Xubo Yang, Hongmei Tang, Lu He, Tingting Peng, Jinling Li, Jingbo Zhang, Liru Liu, Hongyu Zhou, Zhaofang Chen, Jingyi Zhao, Yage Zhang, Mengru Zhong, Mingshan Han, Mengqing Zhang, Huiran Niu, Kaishou Xu
PURPOSE: The study aims to explore the proteomic profile and specific target proteins associated with muscle growth in response to botulinum neurotoxin A (BoNT-A) treatment, in order to improve spasticity management in children with cerebral palsy (CP). EXPERIMENTAL DESIGN: A total of 54 participants provided 60 plasma samples for proteomic analysis. Among them, six children were sampled before and after receiving their first BoNT-A injection. In addition, 48 unrelated children were enrolled, among whom one group had never received BoNT-A injections and another group was sampled after their first BoNT-A injection...
March 8, 2024: Proteomics. Clinical Applications