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Contrast Media & Molecular Imaging

Valeriy G Ostapchenko, Jonatan Snir, Mojmir Suchy, Jue Fan, M Rebecca Cobb, Blaine A Chronik, Michael Kovacs, Vania F Prado, Robert H E Hudson, Stephen H Pasternak, Marco A M Prado, Robert Bartha
Apoptosis is a feature of stroke and Alzheimer's disease (AD), yet there is no accepted method to detect or follow apoptosis in the brain in vivo. We developed a bifunctional tracer [68 Ga]Ga-TC3-OGDOTA containing a cell-penetrating peptide separated from fluorescent Oregon Green and 68 Ga-bound labels by the caspase-3 recognition peptide DEVD. We hypothesized that this design would allow [68 Ga]Ga-TC3-OGDOTA to accumulate in apoptotic cells. In vitro, Ga-TC3-OGDOTA labeled apoptotic neurons following exposure to camptothecin, oxygen-glucose deprivation, and β -amyloid oligomers...
2019: Contrast Media & Molecular Imaging
Katie M Parkins, Amanda M Hamilton, Veronica P Dubois, Suzanne M Wong, Paula J Foster, John A Ronald
Purpose: The combined use of anatomical magnetic resonance imaging (MRI), cellular MRI, and bioluminescence imaging (BLI) allows for sensitive and improved monitoring of brain metastasis in preclinical cancer models. By using these complementary technologies, we can acquire measurements of viable single cell arrest in the brain after systemic administration, the clearance and/or retention of these cells thereafter, the growth into overt tumours, and quantification of tumour volume and relative cancer cell viability over time...
2019: Contrast Media & Molecular Imaging
Seval Beykan, Melpomeni Fani, Svend Borup Jensen, Guillaume Nicolas, Damian Wild, Jens Kaufmann, Michael Lassmann
Introduction: 177 Lu-OPS201 is a high-affinity somatostatin receptor subtype 2 antagonist for PRRT in patients with neuroendocrine tumors. The aim is to find the optimal scaling for dosimetry and to compare the biokinetics of 177 Lu-OPS201 in animals and humans. Methods: Data on biokinetics of 177 Lu-OPS201 were analyzed in athymic nude Foxn1 nu mice (28 F, weight: 26 ± 1 g), Danish Landrace pigs (3 F-1 M, weight: 28 ± 2 kg), and patients (3 F-1 M, weight: 61 ± 17 kg) with administered activities of 0...
2019: Contrast Media & Molecular Imaging
Piotr Andrzejewski, Georg Wengert, Thomas H Helbich, Heinrich Magometschnigg, Dietmar Georg, Marcus Hacker, Pascal Baltzer, Paola Clauser, Panagiotis Kapetas, Petra Georg, Wolfgang Wadsak, Katja Pinker
The aim of this study was to assess whether sequential multiparametric 18 [F]fluoro-desoxy-glucose (18 [F]FDG)/[18 F]fluoromisonidazole ([18 F]FMISO) PET-MRI in breast cancer patients is possible, facilitates information on tumor heterogeneity, and correlates with prognostic indicators. In this pilot study, IRB-approved, prospective study, nine patients with ten suspicious breast lesions (BIRADS 5) and subsequent breast cancer diagnosis underwent sequential combined [18 F]FDG/[18F]FMISO PET-MRI. [18 F]FDG was used to assess increased glycolysis, while [18 F]FMISO was used to detect tumor hypoxia...
2019: Contrast Media & Molecular Imaging
Ruohua Chen, Xiang Zhou, Gang Huang, Jianjun Liu
Purpose: To determine the relationship between fructose 1,6-bisphosphatase 1 (FBP1) expression and fluorine 18 (18 F) fluorodeoxyglucose (FDG) uptake in patients with clear cell renal cell carcinoma (ccRCC), and to investigate how 18 F-FDG uptake and FBP1 expression are related to tumor metabolism and tumor differentiation grade. Materials and Methods: A total of 54 patients with ccRCC underwent 18 F-FDG combined positron emission tomography and computed tomography (PET/CT) before tumor resection...
2019: Contrast Media & Molecular Imaging
Vincent J Huber, Hironaka Igarashi, Satoshi Ueki, Mika Terumitsu-Tsujita, Chikako Nito, Ken Ohno, Yuji Suzuki, Kosuke Itoh, Ingrid L Kwee, Tsutomu Nakada
Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new 19 F-molecular ligand, TGF-019, for visualizing the distribution of MMPs in vivo using 19 F-magnetic resonance spectroscopic imaging (19 F-MRSI)...
2019: Contrast Media & Molecular Imaging
Isabella Castiglioni, Francesca Gallivanone, Claudio Losio
No abstract text is available yet for this article.
