journal
https://read.qxmd.com/read/37000841/the-epidemiology-of-human-taenia-solium-infections-a-systematic-review-of-the-distribution-in-eastern-and-southern-africa
#1
JOURNAL ARTICLE
Gideon Zulu, Dominik Stelzle, Kabemba E Mwape, Tamara M Welte, Hilde Strømme, Chishimba Mubanga, Wilbroad Mutale, Annette Abraham, Alex Hachangu, Veronika Schmidt, Chummy S Sikasunge, Isaac K Phiri, Andrea S Winkler
BACKGROUND: Taenia solium is a tapeworm that causes taeniosis in humans and cysticercosis in humans and pigs. Within Eastern and Southern Africa (ESA), information on the presence of human taeniosis and cysticercosis seems scarce. This systematic review aimed to describe the current information available and gaps in the epidemiology of human T. solium infections in ESA. METHODS/PRINCIPLE FINDINGS: Scientific literature published between 1st January 2000 and 20th June 2022 in international databases [MEDLINE (Ovid), Embase (Ovid), Global Health (Ovid), Scopus (Elsevier), African Index Medicus (via WHO Global Index Medicus), and Open Grey] was systematically reviewed for ESA...
March 31, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37000840/factors-influencing-community-acceptability-of-mass-drug-administration-for-the-elimination-of-onchocerciasis-in-the-asante-akim-south-municipal-ghana
#2
JOURNAL ARTICLE
Emmanuel Kumah, Patrick Owusu, Godfred Otchere, Samuel E Ankomah, Adam Fusheini, Collins Kokuro, Frederick Mensah-Acheampong, Joseph Amankwah Atta, Samuel Kofi Agyei
INTRODUCTION: Onchocerciasis is one of the eleven neglected tropical diseases (NTDs) recently targeted by the World Health Organization (WHO) for elimination. Mass drug administration (MDA) of ivermectin has become the main intervention for reducing the burden of onchocerciasis and controlling its transmission. However, despite the considerable gains in the fight against onchocerciasis in Ghana, the infection remains endemic in some communities. This study aimed to ascertain community members' acceptability levels and factors associated with ivermectin MDA for the elimination of onchocerciasis in the Asante Akim South Municipal in the Ashanti Region of Ghana...
March 31, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36996260/early-diagnosis-of-dengue-diagnostic-utility-of-the-sd-bioline-dengue-duo-rapid-test-in-reunion-island
#3
JOURNAL ARTICLE
Olivier Maillard, Jeanne Belot, Thibault Adenis, Olivier Rollot, Antoine Adenis, Bertrand Guihard, Patrick Gérardin, Antoine Bertolotti
BACKGROUND: In Reunion Island, dengue outbreaks have been occurring since 2018. The healthcare facilities are facing the problem of managing a massive influx of patients and a growing care burden. The aim of this study was to evaluate the performance of the SD Bioline Dengue Duo rapid diagnostic test in adults consulting at an emergency department during the 2019 epidemic. METHODOLOGY/PRINCIPAL FINDINGS: This retrospective study of diagnostic accuracy included patients over 18 years old, suspected of dengue, who were admitted to emergency units of the University Hospital of Reunion between the 1st of January and 30th of June, 2019, and were tested for dengue fever with the SD Bioline Dengue Duo rapid diagnostic test and reverse transcriptase polymerase chain reaction...
March 30, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36996245/development-of-sandwich-elisa-and-lateral-flow-assay-for-the-detection-of-bungarus-multicinctus-venom
#4
JOURNAL ARTICLE
Ji-Fei Nong, Zhou Huang, Zheng-Zhuang Huang, Jie Yang, Jin-Cheng Li, Feng Yang, Dong-Ling Huang, Fan Wang, Wei Wang
Snakebite envenoming adversely affects human health and life worldwide. Presently, no suitable diagnostic tools for snakebite envenoming are available in China. Therefore, we sought to develop reliable diagnostic tests for snakebite management. We conducted affinity purification experiments to prepare species-specific antivenom antibody (SSAb). In brief, affinity chromatography with an antibody purification column (Protein A) was conducted to purify immunoglobulin G from Bungarus multicinctus (BM) venom hyperimmunized rabbit serum...
March 30, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36996185/a-randomized-controlled-phase-1b-trial-of-the-sm-tsp-2-vaccine-for-intestinal-schistosomiasis-in-healthy-brazilian-adults-living-in-an-endemic-area
#5
JOURNAL ARTICLE
David J Diemert, Rodrigo Correa-Oliveira, Carlo Geraldo Fraga, Frederico Talles, Marcella Rezende Silva, Shital M Patel, Shirley Galbiati, Jessie K Kennedy, Jordan S Lundeen, Maria Flavia Gazzinelli, Guangzhao Li, Lara Hoeweler, Gregory A Deye, Maria Elena Bottazzi, Peter J Hotez, Hana M El Sahly, Wendy A Keitel, Jeffrey Bethony, Robert L Atmar
BACKGROUND: Recombinant Schistosoma mansoni Tetraspanin-2 formulated on Alhydrogel (Sm-TSP-2/Alhydrogel) is being developed to prevent intestinal and hepatic disease caused by S. mansoni. The tegumentary Sm-TSP-2 antigen was selected based on its unique recognition by cytophilic antibodies in putatively immune individuals living in areas of ongoing S. mansoni transmission in Brazil, and preclinical studies in which vaccination with Sm-TSP-2 protected mice following infection challenge...
March 30, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36989328/bacterial-communities-of-aedes-aegypti-mosquitoes-differ-between-crop-and-midgut-tissues
#6
JOURNAL ARTICLE
Luis E Martinez Villegas, James Radl, George Dimopoulos, Sarah M Short
Microbiota studies of Aedes aegypti and other mosquitoes generally focus on the bacterial communities found in adult female midguts. However, other compartments of the digestive tract maintain communities of bacteria which remain almost entirely unstudied. For example, the Dipteran crop is a food storage organ, but few studies have looked at the microbiome of crops in mosquitoes, and only a single previous study has investigated the crop in Ae. aegypti. In this study, we used both culture-dependent and culture-independent methods to compare the bacterial communities in midguts and crops of laboratory reared Ae...
March 29, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36989319/differences-in-gene-expression-in-field-populations-of-wolbachia-infected-aedes-aegypti-mosquitoes-with-varying-release-histories-in-northern-australia
#7
JOURNAL ARTICLE
B M C Randika Wimalasiri-Yapa, Bixing Huang, Perran A Ross, Ary A Hoffmann, Scott A Ritchie, Francesca D Frentiu, David Warrilow, Andrew F van den Hurk
Aedes aegypti is the principal mosquito vector of dengue, yellow fever, Zika and chikungunya viruses. The wMel strain of the endosymbiotic bacteria Wolbachia pipientis was introduced into the vector as a novel biocontrol strategy to stop transmission of these viruses. Mosquitoes with Wolbachia have been released in the field in Northern Queensland, Australia since 2011, at various locations and over several years, with populations remaining stably infected. Wolbachia infection is known to alter gene expression in its mosquito host, but whether (and how) this changes over the long-term in the context of field releases remains unknown...
March 29, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36976804/maldi-tof-a-new-tool-for-the-identification-of-schistosoma-cercariae-and-detection-of-hybrids
#8
JOURNAL ARTICLE
Antoine Huguenin, Julien Kincaid-Smith, Jérôme Depaquit, Jérôme Boissier, Hubert Ferté
Schistosomiasis is a neglected water-born parasitic disease caused by Schistosoma affecting more than 200 million people. Introgressive hybridization is common among these parasites and raises issues concerning their zoonotic transmission. Morphological identification of Schistosoma cercariae is difficult and does not permit hybrids detection. Our objective was to assess the performance of MALDI-TOF (Matrix Assistated Laser Desorption-Ionization-Time Of Flight) mass spectrometry for the specific identification of cercariae in human and non-human Schistosoma and for the detection of hybridization between S...
