journal
https://read.qxmd.com/read/38787898/modelling-the-cost-of-engage-treat-and-test-treat-strategies-towards-the-elimination-of-lymphatic-filariasis-in-ghana
#1
JOURNAL ARTICLE
Nathaniel N K Adams, Collins S Ahorlu, Dziedzom K de Souza, Moses Aikins
BACKGROUND: Despite several years of LF-MDA implementation, Ghana still has some districts with mf prevalence >1%, partly due to poor treatment coverage levels resulting from non-participation in MDA. To address the challenges, we implemented an Engage & Treat (E&T) and Test & Treat (T&T) strategies for individuals who miss or refuse MDA respectively, in a hotspot district, enabling us to reach many of those who seldom, or never, take part in MDA. This financial cost study was undertaken to analyse data on the LF-MDA, E&T and T&T implementation in 2021 and the financial cost to inform the rollout of the E&T and T&T as mop-up strategies in future LF-MDAs...
May 24, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38787872/cryptosporidium-parvum-disrupts-intestinal-epithelial-barrier-in-neonatal-mice-through-downregulation-of-cell-junction-molecules
#2
JOURNAL ARTICLE
Chaowei Luo, Yanhua Xu, Jie Zhang, Qing Tian, Yaqiong Guo, Na Li, Yaoyu Feng, Rui Xu, Lihua Xiao
BACKGROUND: Cryptosporidium spp. cause watery diarrhea in humans and animals, especially in infants and neonates. They parasitize the apical surface of the epithelial cells in the intestinal lumen. However, the pathogenesis of Cryptosporidium-induced diarrhea is not fully understood yet. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we infected C57BL/6j neonatal mice with C. parvum IIa and IId subtypes, and examined oocyst burden, pathological changes, and intestinal epithelial permeability during the infection...
May 24, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38781277/evaluation-of-knowledge-attitude-and-practice-towards-loiasis-in-the-rural-community-of-sindara-in-central-african-gabon
#3
JOURNAL ARTICLE
Teite Rebecca Hildebrandt, Saskia Dede Davi, Anita Lumeka Kabwende, Lilian Rene Endamne, Esther Mehmel, Maximilian Rakotonirinalalao, Ayodele Alabi, Rella Zoleko Manego, Peter G Kremsner, Bertrand Lell, Ayôla Akim Adegnika, Ghyslain Mombo-Ngoma, Johannes Mischlinger, Selidji Todagbe Agnandji, Michael Ramharter
BACKGROUND: More than 20 million people are infected with L. loa, and around 40 million live in high or intermediate-risk areas in West- and Central Africa. Although loiasis is associated with significant morbidity and excess mortality, little is known about the perception of loiasis by affected communities. This study assessed the knowledge, attitudes, and practices in the rural population of Sindara, Gabon, a region characterized by high loiasis prevalence. METHODS: A community-based cross-sectional survey was conducted in Gabon between January and June 2022...
May 23, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38781272/toxoplasma-gondii-seroprevalence-among-pregnant-women-in-africa-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Yared Mulu Gelaw, Gizachew Worku Dagnew, Getu Degu Alene, Jean-Pierre Gangneux, Florence Robert-Gangneux
BACKGROUND: Toxoplasmosis is a serious endemic zoonotic disease caused by the protozoan parasite Toxoplasma gondii. Toxoplasma infection during pregnancy can result in congenital transmission and serious fetal and neonatal complications. This systematic review and meta-analysis aimed to assess the pooled seroprevalence of T. gondii infection and its determinants among pregnant women in African countries. METHODS: All articles reporting the seroprevalence of toxoplasmosis among pregnant women in African countries and published from 2010 to 2023 were searched using various databases...
