Jeremy Shefner, Jesse M Cedarbaum, Merit E Cudkowicz, Nicholas Maragakis, Jacqueline Lee, Drew Jones, Mary Lou Watson, Katy Mahoney, Michael Chen, Khalil Saikali, John Mao, Alan J Russell, Richard L Hansen, Fady Malik, Andrew A Wolff
This study was designed to evaluate the safety and tolerability of single doses of CK-2017357, an orally bioavailable fast skeletal muscle troponin activator, in patients with amyotrophic lateral sclerosis (ALS), and to explore pharmacodynamic markers related to strength, endurance, and function. Sixty-seven patients with ALS received single doses of placebo, CK-2017357 at 250 mg and 500 mg in random order, separated by one week. Safety measures assessments were performed, as well as tests of pulmonary function, limb muscle strength and endurance, and global impression of change...
September 2012: Amyotrophic Lateral Sclerosis