March 28, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36972298/treatment-with-benznidazole-and-pentoxifylline-regulates-microrna-transcriptomic-profile-in-a-murine-model-of-chagas-chronic-cardiomyopathy
#9
JOURNAL ARTICLE
Priscila Silva Grijó Farani, Beatriz Iandra da Silva Ferreira, Khodeza Begum, Glaucia Vilar-Pereira, Isabela Resende Pereira, Edith Araceli Fernández Figueroa, Roberto Alejandro Cardenas-Ovando, Igor C Almeida, Sourav Roy, Joseli Lannes-Vieira, Otacilio Cruz Moreira
Chronic Chagas cardiomyopathy (CCC) is one of the leading causes of morbidity and mortality due to cardiovascular disorders in endemic areas of Chagas disease (CD), a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. CCC is characterized by parasite persistence and inflammatory response in the heart tissue, which occur parallel to microRNA (miRNA) alterations. Here, we investigated the miRNA transcriptome profiling in the cardiac tissue of chronically T. cruzi-infected mice treated with a suboptimal dose of benznidazole (Bz), the immunomodulator pentoxifylline alone (PTX), or the combination of both (Bz+PTX), following the CCC onset...
March 27, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36972287/sporotrichosis-in-the-nasal-mucosa-a-single-center-retrospective-study-of-37-cases-from-1998-to-2020
#10
JOURNAL ARTICLE
Carlos Felipe Gomes Izoton, Antonio Xavier de Brito Sousa, Cláudia Maria Valete, Armando de Oliveira Schubach, Anna Carolina Procópio-Azevedo, Rosely Maria Zancopé-Oliveira, Priscila Marques de Macedo, Maria Clara Gutierrez-Galhardo, Julio Castro-Alves, Rodrigo Almeida-Paes, Ana Cristina da Costa Martins, Dayvison Francis Saraiva Freitas
BACKGROUND: Sporotrichosis is a subcutaneous or implantation mycosis caused by some species of the genus Sporothrix. Rio de Janeiro state, Brazil, experiences hyperendemic levels of zoonotic sporotrichosis, with increasing cases of disseminated disease, especially in people living with HIV (PLHIV). Involvement of the nasal mucosa is rare and occurs isolated or in disseminated cases, with a delayed resolution. METHODOLOGY/PRINCIPAL FINDINGS: This study aimed to describe the epidemiological, clinical, and therapeutic profiles of 37 cases of sporotrichosis with involvement of the nasal mucosa treated at the ear, nose, and throat (ENT) outpatient clinic of the Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, from 1998 to 2020...
March 27, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36972285/randomized-trial-evaluating-an-mhealth-intervention-for-the-early-community-based-detection-and-follow-up-of-cutaneous-leishmaniasis-in-rural-colombia
#11
JOURNAL ARTICLE
Mabel Castillo, Neal Alexander, Luisa Rubiano, Carlos Rojas, Andrés Navarro, Domiciano Rincon, Leonardo Vargas Bernal, Yenifer Orobio Lerma, Nancy Gore Saravia, Eliah Aronoff-Spencer
BACKGROUND: In Latin America, cutaneous leishmaniasis primarily affects dispersed rural communities, that have limited access to the public health system and medical attention. Mobile health (mHealth) strategies have shown potential to improve clinical management and epidemiological surveillance of neglected tropical diseases, particularly those of the skin. METHODS: The Guaral +ST app for Android was designed to monitor cutaneous leishmaniasis treatment and assess therapeutic response...
March 27, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36972284/on-target-inhibition-of-cryptosporidium-parvum-by-nitazoxanide-ntz-and-paclitaxel-ptx-validated-using-a-novel-mdr1-transgenic-host-cell-model-and-algorithms-to-quantify-the-effect-on-the-parasite-target
#12
JOURNAL ARTICLE
Bo Yang, Yueyang Yan, Dongqiang Wang, Ying Zhang, Jigang Yin, Guan Zhu
Cryptosporidium parvum is a globally distributed zoonotic protozoan parasite that causes moderate to severe, sometime deadly, watery diarrhea in humans and animals, for which fully effective treatments are yet unavailable. In studying the mechanism of action of drugs against intracellular pathogens, it is important to validate whether the observed anti-infective activity is attributed to the drug action on the pathogen or host target. For the epicellular parasite Cryptosporidium, we have previously developed a concept that the host cells with significantly increased drug tolerance by transient overexpression of the multidrug resistance protein-1 (MDR1) could be utilized to evaluate whether and how much the observed anti-cryptosporidial activity of an inhibitor was attributed to the inhibitor's action on the parasite target...