May 23, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38776344/the-beneficial-effect-of-fluoxetine-on-behavioral-and-cognitive-changes-in-chronic-experimental-chagas-disease-unveils-the-role-of-serotonin-fueling-astrocyte-infection-by-trypanosoma-cruzi
#5
JOURNAL ARTICLE
Glaucia Vilar-Pereira, Daniel Gibaldi, Leda Castaño-Barrios, Andrea Alice da Silva, Isabela Resende Pereira, Otacílio Cruz Moreira, Constança Britto, Hílton Antônio Mata Dos Santos, Raquel de Oliveira Lopes, Luzineide Wanderley Tinoco, Wilson Oliveira, Joseli Lannes-Vieira
BACKGROUND: In Chagas disease (CD), a neglected tropical disease caused by the parasite Trypanosoma cruzi, the development of mental disorders such as anxiety, depression, and memory loss may be underpinned by social, psychological, and biological stressors. Here, we investigated biological factors underlying behavioral changes in a preclinical model of CD. METHODOLOGY/PRINCIPAL FINDINGS: In T. cruzi-infected C57BL/6 mice, a kinetic study (5 to 150 days postinfection, dpi) using standardized methods revealed a sequential onset of behavioral changes: reduced innate compulsive behavior, followed by anxiety and depressive-like behavior, ending with progressive memory impairments...
May 22, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38776337/tungiasis-among-children-in-kenya-is-associated-with-poor-nutrition-status-absenteeism-poor-school-performance-and-high-impact-on-quality-of-life
#6
JOURNAL ARTICLE
Lynne Elson, Christopher Kamau, Sammy Koech, Christopher Muthama, George Gachomba, Erastus Sinoti, Elwyn Chondo, Eliud Mburu, Miriam Wakio, Jimmy Lore, Marta Maia, Ifedayo Adetifa, Benedict Orindi, Phillip Bejon, Ulrike Fillinger
Tungiasis is a highly neglected tropical skin disease caused by the sand flea, Tunga penetrans. The flea burrows into the skin inducing a strong inflammatory response, leading to pain and mobility restrictions with potential impacts on quality of life. Few countries implement control efforts and there are few data on the impact of the disease to support policy decisions. We conducted a survey to determine the impact of tungiasis among primary school children across nine counties of Kenya. A total of 10,600 pupils aged 8 to 14 years were randomly selected from 97 primary schools and examined for tungiasis...
May 22, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38771890/the-international-classification-of-functioning-disability-and-health-to-map-leprosy-related-disability-in-rural-and-remote-areas-in-indonesia
#7
JOURNAL ARTICLE
Luh Karunia Wahyuni, Nelfidayani Nelfidayani, Melinda Harini, Fitri Anestherita, Rizky Kusuma Wardhani, Sri Linuwih Menaldi, Yunia Irawati, Tri Rahayu, Gitalisa Andayani, Hisar Daniel, Intan Savitri, Petrus Kanisius Yogi Hariyanto, Isabela Andhika Paramita
The International Classification of Function, Disability, and Health (ICF-WHO, 2001) recognizes several dimensions of disability, such as body structure and function (and impairment thereof), activity (and activity restrictions) and participation (and participation restriction) and their interactions with contextual factor (personal and environmental). In this study, we map and analyse the relationship between the components of ICF in leprosy patients from two rural areas in Indonesia: Lewoleba (East Nusa Tenggara) and Likupang (North Minahasa)...
May 21, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38771861/eosinophils-basophils-and-myeloid-derived-suppressor-cells-in-chronic-loa-loa-infection-and-its-treatment-in-an-endemic-setting
#8
JOURNAL ARTICLE
Gerrit Burger, Rafiou Adamou, Ruth Kreuzmair, Wilfrid Ndzebe Ndoumba, Dorothea Ekoka Mbassi, Anne Marie Nkoma Mouima, Carole Mamgno Tabopda, Roukoyath Moyoriola Adegnika, Ayong More, Dearie Glory Okwu, Lia-Betty Dimessa Mbadinga, Carlos Lamsfus Calle, Luzia Veletzky, Wolfram Gottfried Metzger, Benjamin Mordmüller, Michael Ramharter, Ghyslain Mombo-Ngoma, Ayola Akim Adegnika, Rella Zoleko-Manego, Matthew B B McCall
BACKGROUND: Chronic infection by Loa loa remains an unsolved immunological paradox. Despite harboring subcutaneously migrating adult worms and often high densities of microfilariae, most patients experience only relatively mild symptoms, yet microfilaricidal treatment can trigger life-threatening inflammation. Here, we investigated innate cell populations hypothesized to play a role in these two faces of the disease, in an endemic population in Gabon. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed numbers and activation of eosinophils and basophils, as well as myeloid-derived suppressor cell (MDSC) subsets and associated circulating cytokine levels by flow cytometry in sex- and age-matched L...
