Fang-Cheng Jiang, Gao-Qiang Zhai, Jia-Lin Liu, Rui-Gong Wang, Yuan-Ping Yang, Harivignesh Murugesan, Xiao-Xiang Yu, Xiu-Fang Du, Juan He, Zhen-Bo Feng, Shang Ling Pan, Gang Chen, Sheng-Hua Li, Zhi-Guang Huang
The progression of prostate cancer (PCa) leads to poor prognosis. However, the molecular mechanism of PCa is still not completely clear. This study aimed to elucidate the important role of centromere protein A (CENPA) in PCa. Large numbers of bulk RNA sequencing (RNA-seq) data and in-house immunohistochemistry data were used in analysing the expression level of CENPA in PCa and metastatic PCa (MPCa). Single-cell RNA-seq data was used to explore the expression status of CENPA in different prostate subpopulations...
July 24, 2023: IET Systems Biology