2019: Contrast Media & Molecular Imaging
Chengyue Li, Xiaochun Xu, Nathan McMahon, Omar Alhaj Ibrahim, Husain A Sattar, Kenneth M Tichauer
Purpose: Paired-agent molecular imaging methods, which employ coadministration of an untargeted, "control" imaging agent with a targeted agent to correct for nonspecific uptake, have been demonstrated to detect 200 cancer cells in a mouse model of metastatic breast cancer. This study demonstrates that indocyanine green (ICG), which is approved for human use, is an ideal control agent for future paired-agent studies to facilitate eventual clinical translation. Methods: The kinetics of ICG were compared with a known ideal control imaging agent, IRDye-700DX-labeled antibody in both healthy and metastatic rat popliteal lymph nodes after coadministration, intradermally in the footpad...
2019: Contrast Media & Molecular Imaging
Hans Jonas Meyer, Leonard Leifels, Gordian Hamerla, Anne Kathrin Höhn, Alexey Surov
Background: Our purpose was to elucidate possible correlations between histogram parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) with several histopathological features in head and neck squamous cell carcinomas (HNSCC). Methods: Thirty patients with primary HNSCC were prospectively acquired. Histogram analysis was derived from the DCE-MRI parameters: K trans , K ep , and V e . Additionally, in all cases, expression of human papilloma virus (p16) hypoxia-inducible factor-1-alpha (Hif1-alpha), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and tumor suppressor protein p53 were estimated...
2019: Contrast Media & Molecular Imaging
Yuyang Li, Kian Shaker, Jakob C Larsson, Carmen Vogt, Hans M Hertz, Muhammet S Toprak
Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally matched K-shell absorption for the laboratory scale X-ray source...
2018: Contrast Media & Molecular Imaging
Jing Zhao, Yu-Liang Wang, Xin-Bei Li, Si-Yuan Gao, Shao-Yu Liu, Yu-Kun Song, Jing-Yan Wang, Ying Xiong, Hui Ma, Li Jiang, Zhi-Yun Yang, Gang-Hua Tang, Jian-Ping Chu
Purposes: Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma. In this work, radiosynthesis of [18 F]-fluoropropionyl-chlorotoxin ([18 F]-FP-chlorotoxin) as a novel PET tracer was investigated, and biodistribution in vivo and PET imaging were performed in the C6 glioma model. Procedures: [18 F]-FP-chlorotoxin was prepared from the reaction of chlorotoxin with [18 F]-NFB (4-nitrophenyl 2-[18 F]-fluoropropionate), which was synthesized from multistep reactions...
2018: Contrast Media & Molecular Imaging
Paulo Henrique Rosado-De-Castro, David Yang, Hwan-Jeong Jeong, Kazuma Ogawa, Marcos Fabio Henriques DosSantos, Skye Hsin-Hsien Yeh
No abstract text is available yet for this article.
2018: Contrast Media & Molecular Imaging
Mahdieh Moghiseh, Chiara Lowe, John G Lewis, Dhiraj Kumar, Anthony Butler, Nigel Anderson, Aamir Raja
The purpose of the present study was to demonstrate an in vitro proof of principle that spectral photon-counting CT can measure gold-labelled specific antibodies targeted to specific cancer cells. A crossover study was performed with Raji lymphoma cancer cells and HER2-positive SKBR3 breast cancer cells using a MARS spectral CT scanner. Raji cells were incubated with monoclonal antibody-labelled gold, rituximab (specific antibody to Raji cells), and trastuzumab (as a control); HER2-positive SKBR3 breast cancer cells were incubated with monoclonal antibody-labelled gold, trastuzumab (specific antibody to HER2-positive cancer cells), and rituximab (as a control)...
2018: Contrast Media & Molecular Imaging
Ignacio Alvarez Illan, Javier Ramirez, J M Gorriz, Maria Adele Marino, Daly Avendano, Thomas Helbich, Pascal Baltzer, Katja Pinker, Anke Meyer-Baese
Nonmass-enhancing (NME) lesions constitute a diagnostic challenge in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast. Computer-aided diagnosis (CAD) systems provide physicians with advanced tools for analysis, assessment, and evaluation that have a significant impact on the diagnostic performance. Here, we propose a new approach to address the challenge of NME lesion detection and segmentation, taking advantage of independent component analysis (ICA) to extract data-driven dynamic lesion characterizations...
