journal
https://read.qxmd.com/read/38635079/author-correction-top-ihc-ish-hacks-for-and-molecular-surrogates-of-poorly-differentiated-sinonasal-small-round-cell-tumors
#1
Diana Bell
No abstract text is available yet for this article.
April 18, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38635068/seven-steps-to-financial-health
#2
LETTER
Lester D R Thompson, Pamela A Thompson
Physicians and dentists have a very limited exposure to personal financial management and yet find themselves in the top 10% of earners in the United States of America. Education loans, practice expenses, and high standards of living obligate them to be good financial stewards to succeed financially. Anecdotal personal experience and review. The article establishes seven steps to implement as medical/dental students, interns, residents, or practicing doctors to move towards financial health and security. The steps include (1) saving enough; (2) good debt management; (3) being tax savvy; (4) obtaining the correct insurance; (5) making wise investments; (6) if choosing to marry, avoid divorce; and (7) keeping track with periodic progress assessment...
April 18, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536624/validation-of-the-visionarray%C3%A2-chip-assay-for-hpv-dna-testing-in-histology-specimens-of-oropharyngeal-squamous-cell-carcinoma
#3
JOURNAL ARTICLE
Hani Ibrahim Channir, Simone Kloch Bendtsen, Linea Cecilie Melchior, Pia Rovsing Sandholm, Christine Mordhorst, Amanda-Louise Fenger Carlander, Christian von Buchwald, Katalin Kiss
BACKGROUND: The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536520/expression-profile-of-circulating-exosomal-micrornas-in-leukoplakia-oral-submucous-fibrosis-and-combined-lesions-of-leukoplakia-and-oral-submucous-fibrosis
#4
JOURNAL ARTICLE
Dinesh Yasothkumar, Pratibha Ramani, Selvaraj Jayaraman, Karthikeyan Ramalingam, W M Tilakaratne
OBJECTIVES: This study aims to elucidate the expression of circulating exosomal miRNAs miRNA 21, miRNA 184, and miRNA 145 in the studied groups, including patients with (i) leukoplakia; (ii) oral submucous fibrosis; (iii) oral submucous fibrosis with leukoplakia; (iv) oral squamous cell carcinoma; and (v) healthy individuals. STUDY DESIGN: An observational study was conducted among 54 patients who reported to the outpatient department of Saveetha Dental College and Hospitals...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38526831/reticular-myxoid-odontogenic-neoplasm-with-novel-strn-alk-fusion-report-of-2-cases-in-3-year-old-males
#5
JOURNAL ARTICLE
Molly S Rosebush, Molly Housley Smith, Kitrina G Cordell, Nicholas Callahan, Waleed Zaid, Jeffrey Gagan, Justin A Bishop
Odontogenic tumors represent a collection of entities ranging from hamartomas to destructive benign and malignant neoplasms. Occasionally, pathologists encounter gnathic lesions which clearly exhibit an odontogenic origin but do not fit within the confines of established diagnoses. Here, we describe two such odontogenic tumors, both affecting 3-year-old males. Each case presented as a destructive, radiolucent mandibular lesion composed of mesenchymal cells, some with unique multi-lobed nuclei, frequently arranged in a reticular pattern and supported by a myxoid stroma with focal laminations...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38526767/a-comparison-of-clear-cell-sarcoma-to-jaw-and-salivary-tumors-bearing-ews-fusions
#6
REVIEW
Ornela Xhori, Navkiran Deol, Camron M Rivera, Jason Zavras, Sophia G Weil, Hirad Zafari, Julia C Thierauf, William C Faquin, Edwin Choy, Miguel N Rivera, A John Iafrate, Alexandre Jaquinet, Maria J Troulis
OBJECTIVE: To review tumors identified as "clear cell sarcoma" in order to determine similarities to the rare EWS fusion positive jaw and salivary gland tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma of the salivary gland (CCC). METHODS: PubMed was used to collect all reports of clear cell sarcoma (CCS). Search parameters were "clear cell sarcoma" and "CCS." References in the publications were screened and cross-referenced. Data extracted included demographic characteristics, presenting signs and symptoms, radiographic findings, histological and immunohistochemical features and known molecular/genetic aberrations...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38526755/proceedings-of-the-2024-north-american-society-of-head-and-neck-pathology-companion-meeting-baltimore-md-march-24-2024-navigating-ancillary-studies-in-basaloid-blue-salivary-tumors
#7
REVIEW
Kristine S Wong
BACKGROUND: Basaloid salivary tumors can demonstrate significant morphologic overlap and be challenging to diagnose. METHODS: A review of select ancillary studies in basaloid salivary tumors was performed. RESULTS: A number of immunohistochemical stains, including PLAG1, HMGA2, β-catenin, MYB, and RAS Q61R, have been more recently incorporated into the diagnostic workup of basaloid salivary tumors. CONCLUSIONS: Although reported variability in their performance has perhaps limited their widespread adoption, these immunohistochemical studies can nevertheless be useful in supporting pathologic diagnoses, particularly when considered in more specific differentials or when used as a panel with other markers...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38504068/braf-p-v600e-mutational-status-does-not-correlate-with-biological-behavior-in-conventional-ameloblastomas-a-disease-free-survival-analysis
#8
JOURNAL ARTICLE
Allan Vinícius Martins-de-Barros, Fábio Andrey da Costa Araújo, Tatiane Fonseca Faro, Arthur Alves Thomaz de Aquino, Adauto Gomes Barbosa Neto, Helker Albuquerque Macedo da Silva, Elker Lene Santos de Lima, Maria Tereza Cartaxo Muniz, Emanuel Dias de Oliveira E Silva, Marianne de Vasconcelos Carvalho
BACKGROUND: Dysregulation of the MAPK pathway appears to exert a pivotal role in the pathogenesis of ameloblastomas, since BRAF p.V600E has been reported in over 65% of the tumors. Therefore, the purpose of this study was to investigate whether the BRAF p.V600E is related to biological behavior and disease-free survival in patients with conventional ameloblastomas. METHODS: This is a retrospective cohort study based on the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) recommendations...
