Luis M Sousa-Filho, Cleverson D T Freitas, Marina D P Lobo, Ana C O Monteiro-Moreira, Renan O Silva, Lucas A B Santana, Ronaldo A Ribeiro, Marcellus H L P Souza, Gustavo P Ferreira, Anna C T C Pereira, André L R Barbosa, Mauro S C S Lima, Jefferson S Oliveira
Parotoid glands of amphibians are known for the production of several biologically active compounds having pharmacological and toxic effects in mammals. In the present work, a protein fraction obtained from Rhinella schneideri parotoid gland (RsPP) was characterized to study its biological and toxic effects. Rhinella schneideri parotoid secretion is composed of up to 30% (w/w) of soluble proteins. Tandem mass spectrometric analysis of the RsPP identified 104 proteins, including actin, beta-actin, ribosomal proteins, catalase, galectin, and uncharacterized proteins; however, no peptidases were found, and this result was reinforced by the absence of proteolytic activity...
October 2016: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology