journal
https://read.qxmd.com/read/38514214/a-new-epoch-in-treating-diseases-of-the-heart
#21
EDITORIAL
Jonathan Q Purnell, Samuel A Camacho
No abstract text is available yet for this article.
2024: Journal of Clinical Lipidology
https://read.qxmd.com/read/38514213/from-the-editors-new-insights-into-lipid-disorders-in-children-and-adolescents-as-well-as-cardiovascular-benefits-of-pharmacotherapy-for-weight-loss
#22
EDITORIAL
Kevin C Maki, P Barton Duell
No abstract text is available yet for this article.
2024: Journal of Clinical Lipidology
https://read.qxmd.com/read/38040539/comparison-of-virtual-vs-face-to-face-medical-nutrition-therapy-in-patients-with-hyperlipidemia
#23
JOURNAL ARTICLE
Shannon Zoulek, Jackson Shriver, Navkiranjot Kaur, Beverly Kuznicki, Eric J Brandt
Since the COVID-19 pandemic, utilization of telemedicine visits has increased. The outcomes of virtual compared to face-to-face (F2F) visits for treating hyperlipidemia are uncharacterized. This observational study compared pre- to post-visit change in lipid markers between 41 virtual and 151 F2F visits with a registered dietitian nutritionist at the University of Michigan Preventive Cardiology program from 3/31/2019-9/31/2022. Total cholesterol (TC), high-density lipoprotein (HDL), and triglycerides (TG) were collected pre- and post-visit with a median 33 days between collections...
2024: Journal of Clinical Lipidology
https://read.qxmd.com/read/38040538/cascade-testing-of-children-and-adolescents-for-elevated-lp-a-in-pedigrees-with-familial-hypercholesterolaemia
#24
JOURNAL ARTICLE
Wann Jia Loh, Jing Pang, Anindita Chakraborty, Natalie C Ward, Dick C Chan, Amanda J Hooper, Damon A Bell, John R Burnett, Andrew C Martin, Gerald F Watts
Elevated plasma lipoprotein(a) [Lp(a)] is a common, inherited condition independently causing cardiovascular disease. Recent expert recommendations suggest opportunistically testing for elevated Lp(a) during cascade testing for familial hypercholesterolaemia (FH). We investigated the effectiveness of detecting elevated Lp(a) in 103 children and adolescents who were first-degree relatives of 66 adult index FH cases as part of an established FH cascade screening program. The yield of detection of elevated Lp(a) using a threshold of ≥30 mg/dL in children and adolescents was assessed...
2024: Journal of Clinical Lipidology
https://read.qxmd.com/read/38030518/comparison-of-the-burden-of-familial-hypercholesterolemia-between-two-cohorts-of-french-canadians-hospitalized-25-years-apart-for-coronary-heart-disease
#25
JOURNAL ARTICLE
Alex Lauzière, Diane Brisson, Gérald Tremblay, Sophie Bédard, Etienne Khoury, Daniel Gaudet
BACKGROUND: Familial hypercholesterolemia (FH) is associated with lifelong elevated plasma concentrations of low-density lipoprotein cholesterol (LDL-C) and high risk of premature coronary heart disease (CHD). Clinical recommendations and treatments have emerged to facilitate the management of FH patients. Their impact on the burden of FH is however not well documented. OBJECTIVE: To compare the burden of FH between patients hospitalized for a CHD event 25 years apart in the French-Canadian founder population...
2024: Journal of Clinical Lipidology
https://read.qxmd.com/read/38185588/association-of-cumulative-low-density-lipoprotein-cholesterol-exposure-with-vascular-function
#26
JOURNAL ARTICLE
Takayuki Yamaji, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Kenichi Yoshimura, Yukiko Nakano, Chikara Goto, Takahiro Harada, Aya Mizobuchi, Shunsuke Tanigawa, Tatsuya Maruhashi, Yukihito Higashi
BACKGROUND: The relationship between cumulative low-density lipoprotein cholesterol (LDL-C) exposure and progression of atherosclerosis remains uncertain. OBJECTIVE: The aim of this study was to determine the relationship between cumulative LDL-C level and flow-mediated vasodilation (FMD), nitroglycerine-induced vasodilation (NID) and the presence of plaque in the common carotid artery (CCA). METHODS: This was a cross-sectional study. We measured FMD in 8208 subjects, NID in 1822 subjects, and CCA plaque in 591 subjects who were not taking lipid-lowering drugs...
