journal
https://read.qxmd.com/read/29720824/optimization-of-extraction-conditions-for-phenolic-acids-from-the-leaves-of-melissa-officinalis-l-using-response-surface-methodology
#21
JOURNAL ARTICLE
Guijae Yoo, Il Kyun Lee, Seonju Park, Nanyoung Kim, Jun Hyung Park, Seung Hyun Kim
Background: Melissa officinalis L. is a well-known medicinal plant from the family Lamiaceae , which is distributed throughout Eastern Mediterranean region and Western Asia. Objective: In this study, response surface methodology (RSM) was utilized to optimize the extraction conditions for bioactive compounds from the leaves of M. officinalis L. Materials and Methods: A Box-Behnken design (BBD) was utilized to evaluate the effects of three independent variables, namely extraction temperature (°C), methanol concentration (%), and solvent-to-material ratio (mL/g) on the responses of the contents of caffeic acid and rosmarinic acid...
April 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29720823/-in-vitro-induction-and-generation-of-tetraploid-plants-of-sophora-tonkinensis-gapnep
#22
JOURNAL ARTICLE
Kun Hua Wei, Jian Ping Xu, Lin Xuan Li, Jin Yuan Cai, Jian Hua Miao, Min Hui Li
Background: Sophora tonkinensis Gapnep. is an important medical plant in China. Early researches of S. tonkinensis were focused on rapid propagation and quality analysis of in vitro tissue culture plantlet, and still no research focuses on the plant breeding of and there were no excellent varieties for artificial cultivation of S. tonkinensis . Objective: To set up a method to generate and select the best varieties of S. tonkinensis by polyploid breeding after induction by colchicine treatment...
April 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29720822/herbal-medicines-showing-synergistic-effects-with-tumor-necrosis-factor-related-apoptosis-inducing-ligand-trail-against-a549-trail-resistant-lung-cancer-cells-a-screening-study
#23
JOURNAL ARTICLE
Shuen Cheng Chiang, Yeon-Jung Choi, Shi-Eun Kang, Miyong Yun, Beom-Joon Lee
BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that activates apoptosis through death receptors on the cell surface and is regarded as a potential anticancer agent. However, many cancer cells are resistant to TRAIL-induced apoptosis. OBJECTIVE: The aim is to identify the herbal medicines that could help overcome resistance in TRAIL-resistant lung cancer cells. MATERIALS AND METHODS: TRAIL-resistant A549 cells and 13 herbal medicines with known apoptosis-related anticancer effects were used in this study: Clematidis Radix , Corydalis Tuber Rhizoma , Paeoniae Radix Rubra , Corni Fructus , Curcumae longae Rhizoma (CLR) , Moutan Cortex , Salviae miltiorrhizae Radix , Phellodendri Cortex , Farfarae Flos , Paeoniae Radix Alba , Angelicae gigantis Radix , Coptidis Rhizoma (CR), and Taraxaci Herba ...
April 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29720821/chemical-composition-and-cytotoxic-activity-of-methanol-extract-and-its-fractions-of-streblus-asper-leaves-on-human-cancer-cell-lines
#24
JOURNAL ARTICLE
Preeti Rawat, Anil Kumar, Tryambak Deo Singh, Mahesh Pal
BACKGROUND: Streblus asper , family Moraceae is well-known important medicinal plant used in the Indian system of medicine. In Ayurveda, stem bark of S. asper is recommended against elephantiasis for which there is still no any other effective medicine in the modern system of medicine. OBJECTIVES: In the present work, methanol extract (SAM) and its fractions of S. asper leave tested for in vitro anticancer activity against cancer cell lines (MCF-7, A-549, Hep-G2, and K-562) which claims its folklore importance in cancer and gas chromatography-mass spectrometry identification of extracts was also performed...
