Vipin Thomas, Navya Raj, Deepthi Varughese, Naveen Kumar, Seema Sehrawat, Abhinav Grover, Shailja Singh, Pawan K Dhar, Achuthsankar S Nair
Expression of synthetic proteins from intergenic regions of E. coli and their functional association was recently demonstrated (Dhar et al. in J Biol Eng 3:2, 2009. doi:10.1186/1754-1611-3-2). This gave birth to the question: if one can make 'user-defined' genes from non-coding genome-how big is the artificially translatable genome? (Dinger et al. in PLoS Comput Biol 4, 2008; Frith et al. in RNA Biol 3(1):40-48, 2006a; Frith et al. in PLoS Genet 2(4):e52, 2006b). To answer this question, we performed a bioinformatics study of all reported E...
December 2015: Systems and Synthetic Biology