December 25, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38245457/jcl-roundtable-evolution-of-preventive-cardiology-and-clinical-lipidology
#27
JOURNAL ARTICLE
Martha Gulati, Erin D Michos, William E Boden, John R Guyton
It's a privilege to discuss preventive cardiology with 3 of the foremost U.S. leaders in this growing subspecialty. Preventive cardiology is the practice of primordial, primary, and secondary prevention of cardiovascular disease. It employs an integrated team of clinicians committed to preventing all forms of cardiovascular disease, including ischemic heart disease, heart failure, atrial fibrillation, and other conditions. Thus, contemporary preventive cardiology extends management beyond dyslipidemic risk reduction and now commonly includes treatment of hypertension, diabetes and other related cardiometabolic disorders, novel cardiovascular risk factors, thrombotic risk, some cardiac genetic disorders, and cardiac disorders specific to women's health, as well as attention to tobacco- and drug-related risks...
December 15, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38177036/no-benefit-of-vitamin-d-supplementation-on-muscle-function-and-health-related-quality-of-life-in-primary-cardiovascular-prevention-patients-with-statin-associated-muscle-symptoms-a-randomized-controlled-trial
#28
JOURNAL ARTICLE
Paul Peyrel, Pascale Mauriège, Jérôme Frenette, Nathalie Laflamme, Karine Greffard, Sébastien S Dufresne, Claire Huth, Jean Bergeron, Denis R Joanisse
BACKGROUND: Statins are the leading lipid-lowering drugs, reducing blood cholesterol by controlling its synthesis. Side effects are linked to the use of statins, in particular statin-associated muscle symptoms (SAMS). Some data suggest that vitamin D supplementation could reduce SAMS. OBJECTIVE: The purpose of this study was to evaluate the potential benefits of the vitamin D supplement in a randomized controlled trial. METHODS: Men (n = 23) and women (n = 15) (50...
December 15, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38158247/modern-approaches-to-the-management-of-homozygous-familial-hypercholesterolemia-in-the-middle-east-and-north-africa
#29
REVIEW
Abdullah Al-Ashwal, Afaf Alsagheir, Mohammed Al Dubayee, Mutaz Al-Khnifsawi, Ahmed Al-Sarraf, Zuhier Awan, Tawfeg Ben-Omran, Saif Al-Yaarubi, Angham Almutair, Abdelhadi Habeb, Faouzi Maatouk, Manal Alshareef, Naji Kholaif, Dirk Blom
Homozygous familial hypercholesterolaemia (HoFH) is a severe form of FH in which inheritance of two defective or null mutations in genes associated with metabolism of low-density lipoprotein cholesterol (LDL-C) results in extremely high LDL-C, premature atherosclerotic cardiovascular disease (ASCVD) and mortality. Treatment of HoFH comprises a multi-modal approach of statins, ezetimibe, lipoprotein apheresis; and inhibitors of proprotein convertase subtilisin/kexin type, angiopoietin-like protein 3 (ANGPTL3) and microsomal triglyceride transfer protein...
December 15, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38158248/hepatic-fat-changes-with-antisense-oligonucleotide-therapy-targeting-angptl3
#30
JOURNAL ARTICLE
Andre Zimerman, Stephen D Wiviott, Jeong-Gun Park, Sabina A Murphy, Xinhui Ran, Candace R Bramson, Madelyn Curto, Vesper Ramos, Alexandra Jevne, Julia F Kuder, Subodh Verma, Wojtek Wojakowski, Steven G Terra, Marc S Sabatine, Brian A Bergmark, Nicholas A Marston
BACKGROUND: Angiopoietin-like protein 3 (ANGPTL3) is a novel therapeutic target for hyperlipidemia. Vupanorsen, an antisense oligonucleotide targeting ANGPTL3, reduced triglycerides up to 57% in a phase 2b trial, but caused dose-dependent increases in hepatic fat fraction (HFF). OBJECTIVE: To determine the degree of HFF progression with escalating doses of vupanorsen, differential HFF increases in key patient subgroups, and the correlation between changes in HFF and liver enzymes...
