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World Journal of Nuclear Medicine

Ciska-Anne Van Keerberghen, Antoine Harrouk, Luca Leone
Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis, with multisystem manifestation such as bone pain, being the most common presenting symptom, cardiovascular or central nervous system involvement, interstitial lung disease, skin and orbital lesions, adrenal enlargement, retroperitoneal fibrosis and renal impairment as well fever, and weight loss. The disease is challenging to diagnose due to its rarity and mimicry of other infiltrative processes. Technetium-99 m bone scintigraphy showing pathological bone activity in the long bones is highly suggestive of ECD...
April 2019: World Journal of Nuclear Medicine
N T K Thanseer, Ashwin Singh Parihar, Ashwani Sood, Sanjay Kumar Bhadada, Divya Dahiya, Priyanka Singh, Bhagwant Rai Mittal
Parathyroid carcinoma (PTC) is a rare endocrine tumor and uncommon cause for primary hyperparathyroidism. 18 F-fluorocholine (FCH) positron emission tomography and computed tomography (PET/CT) has shown promising results in the detection of parathyroid adenoma, though its role in PTC is undefined due to the paucity of incidence. The authors in this case report discuss the possible complimentary role of FCH PET/CT with 18 F-fluorodeoxyglucose PET/CT in the evaluation of the management of suspected recurrence, since this rare entity has high loco-regional and distant recurrence of the disease...
April 2019: World Journal of Nuclear Medicine
Patrick Earl Amparado Fernando, Eduardo Erasto Santiago Ongkeko
Tonsillar carcinoma is not easily diagnosed on [18 F] fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) scan; normal, inflamed, and infected tonsils also exhibit increased tracer uptake. We present a case of a 68-year-old male with colon and prostate carcinomas who was referred for a PET/CT scan. He presented with right cervical lymphadenopathy which, on fine-needle biopsy, was found to have atypical cells suspicious for malignancy. On PET/CT, the right cervical lymph nodes appeared hypermetabolic; subsequent excision biopsy revealed metastatic poorly differentiated carcinoma...
April 2019: World Journal of Nuclear Medicine
Guillaume Chaussé, Gad Abikhzer, Stephan Probst, Jerome Laufer
A 73-year-old woman undergoing hormone therapy for previously treated localized breast cancer presented at oncology follow-up 4 years after mastectomy/radiation therapy with weight loss, night sweats, and abdominal pain. Contrast computed tomography (CT) abdomen revealed a soft-tissue mass posterior to the pancreas, several enlarged retroperitoneal lymph nodes, and a dilated portal vein. On 18F-fluorodeoxyglucose positron emission tomography/CT, metabolic activity extended along the portal vein, outlining most of the liver venous system...
April 2019: World Journal of Nuclear Medicine
Mohsen Qutbi, Sajad Ghanbari, Isa Neshandar Asli, Babak Shafiei
Jaffe-Campanacci syndrome (JCS) is a rare clinical disorder with almost unknown etiology. The main feature of this syndrome is skeletal involvement as nonossifying fibroma which may cause severe morbidity to these patients. X-ray imaging is the widely available modality for evaluation of skeleton, but radionuclide imaging modalities may have a role in workup. Herein, we present a case of JCS evaluated with 99m Tc-methylene diphosphonate bone and 99m Tc-octreotide scans for the extent of skeletal involvement...
April 2019: World Journal of Nuclear Medicine
Demetrio Arico', Claudio Giardina, Carmelo Tuscano, Antonio Picone, Vincenzo Militano
A 69-year-old male patient, with bilateral hypoacusia and tinnitus, had a diagnosis of left vestibular schwannoma with synchronous meningioma on the left frontal lobe. After partial surgical resection of the acoustic schwannoma, this was followed by stereotactic radiosurgery on the residual lesion. The patient had a metachronous prostate cancer treated with conformal radiotherapy associated to 6 months of hormone therapy with luteinizing hormone/releasing hormone analog. During follow-up, prostate-specific antigen value increased to 0...
April 2019: World Journal of Nuclear Medicine
Jens Peder Dreyer Paludan, Sven Robert Andresen, Jan Abrahamsen, Lars Jelstrup Petersen, Christian Høyer
Ventilation/perfusion single-photon emission computed tomography performed using an aerosol of carbon-coated technetium is frequently used for diagnosing pulmonary embolism. Certain patients may suffer from chronic obstructive pulmonary disease (COPD); for such patients, the formation of mucus clots in airways can cause accumulation of the aerosol in the larger airways. This centralized deposition of the aerosol leads to insufficient activity in peripheral lung segments and subsequently results in ventilation images of substandard or even nondiagnostic quality...
