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Biomedical Materials

Ceren Kimna, Sibel Deger, Sedef Tamburaci, Funda Tihminlioglu
Despite the advancements in bone transplantation operations, inflammation is still a serious problem that threatens human health at the post-implantation period. Conventional antibiotic therapy methods may lead to some side effects such as ototoxicity and nephrotoxicity, especially when applied in high doses. Therefore, local drug delivery systems play a vital role in bone disorders due to the elimination of the disadvantages introduced by conventional methods. In the presented study, it was aimed to develop Vancomycin (VC) and Gentamicin (GC) loaded chitosan-montmorillonite nanoclay composites (CS/MMT) to provide required antibiotic doses to combat post-implantation infection...
April 16, 2019: Biomedical Materials
Aswan Al-Abboodi, Shuo Zhang, Mohammed Al-Saady, Jian Wern Ong, Peggy P Y Chan, Jing Fu
To reflect the rapidly growing interest in producing tissue sealants using various chemical/physical processes, we report an approach using visible light to control the crosslinking of 3D printable hydrogels as in situ tissue sealant. Gelatin-hydroxyphenylpropionic acid conjugate (Gtn-HPA) is shown to crosslink effectively within 30 seconds under visible light in the presence of [RuII(bpy)3]2+ and sodium persulphate, which is sufficiently rapid for surgery use. Porous structure can be also introduced by including carboxylmethyl cellulose-tyramine (CMC-Tyr) as a precursor...
April 16, 2019: Biomedical Materials
Nadia Adriana Vázquez-Torres, Francisco Manuel Sanchez-Arevalo, Alfredo Maciel-Cerda, Itzel Marisol Garnica-Palafox, Rodrigo Ontiveros-Tlachi, Casandra Paulina Chaires-Rosas, Gabriela Piñón-Zárate, Miguel Ángel Herrera-Enríquez, Mathieu Hautefeuille, Ricardo Vera-Graziano, Andrés Eliú Castell-Rodríguez
Chronic wounds are a global health problem, and their treatments are difficult and long lasting. The development of medical devices through tissue engineering has been conducted to heal this type of wound. In this study, it was demonstrated that the combination of natural and synthetic polymers, such as poly (D-L lactide-co-glycolide) (PLGA) and gelatin (Ge), were useful for constructing scaffolds for wound healing. The aim of this study was to evaluate the influence of different PLGA/gelatin ratios (9:1, 7:3 and 5:5 (v/v)) on the physical, chemical and biological properties of electrospun scaffolds for wound dressings...
April 8, 2019: Biomedical Materials
Ajay Suryavanshi, Kunal Khanna, Sindhu Kr, Jayesh Bellare, Rohit Srivastava
A novel composite biomaterial for bone-soft tissue fixation applications was developed. MgO-Silk-PCL, Silk-PCL and MgO-PCL composites were prepared with variable filler concentrations (0, 10, 20 and 30% w/w of MgO nanoparticles and 0, 5, 10, 20 and 30% of degummed silk fiber) in PCL polymer. The highest mechanical properties were obtained with 10%MgO and 20%Silk (MSP) wih 1.7x better tensile strength and 7.5x tensile modulus over PCL. It exhibited good cell viability and hemocompatibility, increased cell proliferation and differentiation...
April 5, 2019: Biomedical Materials
Tina Rabiee, Hamid Yeganeh, Reza Gharibi
Radical mediated photochemical thiol-yne click polymerization of thiol-terminated polyurethane prepolymers, with poly(ethylene glycol) (PEG) soft segment at two different molecular weights, a propargyl terminated urethane crosslinker and silver salt was utilized to prepare versatile wound dressings containing well-dispersed Ag° nanoparticles produced via in situ reduction of Ag+ ions. The dressings with optimized chemical structure showed desirable fluid handling capacity (up to 4.84 g/ to provide moist environment over damaged tissue...
April 5, 2019: Biomedical Materials
Lihua Gu, Jinxia Zhang, Lei Li, Zhiyun Du, Qing Cai, Xiaoping Yang
Hydrogels are normally not robust enough to meet the repairing requirements of bone defects, therefore, cryogels of higher mechanical properties are developed as the more proper candidates for the purpose. In view of the organic-inorganic composition of natural bone tissues, hydroxyapatite (HA) is envisioned as a good additive for protein cryogels to achieve biomimetic compositions, additionally, as an excellent reinforcement to increase the mechanical properties of cryogels. In this study, methacrylated gelatin (GelMA) was synthesized and corresponding 3D-structured cryogel was fabricated, followed by the incorporation of HA nanowires (HANWs) at different amounts as reinforcements...