May 21, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38768252/status-of-zoonotic-disease-research-in-refugees-asylum-seekers-and-internally-displaced-people-globally-a-scoping-review-of-forty-clinically-important-zoonotic-pathogens
#9
JOURNAL ARTICLE
Regina Oakley, Nadja Hedrich, Alexandra Walker, Habtamu Merha Dinkita, Rea Tschopp, Charles Abongomera, Daniel H Paris
BACKGROUND: At the end of 2022, there were over 108 million forcibly displaced people globally, including refugees, asylum seekers (AS) and internally displaced people (IDPs). Forced migration increases the risk of infectious disease transmission, and zoonotic pathogens account for 61% of emerging and re-emerging infectious diseases. Zoonoses create a high burden of disease and have the potential to cause large-scale outbreaks. This scoping review aimed to assess the state of research on a range of clinically relevant zoonotic pathogens in displaced populations in order to identify the gaps in literature and guide future research...
May 20, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38768248/dynamics-of-emergence-and-genetic-diversity-of-dengue-virus-in-reunion-island-from-2012-to-2022
#10
JOURNAL ARTICLE
Etienne Frumence, David A Wilkinson, Raphaelle Klitting, Muriel Vincent, Nicolas Mnemosyme, Gilda Grard, Nicolas Traversier, Ghislaine Li-Pat-Yuen, Diana Heaugwane, Laurent Souply, Claude Giry, Marie-Claire Paty, Louis Collet, Patrick Gérardin, Fabian Thouillot, Xavier De Lamballerie, Marie-Christine Jaffar-Bandjee
BACKGROUND: Dengue is a major public health concern in Reunion Island, marked by recurrent epidemics, including successive outbreaks of dengue virus serotypes 1 and 2 (DENV1 and DENV2) with over 70,000 cases confirmed since 2017. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we used Oxford Nanopore NGS technology for sequencing virologically-confirmed samples and clinical isolates collected between 2012 and 2022 to investigate the molecular epidemiology and evolution of DENV in Reunion Island...
May 20, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38768226/c-reactive-protein-and-high-sensitivity-c-reactive-protein-levels-in-asymptomatic-intestinal-parasite-carriers-from-urban-and-rural-areas-of-gabon
#11
JOURNAL ARTICLE
Helena Noéline Kono, Mérédith Flore Ada Mengome, Bedrich Pongui Ngondza, Roger Hadry Sibi Matotou, Luccheri Ndong Akomezoghe, Bernadette Ekomi, Bridy Chesly Moutombi Ditombi, Jeanne Vanessa Koumba Lengongo, Jacques Mari Ndong Ngomo, Noé Patrick M'Bondoukwé, Cyrille Bisseye, Denise Patricia Mawili-Mboumba, Marielle Karine Bouyou Akotet
BACKGROUND: Chronic carriage of intestinal parasitic infections (IPIs) can induce chronic inflammation and dysbiosis, which are risk factors for non-communicable diseases. The objective of this study was to determine the relationship between IPI carriage and inflammation in a population of volunteers living in Gabon. METHODOLOGY AND PRINCIPAL FINDINGS: A cross-sectional study was conducted from September 2020 to November 2021 in asymptomatic volunteers aged 18 years old and over, residing in different areas of Gabon: Libreville (urban area) and Koula-Moutou and Bitam (rural areas)...
May 20, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38768213/amphotericin-b-resistance-in-leishmania-amazonensis-in-vitro-and-in-vivo-characterization-of-a-brazilian-clinical-isolate
#12
JOURNAL ARTICLE
Bianca A Ferreira, Elizabeth M Coser, Stephane de la Roca, Juliana I Aoki, Nilson Branco, Gustavo H C Soares, Mayara I S Lima, Adriano C Coelho
In Brazil, Leishmania amazonensis is the etiological agent of cutaneous and diffuse cutaneous leishmaniasis. The state of Maranhão in the Northeast of Brazil is prevalent for these clinical forms of the disease and also has high rates of HIV infection. Here, we characterized the drug susceptibility of a L. amazonensis clinical isolate from a 46-year-old man with diffuse cutaneous leishmaniasis coinfected with HIV from this endemic area. This patient underwent several therapeutic regimens with meglumine antimoniate, liposomal amphotericin B, and pentamidine, without success...
