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World Journal of Pediatrics: WJP

Zhi-Dan Fan, Qian Cao, Na Huang, Le Ma, Hui-Hui Ma, Ya-Yuan Zhang, Hai-Guo Yu, Guo-Ping Zhou
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood driven by aberrant pathways of T-cell activation. T helper 17 (Th17)/regulatory T cell (Treg) imbalance plays critical roles in the pathogenesis of arthritis. MicroRNA-125b (miR-125b) was upregulated after the activation of the initial CD4+ T cells, and could regulate the differentiation of CD4+ T cells. However, the effects of miR-125b on Th17/Treg imbalance and differentiation of Th17/Treg cells remain unknown...
May 17, 2019: World Journal of Pediatrics: WJP
Ingrid Rabach, Francesca Peri, Marta Minute, Emanuela Aru, Marianna Lucafò, Alberto Di Mascio, Giorgio Cozzi, Egidio Barbi
BACKGROUND: Patients with cognitive impairment due to cerebral palsy experience pain more often than healthy peers and frequently require diagnostic and therapeutic painful procedures. Analgesia and procedural sedation outside the operating room are often required, but they may not adequately be provided because of the inability to accurately recognize and classify the state of pain and for the perceived higher risk of complications. DATA SOURCES: We reviewed the available literature to highlight the specific risk factors and area of criticism, that should be further improved...
May 16, 2019: World Journal of Pediatrics: WJP
Valentina Chiavaroli, John D Gibbins, Wayne S Cutfield, José G B Derraik
BACKGROUND: Paediatric obesity has reached epidemic proportions globally, resulting in significant adverse effects on health and wellbeing. Early life events, including those that happen before, during, and after pregnancy can predispose children to later obesity. The purpose of this review is to examine the magnitude of obesity among New Zealand children and adolescents, and to determine their underlying risk factors and associated comorbidities. DATA SOURCES: PubMed, Web of Science, and Google Scholar searches were performed using the key terms "obesity", "overweight", "children", "adolescents", and "New Zealand"...
May 11, 2019: World Journal of Pediatrics: WJP
Sílvia Bouissou Morais Soares, Luiz Alberto Wanderley de Menezes Silva, Flávia Cristina de Carvalho Mrad, Ana Cristina Simões E Silva
BACKGROUND: Distal renal tubular acidosis (dRTA) is a kidney tubulopathy that causes a state of normal anion gap metabolic acidosis due to impairment of urine acidification. This review aims to summarize the etiology, pathophysiology, clinical findings, diagnosis and therapeutic approach of dRTA, with emphasis on genetic causes of dRTA. DATA SOURCES: Literature reviews and original research articles from databases, including PubMed and Google Scholar. Manual searching was performed to identify additional studies about dRTA...
May 11, 2019: World Journal of Pediatrics: WJP
Philip Zeitler
BACKGROUND: Due to the dramatic increase in the rates of childhood obesity and youth-onset type 2 diabetes (T2D) in the late 1990s in the United States, the US government, through the National Institute of Diabetes, Digestive Disease, and Kidney (NIDDK) and the Centers for Disease Control, funded a series of large studies and trials which, together, have formed the basis for much of what we currently understand about youth-onset T2D. DATA SOURCES: The review focus on the recent results and implications of the treatment options for Type 2 Diabetes in Adolescents and Youth (TODAY) study and the Restoring Insulin Secretion (RISE) study...
May 10, 2019: World Journal of Pediatrics: WJP
Paola Muggeo, Vito Michele Rosario Muggeo, Paola Giordano, Maurizio Delvecchio, Maria Altomare, Chiara Novielli, Marco Matteo Ciccone, Gabriele D'Amato, Maria Felicia Faienza, Nicola Santoro
BACKGROUND: Vitamin D (25-OHD) has a role in bone health after treatment for cancer. 25-OHD deficiency has been associated with risk factors for cardiovascular disease, but no data focusing on this topic in childhood cancer survivors have been published. We investigated the 25-OHD status in children treated for acute lymphoblastic leukemia (ALL), and evaluated its influence on vascular function. METHODS: 25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy controls...
May 4, 2019: World Journal of Pediatrics: WJP
Charles Ituka Mosimah, Christa Lilly, Awung-Njia Forbin, Pamela J Murray, Lee Pyles, Elloise Elliot, William Neal
BACKGROUND: In West Virginia (WV), 47% of fifth-grade children are either overweight or obese. There is no clear consensus regarding the definition of insulin resistance in children, and directly measuring insulin on the population level is costly. Two proposed measures examined further in this study include triglyceride (TRIG)/high-density lipoprotein cholesterol (HDL-C) ratio and TRIG/low-density lipoprotein (LDL-C) ratio. The purpose of this study is to examine the relationship between TRIG/HDL-C ratio, TRIG/LDL-C ratio and insulin resistance in fifth-graders with acanthosis nigricans (AN)...
May 4, 2019: World Journal of Pediatrics: WJP
Hai-Xia Chen, Qia Cheng, Fang Li, Qing-Nan He, Yan Cao, Zhu-Wen Yi, Xiao-Chuan Wu
BACKGROUND: Tacrolimus, a calcineurin inhibitor, is recommended by the recent guidelines from the Kidney Disease Improving Global Outcomes Group as the first-line treatment for steroid-resistant nephrotic syndrome (SRNS), but its clinical application in China is still limited. We investigated the efficacy and safety of tacrolimus combined with low-dose corticosteroids in a population of Chinese children with SRNS. METHODS: In this prospective non-randomized, non-controlled study, Chinese children with SRNS who failed the previous full-dose prednisone treatment were given tacrolimus (0...