April 2019: World Journal of Nuclear Medicine
Ashwin Singh Parihar, Shelvin Kumar Vadi, Bhagwant Rai Mittal, Harmandeep Singh, Rajender Kumar, Arunanshu Behera
Hepatic epithelioid hemangioendothelioma (EHE) is an uncommon vascular tumor, primarily seen in 20-40 years of age. We report the case of a 14-year-old boy with EHE and distant metastases identified on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT), leading to a change in the management plan. 18 F-FDG PET/CT proved to be useful in identifying the rare sites of metastasis and planning further treatment.
April 2019: World Journal of Nuclear Medicine
Dharmender Malik, Ashwani Sood, Bhagwant Rai Mittal, Rajender Kumar Basher, Anish Bhattacharya, Gurpreet Singh
Malignant melanoma is a highly aggressive tumor and surgical resection is the primary treatment. However, the chances of recurrence are quite high despite complete resection. The aim of study was to evaluate the 18 F-fluorodeoxyglucose(18 F-FDG) positron emission tomography-computed tomography (PET/CT) in detection of recurrent melanoma after curative surgery and its prognostic value. Fifty-four melanoma patients (32 women) with prior primary lesion resection were evaluated with 18 F-FDG PET/CT for clinically suspicious recurrent disease...
April 2019: World Journal of Nuclear Medicine
Justin Benjamin, Julie Hephzibah, Anish Jacob Cherian, David Mathew, Nylla Shanthly, Regi Oommen
In low-risk differentiated thyroid carcinoma (LRDTC), appropriate surgical procedure in terms of hemi/total thyroidectomy (TT) has been an area of debate. The aim was to determine whether in LRDTC patients, hemithyroidectomy would be an adequate treatment, determine incidence of disease in contralateral lobe and evaluate the effect of radioactive iodine ablation (RAIA). Retrospective study was done from 2008 to 2014 at a single institution. Preoperative ultrasound (USG) and histopathology reports of all LRDTC patients following total/completion thyroidectomy were recorded...
April 2019: World Journal of Nuclear Medicine
Rahul V Parghane, Sanjay Talole, Sandip Basu
There is a relative paucity of data in the literature regarding the prevalence of meningiomas and their detection in the clinical setting of neuroendocrine tumors (NETs). The primary aim of this study was to study incidentally detected meningiomas (on 68 Ga-DOTATATE/ 18 F fluorodeoxyglucose positron-emission tomography/computed tomography [18 F-FDG PET/CT]) in metastatic NET patients referred for peptide receptor radionuclide therapy (PRRT). The secondary aims of this study were to evaluate the response rate of these incidentally detected meningiomas following PRRT and determine progression-free survival (PFS) in this group of patients...
April 2019: World Journal of Nuclear Medicine
Nosheen Fatima, Maseeh Uz Zaman, Areeba Zaman, Unaiza Zaman, Rabia Tahseen, Sidra Zaman
The purpose of this prospective study was to determine metabolic response predictor(s) in propensity-matched patients having lymphomas who had baseline and interim 18 fluorodeoxyglucose (FDG) positron-emission tomography/computed tomography (PET/CT) using strict standardized imaging and reporting protocols. This prospective study was conducted at PET/CT section of a JCI-accredited healthcare facility from April 2017 to February 2018. Patients with baseline and interim 18 FDG PET/CT scans using standardized protocol were selected...
April 2019: World Journal of Nuclear Medicine
Ahmed Fathala, Mervat Aboulkheir, Salwa Bukhari, Mohamed M Shoukri, Moheieldin M Abouzied
There have been little and conflicting data regarding the relationship between coronary artery calcification score (CACS) and myocardial ischemia on positron emission tomography myocardial perfusion imaging (PET MPI). The aims of this study were to investigate the relationship between myocardial ischemia on PET MPI and CACS, the frequency and severity of CACS in patients with normal PET MPI, and to determine the optimal CACS cutoff point for abnormal PET. This retrospective study included 363 patients who underwent same-setting stress PET perfusion imaging and CACS scan because of clinically suspected coronary artery disease (CAD)...