May 20, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38768194/employing-digital-pcr-for-enhanced-detection-of-perinatal-toxoplasma-gondii-infection-a-cross-sectional-surveillance-and-maternal-infant-outcomes-study-in-el-salvador
#13
JOURNAL ARTICLE
Mary K Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F Torres-Romero, Hanson Cowan, Madeleine M Meyer, Willber D Castro-Godoy, Mufaro Kanyangarara, Stella C W Self, Berry A Campbell, Melissa S Nolan
Toxoplasma gondii is a parasitic infection that can be transmitted in utero, resulting in fetal chorioretinitis and other long-term neurological outcomes. If diagnosed early, pregnancy-safe chemotherapeutics can prevent vertical transmission. Unfortunately, diagnosis of acute, primary infection among pregnant women remains neglected, particularly in low-and-middle-income countries. Clinically actionable diagnosis is complex due to the commonality of infection during childhood and early adulthood which spawn long-last antibody titers and historically unreliable direct molecular diagnostics...
May 20, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38768190/combining-species-distribution-models-and-big-datasets-may-provide-finer-assessments-of-snakebite-impacts
#14
JOURNAL ARTICLE
Mohammad Abdul Wahed Chowdhury, Johannes Müller, Aniruddha Ghose, Robed Amin, Abdullah Abu Sayeed, Ulrich Kuch, Mohammad Abul Faiz
BACKGROUND: Snakebite is a major poverty-related neglected tropical disease. An integrated scientific approach is needed to understand the dynamics of this important health issue. Our objective was to estimate snakebite occurrence in a tropical area by using a blend of ecological modelling and robust statistical analysis. METHODS: The present study used climatic, environmental, and human population density data to determine the area with snakebite occurrence-probability for the first time in Bangladesh...
May 20, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38758964/characteristics-risk-factors-and-outcomes-related-to-zika-virus-infection-during-pregnancy-in-northeastern-thailand-a-prospective-pregnancy-cohort-study-2018-2020
#15
JOURNAL ARTICLE
Jurai Wongsawat, Somsak Thamthitiwat, Victoria J Hicks, Sumonmal Uttayamakul, Phanthaneeya Teepruksa, Pongpun Sawatwong, Beth Skaggs, Philip A Mock, John R MacArthur, Inthira Suya, Patranuch Sapchookul, Paul Kitsutani, Terrence Q Lo, Apichart Vachiraphan, Ekachai Kovavisarach, Chulwoo Rhee, Pamorn Darun, Kamol Saepueng, Chamnan Waisaen, Doungporn Jampan, Pravit Sriboonrat, Buncha Palanuwong, Punchawee Sukbut, Darin Areechokchai, Chakrarat Pittayawonganon, Sopon Iamsirithaworn, Emily Bloss, Carol Y Rao
BACKGROUND: In response to the 2015-2016 Zika virus (ZIKV) outbreak and the causal relationship established between maternal ZIKV infection and adverse infant outcomes, we conducted a cohort study to estimate the incidence of ZIKV infection in pregnancy and assess its impacts in women and infants. METHODOLOGY/PRINCIPAL FINDINGS: From May 2018-January 2020, we prospectively followed pregnant women recruited from 134 participating hospitals in two non-adjacent provinces in northeastern Thailand...
May 17, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38758959/transcriptomic-analysis-of-n-terminal-mutated-trypanosoma-cruzi-ubp1-knockdown-underlines-the-importance-of-this-rna-binding-protein-in-parasite-development
#16
JOURNAL ARTICLE
Karina B Sabalette, Vanina A Campo, José R Sotelo-Silveira, Pablo Smircich, Javier G De Gaudenzi
BACKGROUND: During its life cycle, the human pathogen Trypanosoma cruzi must quickly adapt to different environments, in which the variation in the gene expression of the regulatory U-rich RNA-binding protein 1 (TcUBP1) plays a crucial role. We have previously demonstrated that the overexpression of TcUBP1 in insect-dwelling epimastigotes orchestrates an RNA regulon to promote differentiation to infective forms. METHODS: In an attempt to generate TcUBP1 knockout parasites by using CRISPR-Cas9 technology, in the present study, we obtained a variant transcript that encodes a protein with 95% overall identity and a modified N-terminal sequence...
