Fuqiang Huang, Na Zhao, Pei Cai, Mengjie Hou, Shuhui Yang, Bohao Zheng, Qian Ma, Jingpeng Jiang, Xiaochen Gai, Yilei Mao, Lianmei Wang, Zhongdong Hu, Xiaojun Zha, Fangming Liu, Hongbing Zhang
Due to soared obesity population worldwide, hepatosteatosis is becoming a major risk factor for hepatocellular carcinoma (HCC). Undertaken molecular events during the progression of steatosis to liver cancer are thus under intensive investigation. In this study, we demonstrated that high-fat diet potentiated mouse liver AKT2. Hepatic AKT2 hyperactivation through gain-of-function mutation of Akt2 (Akt2E17K) caused spontaneous hepatosteatosis, injury, inflammation, fibrosis, and eventually HCC in mice. AKT2 activation also exacerbated lipopolysaccharide and D-galactosamine hydrochloride-induced injury/inflammation and N-Nitrosodiethylamine (DEN)-induced HCC...
January 18, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine