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Translational Research: the Journal of Laboratory and Clinical Medicine

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https://read.qxmd.com/read/30738861/bm-mscs-derived-ecm-modifies-multiple-myeloma-phenotype-and-drug-response-in-a-source-dependent-manner
#1
Amjd Ibraheem, Oshrat Attar-Schneider, Mahmoud Dabbah, Osnat Dolberg Jarchowsky, Shelly Tartakover Matalon, Michael Lishner, Liat Drucker
Multiple myeloma (MM) malignant plasma cells accumulate in the bone marrow (BM) where their interaction with the microenvironment promotes disease progression and drug resistance. Previously, we have shown that MM cells cocultured with BM-mesenchymal stem cells (MSCs) comodulated cells' phenotype in a MAPKs/translation initiation (TI)-dependent manner. Dissection of the coculture model showed that BM-MSCs secretomes and microvesicles (MVs) participate in this crosstalk. Here, we addressed the role of the BM-MSCs extracellular matrix (ECM)...
January 23, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30738862/mast-cell-deficiency-protects-mice-from-streptozotocin-induced-diabetic-cardiomyopathy
#2
Aina He, Wenqian Fang, Kun Zhao, Yajun Wang, Jie Li, Chongzhe Yang, Feriel Benadjaoud, Guo-Ping Shi
Mast cells (MCs) have been implicated in the pathogenesis of cardiometabolic diseases by releasing pro-inflammatory mediators. Patients and animals with diabetic cardiomyopathy (DCM) also show inflammatory cell accumulation in the heart. Here, we detected MCs in mouse heart after streptozotocin (STZ)-induced DCM. DCM production caused significant systole and diastole interventricular septum and left ventricular (LV) posterior wall thinning, and systolic LV internal dilation in wild-type (WT) mice. DCM production also led to significant reductions of fractional shortening percentage, heart rate, body weight, heart weight, and significant increases of kidney, pancreas, and lung weight to body weight ratios, and blood hemoglobin HbA1c and glucose levels in WT mice...
January 19, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30738860/selenium-and-selenoproteins-from-endothelial-cytoprotection-to-clinical-outcomes
#3
REVIEW
Emilio Lopes Junior, Heitor Pons Leite, Tulio Konstantyner
The role of the vascular endothelium in inflammation was demonstrated experimentally through biomarkers of endothelial dysfunction and cytoprotection. Selenium is a trace element essential for cell protection against oxidative lesions triggered by reactive oxygen species or inflammatory responses. Preclinical studies have demonstrated a relationship between adhesion molecules as biomarkers of endothelial dysfunction and selenoproteins as biomarkers of selenium status under conditions that mimic different diseases...
January 19, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30731068/alcohol-dependence-treating-agent-acamprosate-prevents-traumatic-brain-injury-induced-neuron-death-through-vesicular-zinc-depletion
#4
Bo Young Choi, Song Hee Lee, Hui Chul Choi, Sang-Kyu Lee, Hyo Seop Yoon, Jae Bong Park, Won Suk Chung, Sang Won Suh
Acamprosate, also known as N-acetyl homotaurine, is an N-methyl-d-aspartate receptor antagonist that is used for treating alcohol dependence. Although the exact mechanism of acamprosate has not been clearly established, it appears to work by promoting a balance between the excitatory and inhibitory neurotransmitters, glutamate, and gamma-aminobutyric acid, respectively. Several studies have demonstrated that acamprosate provides neuroprotection against ischemia-induced brain injury. However, no studies have been performed evaluating the effect of acamprosate on traumatic brain injury (TBI)...
January 17, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30653941/chronic-exposure-to-e-cig-aerosols-during-early-development-causes-vascular-dysfunction-and-offspring-growth-deficits
#5
Marcus R Orzabal, Emilie R Lunde-Young, Josue I Ramirez, Selene Y F Howe, Vishal D Naik, Jehoon Lee, Cristine L Heaps, David W Threadgill, Jayanth Ramadoss
Increasing popularity of electronic cigarettes (e-cigs), including among women of reproductive age, is attributed to its perceived safety compared to conventional tobacco. However, there is a major knowledge gap surrounding the effects of e-cig aerosols on pregnancy and fetal development. We aimed to evaluate the effects of vaping e-cigs during gestation on offspring growth and to asses if growth deficits are accompanied by altered maternal and fetal vascular hemodynamics. Sprague-Dawley dams were assigned to Pair-Fed Control, Pair-Fed Juice, or Juice+Nicotine groups, and then underwent either a prenatal or prenatal+postnatal exposure paradigm in a custom-engineered vaping system...