May 17, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38758957/factors-associated-with-differential-seropositivity-to-leptospira-interrogans-and-leptospira-kirschneri-in-a-high-transmission-urban-setting-for-leptospirosis-in-brazil
#17
JOURNAL ARTICLE
Daiana de Oliveira, Hussein Khalil, Fabiana Almerinda G Palma, Roberta Santana, Nivison Nery, Juan C Quintero-Vélez, Caio Graco Zeppelini, Gielson Almeida do Sacramento, Jaqueline S Cruz, Ricardo Lustosa, Igor Santana Ferreira, Ticiana Carvalho-Pereira, Peter J Diggle, Elsio A Wunder, Albert I Ko, Yeimi Alzate Lopez, Mike Begon, Mitermayer G Reis, Federico Costa
BACKGROUND: Leptospirosis is a zoonosis caused by pathogenic species of bacteria belonging to the genus Leptospira. Most studies infer the epidemiological patterns of a single serogroup or aggregate all serogroups to estimate overall seropositivity, thus not exploring the risks of exposure to distinct serogroups. The present study aims to delineate the demographic, socioeconomic and environmental factors associated with seropositivity of Leptospira serogroup Icterohaemorraghiae and serogroup Cynopteri in an urban high transmission setting for leptospirosis in Brazil...
May 17, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38748731/accuracy-of-rapid-lateral-flow-immunoassays-for-human-leptospirosis-diagnosis-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Teerapat Nualnoi, Luelak Lomlim, Supawadee Naorungroj
BACKGROUND: In the last two decades, several rapid lateral flow immunoassays (LFIs) for the diagnosis of human leptospirosis were developed and commercialized. However, the accuracy and reliability of these LFIs are not well understood. In this study, we aimed to evaluate the accuracy of leptospirosis LFIs as well as the factors affecting the test efficiency using systematic review and meta-analysis. METHODS AND RESULTS: Original articles reporting the accuracy of human leptospirosis LFIs against microagglutination tests (MAT) or immunofluorescent assays (IFA) were searched from PubMed, Embase, and Scopus, and selected as per pre-set inclusion and exclusion criteria...
May 15, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38743784/a-regressive-analysis-of-the-main-environmental-risk-factors-of-human-echinococcosis-in-370-counties-in-china
#19
JOURNAL ARTICLE
Liying Wang, Zhiyi Wang, Min Qin, Jiaxi Lei, Xixi Cheng, Jun Yan, Laurent Gavotte, Roger Frutos
BACKGROUND: Echinococcosis is a natural focal, highly prevalent disease in China. Factors influencing the spread of echinococcosis are not only related to personal exposure but also closely related to the environment itself. The purpose of this study was to explore the influence of environmental factors on the prevalence of human echinococcosis and to provide a reference for prevention and control of echinococcosis in the future. METHODS: Data were collected from 370 endemic counties in China in 2018...
May 14, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38739673/great-genetic-diversity-of-vector-borne-bacteria-and-protozoan-in-wild-rodents-from-guangxi-china
#20
JOURNAL ARTICLE
Jing Xue, Si-Si Chen, Rui Jian, Guo-Qing Chen, Xincheng Qin, Miao Lu, Wen Wang, Guang-Cheng Xie, Luanying Du, Kun Li, Wen-Ping Guo
BACKGROUND: Rodents are recognized as the hosts of many vector-borne bacteria and protozoan parasites and play an important role in their transmission and maintenance. Intensive studies have focused on their infections in vectors, especially in ticks, however, vector-borne bacterial and protozoan infections in rodents are poorly understood although human cases presenting with fever may due to their infection have been found. METHODS: From May to October 2019, 192 wild rodents were trapped in wild environment of Guangxi Province, and the spleen samples were collected to reveal the presence of vector-borne bacterial and protozoan infections in them...
May 13, 2024: PLoS Neglected Tropical Diseases
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