April 2019: World Journal of Nuclear Medicine
Yaw Ampem Amoako, Emmanuel Nii Boye Hammond, Awo Assasie-Gyimah, Dennis Odai Laryea, Alfred Ankrah, George Amoah
We aimed to assess the relationship between bone scintigraphy findings and prostate-specific antigen (PSA) and Gleason score in a group of treatment naïve West Africans with prostate cancer. The age, PSA, and Gleason scores of 363 patients with prostate cancer were collected. Patients were risk stratified using the D'Amico criteria. Logistic regression was performed to assess the relationship between bone scan results and PSA and Gleason score. Receiver operating characteristics (ROC) analysis was used to determine the diagnostic reliability of the bone scan findings...
April 2019: World Journal of Nuclear Medicine
Naima Al Bulushi, Badriya Al Suqri, Marwa Al Aamri, Aymen Al Hadidi, Hafidh Al Jahdami, Mohammed Al Zadjali, Mimouna Al Risi
The aim of this observational cross-sectional study with retrospective review of the data is to evaluate the efficacy of using technetium-99m-octreotide (Tc-99m-OCT) in imaging neuroendocrine tumors (NETs) in our tertiary care hospital. A total of 58 patients had Tc-99m-OCT were identified in our database, from January 2013 to December 2016. Forty-one patients (age range of 15-75 years) meet our inclusion criteria, namely histopathology proven NETs, Tc-99m-OCT scan, computed tomography (CT), or magnetic resonance imaging (MRI) done in our institute for correlation...
April 2019: World Journal of Nuclear Medicine
Guray Gurkan, Ismet Sarikaya, Ali Sarikaya
Bone scintigraphy is widely used to detect bone metastases, particularly osteoblastic ones, and F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scan is useful in detecting lytic bone metastases. In routine studies, images are assessed visually. In this retrospective study, we aimed to assess the osteoblastic, osteolytic, and mixed lytic-sclerotic bone lesions semiquantitatively by measuring maximum standardized uptake value (SUVmax ) on FDG PET/computed tomography (CT), maximum lesion to normal bone count ratio (ROImax) on bone scintigraphy, and Hounsfield unit (HU) on CT...
April 2019: World Journal of Nuclear Medicine
John Freebody, Shane Fernando, Monica A Rossleigh
Sentinel lymph node (SLN) biopsy (SLNB) has demonstrated accuracy in the axillary staging of breast cancer patients. Despite variability in selection criteria and technique, an SLN is consistently identified in approximately 96% of cases and in most series predicts the status of remaining axillary LNs in >95% of cases. The false-negative rate of sentinel lymph node biopsy (SLNB) was originally reported as 5%-10% (sensitivity 90%-95%), but improved rates are attainable by experienced surgeons. Radiolocalization with lymphoscintigraphy (LSG) increases SLN identification rates...
April 2019: World Journal of Nuclear Medicine
S Dizdarevic, M Tulchinsky, V R McCready, J Mihailovic, S Vinjamuri, J R Buscombe, S T Lee, S Frangos, M Sathekge, Q Siraj, P Choudhury, H Bom, M Franceschi, A Ugrinska, D Paez, R Hussain, J Mailman, M Luster, I Virgolini
No abstract text is available yet for this article.
April 2019: World Journal of Nuclear Medicine
Hitesh Aggarwal, Maria D'souza, Puja Panwar, Neeru Jyotsna, Tauheed Alvi, Yachna Solanki, Tarakant Kumar, Rajnish Sharma
Ewing's sarcoma is a kind of undifferentiated reticulocytic sarcoma, which was first reported in 1921 by James Ewing. It is difficult to differentiate Ewing's sarcoma from osteomyelitis on computed tomography (CT) and X-ray and hence cytological confirmation is needed. Fluorodeoxy glucose being a nonspecific tracer cannot differentiate between malignant and inflammatory lesions. However, it is found that Ewing's sarcoma has increased LAT1 transporter expression at the cell surface. This property has been utilized to specifically target the tumor cells and differentiate them from inflammatory lesions...
January 2019: World Journal of Nuclear Medicine
Francis T Delaney, Emma L Gray, Joseph C Lee
We present a case of lung cancer incidentally detected as a pulmonary nodule on computed tomography attenuation correction (CTAC) images during myocardial perfusion scintigraphy (MPS). Unfortunately, the incidental lesion was not fully investigated following MPS report and had developed into metastatic lung carcinoma when diagnosed over 1 year later, with failure of subsequent emergent chemotherapy. The disease appeared to be localized when initially detected during MPS. This case highlights the importance and potential clinical value of routine review of CTAC images in MPS with appropriate reporting and further investigation of suspicious incidental findings...
January 2019: World Journal of Nuclear Medicine
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