Journal of Digestive Diseases

OBJECTIVE: To investigate the clinicopathological and prognostic significance of intestinal metaplasia (IM) in endoscopically resected early gastric carcinoma (EGC). METHODS: The study included 136 consecutive EGC cases, resected by endoscopic submucosal dissection over a 5-year period, divided into early gastric cardiac (EGCC, n=60) and non-cardiac (EGNCC, n=76) groups. Goblet cell IM and subtypes were determined with histologic and immunostaining methods. Recurrence-free survival was compared among various IM subtype groups...

Pyroptosis is an inflammasome-dependent form of programmed cell death that is mediated by caspase-1,caspase-4/5/11 and the gasdermin protein family. It is characterized by the rupture of cell membranes, the release of cell contents and interleukins, the associated inflammatory reaction and immune system activation. Recent studies have suggested that pyroptosis plays a role in the development of digestive tract tumors，both impeding tumor generation and progression, as well as providing a favorable microenvironment for tumor growth...

OBJECTIVES: Covert hepatic encephalopathy (CHE) negatively affects the health-related quality of life and increases the risk of overt HE (OHE) in patients with liver cirrhosis. However, the impact of CHE on long-term patient outcomes remains controversial. This study aimed to explore the association between CHE and disease progression and survival among cirrhotic patients. METHODS: This was a single-center prospective study that enrolled 132 hospitalized patients with cirrhosis, with an average follow-up period of 45...

BACKGROUND & AIMS: In patients with acute pancreatitis, minimally invasive treatment and the step-up approach have been introduced and widely used to deal with infected pancreatic necrosis (IPN) in the last decade. It is unclear whether IPN has become a less important determinant of mortality relative to organ failure (OF). We aimed to statistically aggregate recent evidence from published studies to determine the relative importance of IPN and OF as determinants of mortality in patients with AP (PROSPERO: CRD42020176989)...

No abstract text is available yet for this article.

AIM: To estimate the performance of the FibroTouch-based ultrasound attenuation parameter (UAP) for assessing hepatic steatosis in non-alcoholic fatty liver disease (NAFLD), with MRI proton density fat fraction (MRI-PDFF) as the reference standard. METHODS: This prospective and cross-sectional study included 275 individuals in the training group and 110 individuals in the validation group, all of whom completed a standardized research visit, laboratory tests, MRI-PDFF, and UAP measurements over the course of one month...

OBJECTIVE: This study aimed to develop and validate a scoring system for predicting the need for esophagogastroduodenoscopy (EGD) in clinical practice to enhance accuracy and reduce misapplications. METHODS: From February 2021 to April 2022, outpatients scheduled for EGD at the Department of Gastroenterology in our hospital were recruited. Patients completed the system evaluation by providing clinical symptoms, relevant medical history, and endoscopic findings. Patients were randomly divided into the training and validation cohorts (at 2:1 ratio)...

BACKGROUND AND AIMS: Although portal vein thrombosis (PVT) was considered worsening portal hypertension and leading to poor prognosis, the risk stratification still be unclear. This study was to evaluate its effect on the risk of variceal rehemorrhage, accordingly identify the clinical predictors and develop a competitive risk model utilized for cirrhotic patients with PVT. METHODS: Cirrhotic patients with and without PVT admitted for variceal hemorrhage were retrospectively included by matching (1:1) for sex, age and etiology from two tertiary centres for 1-year follow-up, of which patients with PVT were divided into the training and validation cohort...

BACKGROUND: Anti-reflux mucosectomy (ARMS) is an emerging and promising endoscopic treatment for gastroesophageal reflux disease (GERD). The current study aimed to evaluate the safety and efficacy of ARMS in treating Chinese GERD patients. METHODS: This was a single-center prospective cohort study. ARMS was performed in enrolled GERD patients by experienced endoscopist. These patients were required to undergo symptom assessment as well as endoscopy examination, high resolution manometry (HRM) and impedance-pH monitoring before and after ARMS...

OBJECTIVE: This pilot study aimed to evaluate the efficacy and safety of domperidone for the treatment of Chinese patients with functional dyspepsia (FD) who were diagnosed according to the Rome IV criteria and to identify the FD subtypes that potentially responded better to domperidone. METHODS: This multicenter prospective study was conducted in China from August 2018 to July 2020, consisting of a 1-week screening phase and a 2-week double-blind treatment phase...

OBJECTIVES: The incidence and prevalence of inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn's disease (CD), are increasing globally. We aimed to evaluate the potential association between IBD and nephrolithiasis, tubulointerstitial nephritis, and chronic kidney disease (CKD). METHODS: Data of hospitalized adults ≥20 years of age were extracted from the U.S. National Inpatient Sample (NIS) during 2016-2018. Patients with UC, CD, or CKD were identified through the International Classification of Diseases, Tenth Revision (ICD-10) codes...

BACKGROUND: Intestinal Behcet's disease (BD) predominantly affects the ileocecal region and is currently diagnosed based on endoscopic features and clinical manifestations. It is difficult to distinguish between BD and Crohn's disease (CD) due to the similar patients' population, gastrointestinal involvement, extraintestinal presentation, and long recurrent course. We performed a study to compare the clinicopathological and immunophenotypic features of intestinal BD to CD. METHODS: The medical and pathological records of 29 cases of intestinal BD and 120 cases of CD diagnosed at Sir Run Run Shaw Hospital were retrospectively analyzed...

BACKGROUND: Currently, most colorectal neoplasia (CRN) screening strategies target asymptomatic patients. It is unclear whether patients with non-specific gastrointestinal symptoms should undergo risk stratification for CRN. AIMS: To develop a CRN risk score specifically for patients with non-specific gastrointestinal symptoms. METHODS: We prospectively collected data from patients who underwent initial colonoscopy between June 2020 and June 2021...

OBJECTIVE: Laser lithotripsy under fluoroscopic guidance was difficult and risky due to the invisibility of laser fiber under fluoroscopy. The study aimed to investigate the feasibility of a novel endoscopic auxiliary system (NEAS)-assisted lithotripsy under fluoroscopy for difficult common bile duct (CBD) stones. METHODS: Patients with difficult CBD stones treated with NEAS-assisted laser lithotripsy (NEAS group) or conventional mechanical lithotripsy (ML) under fluoroscopy (ML group) were retrospectively evaluated...

AIM: The risk of cerebrovascular accidents (CVA) in patients with inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is controversial. This study aimed to estimate the incidence rate and identify the risk factors for CVA in patients with IBD. METHODS: PubMed, Embase and Web of Science were searched until 13 January 2023, to identify studies that reported the incidence of CVA in IBD patients, along with the total person-years or related data to calculate it...

OBJECTIVES: We aimed to evaluate the association between LGI and the severity of patients with HTG-AP. METHODS: We retrospectively reviewed 311 patients with HTG-AP who were admitted to the Department of Fujian Provincial Hospital between April 2012 and March 2021. Inpatient medical and radiologic records were reviewed to determine clinical features, severity, and complications. C-reactive protein (CRP) level, white blood cell (WBC) count, platelet (PLT) count, and neutrophil-to-lymphocyte ratio (NLR) were considered low-grade inflammation biomarkers and were combined into a standardized LGI score...

AIM: the aortic carboxypeptidase-like protein (ACLP) is an extracellular protein involved in adipogenesis, epithelial-mesenchymal transition, epithelial cell hyperplasia and collagen fibrogenesis. The main study objective was to analyze the potential of ACLP encoding gene (AEBP1) as a pathological target or prognostic marker for liver fibrosis regardless of etiology. METHODS: dysregulation pattern, clinical relevance and biological significance of AEBP1 gene in liver fibrosis were analyzed using publicly available transcriptomic profiles, different liver fibrosis mouse models, biological databases, and AEBP1 gene silence followed by RNA sequencing in human hepatic stellate cells (HSCs)...

The discovery of the constitutive activation of KIT/PDGFRA tyrosine kinases in gastrointestinal stromal tumors (GISTs) led to the development of the targeted drug imatinib. However, the inevitable development of imatinib resistance remains a major issue. Ripretinib is a novel targeted drug that inhibits the activity of a broad spectrum of drug-resistant KIT/PDGFRA mutants. It was approved in 2020 and is currently recommended in major international guidelines as fourth-line and beyond therapy for advanced GISTs...

No abstract text is available yet for this article.

AIMS: This study aimed to compare the need for further examination with conventional gastroscopy between patients with gastrointestinal symptoms and asymptomatic patients who underwent magnetically assisted capsule endoscopy. METHODS: We retrospectively enrolled 372 patients with gastrointestinal symptoms and 372 asymptomatic patients who had undergone magnetically assisted capsule endoscopy at the First Affiliated Hospital of Sun Yat-sen University from January 1, 2019, to December 30, 2020...