March 27, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36972237/the-baikal-subtype-of-tick-borne-encephalitis-virus-is-evident-of-recombination-between-siberian-and-far-eastern-subtypes
#13
JOURNAL ARTICLE
Grigorii A Sukhorukov, Alexey I Paramonov, Oksana V Lisak, Irina V Kozlova, Georgii A Bazykin, Alexey D Neverov, Lyudmila S Karan
Tick-borne encephalitis virus (TBEV) is a flavivirus which causes an acute or sometimes chronic infection that frequently has severe neurological consequences, and is a major public health threat in Eurasia. TBEV is genetically classified into three distinct subtypes; however, at least one group of isolates, the Baikal subtype, also referred to as "886-84-like", challenges this classification. Baikal TBEV is a persistent group which has been repeatedly isolated from ticks and small mammals in the Buryat Republic, Irkutsk and Trans-Baikal regions of Russia for several decades...
March 27, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36961865/a-whole-blood-intracellular-cytokine-assay-optimised-for-field-site-studies-demonstrates-polyfunctionality-of-cd4-t-cells-in-acute-scrub-typhus
#14
JOURNAL ARTICLE
Manutsanun Inthawong, Nattapon Pinthong, Areerat Thaiprakhong, Tri Wangrangsimakul, Piyanate Sunyakumthorn, Jennifer Hill, Piengchan Sonthayanon, Daniel H Paris, Susanna J Dunachie, Barbara Kronsteiner
BACKGROUND: Assessment of cellular immune responses by combining intracellular cytokine staining and immunophenotyping using flow cytometry enables the simultaneous measurement of T cell phenotype and effector function in response to pathogens and vaccines. The use of whole blood samples rather than peripheral blood mononuclear cells avoids both the need for immediate processing and loss of functional antigen presenting cells due to processing and cryopreservation. Using whole blood provides the possibility to stimulate peripheral T cells in situ, and is more suitable for studies where sample volume is limited, such as those involving children, the elderly and critically ill patients...
March 24, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36961841/a-genome-sequence-for-biomphalaria-pfeifferi-the-major-vector-snail-for-the-human-infecting-parasite-schistosoma-mansoni
#15
JOURNAL ARTICLE
Lijing Bu, Lijun Lu, Martina Laidemitt, Si-Ming Zhang, Martin Mutuku, Gerald Mkoji, Michelle Steinauer, Eric S Loker
BACKGROUND: Biomphalaria pfeifferi is the world's most widely distributed and commonly implicated vector snail species for the causative agent of human intestinal schistosomiasis, Schistosoma mansoni. In efforts to control S. mansoni transmission, chemotherapy alone has proven insufficient. New approaches to snail control offer a way forward, and possible genetic manipulations of snail vectors will require new tools. Towards this end, we here offer a diverse set of genomic resources for the important African schistosome vector, B...
March 24, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36961830/improving-understanding-of-disease-control-implementation-research-through-a-mooc-with-participants-from-low-and-middle-income-countries-evaluating-participant-reactions-and-learning
#16
JOURNAL ARTICLE
Adanna Nwameme, Phyllis Dako-Gyeke, Emmanuel Asampong, Pascale Allotey, Daniel D Reidpath, Edith Certain, Mahnaz Vahedi, Bella Ross, Dermot Maher, Pascal Launois
The Special Programme for Research and Training in Tropical Diseases developed a massive open online course (MOOC) on implementation research with a focus on infectious diseases of poverty (IDPs) to reinforce the explanation of implementation research concepts through real case studies. The target MOOC participant group included public health officers, researchers and students. By reshaping institutions and building resilience in communities and systems, implementation research will allow progress towards universal health coverage and sustainable development goals...
