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Iranian Journal of Immunology: IJI

Mohammad Hadi Abbasian, Bahare Abbasi, Nafiseh Ansarinejad, Ali Motevalizadeh Ardekani, Esmaeil Samizadeh, Katayoun Gohari Moghaddam, Mahmood Reza Hashemi
BACKGROUND: Chronic inflammation is associated with neoplasms and several types of cancer. Therefore, polymorphisms in the inflammation-related genes could modify the cancer susceptibility. OBJECTIVE: To investigate the associations between IL-1RN VNTR and rs419598 polymorphisms in IL-1 receptor antagonist (IL-1ra) and colorectal cancer (CRC) and gastric cancer (GC) in an Iranian population. METHODS: In this study, 126 cancer cases (91 CRC and 35 GC) and 97 healthy controls were included...
December 2018: Iranian Journal of Immunology: IJI
Ferah Genel, Semiha Bahceci Erdem, Nesrin Gülez, Sait Karaman, Hikmet Tekin Nacaroglu, Lillemor Skattum, Lennart Truedsson
BACKGROUND: Primary complement deficiencies are rare diseases. OBJECTIVE: To retrospectively evaluate the clinical and laboratory findings and complications of patients to increase awareness of pediatricians about complement deficiencies, which are rarely encountered. METHODS: In this study, the clinical and immunological characteristics of 21 patients who consulted the Immunology Department of our hospital between 2003 and 2017 and were diagnosed with classical or alternative pathway complement deficiency were obtained from the file records...
December 2018: Iranian Journal of Immunology: IJI
Surbhi Khurana, Minu Kumari, Nidhi Bhardwaj, Subodh Kumar, Sushma Sagar, Rajesh Malhotra, Purva Mathur
BACKGROUND: Bacteremia and sepsis are associated with high mortality, increased hospital stays, and associated costs, especially in trauma patients. Sepsis is a fatal immunological disorder and its pathophysiology is still poorly understood. OBJECTIVE: To ascertain the role of T-helper lymphocyte-related inflammatory serum cytokines in trauma patients with blood culture positive with Gram-negative bacteria. METHODS: Peripheral blood samples (5 ml) were collected from 40 trauma patients on the day of obtaining positive blood culture (i...
December 2018: Iranian Journal of Immunology: IJI
Maryam Moradi, Abbas Fayezi, Mana Momeni, Asyeh Javanian, Suzan Amini, Mohammad Shahrooei
BACKGROUND: The frequency of sensitization to respiratory allergens is different in various geographical regions. OBJECTIVE: To determine the level of specific IgE to respiratory allergens in patients with atopy in Ahvaz, Iran. METHODS: In this retrospective cross-sectional study, the total and specific IgE data were recorded for 408 patients with allergic rhinitis and asthma referred to allergy diagnostic laboratory in Ahvaz from 2014 to 2017...
December 2018: Iranian Journal of Immunology: IJI
Mansure Hojatizade, Mahsa Soleymani, Mohsen Tafaghodi, Ali Badiee, Omid Chavoshian, Mahmoud Reza Jaafari
BACKGROUND: Although there have been numerous attempts to develop vaccines for Leishmaniasis, no vaccine can be found against Leishmania in routine use for an effective global vaccination. It seems that one of the reasons for the low efficacy of such vaccines is the lack of a suitable adjuvant. OBJECTIVE: To evaluate the effects of chitosan nanoparticles containing whole Leishmania lysate antigen (WLL) and soluble leishmania antigens (SLA), a first generation Leishmania vaccine, on the type of immune response generated in BALB/c in a murine model of leishmaniasis...
December 2018: Iranian Journal of Immunology: IJI
Alireza Tahamtan, Mohammad Barati, Alijan Tabarraei, Seyed Reza Mohebbi, Sadegh Shirian, Ali Gorji, Amir Ghaemi
BACKGROUND: In recent years attention has been paid to develop effective adjuvant systems for DNA vaccines. Co-formulation of a gene delivery vector with an immunostimulator can enhance therapeutic efficiency of DNA vaccine. OBJECTIVE: To investigate the efficacy of chitosan as a nanodelivery system to enhance antitumor effects of human papilloma virus (HPV)-16 DNA vaccine with IL-12 gene for protection against TC-1 tumor using an animal model. METHODS: The mice were challenged by subcutaneous injection of TC-1 cells and immunized intramuscularly with DNA vaccine thrice at seven-day intervals...