January 7, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30653942/enhancing-responsiveness-of-pancreatic-cancer-cells-to-gemcitabine-treatment-under-hypoxia-by-heme-oxygenase-1-inhibition
#6
Maher Y Abdalla, Iman M Ahmad, Satyanarayana Rachagani, Kasturi Banerjee, Christopher M Thompson, Hans C Maurer, Kenneth P Olive, Katie L Bailey, Bradley E Britigan, Sushil Kumar
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and has one of the worst prognoses leading to a meager 5-year survival rate of ∼8%. Chemotherapy has had limited success in extending the life span of patients with advanced PDAC due to poor tumor perfusion and hypoxia-induced resistance. Hypoxia reprograms the gene expression profile and upregulates the expression of multiple genes including heme oxygenase-1 (HO-1), which provide survival advantage to PDAC cells. However, the relationships between HO-1, hypoxia, and response to chemotherapy is unclear...
January 4, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30639369/tetraspanin-cd151-impairs-heterodimerization-of-erbb2-erbb3-in-breast-cancer-cells
#7
Magdalena Mieszkowska, Dominika Piasecka, Piotr Potemski, Sylwia Debska-Szmich, Michal Rychlowski, Radzislaw Kordek, Rafal Sadej, Hanna M Romanska
CD151/Tspan24 (SFS-1, PETA3) is one of the best characterized members of the tetraspanin family, whose involvement in breast cancer (BCa) progression was demonstrated both in vitro and in vivo. We have recently reported that in ErbB2-overexpressing BCa cells grown in 3D laminin-rich extracellular matrix, CD151 regulated basal phosphorylation and homodimerization of ErbB2 and sensitized the cells to Herceptin (trastuzumab). Following from these data, we have here analyzed an involvement of CD151 in regulation of ErbB2/ErbB3 heterodimerization and its impact on cell response to Herceptin...
December 28, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30639368/m%C3%A3-ller-cells-in-pathological-retinal-angiogenesis
#8
REVIEW
Xiaorui Li, Jing Liu, Josephine Hoh, Ju Liu
Müller cells are the major glial cells spanning the entire layer of the retina and maintaining retinal structure. Under pathological conditions, Müller cells are involved in retinal angiogenesis, a process of growing new blood vessels from pre-existing capillaries. In response to hypoxia, high glucose, and inflammation conditions, multiple signaling pathways are activated in Müller cells, followed by the increased production of proangiogenic factors including vascular endothelial growth factor, basic fibroblast growth factor, matrix metalloproteinases, Netrin-4, and angiopoietin-like 4...
December 27, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30633889/establishment-of-vaginal-microbiota-composition-in-early-pregnancy-and-its-association-with-subsequent-preterm-prelabor-rupture-of-the-fetal-membranes
#9
Richard G Brown, Maya Al-Memar, Julian R Marchesi, Yun S Lee, Ann Smith, Denise Chan, Holly Lewis, Lindsay Kindinger, Vasso Terzidou, Tom Bourne, Phillip R Bennett, David A MacIntyre
Vaginal bacterial community composition influences pregnancy outcome. Preterm prelabor rupture of the fetal membranes (PPROM), which precedes 30% of all spontaneous preterm births, is associated with high vaginal bacterial diversity prior to rupture. The point at which vaginal bacterial diversity is established before PPROM is unknown. In this study, we use metataxonomics to longitudinally characterize the vaginal bacterial composition from as early as 6 weeks of gestation in women at high (n = 38) and low (n = 22) risk of preterm birth who subsequently experience PPROM and in women delivering at term without complications (n = 36)...
