journal
https://read.qxmd.com/read/37773953/mining-host-candidate-regulators-of-schistosomiasis-induced-liver-fibrosis-in-response-to-artesunate-therapy-through-transcriptomics-approach
#1
JOURNAL ARTICLE
Yajie Yuan, Xinyue Lv, Yahan Wu, Youhong Weng, Fangwei Dai, Haojie Ding, Riping Chen, Bin Zheng, Wenxia Zhao, Qunbo Tong, Jianzu Ding, Di Lou, Yunru Lai, Xiaofeng Chu, Longyou Zhao, Shaohong Lu, Qingming Kong
BACKGROUND: Artesunate (ART) has been reported to have an antifibrotic effect in various organs. The underlying mechanism has not been systematically elucidated. We aimed to clarify the effect of ART on liver fibrosis induced by Schistosoma japonicum (S. japonicum) in an experimentally infected rodent model and the potential underlying mechanisms. METHODS: The effect of ART on hepatic stellate cells (HSCs) was assessed using CCK-8 and Annexin V-FITC/PI staining assays...
September 29, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37773943/gestational-toxoplasmosis-treatment-changes-the-child-s-prognosis-a-cohort-study-in-southern-brazil
#2
JOURNAL ARTICLE
Ana Gabriela Gomes Ferrari Strang, Rafaela Gomes Ferrar, Ana Lúcia Falavigna-Guilherme
BACKGROUND: We evaluate the drug treatment for pregnant women with acute toxoplasmosis to reduce the risk of congenital infection, side effects (prenatal and postnatal treatment in children) and the hazard of discontinuing the infant's medication. METHODS: We conducted a prospective cohort study to assess the risks of congenital toxoplasmosis among children born to acutely infected women with and without treatment. We examined the relationship between "exposed" and "infected children", "number of infant neutrophils", "prenatal" and "postnatal treatment"...
September 29, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37769025/discovery-of-long-non-coding-rnas-in-the-liver-fluke-fasciola-hepatica
#3
JOURNAL ARTICLE
Paul McVeigh, Erin McCammick, Emily Robb, Peter Brophy, Russell M Morphew, Nikki J Marks, Aaron G Maule
Long non-coding (lnc)RNAs are a class of eukaryotic RNA that do not code for protein and are linked with transcriptional regulation, amongst a myriad of other functions. Using a custom in silico pipeline we have identified 6,436 putative lncRNA transcripts in the liver fluke parasite, Fasciola hepatica, none of which are conserved with those previously described from Schistosoma mansoni. F. hepatica lncRNAs were distinct from F. hepatica mRNAs in transcript length, coding probability, exon/intron composition, expression patterns, and genome distribution...
September 28, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37769013/epidemiological-and-molecular-evidence-of-intrafamilial-transmission-through-sexual-and-vertical-routes-in-bahia-the-state-with-the-highest-prevalence-of-htlv-1-in-brazil
#4
JOURNAL ARTICLE
Aidê Nunes da Silva, Thessika Hialla Almeida Araújo, Ney Boa-Sorte, Giovanne Farias, Ana Karina Galvão-Barroso, Antônio de Carvalho, Ana Carolina Vicente, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi
INTRODUCTION: Familial clustering of HTLV-1 and related diseases has been reported in Brazil. However, intrafamilial transmission of HTLV-1 based on molecular analysis has been studied only in a few communities of Japanese immigrants and African-Brazilians. OBJECTIVE: To investigate the familial clustering of HTLV-1 infection and to determine the likely routes of transmission through epidemiological and genetic analyzes. METHODS: Medical records of 1,759 HTLV-1+ patients from de the Center for HTLV in Salvador, Brazil, were evaluated to identify first-degree relatives previously tested for HTLV-1...
