journal
https://read.qxmd.com/read/38780745/an-incidental-detection-of-a-rare-upd-in-snp-array-based-pgt-sr-a-case-report
#1
JOURNAL ARTICLE
Yuanlin Ma, Jing Wang, Tianrui Wen, Yan Xu, Linhuan Huang, Qingyun Mai, Yanwen Xu
Uniparental disomies (UPD) refers to the inheritance of both homologs of a chromosome from only one parent with no representative copy from the other parent. UPD was with an estimated prevalence of 0.15‰ in population. Current understanding of UPD was limited to subjects for which UPD was associated with clinical manifestation due to imprinting disorders or recessive diseases. Segmental UPD was rare, especially for a segmental UPD with a combination of hetero- and isodisomy. This paper presents a couple with reciprocal translocation 46,XY, t(14;22)(q32...
May 23, 2024: Reproductive Sciences
https://read.qxmd.com/read/38780744/artificial-gametes-and-human-reproduction-in-the-21st-century-an-ethical-analysis
#2
REVIEW
Adrian Villalba
Artificial gametes, derived from stem cells, have the potential to enable in vitro fertilization of embryos. Currently, artificial gametes are only being generated in laboratory animals; however, considerable efforts are underway to develop artificial gametes using human cell sources. These artificial gametes are being proposed as a means to address infertility through assisted reproductive technologies. Nonetheless, the availability of artificial gametes obtained from adult organisms can potentially expand the possibilities of reproduction...
May 23, 2024: Reproductive Sciences
https://read.qxmd.com/read/38777949/association-between-vitamin-d-level-and-clinical-outcomes-of-assisted-reproductive-treatment-a-systematic-review-and-dose-response-meta-analysis
#3
REVIEW
Chenhao Xu, Xinqi An, Xiumei Tang, Yunxiao Yang, Qi Deng, Quanling Kong, Ying Hu, Dongzhi Yuan
The investigation about association between vitamin D level and clinical outcomes of assisted reproductive treatment showed various outcomes. This study aimed to review the correlation between vitamin D and outcomes of assisted reproductive treatment. The search was registered on the PROSPERO database (CRD42023458040). PubMed, Embase, Medline, ClinicalTrials.gov, and Cochrane databases were searched up to July 2023. Twenty-three observational studies were selected for meta-analysis. Comparing groups with deficient and 'insufficient + sufficient' vitamin D level, meta-analysis showed positive correlation between clinical pregnancy rate and vitamin D (OR 0...
May 22, 2024: Reproductive Sciences
https://read.qxmd.com/read/38777948/synergistic-amelioration-of-letrozole-induced-polycystic-ovary-syndrome-in-rats-a-therapeutic-approach-with-apple-cider-vinegar-and-metformin-combination
#4
JOURNAL ARTICLE
Ravi Chandra Sekhara Reddy Danduga, Aarathi Shalom Kurapati, Roohi Anju Shaik, Phani Kumar Kola, Sathish Kumar Konidala, Hema Bharathi Varada
The present study was conducted to evaluate the combination effect of apple cider vinegar (ACV) and metformin against letrozole-induced polycystic ovary syndrome (PCOS). Female Wistar rats were administered letrozole (1 mg/kg/day, p.o) for 21 days, except for the control group of animals. On the 22nd day, PCOS-induced animals were segregated into 4 groups and administered with CMC, ACV, metformin, and a combination of ACV and metformin, respectively. The treatments were continued for 15 days, and on the 36th day, all the animals were sacrificed for biochemical (blood glucose, lipid profile), hormonal (sex hormones and adiponectin), and pro-inflammatory mediator estimations in blood samples...
May 22, 2024: Reproductive Sciences
https://read.qxmd.com/read/38777947/streamlined-analysis-of-maternal-plasma-indicates-small-extracellular-vesicles-are-significantly-elevated-in-early-onset-preeclampsia
#5
JOURNAL ARTICLE
Scout Bowman-Gibson, Chandni Chandiramani, Madison L Stone, Christopher A Waker, Traci M Rackett, Rose A Maxwell, David N Dhanraj, Thomas L Brown
Preeclampsia (PE) is a leading cause of maternal and fetal mortality and morbidity. While placental dysfunction is a core underlying issue, the pathogenesis of this disorder is thought to differ between early-onset (EOPE) and late-onset (LOPE) subtypes. As recent reports suggest that small extracellular vesicles (sEVs) contribute to the development of PE, we have compared systemic sEV concentrations between normotensive, EOPE, and LOPE pregnancies. To circumvent lengthy isolation techniques and intermediate filtration steps, a streamlined approach was developed to evaluate circulating plasma sEVs from maternal plasma...
