Oladunni Alomaja, Frances S Shofer, John C Greenwood, Sarah Piel, Carly Clayman, Clementina Mesaros, Shih-Han Kao, Samuel S Shin, Johannes K Ehinger, Todd J Kilbaugh, David H Jang
INTRODUCTION: Cyanide exposure can occur in various settings such as industry and metallurgy. The primary mechanism of injury is cellular hypoxia from Complex IV (CIV) inhibition. This leads to decreased ATP production and increased reactive oxygen species production. The brain and the heart are the organs most affected due to their high metabolic demand. While the cardiac effects of cyanide are well known, the cerebral effects on cellular function are less well described. We investigated cerebral metabolism with a combination of brain respirometry, microdialysis, and western blotting using a rodent model of sub-lethal cyanide poisoning...
February 9, 2023: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology