journal
https://read.qxmd.com/read/37735289/orofacial-manifestations-in-a-middle-aged-woman-with-cowden-syndrome-a-case-image
#1
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Clara Herrera Freire, Taísa Domingues Boehmer Leite, César Werneck Noce, Israel Leal Cavalcante, Jéssica de Oliveira Vogel, Ricardo Alves Mesquita, Jefferson R Tenório, Bruno Augusto Benevenuto de Andrade
A 56-year-old Brazilian woman sought dental care, presenting with multiple asymptomatic papillomatous lesions with a coalescent pattern and intermingled cobblestone-like clefts along the alveolar ridge and marginal and attached gingivae. Multiple whitish papules were also observed on the face, neck, and limbs. Incisional biopsies of these lesions were performed. Microscopically, the skin lesion revealed epithelial clear cells and intraepithelial keratinization with areas of orthokeratosis, while the gingival lesions showed a parakeratinized stratified squamous epithelium with collagenous connective tissue...
September 21, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37735288/lytic-mastoid-lesion-in-a-patient-with-otalgia
#2
JOURNAL ARTICLE
Roee Noy, Ido Livneh, Inna Naroditsky, Yona Vaisbuch
The differential diagnosis for an isolated lytic mastoid lesion is broad, encompassing various conditions requiring careful consideration. These include granulomatous disorders such as Langerhans cell histiocytosis and sarcoidosis, neoplastic processes like multiple myeloma, leukemia, lymphoma, and metastases, primary bone diseases such as Paget's disease, fibrous dysplasia, and osteitis fibrosa cystica, as well as infectious causes like osteomyelitis. In this report, we present a patient with otalgia and an isolated lytic mastoid lesion...
September 21, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37735287/hpv-associated-squamous-cell-carcinoma-of-the-eyelid-diagnostic-utility-of-p16-immunohistochemistry-and-mrna-in-situ-hybridization
#3
JOURNAL ARTICLE
Aanchal Kakkar, Kirti Srivastava, S Deepa, Seema Kashyap, Seema Sen, Sandeep Bhoriwal, Kavneet Kaur, Suryanarayan V S Deo
BACKGROUND: High-risk (HR) Human papillomavirus (HPV) has been implicated in pathogenesis of squamous cell carcinomas (SCC) at several sites with mucocutaneous junctions, including the head and neck. SCC is the second most common eyelid malignancy. However, its association with transcriptionally active HR-HPV has not been adequately studied. METHODS: Two index cases of eyelid HPV-associated SCC are described in detail. A retrospective cohort of eyelid SCC was examined for p16 immunoexpression...
September 21, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37735286/clear-cell-squamous-cell-carcinoma-of-the-maxillary-gingiva-associated-with-pik3ca-and-hras-mutations-report-of-a-case-and-literature-review
#4
JOURNAL ARTICLE
Katsutoshi Hirose, Takumi Shibahara, Akari Teramoto, Yu Usami, Sawako Ono, Yuri Iwamoto, Shumei Murakami, Kaori Oya, Narikazu Uzawa, Daisuke Motooka, Yumiko Hori, Eiichi Morii, Satoru Toyosawa
BACKGROUND: Squamous cell carcinoma (SCC) is the most common oral malignancy, and somatic mutations in some driver genes have been implicated in SCC development. Clear cell SCC (CCSCC) is a rare histological variant of SCC, and various clear cell neoplasms must be considered in the differential diagnosis of CCSCC in the oral cavity. Based on a limited number of CCSCC cases reported in the oral cavity, CCSCC is considered an aggressive variant of SCC with a poor prognosis; however, its genetic characteristics remain unknown...
September 21, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37612574/histopathological-analysis-of-nodal-disease-after-chemoradiation-reveals-viable-tumor-cells-as-the-most-important-prognostic-factor-in-head-and-neck-squamous-cell-carcinoma-doi-10-1007-s12105-023-01557-7
#5
LETTER
Grégoire B Morand, Aline Golliez, Niels J Rupp
No abstract text is available yet for this article.
August 23, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37612573/is-viable-tumor-cell-the-most-important-prognostic-factor-in-head-and-neck-squamous-cell-carcinoma
#6
LETTER
Elaheh Sanjari, Hadi Raeisi Shahraki
No abstract text is available yet for this article.
August 23, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37594632/loss-of-bap1-protein-expression-by-immunohistochemistry-in-the-salivary-duct-carcinoma-component-of-an-intracapsular-carcinoma-ex-pleomorphic-adenoma-of-the-parotid-gland
#7
JOURNAL ARTICLE
Eleonora Fiorletta Quiroga, Patricia R Connor, Lisa Rooper, Mauricio A Moreno, J Stephen Nix
BACKGROUND: BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that is altered in a variety of neoplasms as well as in BAP1 tumor predisposition syndrome. BAP1 alterations are associated with aggressive behavior in some malignancies and may have treatment implications in future. We present the first documented case of loss of BAP1 protein expression by immunohistochemistry in the salivary duct carcinoma (SDC) component of an intracapsular carcinoma ex pleomorphic adenoma (CXPA) in the context of molecular loss of function of BAP1 in the neoplasm...
August 18, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37541995/true-oncocytic-acinic-cell-carcinoma-a-case-image
#8
JOURNAL ARTICLE
Matthew G Romanish, Raja R Seethala
A 67-year-old female with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) presented with right sided otalgia and a 2-3 cm firm, tender right posterior parotid mass. Fine needle aspiration biopsy (FNAB) established a diagnosis of acinic cell carcinoma (AciCC). Further workup demonstrated lung nodules which were confirmed by FNAB to represent metastatic AciCC. A right radical parotidectomy with sacrifice of the facial nerve, segmental mandibulectomy, and selective neck dissection (levels II-IV) was performed...
August 4, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37540486/low-grade-myofibroblastic-sarcoma-of-the-oral-and-maxillofacial-region-an-international-clinicopathologic-study-of-13-cases-and-literature-review
#9
JOURNAL ARTICLE
Daniela Giraldo-Roldan, Brendo Vinicius Rodrigues Louredo, Paulo Victor Mendes Penafort, Hélder Antônio Rebelo Pontes, Aline Pinheiro Alves, Fernando C A Lima, Thamyres Campos Fonseca, Aline Corrêa Abrahão, Mário José Romañach, Felipe Paiva Fonseca, Wilson A Delgado, Liam Robinson, Willie F P Van Heerden, Oslei Paes de Almeida, Pablo Agustin Vargas
Low-grade myofibroblastic sarcoma (LGMS) represents an atypical tumor composed of myofibroblasts with a variety of histological patterns and with a high tendency to local recurrence and a low probability of distant metastases. LGMS has predilection for the head and neck regions, especially the oral cavity. This study aimed to report 13 new cases of LGMS arising in the oral and maxillofacial region. This study included LGMS cases from five oral and maxillofacial pathology laboratories in four different countries (Brazil, Peru, Guatemala, and South Africa)...
August 4, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37540485/a-systematic-review-of-adenoid-ameloblastoma-a-newly-recognized-entity
#10
JOURNAL ARTICLE
Hannah Gil de Farias Morais, Rani Iani Costa Gonçalo, Carla Samily de Oliveira Costa, Hévila de Figueiredo Pires, Rodrigo Porpino Mafra, Everton Freitas de Morais, Márcia Cristina da Costa Miguel, Roseana de Almeida Freitas
BACKGROUND: Recently, a new odontogenic tumor has been described, the so-called adenoid ameloblastoma (AdAM). The aim of this review was to determine the clinical and imaging features of AdAM and to describe its main histopathological findings. METHODS: The systematic review included published cases with a diagnosis of AdAM in the gnathic bones, which had sufficient clinical, imaging, and histopathological data to confirm its diagnosis. The following histopathological diagnostic criteria were adopted: presence of ameloblastoma-like components, duct-like structures, spiral cellular condensations, and a cribriform architecture...