April 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576714/rhubarb-attenuates-cerebral-edema-via-inhibition-of-the-extracellular-signal-regulated-kinase-pathway-following-traumatic-brain-injury-in-rats
#25
JOURNAL ARTICLE
Zhaoyu Yang, Rong Fan, Peng Sun, Hanjin Cui, Weijun Peng, Jiekun Luo, Chunhu Zhang, Xingui Xiong, Wei Huang, Wei Liu
Background: Rhubarb is a traditional Chinese medicine for treating traumatic brain injury (TBI). Purpose: The purpose of this study is to elucidate the potential mechanism of rhubarb by suppressing extracellular signal-regulated kinase (ERK) to ameliorate brain edema. Materials and Methods: Sprague-Dawley rats were separated into four groups at random. One group received 3 g/kg rhubarb, and another group received 12 g/kg rhubarb, and the vehicle group and sham group were administered the same dose of saline solution...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576713/determination-of-eupatilin-in-folium-artemisiae-argyi-and-its-inhibitory-effect-on-hepatoma-cells
#26
JOURNAL ARTICLE
Rui Liu, Jin Zhao, Ke He, Xiaodong Zhang, Liang Chang, Guoan Xiang
Aim: The aim of this study is to establish a method for determination of eupatilin in Folium artemisiae Argyi and observe the inhibitory effect of Folium artemisiae Argyi extract on human hepatoma SMMC-7721 cells. Methods: High-performance liquid chromatograph system with 2910 pump, 2930 UV detector, and N2000 workstation was used for determination of eupatilin in Folium artemisiae Argyi. Human hepatoma SMMC-7721 cells were cultured and cell proliferation was measured using the MTT assay...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576712/computational-tool-for-immunotoxic-assessment-of-pyrethroids-toward-adaptive-immune-cell-receptors
#27
JOURNAL ARTICLE
Anoop Kumar, Padma Charan Behera, Naresh Kumar Rangra, Suddhasattya Dey, Kamal Kant
Background: Pyrethroids have prominently known for their insecticidal actions worldwide, but recent reports as anticancer and antiviral applications gained a lot of interest to further understand their safety and immunotoxicity. Objective: This encouraged us to carry out our present study to evaluate the interactions of pyrethroids toward adaptive immune cell receptors. Materials and Methods: Type 1 and Type 2 pyrethroids were tested on T (CD4 and CD8) and B (CD28 and CD45) immune cell receptors using Maestro 9...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576711/-cordyceps-militaris-fraction-induces-apoptosis-and-g2-m-arrest-via-c-jun-n-terminal-kinase-signaling-pathway-in-oral-squamous-carcinoma-kb-cells
#28
JOURNAL ARTICLE
Wangshi Xie, Zhang Zhang, Liyan Song, Chunhua Huang, Zhongyi Guo, Xianjing Hu, Sixue Bi, Rongmin Yu
Background: Cordyceps militaris fraction (CMF) has been shown to possess in vitro antitumor activity against human chronic myeloid leukemia K562 cells in our previous research. Materials and Methods: The in vitro inhibitory activities of CMF on the growth of KB cells were evaluated by viability assay. The apoptotic and cell cycle influences of CMF were detected by 4',6-diamidino-2-phenylindole staining and flow cytometry assay. The expression of different apoptosis-associated proteins and cell cycle regulatory proteins was examined by Western blot assay...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576710/capsaicin-reverses-the-inhibitory-effect-of-licochalcone-a-%C3%AE-arbutin-on-tyrosinase-expression-in-b16-mouse-melanoma-cells
#29
JOURNAL ARTICLE
Jun-Hui Hong, Huo-Ji Chen, Shi-Jian Xiang, Si-Wei Cao, Bai-Chao An, Shi-Fa Ruan, Bin Zhang, Li-Dong Weng, Hong-Xia Zhu, Qiang Liu
Introduction: Melanin is synthesized by melanocytes, which are located in the basal layer of the skin. After synthesis, melanin is further deposited on the surface of the skin to form black spots or chloasma. Tyrosinase is a rate-limiting enzyme that plays an important role in melanogenesis. Currently, there are many drugs that inhibit tyrosinase expression to further reduce melanogenesis. Nevertheless, some of these could reverse the pharmacological effect of other drugs, when used simultaneously...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576709/antioxidant-and-hemolysis-protective-effects-of-polyphenol-rich-extract-from-mulberry-fruits
#30
JOURNAL ARTICLE
Palanigounder Ganeshan Ajay Krishna, Thasma Raman Sivakumar, Chao Jin, Shao-Hu Li, Yu-Jie Weng, Juan Yin, Jun-Qiang Jia, Chu-Yan Wang, Zhong-Zheng Gui