December 2018: Iranian Journal of Immunology: IJI
Wei-Sung Li, Ching-Liang Chu, Mei-Hsing Chen, Yun-Sheng Lu, Jui-Sheng Lai, Bang-Jau You, Chi-Chien Lin
BACKGROUND: Lepista sordida (LS) extract has been shown to possess anti-oxidant, anti-aging, and anti-tumor activities. However, the immunostimulatory effect of LS extract has not been elucidated. OBJECTIVE: To characterize the impact of a water extract of LS (WE-LS) on the maturation and function of mouse dendritic cell (DC) in vitro and in vivo. METHODS: Mouse bone marrow-derived DCs (BMDCs) were generated. Next, DC maturation was determined by flow cytometry, and cytokine production was measured by ELISA after WE-LS treatment...
December 2018: Iranian Journal of Immunology: IJI
Piyachat Evelyn Roopngam
BACKGROUND: Infection with human papillomavirus type 16 (HPV-16) is known to cause cervical cancer, hence the several HPV therapeutic vaccines are developed in E7 oncoproteins and targeted on cell-mediated immunity. Human dendritic cells (HuDCs) are extensively employed in HPV therapeutic vaccines as the carrier or platform for inducing adaptive immune responses. However, the immunomodulators need to be further investigated for vaccine effects. Gray oyster mushroom (Pleurotus sajor-caju) containing β-glucans is a potent immunomodulator with potential to be used in vaccines...
December 2018: Iranian Journal of Immunology: IJI
Yue Zhi, Peng Gao, Wei Li, Fengling Gao, Jichun Zhang, Haitao Lin, Jie Zhang
BACKGROUND: CD163-expressing macrophages are involved in the inflammatory response in asthma. OBJECTIVE: To assess sputum and serum soluble CD163 (sCD163) and cytokine levels in patients with asthma. Further discussed was the difference between sCD163 and other classic inflammatory mediators. METHODS: Sputum was successfully induced in asthma patients (n=85) and healthy controls (n=21). Interleukin (IL)-4, IL-5, IL-1β, IL-8, IL-9, IL-6, and sCD163 levels in sputum were measured...
September 2018: Iranian Journal of Immunology: IJI
Fei Ge, Longbao Zhu, Liangjun Yang, Wanzhen Li, Shenghua Wei, Yugui Tao, Guocheng Du
BACKGROUND: Alginate materials have been widely employed for biomedical applications ranging from wound healing to cancer treatment. However, how alginate materials affect the immune system is largely unknown. OBJECTIVE: To explore the impact of alginate materials on immune system. METHODS: The effect of three types of alginate materials, low viscosity, high viscosity and particulate alginate, were examined by both in vivo and in vitro analyses...
September 2018: Iranian Journal of Immunology: IJI
Sadegh Izadi, Afshin Borhani-Haghighi, Kamal Bastani, Bahareh Kardeh, Golnaz Yadollahi-Khales, Mojtaba Neydavoodi
BACKGROUND: Cerebral sinovenous thrombosis (CSVT) is a neurovascular disorder that occurs when a blood clot develops in a vein near the brain. Evaluating the subsequent changes in inflammatory cytokines can better reveal the underlying pathogeneses. OBJECTIVE: To assess the serum levels of interleukin-10 (an anti-inflammatory cytokine) and IL-17 (a pro-inflammatory cytokine) in patients with aseptic non-vasculitic CSVT. METHODS: In this prospective case-control study, 31 patients with aseptic non-vasculitic CSVT (admitted in Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran) were enrolled...
September 2018: Iranian Journal of Immunology: IJI
Atina Vakili, Seyed Latif Mousavi Gargari, Shahram Nazarian, Jafar Amani
BACKGROUND: Cholera disease caused by Vibrio cholerae remains a major cause of morbidity and mortality throughout the world. Various strategies with different proteins as immunogens have been tried for vaccine development, none of which have been sufficiently effective to preclude cholera. Chimeric proteins, with their ability to present multiple antigens at the same time, can play important roles in immunization. OBJECTIVE: To evaluate the immunogenicity of a chimeric construct, comprised of OmpW and CtxB as immunogenic proteins of Vibrio cholera, in BALB/c mice...