2018: Contrast Media & Molecular Imaging
Manuel Scimeca, Nicoletta Urbano, Bonfiglio Rita, Sarah Natalia Mapelli, Carlo Vittorio Catapano, Giuseppina Maria Carbone, Sara Ciuffa, Mario Tavolozza, Orazio Schillaci, Alessandro Mauriello, Elena Bonanno
The main aim of this study was to investigate the putative association among the presence of prostate cancer cells, defined as prostate osteoblast-like cells (POLCs), and showing the expression of typical morphological and molecular characteristics of osteoblasts, the development of bone metastasis within 5 years of diagnosis, and the uptake of 18F-choline evaluated by PET/CT analysis. To this end, prostate biopsies ( n = 110) were collected comprising 44 benign lesions and 66 malignant lesions. Malignant lesions were further subdivided into two groups: biopsies from patients that had clinical evidence of bone metastasis (BM+, n = 23) and biopsies from patients that did not have clinical evidence of bone metastasis within 5 years (BM-, n = 43)...
2018: Contrast Media & Molecular Imaging
Ramin Sadeghi, Sara Harsini, Mohammad Ali Qodsi Rad, Vahid Reza Dabbagh, Giorgio Treglia
Purpose: Prognostic significance of fluorine-18 fluorodeoxyglucose positron emission tomography (18 F-FDG-PET) in anal squamous cell carcinoma (SCC) has been evaluated in several studies; however, the results seem to be controversial and no consensus exists about its predictive capability. The current meta-analysis was carried out to comprehensively investigate the prognostic significance of 18 F-FDG-PET parameters in patients with anal SCC. Methods: A comprehensive literature search of PubMed/MEDLINE and Scopus databases was performed to retrieve pertinent articles published until August 5th 2018, concerning the prognostic significance of 18 F-FDG-PET in patients with anal SCC...
2018: Contrast Media & Molecular Imaging
Pierre-Simon Bellaye, Alexandra Oudot, Jean-Marc Vrigneaud, Olivier Raguin, Francis Bichat, Anne Vaslin, Hélène Maby-El Hajjami, Claudio Zanna, Grégoire Vuagniaux, Pierre Fumoleau, Franck Denat, François Brunotte, Bertrand Collin
Background: Debio 1143, a potent orally available SMAC mimetic, targets inhibitors of apoptosis proteins (IAPs) members and is currently in clinical trials. In this study, nuclear imaging evaluated the effects of Debio 1143 on tumor cell death and metabolism in a triple-negative breast cancer (TNBC) cell line (MDA-MB-231)-based animal model. Methods: Apoptosis induced by Debio 1143 was assessed by FACS (caspase-3, annexin 5 (A5)), binding of 99m Tc-HYNIC-Annexin V, and a cell proliferation assay...
2018: Contrast Media & Molecular Imaging
Anastasia Zikou, Chrissa Sioka, George A Alexiou, Andreas Fotopoulos, Spyridon Voulgaris, Maria I Argyropoulou
Glioblastoma (GBM) is the most common primary malignant type of brain neoplasm in adults and carries a dismal prognosis. The current standard of care for GBM is surgical excision followed by radiation therapy (RT) with concurrent and adjuvant temozolomide-based chemotherapy (TMZ) by six additional cycles. In addition, antiangiogenic therapy with an antivascular endothelial growth factor (VEGF) agent has been used for recurrent glioblastoma. Over the last years, new posttreatment entities such as pseudoprogression and pseudoresponse have been recognized, apart from radiation necrosis...
2018: Contrast Media & Molecular Imaging
Te-I Weng, Huang Jen Chen, Chen-Wen Lu, Yu-Chin Ho, Jia-Lun Wu, Shing-Hwa Liu, Jong-Kai Hsiao
The toxicity of gadolinium-based contrast agents (GBCAs) has drawn a lot of attention. Nephrogenic systemic fibrosis (NSF), a lethal disease related to the use of GBCAs, is still not understood. Recently, gadolinium retention is found in brain tissues after repeated use of GBCAs in magnetic resonance imaging (MRI). However, most of the works investigating the toxicity of GBCAs are focusing on its high-concentration (0.5-10 mM) part, which is not reflective of the physiological conditions in human beings. Macrophages play a regulatory role in immune responses and are responsible for the fibrosis process...
2018: Contrast Media & Molecular Imaging
Arthur Taylor, Jack Sharkey, Antonius Plagge, Bettina Wilm, Patricia Murray
The ability to track the biodistribution and fate of multiple cell populations administered to rodents has the potential to facilitate the understanding of biological processes in a range of fields including regenerative medicine, oncology, and host/pathogen interactions. Bioluminescence imaging is an important tool for achieving this goal, but current protocols rely on systems that have poor sensitivity or require spectral decomposition. Here, we show that a bioluminescence resonance energy transfer reporter (BRET) based on NanoLuc and LSSmOrange in combination with firefly luciferase enables the unambiguous discrimination of two cell populations in vivo with high sensitivity...
2018: Contrast Media & Molecular Imaging
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