December 10, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38172009/universal-lipid-screening-in-adolescents-to-identify-familial-hypercholesterolemia-in-a-large-healthcare-system
#31
JOURNAL ARTICLE
Alan B Cortez, Miriam Salvador, Qiaowu Li, Audrey Briscoe
BACKGROUND: Familial Hypercholesterolemia (FH) is an inherited condition that likely affects 1 in 300 people often requiring pharmacologic intervention in childhood. OBJECTIVES: We hypothesized that current strategies for pediatric lipid screening fail to detect and treat most FH, but data analysis may suggest specific methods to improve outcomes. METHODS: We retrospectively searched 392,129 patient records of 11-17-year-olds in Kaiser Permanente Southern California for data related to recommended universal pediatric lipid screening...
December 8, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38172008/a-case-report-of-tangier-disease-presents-with-acute-sensorimotor-polyneuropathy-and-its-treatment-approach
#32
JOURNAL ARTICLE
Saniye Karabudak, Vildan Güzel, Beril Güler, Bülent Uyanık, Azize Esra Gürsoy
Polyneuropathy is a frequently encountered clinical presentation where peripheral nerves are affected due to the same cause and physiopathological processes. We report a case of acute sensorimotor polyneuropathy in a patient with Tangier disease (TD) who was treated with miglustat which is a glycosphingolipid synthesis inhibitor. TD is a very rare genetic disorder caused by mutations in the ABCA1 gene which encodes the cholesterol efflux regulatory protein. It leads to accumulation of cholesterol esters within various tissues and affects lipid metabolism by deficiency of high-density lipoprotein (HDL) in the blood...
December 2, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38092592/fatty-acid-analysis-in-serum-of-patients-with-elevated-lipoprotein-a-and-cardiovascular-disease-undergoing-lipoprotein-apheresis
#33
JOURNAL ARTICLE
Agnieszka Mickiewicz, Joanna Marlęga-Linert, Monika Czapiewska, Marta Marcinkowska, Aleksandra Krzesińska, Agnieszka Kuchta, Marcin Fijałkowski, Marcin Gruchała, Adriana Mika
BACKGROUND: Lipoprotein apheresis (LA) is an extracorporeal treatment that transiently reduces lipoprotein (a) by 60% and leads to an 80-92% reduction in major adverse cardiovascular events. LA has a significant impact on lipid profile in serum of patients with atherosclerotic cardiovascular disease. OBJECTIVE: To investigate the effects of LA on the composition of serum fatty acids (FAs), focusing on those which could have an impact on cardiovascular disease (CVD)...
November 28, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38065716/habitual-fish-oil-supplementation-genetic-susceptibility-of-kidney-stones-and-the-risk-of-new-onset-kidney-stones
#34
JOURNAL ARTICLE
Xiaoqin Gan, Mengyi Liu, Panpan He, Ziliang Ye, Hao Xiang, Chun Zhou, Sisi Yang, Yanjun Zhang, Yuanyuan Zhang, Yu Huang, Xianhui Qin
OBJECTIVE: We aimed to assess the association between habitual fish oil use and new-onset kidney stones in participants with different levels of genetic risks of kidney stones. METHODS: 477,311 participants free of kidney stones at baseline from the UK Biobank cohort were included. Fish oil use was collected by both food frequency questionnaires and 24-h dietary recalls. A genetic risk score (GRS) for kidney stones was calculated based on 20 single-nucleotide polymorphisms associated with kidney stones...
November 27, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38065715/lipoprotein-a-levels-and-carotid-intima-media-thickness-in-children-a-20-year-follow-up-study
#35
JOURNAL ARTICLE
L M de Boer, B A Hutten, S Tsimikas, C Yeang, A H Zwinderman, J Kroon, A Revers, J J P Kastelein, A Wiegman
Elevated lipoprotein(a) [Lp(a)] is independently associated with cardiovascular disease (CVD). In a recent long-term follow-up study involving children with familial hypercholesterolemia, Lp(a) levels contributed significantly to early atherosclerosis, as measured by carotid intima-media thickness (cIMT). To determine if this holds true for children without FH, we conducted a 20-year follow-up study, examining 88 unaffected siblings (mean age: 12.9 years) of children with FH. No significant association was found between Lp(a) and cIMT during follow-up (ß-adjusted [95% CI] = 0...