September 28, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37769008/epidemiological-and-genomic-investigation-of-chikungunya-virus-in-rio-de-janeiro-state-brazil-between-2015-and-2018
#5
JOURNAL ARTICLE
Filipe Romero Rebello Moreira, Mariane Talon de Menezes, Clarisse Salgado-Benvindo, Charles Whittaker, Victoria Cox, Nilani Chandradeva, Hury Hellen Souza de Paula, André Frederico Martins, Raphael Rangel das Chagas, Rodrigo Decembrino Vargas Brasil, Darlan da Silva Cândido, Alice Laschuk Herlinger, Marisa de Oliveira Ribeiro, Monica Barcellos Arruda, Patricia Alvarez, Marcelo Calado de Paula Tôrres, Ilaria Dorigatti, Oliver Brady, Carolina Moreira Voloch, Amilcar Tanuri, Felipe Iani, William Marciel de Souza, Sergian Vianna Cardozo, Nuno Rodrigues Faria, Renato Santana Aguiar
Since 2014, Brazil has experienced an unprecedented epidemic caused by chikungunya virus (CHIKV), with several waves of East-Central-South-African (ECSA) lineage transmission reported across the country. In 2018, Rio de Janeiro state, the third most populous state in Brazil, reported 41% of all chikungunya cases in the country. Here we use evolutionary and epidemiological analysis to estimate the timescale of CHIKV-ECSA-American lineage and its epidemiological patterns in Rio de Janeiro. We show that the CHIKV-ECSA outbreak in Rio de Janeiro derived from two distinct clades introduced from the Northeast region in mid-2015 (clade RJ1, n = 63/67 genomes from Rio de Janeiro) and mid-2017 (clade RJ2, n = 4/67)...
September 28, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37756346/subcutaneous-mycoses-endemic-but-neglected-among-the-neglected-tropical-diseases-in-ethiopia
#6
JOURNAL ARTICLE
Wendemagegn Enbiale, Alemayehu Bekele, Nigus Manaye, Fikre Seife, Zeyede Kebede, Filmon Gebremeskel, Johan van Griensven
BACKGROUND: Subcutaneous (deep) mycoses are a chronic infectious disease of the skin and underlying structures endemic in tropical countries. The disease has serious medical and socioeconomic consequences for patients, communities and health services in endemic areas. The inclusion of mycetoma and other subcutaneous mycoses in the list of Neglected Tropical Diseases by WHO highlights the need to assess the burden of these diseases and establish control programs where necessary. In Ethiopia no strategies can be devised because of a lack of epidemiologic information...
September 27, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37747922/geographical-distribution-of-scrub-typhus-and-risk-of-orientia-tsutsugamushi-infection-in-indonesia-evidence-mapping
#7
JOURNAL ARTICLE
Kartika Saraswati, Ivo Elliott, Nicholas P J Day, J Kevin Baird, Stuart D Blacksell, Ristiyanto, Catherine L Moyes
BACKGROUND: Scrub typhus is a potentially fatal acute febrile illness caused by bacteria in the genus Orientia. Though cases have been documented, a comprehensive body of evidence has not previously been compiled to give an overview of scrub typhus in Indonesia. This study aimed to address this key knowledge gap by mapping and ranking geographic areas based on existing data on the presence or absence of the pathogen in humans, vectors, and host animals. METHODOLOGY/PRINCIPAL FINDINGS: We performed searches on local and international electronic databases, websites, libraries, and collections including Embase, Medline, and Scopus to gather relevant evidence (including grey literature)...
September 25, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37747907/knowledge-attitude-and-practice-kap-and-risk-factors-on-dengue-fever-among-children-in-brazil-fortaleza-a-cross-sectional-study
#8
JOURNAL ARTICLE
Yang Zhang, Monica Zahreddine, Kellyanne Abreu, Mayana Azevedo Dantas, Katia Charland, Laura Pierce, Valery Ridde, Kate Zinszer
BACKGROUND: Dengue fever is a mosquito-borne viral disease that is associated with four serotypes of the dengue virus. Children are vulnerable to infection with the dengue virus, particularly those who have been previously infected with a different dengue serotype. Sufficient knowledge, positive attitudes, and proper practices (KAP) are essential for dengue prevention and control. This study aims to estimate the dengue seropositivity for study participants and to examine the association between households' dengue-related knowledge, attitudes, and practices (KAP), and children's risk of dengue seropositivity, while accounting for socioeconomic and demographic differences in Brazil...
