Yongkang Wei, Yanwei Li, Yurong Li, Gang Xu, Tangfeng Wu, Xiang Li, Ruixi Ye, Meilin Xi, Xiaomei Li, Guozheng Zhang, Yeshun Zhang
Wound healing in diabetics is often impaired or delayed due to the presence of high reactive oxygen species and low antioxidant levels. Here, a sericin-honey semi-interpenetrating network hydrogel with excellent antioxidant activity was prepared. Besides, the sericin-honey hydrogel is transparent, injectable, sticky, highly porous, and has good swelling properties, antibacterial activity, and cell compatibility. Based on its good performance in vitro, sericin-honey hydrogel achieved effective in vivo treatment on a mouse diabetic wound model, significantly accelerating the wound healing process...
February 29, 2024: Biomedical Materials