Background: Mulberry fruits are a superior source of polyphenol, especially anthocyanins that contribute potentially to the beneficial effects which include reducing the risk of cardiovascular diseases and cancers with antioxidant, anti-inflammatory, and chemoprotective properties. Objectives: In this study, purification of the polyphenol-rich extract from mulberry fruit (MPE) was purified and assessed the activities of antioxidant and hemolysis protective in vivo and in vitro ...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576708/further-study-of-influence-of-panax-notoginseng-on-intestinal-absorption-characteristics-of-triptolide-and-tripterine-in-rats-with-tripterygium-wilfordii
#31
JOURNAL ARTICLE
Yiqun Li, Benyong Zhang, Mengzhu Liu, Xinlong Zhang, Donglei Shi, Liwei Guo, Jinao Duan, Xueping Zhou, Huaxu Zhu, Qichun Zhang
Background: Tripterygium wilfordii (TW) is widely employed to treat rheumatoid arthritis and autoimmune disorders clinically, which, however, accompany with disturbing hepatotoxicity and nephrotoxicity. The previous research showed that Panax notoginseng (PN) compatibly and significantly reduces the TW-induced hepatotoxicity. Objective: To explore the underlying mechanism, the present study was designed to reveal the influence of PN on the intestinal absorption process of TW-derived active components in rat...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576707/novel-method-of-preparation-and-activity-research-on-arctigenin-from-fructus-arctii
#32
JOURNAL ARTICLE
Enbo Cai, Jiahong Han, Limin Yang, Weiyuan Zhang, Yan Zhao, Qiulian Chen, Meng Guo, Xinhong He
Background: Arctigenin has many pharmacological activities with clinical significance and is derived from Arctium lappa L. However, the present extraction method is inefficient and does not have meaningful industrial production. Objective: A new method to directly prepare arctigenin was established by combining enzyme-assisted extraction and central composite design. Arctigenin's further pharmacological activity was also surveyed in vitro . Materials and Methods: β-D-Glucosidase, a food-grade enzyme, was added directly to the fruits of A...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576706/rhynchophylline-downregulates-phosphorylated-camp-response-element-binding-protein-nuclear-receptor-related-1-and-brain-derived-neurotrophic-factor-expression-in-the-hippocampus-of-ketamine-induced-conditioned-place-preference-rats
#33
JOURNAL ARTICLE
Youli Guo, Chaohua Luo, Genghong Tu, Chan Li, Yi Liu, Wei Liu, Ken Kin Lam Yung, Zhixian Mo
Background: Addiction to ketamine is becoming a serious public health issues, for which there exists no effective treatment. Rhynchophylline (Rhy) is an alkaloid extracted from certain Uncaria species that is well known for both its potent anti-addictive and neuroprotective properties. Increasing evidence supports the contributions of cAMP response element binding protein (CREB), nuclear receptor-related-1 (Nurr1), and brain-derived neurotrophic factor (BDNF) in modulating neural and behavioral plasticity which was induced by addictive drugs...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576705/antibacterial-activity-of-azadirachta-indica-pongamia-pinnata-psidium-guajava-and-mangifera-indica-and-their-mechanism-of-action-against-streptococcus-mutans
#34
JOURNAL ARTICLE
Dikonketso Cathrine Bodiba, Preety Prasad, Ajay Srivastava, Brigdet Crampton, Namrita Sharan Lall
Background: Curative plants have reportedly been used to make chewing sticks/toothbrushes intended for the treatment of oral diseases. Objective: The in vitro antibacterial activities of Azadirachta indica , Pongamia pinnata , Psidium guajava , and Mangifera indica were evaluated against Streptococcus mutans , along with the cytotoxicity and antioxidant and synergistic potentials. The effect of M. indica on the expression of crucial virulence genes spaP and gtfB of S...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576704/quantitative-determination-of-bioactive-constituents-in-noni-juice-by-high-performance-liquid-chromatography-with-electrospray-ionization-triple-quadrupole-mass-spectrometry
#35
JOURNAL ARTICLE
Yongqiu Yan, Yu Lu, Shiping Jiang, Yu Jiang, Yingpeng Tong, Limin Zuo, Jun Yang, Feng Gong, Ling Zhang, Ping Wang