May 22, 2024: Reproductive Sciences
https://read.qxmd.com/read/38773027/vitrification-of-human-oocytes-before-or-after-rescue-ivm-does-not-impair-maturation-kinetics-but-induces-meiotic-spindle-alterations
#6
JOURNAL ARTICLE
Gaëlle Marteil, Aïcha Metchat, Sandra Dollet, Camille Cugnot, Laure Chaput, Bruno Pereira, Anne Sophie Gremeau, Florence Brugnon
Cryopreservation of in vitro matured oocytes is still considered as an experimental alternative to mature oocyte vitrification after ovarian stimulation. Here, we investigated whether rescue-IVM should be performed before or after vitrification. For this, 101 immature oocytes (germinal vesicle stage) from women undergoing ICSI were used. Oocytes were divided into three groups: freshly in vitro matured oocytes (IVM), freshly in vitro matured oocytes subsequently vitrified (IVM + VIT) and vitrified/warmed GV oocytes then in vitro matured (VIT + IVM)...
May 21, 2024: Reproductive Sciences
https://read.qxmd.com/read/38773026/apparent-diffusion-coefficient-on-diffusion-weighted-magnetic-resonance-imaging-to-predict-the-prognosis-of-patients-with-endometrial-cancer-a-meta-analysis
#7
JOURNAL ARTICLE
Deyin Zhai, Xiujie Wang, Junlian Wang, Zheng Zhang, Yangang Sheng, Ruining Jiao, Yihua Liu, Peng Liu
Apparent diffusion coefficient (ADC) derived from diffusion-weighted magnetic resonance imaging (DWI) may help diagnose endometrial cancer (EC). However, the association between ADC and the recurrence and survival of EC remains unknown. We performed a systematic review and meta-analysis to investigate whether pretreatment ADC on DWI could predict the prognosis of women with EC. PubMed, Embase, and Cochrane's Library were searched for relevant cohort studies comparing the clinical outcomes between women with EC having low versus high ADC on pretreatment DWI...
May 21, 2024: Reproductive Sciences
https://read.qxmd.com/read/38773025/protective-potential-of-methanol-extract-of-drymaria-cordata-willd-ex-schult-medc-on-letrozole-induced-polycystic-ovary-syndrome-via-modulation-of-apoptotic-markers-sex-hormones-and-antioxidant-status-in-rat-model
#8
JOURNAL ARTICLE
Adeola Oluwakemi Olowofolahan, John Oludele Olanlokun, Olufunso Olabode Olorunsogo
Polycystic ovary syndrome (PCOS) is a gynecological disorder among reproductive-aged women and a major cause of infertility. Different treatment options are being employed but with side effects. This has mandated alternative treatment options, especially complementary therapy. This study therefore investigated the possible protective effects of methanol extract of Drymaria cordata in Letrozole-induced PCOS. The plant is folklorically used in the treatment of diverse ailments including PCOS, fibroids, uterine/ovarian/breast tumors, and cancers...
May 21, 2024: Reproductive Sciences
https://read.qxmd.com/read/38773024/differential-mrna-and-lncrna-expression-profiles-associated-with-early-pregnancy-loss-in-art-patients
#9
JOURNAL ARTICLE
Liyan Wang, Yanbiao Jiang, Xiaorong Luo, Haofei Shen, Liulin Yu, Xia Yang, Hui Wang, Panpan Jin, Xuehong Zhang
Early pregnancy loss (EPL) is the most common complication in assisted reproductive technology (ART). However, the precise causes for nearly 50% patients remain unexplained. In the current study, we aimed to discover the differentially expressed profiling of mRNAs and lncRNAs by RNA sequencing (RNA-seq). Human chorionic villi tissues were collected from patients with EPL and natural control (NC) group. RNA sequencing (RNA-seq) of these specimens was performed for transcriptome analysis. As a result, we identified a total of 141 mRNAs and 137 lncRNAs that were significantly differentially expressed between villi tissues from EPL and NC...
May 21, 2024: Reproductive Sciences
https://read.qxmd.com/read/38769248/endometrial-elasticity-is-an-ultrasound-marker-for-predicting-clinical-pregnancy-outcomes-after-embryo-transfer
#10
JOURNAL ARTICLE
Lin-Lin Zhang, Shuo Huang, Li-Ying Wang, Yuan-Yuan Wang, Shan Lu, Rong Li
Endometrial elasticity is a potential new marker for assessing endometrial receptivity and pregnancy outcomes based on endometrial thickness and type. Currently, little research has been conducted on the elasticity of the endometrium using shear wave elasticity imaging (SWEI). This study aimed to explore whether endometrial elasticity is an ultrasound marker for predicting clinical pregnancy outcomes after embryo transfer. A total of 245 infertile women underwent ultrasonography before embryo transfer at the Peking University Third Hospital...
