathologically, the lesion exhibited histiocytes with eosinophilic cytoplasm and Touton giant cells. Immunohistochemistry revealed histiocytes positive for CD68 and Factor XIIIa, while negative for S-100 protein...
April 30, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38658519/extramammary-paget-disease-of-oral-mucosa-case-report-with-literature-review
#31
REVIEW
Melad N Dababneh, Danielle M Bottalico, Keith M Schneider, Michelle Moh, Ivan J Stojanov
Extramammary Paget disease (EPMD) of the oral mucosa is an unusual and extremely rare condition, with fewer than ten cases documented. Here, we report a case of EMPD extensively involving oral mucosa and underlying salivary ducts in a 72-year-old male and review published clinical, histologic, immunophenotypic, and prognostic features of this rare entity.
April 24, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38658430/molecular-aspects-of-mucoepidermoid-carcinoma-and-adenoid-cystic-carcinoma-of-the-salivary-gland
#32
REVIEW
Raisa Ferreira Costa, Carolinne Alves de Oliveira, Ágatha Nagli de Mello Gomes, Silvia Vanessa Lourenço, Cláudia Malheiros Coutinho-Camillo
BACKGROUND: Salivary gland tumors (SGTs) are rare and highly heterogeneous lesions, making diagnosis a challenging activity. In addition, the small number of studies and samples evaluated difficults the determination of prognosis and diagnosis. Despite the solid advances achieved by research, there is still an intense need to investigate biomarkers for diagnosis, prognosis and that explain the evolution and progression of SGTs. METHODS: We performed a comprehensive literature review of the molecular alterations focusing on the most frequent malignant SGTs: mucoepidermoid carcinoma and adenoid cystic carcinoma...
April 24, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38658429/fna-of-meningioma-with-rhabdoid-features-presenting-as-a-lateral-neck-mass
#33
JOURNAL ARTICLE
Levent Trabzonlu, Maria Martinez-Lage, Daniel Deschler, Jonathan J Paly, William C Faquin
Primary meningioma at extracranial head and neck sites is uncommon. Since fine needle aspiration (FNA) is often the first line diagnostic modality for the evaluation of masses in the head and neck, extracranial meningiomas can create a significant diagnostic pitfall for FNA. We report a case of meningioma with rhabdoid features and BAP1 loss in a 26-year-old woman, presenting as a large neck mass along the carotid sheath. FNA biopsy of the mass demonstrated a highly cellular specimen with clusters of uniform, epithelioid cells with round to ovoid nuclei and moderate nuclear to cytoplasmic ratio...
April 24, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38637356/recurrence-of-glandular-odontogenic-cysts-a-systematic-review
#34
REVIEW
Alberto Peraza Labrador, Ashim Shrestha, Marianela Gonzalez, Nestor Ricardo Gonzalez Marin, Marcelo Villacis, Mathew Kesterke, Juan Pablo Lopez, John Wright
BACKGROUND: The glandular odontogenic cyst (GOC) is a benign developmental cyst of the jaws that is characterized by a high recurrence rate. METHODS: A systematic review is presented of reported cases, case series, and retrospective studies of recurrent cases of glandular odontogenic cysts, to determine the overall and detailed demographic features with documentation of the specific histologic features of the initial presentation of each cyst. Searches of detailed databases were carried out to identify articles published in the English language from 1988 to 2023...
April 18, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38635079/author-correction-top-ihc-ish-hacks-for-and-molecular-surrogates-of-poorly-differentiated-sinonasal-small-round-cell-tumors
#35
Diana Bell
No abstract text is available yet for this article.
April 18, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38635068/seven-steps-to-financial-health
#36
LETTER
Lester D R Thompson, Pamela A Thompson
Physicians and dentists have a very limited exposure to personal financial management and yet find themselves in the top 10% of earners in the United States of America. Education loans, practice expenses, and high standards of living obligate them to be good financial stewards to succeed financially. Anecdotal personal experience and review. The article establishes seven steps to implement as medical/dental students, interns, residents, or practicing doctors to move towards financial health and security. The steps include (1) saving enough; (2) good debt management; (3) being tax savvy; (4) obtaining the correct insurance; (5) making wise investments; (6) if choosing to marry, avoid divorce; and (7) keeping track with periodic progress assessment...
April 18, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536624/validation-of-the-visionarray%C3%A2-chip-assay-for-hpv-dna-testing-in-histology-specimens-of-oropharyngeal-squamous-cell-carcinoma
#37
JOURNAL ARTICLE
Hani Ibrahim Channir, Simone Kloch Bendtsen, Linea Cecilie Melchior, Pia Rovsing Sandholm, Christine Mordhorst, Amanda-Louise Fenger Carlander, Christian von Buchwald, Katalin Kiss
BACKGROUND: The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536520/expression-profile-of-circulating-exosomal-micrornas-in-leukoplakia-oral-submucous-fibrosis-and-combined-lesions-of-leukoplakia-and-oral-submucous-fibrosis
#38
JOURNAL ARTICLE
Dinesh Yasothkumar, Pratibha Ramani, Selvaraj Jayaraman, Karthikeyan Ramalingam, W M Tilakaratne
OBJECTIVES: This study aims to elucidate the expression of circulating exosomal miRNAs miRNA 21, miRNA 184, and miRNA 145 in the studied groups, including patients with (i) leukoplakia; (ii) oral submucous fibrosis; (iii) oral submucous fibrosis with leukoplakia; (iv) oral squamous cell carcinoma; and (v) healthy individuals. STUDY DESIGN: An observational study was conducted among 54 patients who reported to the outpatient department of Saveetha Dental College and Hospitals...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38526831/reticular-myxoid-odontogenic-neoplasm-with-novel-strn-alk-fusion-report-of-2-cases-in-3-year-old-males
#39
JOURNAL ARTICLE
Molly S Rosebush, Molly Housley Smith, Kitrina G Cordell, Nicholas Callahan, Waleed Zaid, Jeffrey Gagan, Justin A Bishop
Odontogenic tumors represent a collection of entities ranging from hamartomas to destructive benign and malignant neoplasms. Occasionally, pathologists encounter gnathic lesions which clearly exhibit an odontogenic origin but do not fit within the confines of established diagnoses. Here, we describe two such odontogenic tumors, both affecting 3-year-old males. Each case presented as a destructive, radiolucent mandibular lesion composed of mesenchymal cells, some with unique multi-lobed nuclei, frequently arranged in a reticular pattern and supported by a myxoid stroma with focal laminations...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38526767/a-comparison-of-clear-cell-sarcoma-to-jaw-and-salivary-tumors-bearing-ews-fusions
#40
REVIEW
Ornela Xhori, Navkiran Deol, Camron M Rivera, Jason Zavras, Sophia G Weil, Hirad Zafari, Julia C Thierauf, William C Faquin, Edwin Choy, Miguel N Rivera, A John Iafrate, Alexandre Jaquinet, Maria J Troulis
OBJECTIVE: To review tumors identified as "clear cell sarcoma" in order to determine similarities to the rare EWS fusion positive jaw and salivary gland tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma of the salivary gland (CCC). METHODS: PubMed was used to collect all reports of clear cell sarcoma (CCS). Search parameters were "clear cell sarcoma" and "CCS." References in the publications were screened and cross-referenced. Data extracted included demographic characteristics, presenting signs and symptoms, radiographic findings, histological and immunohistochemical features and known molecular/genetic aberrations...
March 25, 2024: Head and Neck Pathology
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