September 2018: Iranian Journal of Immunology: IJI
Hossein Golmoghaddam, Shirin Farjadian, Shahdad Khosropanah, Pooyan Dehghani, Mehrnoosh Doroudchi
BACKGROUND: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells. OBJECTIVE: To investigate the association of HLA-DRB1 alleles with atherosclerosis in a sample of southwestern Iranians...
September 2018: Iranian Journal of Immunology: IJI
Reza Amani, Amir Abbasnezhad, Eskandar Hajiani, Bahman Cheraghian, Zahra Abdoli, Razieh Choghakhori
BACKGROUND: Given the variations in clinical presentation and physiopathological mechanisms in irritable bowel syndrome (IBS) subtypes, it is an acknowledged fact that the response to treatments can be disparate. OBJECTIVE: To assess the effect of vitamin D on inflammatory cytokines (IL-17, IL-10, TNF-α), and biomarkers of oxidative stress (total antioxidant capacity (TAC), and malondialdehyde (MDA)) among IBS patients. METHODS: A double-blind, randomized, placebo-controlled 6-month intervention study was carried out on 90 IBS patients (85 were analyzed), as defined by the Rome III criteria...
September 2018: Iranian Journal of Immunology: IJI
Fatemeh Nasri, Mehrnoosh Doroudchi, Bahia Namavar Jahromi, Behrouz Gharesi-Fard
BACKGROUND: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. OBJECTIVE: To investigate the T helper cells type 1 (Th1) /Th2/Th17/Treg paradigms in peripheral blood of infertile PCOS compared with normal fertile women. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated at the late follicular phase from 10 PCOS and 10 fertile women...
September 2018: Iranian Journal of Immunology: IJI
Xiaoying Wang, Keye Xu, Sisi Chen, Yan Li, Mingcai Li
Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 can join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated protein kinases. Almost all reports showed that IL-37 has remarkable anti-inflammatory activity. IL-37 plays an important role in a variety of inflammatory and autoimmune diseases, as well...
September 2018: Iranian Journal of Immunology: IJI
Adel Ebrahimpour, Ahmadreza Mirbolook, Mohammadali Okhovatpour, Mohammadreza Minator Sajjadi, Kamyar Makvandi, Mohammad Sadegh Mousavi, Sepehr Saghary, Mehrdad Sadighi
BACKGROUND: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. OBJECTIVE: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). METHODS: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scoring (ISS) was measured for all patients. RESULTS: The results of this study indicated that there was a significant relationship between the level of IL-6 and ISS on the first and second days post trauma (P=0...
June 2018: Iranian Journal of Immunology: IJI
Yolanda Guadalupe Cataño Cañizales, Edith Elena Uresti Rivera, Rocío Edith García Jacobo, Diana Patricia Portales Perez, Bastian Yadira, Jaime Guillermo Rodriguez Rivera, Roberto Gonzalez Amaro, José Antonio Enciso Moreno, Mariana Haydee García Hernández
BACKGROUND: Chronic inflammation has critical role in Type 2 diabetes (T2D), in which IL-1β contributes in insulin resistance and beta cell dysfunction. The activation of NLRP3 and AIM2 by endogens ligands, such as mtDNA can lead to the release of active form of IL-1β. OBJECTIVE: To evaluate AIM2 expression and activation as well as circulating mtDNA levels in T2D patients. METHODS: AIM2 expression was analyzed by flow cytometry, it's activity was assessed by measuring in vitro release of IL-1β induced by Poly (dA:dT), and mtDNA copy number was determined by quantitative real-time polymerase chain reaction...
June 2018: Iranian Journal of Immunology: IJI
Muhammad Hussain, Jiangshan Xiao, Yixuan Zhang, Peng Chen, Hongwu Du
BACKGROUND: Ribonucleoproteins particles that form the spliceosomes are among the most frequently targeted molecules of the autoimmune response. In the last few years, autoantibodies against all A/B hnRNP proteins have been found in the sera of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), and serve as diagnostic markers for several rheumatic diseases. However, the functional role of hnRNP C1/C2 in autoimmune diseases is still not clearly understood...
June 2018: Iranian Journal of Immunology: IJI
Yan Tan, Si-Wei Tan, Bo-Ya Fan, Lei Li, Yuan-Guo Zhou
BACKGROUND: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. OBJECTIVE: To investigate whether or not hemin regulates microglia-mediated secondary injury through activating the NLRP3/caspase-1 signaling pathway in microglia...
June 2018: Iranian Journal of Immunology: IJI
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