September 25, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37747880/variable-microbiomes-between-mosquito-lines-are-maintained-across-different-environments
#9
JOURNAL ARTICLE
Anastasia Accoti, Shannon Quek, Julia Vulcan, Cintia Cansado-Utrilla, Enyia R Anderson, Angel Elma I Abu, Jessica Alsing, Hema P Narra, Kamil Khanipov, Grant L Hughes, Laura B Dickson
The composition of the microbiome is shaped by both environment and host in most organisms, but in the mosquito Aedes aegypti the role of the host in shaping the microbiome is poorly understood. Previously, we had shown that four lines of Ae. aegypti harbored different microbiomes when reared in the same insectary under identical conditions. To determine whether these lines differed from each other across time and in different environments, we characterized the microbiome of the same four lines of Ae. aegypti reared in the original insectary and at another institution...
September 25, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37738270/the-increasing-complexity-of-arbovirus-serology-an-in-depth-systematic-review-on-cross-reactivity
#10
JOURNAL ARTICLE
Louella M R Kasbergen, David F Nieuwenhuijse, Erwin de Bruin, Reina S Sikkema, Marion P G Koopmans
Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential arbovirus serology. The search included Medline, Embase and Web of Science databases and identified 911 publications which were reduced to 102 after exclusion of studies not providing data on possible cross-reactivity or studies that did not meet the inclusion criteria regarding confirmation of virus exposure of reference population sets...
September 22, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37729272/disruption-of-the-inositol-phosphorylceramide-synthase-gene-affects-trypanosoma-cruzi-differentiation-and-infection-capacity
#11
JOURNAL ARTICLE
Nailma S Aprigio-Santos, Carlos F Estevez-Castro, Juan P Macedo, Daniela F Chame, Thiago Castro-Gomes, Mariana Santos-Cardoso, Gabriela A Burle-Caldas, Courtney N Covington, Patrick G Steel, Terry K Smith, Paul W Denny, Santuza M R Teixeira
Sphingolipids (SLs) are essential components of all eukaryotic cellular membranes. In fungi, plants and many protozoa, the primary SL is inositol-phosphorylceramide (IPC). Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD), a chronic illness for which no vaccines or effective treatments are available. IPC synthase (IPCS) has been considered an ideal target enzyme for drug development because phosphoinositol-containing SL is absent in mammalian cells and the enzyme activity has been described in all parasite forms of T...
September 20, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37729234/effects-of-mating-on-female-reproductive-physiology-in-the-insect-model-rhodnius-prolixus-a-vector-of-the-causative-parasite-of-chagas-disease
#12
JOURNAL ARTICLE
Jimena Leyria, Alessandra A Guarneri, Marcelo G Lorenzo, Marcela Nouzova, Fernando G Noriega, Samiha A M Benrabaa, Francisco Fernandez-Lima, Lilian Valadares Tose, Ian Orchard, Angela B Lange
The blood-sucking hemipteran Rhodnius prolixus is one of the main vectors of Chagas disease, a neglected tropical disease that affects several million people worldwide. Consuming a blood meal and mating are events with a high epidemiological impact since after each meal, mated females can lay fertile eggs that result in hundreds of offspring. Thus, a better knowledge of the control of R. prolixus reproductive capacity may provide targets for developing novel strategies to control vector populations, thereby reducing vector-host contacts and disease transmission...