May 20, 2024: Reproductive Sciences
https://read.qxmd.com/read/38769247/is-the-human-chorionic-gonadotropin-level-on-day-10-after-cleaved-embryo-transfer-a-predictor-of-perinatal-outcome-a-retrospective-cohort-study
#11
JOURNAL ARTICLE
Ryosuke Akino, Kenji Ezoe, Kazuki Ohata, Junichiro Fukuda, Keiichi Kato
This study aimed to determine whether human chorionic gonadotropin (hCG) levels at day 10 after day 2 cleaved embryo transfer can predict pregnancy and perinatal outcomes. Patients who underwent oocyte retrieval with minimal stimulation or natural cycles and fresh or vitrified-warmed transfer of a single, day 2 cleaved embryo at our clinic between November 2018 and December 2020 were included in this study. Patients were classified into four age groups for oocyte retrieval and into ten groups based on the hCG level on day 10 after embryo transfer; pregnancy complications and delivery and neonatal outcomes were examined...
May 20, 2024: Reproductive Sciences
https://read.qxmd.com/read/38767769/cadm2-participates-in-endometriosis-development-by-influencing-the-epithelial-mesenchymal-transition
#12
JOURNAL ARTICLE
Zheng Wang, Qiqi Zhang, Chen Zhang, Jun Yan, Tingting Yang, Aifang Jiang
Endometriosis (EM) is a common gynecologic condition that often leads to infertility in women of reproductive age. Cell adhesion molecule 2 (CADM2) is involved in maintaining cell adhesion and polarity, as well as suppressing tumors. However, the role and mechanism of CADM2 in endometriosis is unclear. Therefore, this study evaluated the expression levels of CADM2 and epithelial-mesenchymal transition (EMT)-related marker proteins (E-cadherin, α-SMA, and N-cadherin). Compared to normal endometrial tissue, CADM2 was expressed at low levels in ectopic endometrial tissue from patients with EM...
May 20, 2024: Reproductive Sciences
https://read.qxmd.com/read/38767768/assessment-of-repetitive-controlled-ovarian-stimulation-cos-cycles-on-oocyte-donors-impact-on-oocyte-quality-and-viable-embryo-yield
#13
JOURNAL ARTICLE
Zalihe Yarkiner, Fazilet Kübra Boynukalın, Önder Coban
The utilization of donor eggs has broadened the options for Assisted Reproductive Technology (ART) among women facing challenges with egg quantity or quality. Given that donors are typically selected from young and fertile individuals, In Vitro Fertilization with egg donation (IVF-ED) tends to exhibit higher rates of implantation, pregnancy, and live births compared to IVF with the woman's own eggs, especially for females over 35 years old. This has led to a projected increase in the demand for IVF-ED, surpassing the number of available donors...
May 20, 2024: Reproductive Sciences
https://read.qxmd.com/read/38750376/the-promise-and-challenges-of-ai-integration-in-ovarian-cancer-screenings
#14
JOURNAL ARTICLE
Sierra Silverwood, Anna Jeter, Margo Harrison
PURPOSE: Ovarian cancer is oftendiagnosed late due to vague symptoms, leading to poor survival rate. Improved screening tests could mitigate this issue. This narrative review examines the potential and challenges of integrating artificial intelligence (A.I.) into ovarian cancer screenings, with a focus on improving early detection, diagnosis, and personalized risk assessment. METHOD: A comprehensive review of existing literature was conducted, analyzing studies and discussions within the scientific community...
May 15, 2024: Reproductive Sciences
https://read.qxmd.com/read/38744800/inhibitory-effect-and-mechanism-upon-glucose-insulin-potassium-administration-on-postpartum-mice-with-uterine-cramping-pain
#15
JOURNAL ARTICLE
Guiying Yang, Zonghong Long, Fang Chen, Xiaohang Bao, Dukun Zuo, Hong Tang, Zhuoxi Wu, Hong Li
This study aimed to explore the effect of glucose-insulin-potassium (GIK) on postpartum uterine cramping pain(UCP) in mice and the possible underlying mechanisms. Thirty full-term pregnancy C57BL/6 mice, within 6 h after spontaneous labor, the mice were randomly assigned into the following three groups: the control group (group C), the oxytocin group (group O), and the GIK plus oxytocin group (group G). Group G and group O were administered GIK and normal saline, respectively, and 10 min later, oxytocin was injected intraperitoneally; group C received normal saline twice...