December 27, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30620888/increased-circulating-levels-of-epidermal-growth-factor-like-domain-7-in-pregnant-women-affected-by-preeclampsia
#10
Micol Massimiani, Lauretta A Lacko, Clare S Burke Swanson, Silvia Salvi, Lissenya B Argueta, Sascia Moresi, Sergio Ferrazzani, Shari E Gelber, Rebecca N Baergen, Nicola Toschi, Luisa Campagnolo, Heidi Stuhlmann
Proper placental development is crucial to establish a successful pregnancy. Defective placentation is the major cause of several pregnancy complications, including preeclampsia (PE). We have previously demonstrated that the secreted factor epidermal growth factor-like domain 7 (EGFL7) is expressed in trophoblast cells of the human placenta and that it regulates trophoblast migration and invasion, suggesting a role in placental development. In the present study, we demonstrate that circulating levels of EGFL7 are undetectable in nonpregnant women, increase during pregnancy and decline toward term...
December 25, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30633890/t-helper-2-differentiation-is-necessary-for-development-of-lymphedema
#11
Catherine L Ly, Gabriela D García Nores, Raghu P Kataru, Babak J Mehrara
T cells infiltrating lymphedematous tissues have a mixed T helper 1 (Th1) and Th2 differentiation profile. Treatment with neutralizing antibodies targeting cytokines that promote Th2 differentiation (interleukin 4 [IL-4] and IL-13) decreases the severity of lymphedema in preclinical models, suggesting that Th2 cells play a key role in the pathology of this disease. However, these previous studies do not address the contribution of Th1 cells and it remains unknown if IL-4 and IL-3 blockade acts primarily on T cells or decreases the pathological changes of lymphedema by other mechanisms...
December 21, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30615845/safety-and-efficacy-of-a-bacteriophage-cocktail-in-an-in-vivo-model-of-pseudomonas-aeruginosa-sinusitis
#12
Stephanie A Fong, Amanda J Drilling, Mian Li Ooi, Sathish Paramasivan, John W Finnie, Sandra Morales, Alkis J Psaltis, Sarah Vreugde, Peter-John Wormald
Pseudomonas aeruginosa (PA) is a bacterial pathogen that frequently displays antibiotic resistance. Its presence within the sinuses of chronic rhinosinusitis sufferers is associated with poorer quality of life. Obligately lytic bacteriophages (phages) are viruses that infect, replicate within, and lyse bacteria, causing bacterial death. The aims of the current study were to assess the safety and efficacy of a PA phage cocktail (CT-PA) in a sheep model of rhinosinusitis. The sheep rhinosinusitis model was adapted to simulate PA infection in sheep frontal sinuses...
December 19, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30615844/the-connection-of-circadian-rhythm-to-inflammatory-bowel-disease
#13
REVIEW
Marie Gombert, JoaquÍn Carrasco-Luna, Gonzalo Pin-Arboledas, Pilar CodoÑer-Franch
Inflammatory bowel disease (IBD) comprises a group of chronic, immune system-mediated inflammatory diseases that primarily affect the gastrointestinal tract. The pathogenesis of the intestinal lesions in IBD remains elusive, but the inflammation process could be the result of dysfunction of the innate and adaptive immune systems induced by genetic and environmental factors. In recent years, research has demonstrated a connection between environmental stressors that can influence day-night variations, also called circadian rhythms, and digestive health...
December 19, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30528322/unbiased-glycomics-a-powerful-tool-in-rare-disease-diagnosis-and-research
#14
EDITORIAL
Nima Niknejad, Hamed Jafar-Nejad
No abstract text is available yet for this article.
November 24, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30528321/a-review-on-the-interactions-between-the-tumor-microenvironment-and-androgen-receptor-signaling-in-prostate-cancer
#15
REVIEW
Milly J McAllister, Mark A Underwood, Hing Y Leung, Joanne Edwards
Prostate cancer growth is controlled by androgen receptor signaling via both androgen-dependent and androgen-independent pathways. Furthermore, the prostate is an immune competent organ with inflammatory changes both within the systemic and local environment contributing to the reprogramming of the prostatic epithelium with consistently elevated lymphocyte infiltration and proinflammatory cytokines being found in prostate cancer. The crosstalk between the tumor microenvironment and androgen receptor signaling is complex with both protumorigenic and antitumorigenic roles observed...