August 4, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486537/significance-of-worst-pattern-of-invasion-5-in-early-stage-oral-cavity-squamous-cell-carcinoma
#11
JOURNAL ARTICLE
Shima Mohamed, Hadeel Jawad, Ryan O' Sullivan, Deirdre Callanan, Patrick Sheahan, Linda Feeley
BACKGROUND: There is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection of patients who may benefit from adjuvant treatment. The objective of this study was to evaluate the prognostic ability of worst pattern of invasion-5 (WPOI-5) defined by the presence of satellite nodules, extratumoural perineural invasion (PNI) and/or extratumoural lymphovascular space invasion (LVI) in low-stage, node negative OCSCC...
July 24, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486536/p-mtor-p-erk-and-pten-expression-in-tumor-biopsies-and-organoids-as-predictive-biomarkers-for-patients-with-hpv-negative-head-and-neck-cancer
#12
JOURNAL ARTICLE
W W B de Kort, E J de Ruiter, W E Haakma, E Driehuis, L A Devriese, R J J van Es, S M Willems
BACKGROUND: Survival rates of head and neck squamous cell carcinoma (HNSCC) have only marginally improved in the last decades. Hence there is a need for predictive biomarkers for long-time survival that can help to guide treatment decisions and might lead to the development of new therapies. The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway is the most frequently altered pathway in HNSCC, genes are often mutated, amplificated and overexpressed causing aberrant signaling affecting cell growth and differentiation...
July 24, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486535/lipoblastoma-arising-in-the-head-and-neck-a-clinicopathologic-analysis-of-20-cases
#13
REVIEW
Zahra Aldawood, Alyaa Al-Ibraheemi
BACKGROUND: Lipoblastomas (LPBs) are benign adipocytic neoplasms believed to recapitulate the development of embryonal fat. METHODS: We investigated the clinicopathologic and immunohistochemical features of 20 lipoblastomas arising in the head and neck in 18 patients. RESULTS: Patients included 6 males and 12 females (1:2 ratio) with age at diagnosis ranging from 4 months to 28 years. Tumors occurred more commonly in the neck (12, 66.7%) and less commonly in the forehead, scalp, and tongue (2, 11...
July 24, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486534/hn-clear-head-and-neck-consensus-language-for-ease-and-reproducibility-a-multidisciplinary-consensus-mechanism-for-head-and-neck-pathology
#14
LETTER
Ruta Gupta, Munita Bal, Justin A Bishop, Keith D Hunter, Kelly Magliocca, Raja R Seethala, Lester D R Thompson, Ilan Weinreb, Peter Angelos, Beth Beadle, R Bryan Bell, Jonathan R Clark, Robert Ferris, Shao Hui Huang, D Neil Hayes, Rahul Ladwa, Jean Yang, Nicole A Cipriani, Brenda L Nelson, Peter M Sadow, James S Lewis
No abstract text is available yet for this article.
July 24, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486533/odontogenic-carcinosarcoma-clinicopathologic-and-molecular-features-of-three-cases-a-literature-review-and-nomenclature-proposal
#15
REVIEW
Grayson Cole, Angela Chi, Daniel R Cook, Mark Kubik, Elizabeth A Bilodeau, Raja R Seethala
BACKGROUND: Odontogenic carcinosarcoma (OCS) is a rare odontogenic malignancy with limited characterization and unexplored molecular features. We report clinicopathologic and molecular findings in 3 additional OCS and review the literature. METHODS: 3 OCS (5.1%) were identified among 59 malignant odontogenic tumors (in our archives from 1992 to 2022). Clinical, radiologic, histopathologic, immunophenotypic, and molecular findings were reviewed. Data from prior case reports and systematic or non-systematic reviews were extracted for analysis...
July 24, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37486532/protease-activated-receptor-1-par1-expression-contributes-to-hpv-associated-oropharyngeal-cancer-prognosis
#16
JOURNAL ARTICLE
Yoshinori Fujita, Yujiro Fukuda, Fumiaki Sanuki, Isao Irei, Yasumasa Monobe, Masako Uno, Takeshi Akisada, Koichiro Shimoya, Hirotaka Hara, Takuya Moriya
BACKGROUND: Human papillomavirus (HPV)-associated oropharyngeal cancer occasionally has a poor prognosis, making prognostic risk stratification crucial. Protease-activated receptor-1 (PAR1) is involved in carcinogenesis, and its expression is regulated by alpha-arrestin domain-containing protein 3 (ARRDC3). It is also involved in the tumor microenvironment. We sought to evaluate the predictive ability of PAR1, ARRDC3, and tumor-infiltrating lymphocyte (TIL) scores in patients with oropharyngeal, hypopharyngeal, and uterine cervical cancers, serving as comparators for HPV-associated oropharyngeal cancer...