May 14, 2024: Reproductive Sciences
https://read.qxmd.com/read/38740655/arid1a-in-gynecologic-precancers-and-cancers
#16
REVIEW
Jaida E Morgan, Nishah Jaferi, Zainab Shonibare, Gloria S Huang
The highest frequency of genetic alterations in the tumor suppressor ARID1A occurs in malignancies of the female reproductive tract. The prevalence of ARID1A alterations in gynecologic precancers and cancers is summarized from the literature, and the putative mechanisms of tumor suppressive action examined both in benign/precursor lesions including endometriosis and atypical hyperplasia and in malignancies of the ovary, uterus, cervix and vagina. ARID1A alterations in gynecologic cancers are usually loss-of-function mutations, resulting in diminished or absent protein expression...
May 13, 2024: Reproductive Sciences
https://read.qxmd.com/read/38728001/transcutaneous-discrimination-of-fetal-heart-rate-from-maternal-heart-rate-a-fetal-oximetry-proof-of-concept
#17
JOURNAL ARTICLE
Begum Kasap, Kourosh Vali, Weitai Qian, Lihong Mo, Zahabiya H Chithiwala, Anna C Curtin, Soheil Ghiasi, Herman L Hedriana
Intrapartum care uses electronic fetal heart rate monitoring (EFHRM) for over 50 years to indirectly assess fetal oxygenation. However, this approach has been associated with an increase in cesarean delivery rates and limited improvements in neonatal hypoxic outcome. To address these shortcomings, a novel transabdominal fetal pulse oximeter (TFO) is being developed to provide an objective measurement of fetal oxygenation. Previous studies have evaluated the performance of TFO on pregnant ewe. Building on the animal model, this study aims to determine whether TFO can successfully capture human fetal heart rate (FHR) signals during non-stress testing (NST) as a proof-of-concept...
May 10, 2024: Reproductive Sciences
https://read.qxmd.com/read/38728000/downregulation-of-sparc-expression-enhances-the-fusion-of-bewo-choriocarcinoma-cells
#18
JOURNAL ARTICLE
Atsuko Togo, Kanako Mitsuzuka, Sachiko Hanawa, Rie Nakajima, Kenji Izumi, Kenji Sato, Hitoshi Ishimoto
Syncytiotrophoblasts, which are formed by the fusion of villous cytotrophoblasts, play an essential role in maintaining a successful pregnancy. Secreted protein acidic and rich in cysteine (SPARC) is a non-structural Ca2+ -binding extracellular matrix glycoprotein involved in tissue remodeling and cell proliferation, differentiation, and migration. Previous studies have revealed that SPARC is expressed in villous and extravillous cytotrophoblasts in the first trimester and that RNA interference targeted at SPARC significantly inhibited invasion of human extravillous trophoblast HTR8/SVneo cells...
May 10, 2024: Reproductive Sciences
https://read.qxmd.com/read/38727999/analysis-of-maternal-and-fetal-oxidative-stress-during-delivery-with-epidural-analgesia
#19
JOURNAL ARTICLE
Tomoo Yuba, Yoshihisa Koyama, Yuki Kinishi, Reiko Uokawa, Chiyo Ootaki, Shoichi Shimada, Yuji Fujino
Childbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, we focused on oxidative stress during delivery and conducted a cross-sectional analysis of maternal and fetal oxidative stress. The participants included 15 women who received LEA (LEA group) and 15 who did not (No LEA group). Participants with a gestational age of < 37 weeks, BMI of ≥ 35 kg/m2 , cerebrovascular or cardiovascular complications, multiple pregnancies, gestational hypertension, gestational diabetes, chronic hypertension, thyroid disease, birth weight of < 2,500 g, emergency cesarean section, or cases in which epidural anesthesia was re-administered during delivery were excluded from the study...
May 10, 2024: Reproductive Sciences
https://read.qxmd.com/read/38720155/association-of-uterine-tissue-innervation-and-peripheral-nerve-density-with-adenomyosis-related-pain-a-systematic-review
#20
REVIEW
Mariana da Cunha Vieira, Marina Paula Andres, Luiza Gama Coelho Riccio, Sara Schmitt Schlindwein, Fernanda Vieira Lins Arcoverde, Attilio Di Spiezio Sardo, Mauricio Simões Abrão
Adenomyosis is associated with dysmenorrhea and chronic pelvic pain; however, the triggering mechanisms of painful stimuli and the role of uterine nerve fibers in the manifestation of pain remain poorly understood. The objective of this study was to systematically review the role of uterine nerve fibers' presence and density in the occurrence of pain in patients with adenomyosis. An electronic search was performed using the Embase, PubMed/Medline, and Cochrane databases. We included all studies from inception to November 2023...
May 8, 2024: Reproductive Sciences
journal
journal
41503
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.