November 24, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30578758/a-proof-of-concept-clinical-trial-using-mesenchymal-stem-cells-for-the-treatment-of-corneal-epithelial-stem-cell-deficiency
#16
Margarita Calonge, Inmaculada Pérez, Sara Galindo, Teresa Nieto-Miguel, Marina López-Paniagua, Itziar Fernández, Mercedes Alberca, Javier García-Sancho, Ana Sánchez, José M Herreras
Ocular stem cell transplantation derived from either autologous or allogeneic donor corneoscleral junction is a functional cell therapy to manage extensive and/or severe limbal stem cell deficiencies that lead to corneal epithelial failure. Mesenchymal stem cells have been properly tested in animal models of this ophthalmic pathology, but never in human eyes despite their potential advantages. We conducted a 6- to 12-month proof-of-concept, randomized, and double-masked pilot trial to test whether allogeneic bone marrow-derived mesenchymal stem cell transplantation (MSCT [mesenchymal stem cell transplantation], n = 17) was as safe and as equally efficient as allogeneic cultivated limbal epithelial transplantation (CLET [cultivated limbal epithelial transplantation], n = 11) to improve corneal epithelial damage due to limbal stem cell deficiency...
November 22, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30528323/systematic-review-and-meta-analysis-of-experimental-studies-evaluating-the-organ-protective-effects-of-histone-deacetylase-inhibitors
#17
REVIEW
Syabira I Yusoff, Marius Roman, Florence Y Lai, Bryony Eagle, Gavin J Murphy, Tracy Kumar, Marcin Wozniak
The clinical efficacy of organ protection interventions are limited by the redundancy of cellular activation mechanisms. Interventions that target epigenetic mechanisms overcome this by eliciting genome wide changes in transcription and signaling. We aimed to review preclinical studies evaluating the organ protection effects of histone deacetylase inhibitors (HDACi) with a view to informing the design of early phase clinical trials. A systematic literature search was performed. Methodological quality was assessed against prespecified criteria...
November 22, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30529050/the-contribution-and-perspectives-of-proteomics-to-uncover-ovarian-cancer-tumor-markers
#18
REVIEW
Vinícius Pereira de Carvalho, Mariana Lopes Grassi, Camila de Souza Palma, Helio Humberto Angotti Carrara, Vitor Marcel Faça, Francisco José Candido Dos Reis, Aline Poersch
Despite all the advances in understanding the mechanisms involved in ovarian cancer (OC) development, many aspects still need to be unraveled and understood. Tumor markers (TMs) are of special interest in this disease. Some aspects of clinical management of OC might be improved by the use of validated TMs, such as differentiating subtypes, defining the most appropriate treatment, monitoring the course of the disease, or predicting clinical outcome. The Food and Drug Administration (FDA) has approved a few TMs for OC: CA125 (cancer antigen 125; monitoring), HE4 (Human epididymis protein; monitoring), ROMA (Risk Of Malignancy Algorithm; HE4+CA125; prediction of malignancy) and OVA1 (Vermillion's first-generation Multivariate Index Assay [MIA]; prediction of malignancy)...
November 20, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30401465/epigenetic-regulators-of-programmed-death-ligand-1-expression-in-human-cancers
#19
REVIEW
Sachin Kumar, Surender Kumar Sharawat
The programmed cell death protein 1-programmed death-ligand 1 (PD-L1) axis has been successfully targeted in clinics and the use of immune check-point inhibitors have shown durable antitumor response in untreated or heavily treated advanced stage cancer. PD-L1 upregulation has been found to correlate with poor prognosis in multiple cancer types and expression of PD-L1 in intratumoral compartment has been suggested to influence immune response and act as a key determinant of checkpoint immunotherapy efficacy...
December 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30165038/mitochondria-in-innate-immune-signaling
#20
REVIEW
Balaji Banoth, Suzanne L Cassel
Mitochondria are functionally versatile organelles. In addition to their conventional role of meeting the cell's energy requirements, mitochondria also actively regulate innate immune responses against infectious and sterile insults. Components of mitochondria, when released or exposed in response to dysfunction or damage, can be directly recognized by receptors of the innate immune system and trigger an immune response. In addition, despite initiation that may be independent from mitochondria, numerous innate immune responses are still subject to mitochondrial regulation as discrete steps of their signaling cascades occur on mitochondria or require mitochondrial components...
December 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
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