March 19, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38503984/ten-ways-to-improve-getting-a-scientific-manuscript-accepted
#9
JOURNAL ARTICLE
Lester D R Thompson
BACKGROUND: Scientific publication is the cornerstone to academic and private practice advancement in patient management and outcomes. Writing a manuscript requires a certain discipline and skill set that can be achieved with diligence and hard work. METHODS: Anecdotal and review. RESULTS: Several factors must be considered in scientific writing and journal manuscript submission and acceptance. Choosing where to submit the manuscript; understanding the instructions to authors; disclosing ethically; formatting correctly; never plagiarizing; supplying high quality appropriate images; creating meaningful tables; curating a pertinent but thorough bibliography; having valid, supported conclusions; and respecting timelines...
March 19, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38502412/unraveling-the-genetic-web-h-ras-expression-and-mutation-in-oral-squamous-cell-carcinoma-a-systematic-review
#10
REVIEW
Priya Devi, Ruby Dwivedi, Roshna Sankar, Ayushi Jain, Sameer Gupta, Shalini Gupta
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a commonly occurring malignancy with complex genetic alterations contributing to its development. The H-Ras, a proto-oncogene, becomes an oncogene when mutated and has been implicated in various cancers. This systematic review aims to research to what extent H-Ras expression and mutation contribute to the development and progression of OSCC, and how does this molecular alteration impacts the clinical characteristics and prognosis in patients with OSCC...
March 19, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38502367/xanthoma-of-the-jaw-bones-cases-series-and-review-of-literature
#11
REVIEW
Shankar Venkat, Mohammed N Islam, Indraneel Bhattacharyya, Donald M Cohen, F James Kratochvil, Tina R Woods, Seema Ganatra, Saja A Alramadhan
BACKGROUND: Intraosseous xanthomas are rare benign lesions sometimes associated with excess lipid production. Xanthoma of the jaw bones (XJB) was first reported in 1964, and fewer than 50 cases have been reported in the English literature to date. The etiopathogenesis of XJB is highly suggestive of a reactive process or a metabolic condition. METHOD: Seven cases of XJBs were retrieved from the archives of 4 oral and maxillofacial pathology services. Clinical, radiographic and histopathologic features of all these cases were retrospectively analyzed...
March 19, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38502259/oncocytoid-salivary-tumors-differential-diagnosis-and-utility-of-newly-described-immunohistochemistry
#12
REVIEW
Nora Katabi
BACKGROUND: Oncocytoid salivary tumors include several entities such as oncocytoma, Warthin tumor, secretory carcinoma (SC), salivary duct carcinoma (SDC), acinic cell carcinoma (AciCC), oncocytic mucoepidermoid carcinoma (OMEC), intraductal carcinoma, and epithelial myoepithelial carcinoma (EMC). This review investigates the differential diagnosis of oncocytoid salivary tumors and explore the role of newly described immunostains as valuable tools for their diagnosing and potentially guiding treatment options...
March 19, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38489075/enigma-of-acantholytic-and-clear-cell-changes-in-oral-squamous-cell-carcinoma
#13
REVIEW
Ayushi Jain, Sharon John, Shalini Gupta
Only limited cases have been reported about the clear cell variant of squamous cell carcinoma occurring in the oral cavity. The present study regards the case showing the histopathological features of both the clear cell and acantholytic variants of oral squamous cell carcinoma. A review of the literature has been done to understand the pathogenesis of those changes. Also, a hypothesis has been given that the clear cell changes could be the consequences of the cascades of the acantholytic process and not a separate entity...
March 15, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38457069/primary-oropharyngeal-smarca4-deficient-carcinoma-expanding-the-diagnostic-spectrum-in-head-and-neck-cancer
#14
JOURNAL ARTICLE
Sunil Pasricha, Sumit Goyal, Meenakshi Kamboj, Himanshi Diwan, Munish Gairola, Jaskaran Singh Sethi, Manoj Gupta, Anurag Mehta
With the advent of molecular immunohistochemistry and next generation sequencing, Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex altered tumors have gained recognition recently. SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily B member 1 (SMARCB1) and SMARCA4 are the primary SWI/SNF components altered in several recently described undifferentiated malignancies in head and neck region with predilection for paranasal sinuses in SMARCB1-deficient tumors and nasal cavity in SMARCA4-deficient tumors...