March 24, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36940228/maternal-and-congenital-toxoplasmosis-in-mayotte-prevalence-incidence-and-management
#17
JOURNAL ARTICLE
Laure Kamus, Sophie Belec, Laurent Lambrecht, Soumeth Abasse, Sophie Olivier, Patrice Combe, Pierre-Emmanuel Bonnave, Christelle Vauloup-Fellous
BACKGROUND: Toxoplasmosis is an infection caused by an intracellular protozoan, Toxoplasma gondii. It is usually asymptomatic, but toxoplasmosis acquired during pregnancy can cause congenital toxoplasmosis, potentially resulting in fetal damage. Epidemiological information is lacking for toxoplasmosis in Mayotte (a French overseas territory). We evaluated (1) the prevalence of maternal toxoplasmosis, (2) the incidence of maternal and congenital toxoplasmosis, and (3) the management of congenital toxoplasmosis in Mayotte...
March 20, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36940217/collection-of-triatomines-from-sylvatic-habitats-by-a-trypanosoma-cruzi-infected-scent-detection-dog-in-texas-usa
#18
JOURNAL ARTICLE
Devin M Christopher, Rachel Curtis-Robles, Gabriel L Hamer, Justin Bejcek, Ashley B Saunders, Walter D Roachell, Thomas Leo Cropper, Sarah A Hamer
BACKGROUND: Triatomine insects, vectors of the etiologic agent of Chagas disease (Trypanosoma cruzi), are challenging to locate in sylvatic habitats. Collection techniques used in the United States often rely on methods to intercept seasonally dispersing adults or on community scientists' encounters. Neither method is suited for detecting nest habitats likely to harbor triatomines, which is important for vector surveillance and control. Furthermore, manual inspection of suspected harborages is difficult and unlikely to reveal novel locations and host associations...
March 20, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36930686/vector-mapping-and-bloodmeal-metabarcoding-demonstrate-risk-of-urban-chagas-disease-transmission-in-caracas-venezuela
#19
JOURNAL ARTICLE
Maikell Segovia, Philipp Schwabl, Salem Sueto, Candy Cherine Nakad, Juan Carlos Londoño, Marlenes Rodriguez, Manuel Paiva, Martin Stephen Llewellyn, Hernán José Carrasco
Chagas disease is a significant public health risk in rural and semi-rural areas of Venezuela. Triatomine infection by the aetiological agent Trypanosoma cruzi is also observed in the Metropolitan District of Caracas (MDC), where foodborne T. cruzi outbreaks occasionally occur but active vector-to-human transmission (infection during triatomine bloodmeal) is considered absent. Citizen science-based domiciliary triatomine collection carried out between 2007 and 2013 in the MDC has advanced understanding of urban T...
March 17, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/36930653/standardized-evaluation-of-zika-nucleic-acid-tests-used-in-clinical-settings-and-blood-screening
#20
JOURNAL ARTICLE
Mars Stone, Sonia Bakkour, Eduard Grebe, Devy M Emperador, Camille Escadafal, Xutao Deng, Honey Dave, Cassandra Kelly-Cirino, Eve Lackritz, Diana P Rojas, Graham Simmons, Ingrid B Rabe, Michael P Busch
Early detection of Zika virus (ZIKV) transmission within geographic regions informs implementation of community mitigation measures such as vector reduction strategies, travel advisories, enhanced surveillance among pregnant women, and possible implementation of blood and organ donor screening or deferral. Standardized, comparative assessments of ZIKV assay and testing lab performance are important to develop optimal approaches to ZIKV diagnostic testing and surveillance. We conducted an expanded blinded panel study to characterize and compare the analytical performance of fifteen diagnostic and blood screening ZIKV NAT assays, including detection among single- and multiplex assays detecting ZIKV, dengue virus (DENV) and chikungunya virus (CHIKV)...
March 17, 2023: PLoS Neglected Tropical Diseases
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