May 2, 2019: World Journal of Pediatrics: WJP
Keegan Kosasih, Udantha Abeyratne
In the original publication of the article "Declaration of conflict of interest" were not included. The following text is given below.
May 2, 2019: World Journal of Pediatrics: WJP
Wei Wen, Meng Guo, Hong-Bing Peng, Li Ma
BACKGROUND: To optimize and apply an approach suitable for large-scale neonatal thalassemia genetic screening in China, thalassemia genotypes were determined by polymerase chain reaction-reverse dot blot using DNA extracted from dried blood spots (DBS) obtained from newborn screening programs. METHODS: Firstly, the most suitable commercial DNA extraction kit for DBS was screened. Then, the appropriate amount of DBS required for the automated high-throughput DNA extraction system was evaluated...
April 27, 2019: World Journal of Pediatrics: WJP
Ke-Liang Li, Ben-Zhen Wang, Zi-Pu Li, Yi-Lei Li, Jing-Jing Liang
BACKGROUND: Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children. METHODS: A total of 120 RRTI children were randomly divided into active group, remission group, intervention group and control group, meanwhile 30 healthy children were selected as the healthy group. Children in the intervention group were given oral Bifidobaeterium tetravaccine tablets (Live) for 2 months, while the control group received routine treatment...
April 24, 2019: World Journal of Pediatrics: WJP
Rui-Zhu Liu, Bing-Tong Li, Guo-Qing Zhao
BACKGROUND: Surgery is an effective therapy for congenital heart disease (CHD) and the management after surgery poses challenges for the clinical workers. We performed this network meta-analysis to enhance the corresponding evidence with respect to the relative efficacy of different drug treatments applied after the CHD surgery. METHODS: Embase and PubMed were systematically retrieved to identify all published controlled trials investigating the effectiveness of drugs for patients up to 25 August, 2018...
April 23, 2019: World Journal of Pediatrics: WJP
Lin-Qian Zhang, Xiao-Bing Li, Yun-Guang Bao
No abstract text is available yet for this article.
April 23, 2019: World Journal of Pediatrics: WJP
Kenji Kishimoto, Masashi Kasai, Noriko Kawamura, Yusuke Ito, Makiko Yoshida, Daiichiro Hasegawa, Keiichiro Kawasaki, Yoshiyuki Kosaka
BACKGROUND: There is limited information concerning the overall epidemiology of invasive fungal disease (IFD) in children. The aim of this study was to clarify the clinical features of IFD in a tertiary pediatric care hospital. METHODS: Patients diagnosed with proven or probable IFD at our hospital between 2011 and 2015 were retrospectively reviewed. Proven and probable IFD were defined according to the European Organization for Research and Treatment of Cancer/Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group consensus...
April 22, 2019: World Journal of Pediatrics: WJP
Rui Wang, Jia-Xian Dong, Lu Wang, Xin-Yan Dong, Eitan Anenberg, Pei-Fang Jiang, Ling-Hui Zeng, Yi-Cheng Xie
BACKGROUND: Formation of protein complexes across synapses is a critical process in neurodevelopment, having direct implications on brain function and animal behavior. Here, we present the understanding, importance, and potential impact of a newly found regulator of such a key interaction. DATA SOURCES: A systematic search of the literature was conducted on PubMed (Medline), Embase, and Central-Cochrane Database. RESULTS: Membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor proteins (MDGAs) were recently discovered to regulate synaptic development and transmission via suppression of neurexins-neuroligins trans-synaptic complex formation...
April 17, 2019: World Journal of Pediatrics: WJP
Li-Qi Shu, Yi-Kan Sun, Lin-Hua Tan, Qiang Shu, Anthony C Chang
No abstract text is available yet for this article.
April 17, 2019: World Journal of Pediatrics: WJP
Fang Fang, Qing-Ying Zhang, Jun Zhang, Xiao-Ping Lei, Zhong-Cheng Luo, Hai-Dong Cheng
BACKGROUND: Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia. We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health. METHODS: Data from the Collaborative Perinatal Project, a longitudinal birth cohort with 54,371 singleton births, were used. 401 recurrent macrosomic infants (macro-macro) and 1327 normal weight babies with a macrosomia in the last pregnancy (macro-normal) were selected to explore risk factors for recurrent macrosomia...
April 16, 2019: World Journal of Pediatrics: WJP
Ara Ko, Young-Mock Lee
No abstract text is available yet for this article.
April 9, 2019: World Journal of Pediatrics: WJP
(no author information available yet)
No abstract text is available yet for this article.
April 6, 2019: World Journal of Pediatrics: WJP
Zhen-Ran Xu, Miao-Ying Zhang, Jin-Wen Ni, Ruo-Qian Cheng, Zhang-Qian Zheng, Li Xi, Fei-Hong Luo
BACKGROUND: The limited available studies have unveiled different natural histories and prognosis associated with pediatric type 2 diabetes (T2D) and adult T2D. To date, data on the clinical features, metabolic profiles and beta-cell function characteristics are still limited in the Chinese pediatric T2D population. METHODS: A total of 56 children with T2D, 31 with prediabetes and 159 with obesity were recruited. Clinical characteristics, metabolic profiles, beta-cell function and insulin resistance were analyzed...
March 25, 2019: World Journal of Pediatrics: WJP
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