September 20, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37729233/belgian-culex-pipiens-pipiens-are-competent-vectors-for-west-nile-virus-while-culex-modestus-are-competent-vectors-for-usutu-virus
#13
JOURNAL ARTICLE
Alina Soto, Lander De Coninck, Ann-Sophie Devlies, Celine Van De Wiele, Ana Lucia Rosales Rosas, Lanjiao Wang, Jelle Matthijnssens, Leen Delang
BACKGROUND: West Nile virus (WNV) and Usutu virus (USUV) are emerging arthropod-borne viruses (arboviruses) in Europe transmitted by Culex mosquitoes. In Belgium, it is currently unknown which Culex species are competent vectors for WNV or USUV and if these mosquitoes carry Wolbachia, an endosymbiotic bacterium that can block arbovirus transmission. The aims of our study were to measure the vector competence of Belgian Culex mosquitoes to WNV and USUV and determine if a naturally acquired Wolbachia infection can influence virus transmission...
September 20, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37729218/phlebotomine-sand-flies-diptera-psychodidae-from-pha-tong-cave-northern-thailand-with-a-description-of-two-new-species-and-taxonomical-thoughts-about-phlebotomus-stantoni
#14
JOURNAL ARTICLE
Marie-Charlotte Renaux Torres, Coline Pellot, Puckavadee Somwang, Pathamet Khositharattanakool, Khamsing Vongphayloth, Fano José Randrianambinintsoa, Bruno Mathieu, Padet Siriyasatien, Frédérick Gay, Jérôme Depaquit
BACKGROUND: In South-East Asia, Thailand is the country with the highest number of human autochthonous cases of leishmaniases mostly due to Leishmania martiniquensis. Their transmission remains unresolved to date even though sand flies are known vectors of leishmaniases. As such, we focused a study on the sand fly fauna of a cave in Thailand to explore the biodiversity of potential Leishmania vectors. MAIN RESULTS: We carried out an inventory in Pha Tong cave. We caught and identified 570 Phlebotomine sand flies (452 females and 118 males) and identified 14 species belonging to the genera Phlebotomus, Idiophlebotomus, Chinius, Sergentomyia and Grassomyia...
September 20, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37721966/quantitative-proteomics-analysis-of-permethrin-and-temephos-resistant-ae-aegypti-revealed-diverse-differentially-expressed-proteins-associated-with-insecticide-resistance-from-penang-island-malaysia
#15
JOURNAL ARTICLE
Abubakar Shettima, Intan Haslina Ishak, Benjamin Lau, Hadura Abu Hasan, Noorizan Miswan, Nurulhasanah Othman
Synthetic insecticides are the primary vector control method used globally. However, the widespread use of insecticides is a major cause of insecticide-resistance in mosquitoes. Hence, this study aimed at elucidating permethrin and temephos-resistant protein expression profiles in Ae. aegypti using quantitative proteomics. In this study, we evaluated the susceptibility of Ae. aegypti from Penang Island dengue hotspot and non-hotspot against 0.75% permethrin and 31.25 mg/l temephos using WHO bioassay method...
September 18, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37721964/safety-and-tolerability-of-moxidectin-and-ivermectin-combination-treatments-for-lymphatic-filariasis-in-c%C3%A3-te-d-ivoire-a-randomized-controlled-superiority-study
#16
JOURNAL ARTICLE
Catherine M Bjerum, Benjamin G Koudou, Allassane F Ouattara, Daphne Lew, Charles W Goss, Pascal T Gabo, Christopher L King, Peter U Fischer, Gary J Weil, Philip J Budge
BACKGROUND: Moxidectin is a macrocyclic lactone registered for the treatment of human onchocerciasis. The drug has a good safety profile, large volume of distribution and a long elimination half-life. This paper reports tolerability data from the first use of moxidectin in persons with Wuchereria bancrofti infection. METHODS: In this randomized, open-label, masked-observer superiority trial, adults with Wuchereria bancrofti microfilaremia in Côte d'Ivoire were randomized to 1 of 4 treatment arms: ivermectin + albendazole (IA), moxidectin + albendazole (MoxA), ivermectin + diethylcarbamazine (DEC) + albendazole (IDA), or moxidectin + DEC + albendazole (MoxDA)...