November 27, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38101971/differential-impacts-of-admission-ldl-cholesterol-on-early-vascular-outcomes-by-ischemic-stroke-subtypes
#36
JOURNAL ARTICLE
Joon-Tae Kim, Ji Sung Lee, Hyunsoo Kim, Beom Joon Kim, Jihoon Kang, Keon-Joo Lee, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Kyungbok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Dong-Eog Kim, Jay Chol Choi, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong-Ho Hong, Sang-Hwa Lee, Man-Seok Park, Wi-Sun Ryu, Kwang-Yeol Park, Juneyoung Lee, Hee-Joon Bae
BACKGROUND: Because ischemic stroke is heterogeneous, the associations between LDL-cholesterol levels and early vascular outcomes might be different according to the stroke subtype in acute ischemic stroke patients. METHODS: This study was an analysis of a prospective, multicenter, stroke registry. Acute ischemic stroke patients previously not treated with statins were included. Admission LDL-cholesterol levels were divided into 7 groups at 20 mg/dl intervals for comparison...
November 26, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38044203/genetic-risk-score-in-patients-with-the-apoe2-e2-genotype-as-a-predictor-of-familial-dysbetalipoproteinemia
#37
JOURNAL ARTICLE
Martin Satny, Veronika Todorovova, Tereza Altschmiedova, Jaroslav A Hubacek, Lucie Dlouha, Vera Lanska, Vladimir Soska, Ondrej Kyselak, Tomas Freiberger, Martin Bobak, Michal Vrablik
BACKGROUND: Familial dysbetalipoproteinemia (FD) is an autosomal recessive (rarely dominant) inherited disorder that is almost exclusively associated with the apolipoprotein E gene (APOE) variability. Nonetheless, only a small proportion of APOE2/E2 subjects develop the phenotype for mixed dyslipidemia; the context of other trigger metabolic or genetic factors remains unknown. METHODS: One hundred and one patients with FD and eighty controls (all APOE2/E2 homozygotes; rs429358) were screened for 18 single-nucleotide polymorphisms (SNPs) within the genes involved in triglyceride metabolism...
November 23, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38142178/advancements-in-non-invasive-imaging-of-atherosclerosis-future-perspectives
#38
REVIEW
Joana Guimarães, José de Almeida, Paulo Lázaro Mendes, Maria João Ferreira, Lino Gonçalves
Atherosclerosis is a chronic inflammatory disease characterized by the buildup of plaques in arterial walls, leading to cardiovascular diseases and high morbidity and mortality rates worldwide. Non-invasive imaging techniques play a crucial role in evaluating patients with suspected or established atherosclerosis. However, there is a growing body of evidence suggesting the need to visualize the underlying processes of plaque progression and rupture to enhance risk stratification. This review explores recent advancements in non-invasive assessment of atherosclerosis, focusing on computed tomography, magnetic resonance imaging, and nuclear imaging...
November 19, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/38044202/effectiveness-of-the-triglyceride-glucose-index-and-triglyceride-glucose-related-indices-in-predicting-cardiovascular-disease-in-middle-aged-and-older-adults-a-prospective-cohort-study
#39
JOURNAL ARTICLE
Hye-Min Park, Taehwa Han, Seok-Jae Heo, Yu-Jin Kwon
BACKGROUNDS: Cardiovascular disease (CVD) risk assessment is a crucial component of public health. We aimed to determine the predictive value of the TyG index and TyG-related indices for new-onset CVD. METHODS: This prospective study included 7,808 participants aged 40-69 years from the Ansung-Ansan cohort database. Our analysis was stratified by diabetes status. The hazard ratio (HR) with a 95% confidence interval (CI) for incident CVD was computed using multiple Cox proportional-hazards regression models...
November 19, 2023: Journal of Clinical Lipidology
https://read.qxmd.com/read/37985275/characteristics-and-prognosis-of-patients-with-elevated-triglycerides-in-acute-myocardial-infarction-observational-data-from-a-large-database-over-a-17-year-period-high-triglycerides-in-acute-myocardial-infarction
#40
JOURNAL ARTICLE
Marianne Zeller, Frédéric Chague, Maud Maza, Florence Bichat, Yves Cottin, Michel Farnier
From a large regional registry, we aimed to address the characteristics and prognosis of patients with elevated triglycerides (TG) among patients hospitalized for an acute myocardial infarction (MI). From the multicenter database of the RICO survey, all consecutive patients hospitalized for an acute MI (2001-2017) and alive at discharge were included. Among the 10,667 patients included, 17.7% had elevated TG. When compared with patients with TG ≤ 200 mg/dL, patients with high TG (>200 mg/dL) were 10 years younger, had a higher BMI, were more frequently men, diabetic, and smokers...
November 10, 2023: Journal of Clinical Lipidology
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