July 24, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37420145/verruciform-xanthoma-clinical-and-morphologic-spectrum-across-oral-genital-and-cutaneous-sites
#17
JOURNAL ARTICLE
Tiffany Javadi, Faisel Saeed, Douglas C Parker, Kelly R Magliocca
BACKGROUND: Verruciform xanthoma (VX) is an uncommon, benign epithelial lesion of the oral mucosa. While this entity can also present extraorally, including on the skin and in anogenital areas, the variation in its histologic features in extraoral sites is not yet well defined. Differences in the demographics and morphologic features of oral versus extraoral VX were assessed to help facilitate the accurate diagnosis and management of this lesion. METHODS: After obtaining IRB approval, 110 cases of diagnosed VX were retrospectively collected from our institutional archives spanning from 2000 to 2022...
July 7, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37378830/biphenotypic-sinonasal-sarcoma-with-a-novel-pax7-ppargc1-fusion-expanding-the-spectrum-of-gene-fusions-beyond-the-pax3%C3%A2-gene
#18
JOURNAL ARTICLE
Sanica Bhele, John S A Chrisinger, Nyssa Fox Farrell, Brian A Van Tine, Constantine A Raptis, Rebecca D Chernock
Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade malignancy occurring in the sinonasal tract that is characterized by dual neural and myogenic differentiation. Rearrangements involving the PAX3 gene, usually with MAML3, are a hallmark of this tumor type and their identification are useful for diagnosis. Rarely, a MAML3 rearrangement without associated PAX3 rearrangement has been described. Other gene fusions have not been previously reported. Herein, we report a 22 year-old woman with a BSNS harboring a novel gene fusion involving the PAX7 gene (specifically PAX7::PPARGC1A), which is a paralogue of PAX3...
June 28, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37335526/liprin-%C3%AE-1-expression-in-tumor-infiltrating-lymphocytes-associates-with-improved-survival-in-patients-with-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#19
JOURNAL ARTICLE
Anni Sjöblom, Henna Pehkonen, Lauri Jouhi, Outi Monni, Reija Randén-Brady, Piia-Riitta Karhemo, Jussi Tarkkanen, Caj Haglund, Petri Mattila, Antti Mäkitie, Jaana Hagström, Timo Carpén
BACKGROUND: Liprin-α1 is a scaffold protein involved in cell adhesion, motility, and invasion in malignancies. Liprin-α1 inhibits the expression of metastatic suppressor CD82 in cancers such as oral carcinoma, and the expression of these proteins has been known to correlate negatively. The role of these proteins has not been previously studied in human papillomavirus (HPV)-related head and neck cancers. Our aim was to assess the clinical and prognostic role of liprin-α1 and CD82 in HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) in comparison to HPV-negative OPSCC...
June 19, 2023: Head and Neck Pathology
https://read.qxmd.com/read/37294412/exploration-of-digital-image-analysis-for-ki67-quantification-in-the-grading-of-medullary-thyroid-carcinoma-a-pilot-study-with-85-cases
#20
JOURNAL ARTICLE
David Blake Behrman, Daniel J Lubin, Kelly Magliocca, Qiuying Shi, Kartik Viswanathan
BACKGROUND: Although uncommon, medullary thyroid carcinoma (MTC) accounts for a significant proportion of thyroid cancer deaths. Recent studies have validated the two-tier International Medullary Thyroid Carcinoma Grading System (IMTCGS) to predict clinical outcomes. A 5% Ki67 proliferative index (Ki67PI) cut-off separates low-grade from high-grade MTC. In this study, we compared digital image analysis (DIA) to manual counting (MC) for determining the Ki67PI in a MTC cohort, and explored the challenges encountered...
June 9, 2023: Head and Neck Pathology
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