April 2, 2019: Biomedical Materials
Wei Qu, Kun Yang, Jun Liu, Ke Liu, Fuqiang Liu, Junhui Ji, Wei Zhang
Traditional broad-spectrum antibacterial agents are limited by high toxicity and the destruction to the bacterial flora balance in the wound site. Herein, we propose an opinion that one or several especial antibacterial peptides are adopted to kill the target bacteria in order to precisely manage the bacteria infected chronic wound under the premise of biobalance, and specially employ nisin to treat S. aureus infected chronic wound as model with positive effects. The results showed that without cytotoxicity to the normal cells, only 25 ppm nisin could contrapuntally kill S...
March 22, 2019: Biomedical Materials
Chunmeng Ma, Zhengyu Ma, Feng Yang, Jing Wang, Changsheng Liu
A composite based on poly (propylene fumarate) (PPF) was investigated as a potential bone repair material for clinical use and it showed low heat release, suitable mechanical property and good biocompatibility. The in-situ curing process would finish in less than 10 minutes. Compared with PMMA, PPF/TCP showed great decrease in heat release as the maximum temperature during curing process was 54.7 ± 1.69℃. The compressive strength were between 109 ± 2 and 133 ± 6 MPa and the compressive modulus was 146 ± 11 to 161 ± 27 MPa, which were believed to be compatible and further supportive to surrounding bone...
March 22, 2019: Biomedical Materials
Christiane Heinemann, Sascha Heinemann, Sina Rößler, Benjamin Kruppke, Hans Peter Wiesmann, Thomas Hanke
Isolated nanospheres consisting of organically modified hydroxyapatite (ormoHAP), prepared by an electric field-assisted ion double migration process, were embedded in foamed gelatin to form a composite scaffold. Degradation rates have been demonstrated to correlate with the crosslinking degree (40%, 80%) as well as with the mineral content of the scaffolds (0%, 20%, 40%). A human co-culture model of osteoblasts and osteoclasts, derived from bone marrow stromal cells and monocytes, respectively, without external addition of the factors RANKL and M-CSF, was run for up to 42 days in order to characterize the action of the ormoHAP-gelatin scaffolds on the co-culture...
March 14, 2019: Biomedical Materials
Bora Onat, Sinem Tuncer, Sinem Ulusan, Sreeparna Banerjee, Irem Erel Goktepe
Biodegradable polymers have been broadly used as agents that can complex with and deliver osteoinductive agents, but osteoinductivity of the polymers themselves has been rarely studied. Here we report the osteoinductivity of poly(4-hydroxy-L-proline ester) (PHPE), a biodegradable cationic polymer with cell penetrating properties. Under physiological conditions, PHPE degrades into trans-4-hydroxy-L-proline (trans-Hyp), a non-coded amino acid with essential functions in collagen fibril formation and fibril stability...
March 11, 2019: Biomedical Materials
Bo Zhang, Naresh Kasoju, Qiongfang Li, Erfan Soliman, Aidong Yang, Zhang Feng Cui, Jinmin Ma, Hui Wang, Hua Cathy Ye
Culturing human Mesenchymal stromal cells (hMSCs) in vitro in hypoxic conditions resulted in reduced senescence, enhanced pluripotency and altered proliferation rate. It has been known that in vitro hypoxia affects expression of cell surface proteins. However, the impact of culture surfaces on the hypoxia-regulated genes (HRG) have not yet been reported. This study utilized Next-Generation sequencing to analyse the changes in the gene expression levels of HRG for hMSCs cultured on different culture surfaces...
March 8, 2019: Biomedical Materials
Jun Tang, Weijing Cao, Yin Zhang, Jiapan Luan, Feng Jiang, Xiang Zhou, Mingming Li
The properties of vaterite-containing tricalcium silicate (referred as V-C3S) bone cement can be significantly affected by graphene oxide (GO) added. The composited bone cement can overcome the problem of poor mechanical properties and low cellular activity of calcium silicate-based bone cement. The material properties, mineralization and cell compatibility were characterized. The results demonstrated that GO/V-C3S had good curing ability, mechanical properties and higher injectability. In general, V-C3S adding with 0...
March 7, 2019: Biomedical Materials
Dinorath Olvera, Rossana Schipani, Binulal Nelson Sathy, Daniel John Kelly
Electrospun fibers offer tremendous potential for tendon and ligament tissue engineering, yet developing porous scaffolds mimicking the size, stiffness and strength of human tissues remains a challenge. Previous studies have rolled, braided, or stacked electrospun sheets to produce 3D scaffolds with tailored sizes and mechanical properties. A common limitation with such approaches is the development of low porosity scaffolds that impede cellular infiltration into the body of the implant, thereby limiting their regenerative potential...
March 7, 2019: Biomedical Materials
Raquel Costa-Almeida, Isabel Calejo, Roberta Altieri, Rui M A Domingues, Emanuele Giordano, Rui L Reis, Manuela Gomes
To engineer functional tissue substitutes, it is required a multi-component, multi-scale approach that combines both physical, chemical and biological cues. Fiber-based techniques have been explored in the field of tissue engineering to produce structures recapitulating tissue architecture and mechanical properties. In this work, we engineered biofunctional composite living fibers (CLF) as multi-compartment fibers with a mechanically competent core and a hydrogel layer. For this purpose, commercial silk suture threads were coated with a platelet lysate (PL) hydrogel by first embedding the threads in a thrombin solution and then incubating in PL...