Background: Noni juice has been extensively used as folk medicine for the treatment of arthritis, infections, analgesic, colds, cancers, and diabetes by Polynesians for many years. Due to the lack of standard scientific evaluation methods, various kinds of commercial Noni juice with different quality and price were available on the market. Objective: To establish a sensitive, reliable, and accurate high-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometry (HPLC-ESI-MS/MS) method for separation, identification, and simultaneous quantitative analysis of bioactive constituents in Noni juice...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576703/identification-of-three-kinds-of-citri-reticulatae-pericarpium-based-on-deoxyribonucleic-acid-barcoding-and-high-performance-liquid-chromatography-diode-array-detection-electrospray-ionization-mass-spectrometry-mass-spectrometry-combined-with-chemometric-analysis
#36
JOURNAL ARTICLE
Xiaoxue Yu, Yafeng Zhang, Dongmei Wang, Lin Jiang, Xinjun Xu
Background: Citri Reticulatae Pericarpium is the dried mature pericarp of Citrus reticulata Blanco which can be divided into "Chenpi" and "Guangchenpi." "Guangchenpi" is the genuine Chinese medicinal material in Xinhui, Guangdong province; based on the greatest quality and least amount, it is most expensive among others. Hesperidin is used as the marker to identify Citri Reticulatae Pericarpium described in the Chinese Pharmacopoeia 2010. However, both "Chenpi" and "Guangchenpi" contain hesperidin so that it is impossible to differentiate them by measuring hesperidin...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576702/the-standardized-extract-of-limonium-tetragonum-alleviates-chronic-alcoholic-liver-injury-in-c57bl-6j-mice
#37
JOURNAL ARTICLE
Na-Hyun Kim, Jeong-Doo Heo, Jung-Rae Rho, Min Hye Yang, Eun Ju Jeong
Background: In traditional folk medicine, Limonium tetragonum is used in the treatment of uterine hemorrhage, tinnitus, and oligomenorrhea. Objective: This study aimed to identify the therapeutic effect of L. tetragonum EtOAc extract (EALT) on liver of mice with chronic alcohol poisoning. Materials and Methods: C57BL/6J mice were administered 100 mg/kg of EALT with a single binge ethanol/Lieber-DeCarli liquid diet for 8 weeks. Results: The chronic-binge ethanol diet induced a significant increase in liver marker enzyme activities...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576701/evaluation-of-antioxidant-antimicrobial-and-antiurolithiatic-potential-of-different-solvent-extracts-of-aerva-lanata-linn-flowers
#38
JOURNAL ARTICLE
Padma Charan Behera, Manik Ghosh
Introduction: Aerva lanata (Linn) of family Amaranthaceae is an important and commonly used plant for its medicinal and pharmacological properties and proving the traditional uses of flowers of A. lanata Linn. Objective: All extracts of A. lanata were further evaluated for antioxidant, antimicrobial, and antiurolithiatic potential to scientifically prove the traditional uses. Materials and Methods: In the present investigation, different solvent extracts of flowers were obtained using a Soxhlet extractor...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576700/combined-antihypertensive-effect-of-paeoniflorin-enriched-extract-and-metoprolol-in-spontaneously-hypertensive-rats
#39
JOURNAL ARTICLE
Bo Li, Zheng-Biao Yang, Shan-Sha Lei, Jie Su, Ze-Wu Jin, Su-Hong Chen, Gui-Yuan Lv
Background: Hypertension is a great global health challenge and it mostly requires drug combination therapy with the various advantages. Metoprolol (MP) and paeoniflorin are both commonly used for the treatment of hypertension. However, whether they exert synergistic effects on antihypertension or not remains unclear, especially on vascular endothelial function. Objective: The purpose of the study is to investigate the advantages of the combined antihypertensive effects of paeoniflorin enriched extract from Radix Paeoniae Alba (RE) and MP in spontaneously hypertensive rats (SHR)...
January 2018: Pharmacognosy Magazine
https://read.qxmd.com/read/29576699/modeling-and-optimum-extraction-of-multiple-bioactive-exopolysaccharide-from-an-endophytic-fungus-of-crocus-sativus-l
#40
JOURNAL ARTICLE
Lu Wen, Yuan Xu, Qiqiu Wei, Wuhai Chen, Gang Chen
Background: Crocus sativus L. (saffron) is a scarce plant that has been used as food flavoring agent, coloring agent, and traditional herbal medicine. Methods: The bioactivity of exopolysaccharide (EPS) extracted from an endophytic fungus of C. sativus was examined for the first time by antioxidative, antitumor, and antibacterial assays. The extraction conditions for EPS were optimized by combining the response surface methodology with Box-Behnken design. Results: EPS exhibited excellent scavenging activities against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals, and moderate cytotoxicities against K562, A549, HL-60, and HeLa cells...
January 2018: Pharmacognosy Magazine
journal
journal
41584
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.