September 18, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37721957/label-free-quantitative-proteomic-analyses-of-mouse-astrocytes-provides-insight-into-the-host-response-mechanism-at-different-developmental-stages-of-toxoplasma-gondii
#17
JOURNAL ARTICLE
Huanhuan Xie, Hang Sun, Hongjie Dong, Lisha Dai, Haozhi Xu, Lixin Zhang, Qi Wang, Junmei Zhang, Guihua Zhao, Chao Xu, Kun Yin
Toxoplasma gondii (T. gondii) is an opportunistic parasite that can infect the central nervous system (CNS), causing severe toxoplasmosis and behavioral cognitive impairment. Mortality is high in immunocompromised individuals with toxoplasmosis, most commonly due to reactivation of infection in the CNS. There are still no effective vaccines and drugs for the prevention and treatment of toxoplasmosis. There are five developmental stages for T. gondii to complete life cycle, of which the tachyzoite and bradyzoite stages are the key to the acute and chronic infection...
September 18, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37721946/specific-and-sensitive-loop-mediated-isothermal-amplification-lamp-method-for-madurella-strains-eumycetoma-filamentous-fungi-causative-agent
#18
JOURNAL ARTICLE
Isato Yoshioka, Yugo Mori, Ahmed Hassan Fahal, Emmanuel Edwar Siddig, Satoshi Kaneko, Takashi Yaguchi
BACKGROUND: Filamentous fungi of the genus Madurella are the primary causative agents of mycetoma, a disease observed in tropical and subtropical regions. Since early diagnostics based on a morphological approach are difficult and have many shortcomings, a molecular diagnostic method suitable for rural settings is required. In this study, we developed the loop-mediated isothermal amplification (LAMP) method to present a foundational technique of the diagnosis of Madurella spp. (M. mycetomatis, M...
September 18, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37713429/genome-informed-investigation-of-the-molecular-evolution-and-genetic-reassortment-of-severe-fever-with-thrombocytopenia-syndrome-virus
#19
JOURNAL ARTICLE
Kyuyoung Lee, Jong Hyeon Seok, Hyunbeen Kim, Sejik Park, Sohyun Lee, Joon-Yong Bae, Kyeongseok Jeon, Jun-Gu Kang, Jeong Rae Yoo, Sang Taek Heo, Nam-Hyuk Cho, Keun Hwa Lee, Kisoon Kim, Man-Seong Park, Jin Il Kim
BACKGROUND: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a viral pathogen causing significant clinical signs from mild fever with thrombocytopenia to severe hemorrhages. World Health Organization has paid special attention to the dramatic increase in human SFTS cases in China, Japan, and South Korea since the 2010s. The present study investigated the molecular evolution and genetic reassortment of SFTSVs using complete genomic sequences. METHODS/PRINCIPAL FINDING: We collected the complete genome sequences of SFTSVs globally isolated until 2019 (L segment, n = 307; M segment, n = 326; and S segment, n = 564) and evaluated the evolutionary profiles of SFTSVs based on phylogenetic and molecular selection pressure analyses...
September 15, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37713416/strasseriolides-display-in-vitro-and-in-vivo-activity-against-trypanosomal-parasites-and-cause-morphological-and-size-defects-in-trypanosoma-cruzi
#20
JOURNAL ARTICLE
Cristina Bosch-Navarrete, Guiomar Pérez-Moreno, Frederick Annang, Rosario Diaz-Gonzalez, Raquel García-Hernández, Hedy Rocha, Francisco Gamarro, Carlos Cordón-Obras, Miguel Navarro, Ana Rodriguez, Olga Genilloud, Fernando Reyes, Francisca Vicente, Luis M Ruiz-Pérez, Dolores González-Pacanowska
Neglected diseases caused by kinetoplastid parasites are a health burden in tropical and subtropical countries. The need to create safe and effective medicines to improve treatment remains a priority. Microbial natural products are a source of chemical diversity that provides a valuable approach for identifying new drug candidates. We recently reported the discovery and bioassay-guided isolation of a novel family of macrolides with antiplasmodial activity. The novel family of four potent antimalarial macrolides, strasseriolides A-D, was isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues...
September 15, 2023: PLoS Neglected Tropical Diseases
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