March 8, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38457034/chronic-lymphocytic-thyroiditis-with-oncocytic-metaplasia-influences-pd-l1-expression-in-papillary-thyroid-carcinoma
#15
JOURNAL ARTICLE
Vitor Barreto Santana, Vitória Machado Krüger, Maria Cristina Yunes Abrahão, Pietru Lentz Martins Cantú, Rosicler Luzia Brackmann, Gisele Moroni Pandolfi, Liane Scheffler Marisco, Gabriela Remonatto, Luciana Adolfo Ferreira, Marcia Silveira Graudenz
BACKGROUND: Despite the increasing recognition of PD-L1 as predictor of immunotherapeutic response in various malignancies, its role and prognostic significance in thyroid cancer remain underexplored and subject to debate. This study begins to address this gap by comprehensively analyzing PD-L1 expression in papillary thyroid carcinoma (PTC) and investigating its correlation with key clinicopathological variables. METHODS: We conducted immunohistochemistry (IHC) to assess PD-L1 expression in whole-tissue sections from 121 primary papillary thyroid carcinoma (PTC) cases...
March 8, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38456974/melanotic-neuroectodermal-tumor-of-infancy-a-case-image
#16
JOURNAL ARTICLE
Ricardo Monsalve, César Arias, Henrique Vélez, Mariana Villarroel-Dorrego, José Alcides Almeida de Arruda, Bruno Augusto Benevenuto de Andrade
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign neoplasm that can be mistaken for malignancies due to its unfamiliarity among clinicians and aggressive clinical appearance. We herein contributed by reporting an additional case of MNTI characterized by an extensive extraoral protrusion in a 2-month-old infant. The lesion involved the anterior maxilla, cheek, and infraorbital region, resulting the displacement of the nose to the contralateral side, and measuring approximately 10 cm in size...
March 8, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38456941/immunophenotypic-and-gene-expression-analyses-of-the-inflammatory-microenvironment-in-high-grade-oral-epithelial-dysplasia-and-oral-lichen-planus
#17
JOURNAL ARTICLE
Andres Flores-Hidalgo, James Phero, Scott Steward-Tharp, Megumi Williamson, David Paquette, Deepak Krishnan, Ricardo Padilla
BACKGROUND: Oral lichen planus (OLP) and oral epithelial dysplasia (OED) present diagnostic challenges due to clinical and histologic overlap. This study explores the immune microenvironment in OED, hypothesizing that immune signatures could aid in diagnostic differentiation and predict malignant transformation. METHODS: Tissue samples from OED and OLP cases were analyzed using immunofluorescence/immunohistochemistry (IF/IHC) for CD4, CD8, CD163/STAT1, and PD-1/PDL-1 expression...
March 8, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38393615/dynamic-role-of-mirnas-in-salivary-gland-carcinomas-from-biomarkers-to-therapeutic-targets
#18
REVIEW
Talita de Carvalho Kimura, Reydson Alcides de Lima-Souza, Tayná Figueiredo Maciel, Luiz Paulo Kowalski, Cláudia Malheiros Coutinho-Camillo, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
BACKGROUND: Salivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs. METHODS: This review provides a comprehensive literature review of the role of miRNAs expression in SGCs focusing on the diagnostic, prognostic, and therapeutic applications...
February 23, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38393494/primary-oral-mixed-neuroendocrine-non-neuroendocrine-neoplasm-minen-a-rare-case-report-and-review-of-the-literature
#19
REVIEW
Pawat Sripodok, Atsumu Kouketsu, Kanako Kuroda, Hitoshi Miyashita, Tsuyoshi Sugiura, Hiroyuki Kumamoto
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare tumors recently characterized by the presence of both neuroendocrine and non-neuroendocrine components within the same tumor tissue. Although MiNEN found their place in the WHO classification for various organs, this composite tumor in the head and neck region remains exceptionally rare. We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocrine carcinoma (NEC) and the patient underwent partial mandibulectomy...
February 23, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38393488/pleomorphic-adenoma-with-a-novel-gene-rearrangement-linc01606-plag1
#20
REVIEW
Udit Naik, Sara E Amin, Mahmoud Elsayad, Karan Saluja
BACKGROUND: Pleomorphic adenoma is a well-known benign salivary gland neoplasm characterized by the presence of varying proportions of three different components, including bi-layered ducts, myoepithelial cells, and admixed within a chondromyxoid/fibrous stroma. METHOD: We report an interesting case of an adult male who presented with bleeding from an extensively degenerated parotid gland mass, concerning for a vascular neoplasm versus primary malignant tumor. Microscopically, majority of the viable tumor exhibited diffuse proliferation of spindle to epithelioid cells, with focal areas depicting cribriform glands, ducts, and scant chondromyxoid stroma...
February 23, 2024: Head and Neck Pathology
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