March 7, 2019: Biomedical Materials
Tzachy Morad, Roni Mina Hendler, Orly Eva Weiss, Eyal Aviv Canji, Ido Merfeld, Zvy Dubinsky, Refael Minnes, Yitshak Francis, Danny Baranes
Astrogilosis is the response of astrocytes to brain trauma which manifest opposite roles on brain injury repair. On the one hand, astrocytes undergoing astrogliosis inhibit tissue regeneration by forming scar tissue, but, on the other hand, they enhance damage repair through secretion of neuro-protecting and neurotrophic factors. Therefore, identifying means that regulate astrogliosis can provide a control over progression and repair of brain damage. We have previously shown that the calcium carbonate skeleton of corals upregulates two manifestations of astrogliosis in astrocytes in culture - expression of the Glial Fibrillay Acidic Protein (GFAP), and shape conversion from non-spiky to reactive spiky cell morphology...
March 6, 2019: Biomedical Materials
Shivam Saretia, Rainhard Machatschek, Burkhard Schulz, Andreas Lendlein
Hydroxyl terminated oligo(<i>ε</i>-caprolactone) (OCL) monolayers are reversibly cross-linked forming two dimensional networks (2D) at the air-water interface. The equilibrium reaction with glyoxal as the cross-linker is pH-sensitive. Pronounced contraction in the area of the prepared 2D OCL films in dependence of surface pressure and time revealed the process of the reaction. Cross-linking inhibited crystallization and retarded enzymatic degradation of the OCL film. Altering the subphase pH led to a cleavage of the covalent acetal cross-links...
March 5, 2019: Biomedical Materials
Krishna Patel, Andrew Joseph Dunn, Muhamed Talovic, Gabriel Haas, Madison Marcinczyk, Hady Elmashhady, Emily Growney, Scott A Sell, Koyal Garg
Volumetric muscle loss (VML) is a loss of over ~10% of muscle mass that results in functional impairment. Although skeletal muscle possesses the ability to repair and regenerate itself following minor injuries, VML injuries are irrecoverable. Currently, there are no successful clinical therapies for the treatment of VML. Previous studies have treated VML defects with decellularized extracellular matrix (D-ECM) scaffolds derived from either pig urinary bladder or small intestinal submucosa. These therapies were unsuccessful due to the poor mechanical stability of D-ECM leading to quick degradation in vivo...
February 27, 2019: Biomedical Materials
Danielle Amaral, Rafaella de Souza Salomão Zanette, Camila Guimaraes Almeida, Leonara Fayer, Luiz Fernando Oliveira, Raphael Marcomini, Breno Nogueira, Marcelo Santos, Humberto de Mello Brandao, Carlos Maranduba, Michele Munk
Nanomaterials can mimic properties of extracellular matrix molecules, promising great potential for scaffold composition in tissue engineering. In the present study, we investigated whether barium titanate nanoparticles (BT NP) combined with alginate polymer would provide a new cytocompatible three-dimensional (3D) scaffold to induce osteogenic stem cell differentiation. In vitro cytocompatibility and osteogenic differentiation potential were investigated using human mesenchymal stem cells (MSC). Firstly, we studied the cell viability and oxidative stress by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) thiazolyl blue tetrazolium bromide (MTT) and superoxide dismutase (SOD) assays...
February 25, 2019: Biomedical Materials
Yue Luo, Donghai Li, Xiaowei Xie, Pengde Kang
Glucocorticoids-induced osteonecrosis of femoral head (GIONFH) is difficult to treat due to the pathophysiology remains uncertain. Core decompression and bone grafting are regarded as effective measures for treating early GIONFH. Furthermore, commonly used bone graft materials at nowadays are still unsatisfactory. We generated a novel calcium polyphosphate(CPP) composite scaffold, which contains Li and VEGF-loaded gelatin microspheres (LiCPP/GMs/VEGF). The LiCPP /GMs/VEGF scaffold also demonstrated a porosity of 70...
February 25, 2019: Biomedical Materials
Catherine Ngan, Cathal D O'Connell, Romane Blanchard, M Boyd-Moss, Richard Williams, Justin Leigh Bourke, Anita Quigley, Penelope McKelvie, Robert Kapsa, Peter F M Choong
3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems and cell culture systems for tissue engineering. Critical to its success is the biocompatibility of the materials used, which should allow long-term tissue culture without affecting cell viability or inducing an inflammatory response for in vitro and in vivo applications. 
 Polyjet 3D printers offer arguably the highest resolution with the fewest design constraints of any commercially available 3D printing systems...
February 22, 2019: Biomedical Materials
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