Joonsik Park, Sook-Hyun Park, Yu-Ra Kwon, So Jin Yoon, Joo Hee Lim, Jung Ho Han, Jeong Eun Shin, Ho Seon Eun, Min Soo Park, Soon Min Lee
BACKGROUND: Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage (IVH) rates. This study explores IVH prevalence and long-term outcomes of very low birth weight (VLBW) infants in Korea over a decade. METHODS: Using Korean National Health Insurance data (NHIS, 2010-2019), we identified 3372 VLBW infants with IVH among 4,129,808 live births. Health-related claims data, encompassing diagnostic codes, diagnostic test costs, and administered procedures were sourced from the NHIS database...
April 13, 2024: World Journal of Pediatrics: WJP
Xiao-Juan Du, Ya-Qian Huang, Xue-Ying Li, Ying Liao, Hong-Fang Jin, Jun-Bao Du
BACKGROUND: Vasovagal syncope (VVS) is the most common type of orthostatic intolerance in children. We investigated whether platelet-related factors related to treatment efficacy in children suffering from VVS treated with metoprolol. METHODS: Metoprolol-treated VVS patients were recruited. The median duration of therapy was three months. Patients were followed and divided into two groups, treament-effective group and treatment-ineffective group. Logistic and least absolute shrinkage selection operator regressions were used to examine treatment outcome variables...
April 13, 2024: World Journal of Pediatrics: WJP
Cornelia Wiechers, Julian Sowula, Karen Kreutzer, Christoph E Schwarz, Christina Weismann, Michael Krimmel, Christian F Poets, Bernd Koos
BACKGROUND: Various conservative and surgical approaches exist to treat Robin sequence (RS), but their effects on facial profile and mandibular catch-up growth are unclear. A functional treatment concept, used in our centre for 25 years, includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding training. METHODS: We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above concept...
April 5, 2024: World Journal of Pediatrics: WJP
Li-Zhong Du
No abstract text is available yet for this article.
March 31, 2024: World Journal of Pediatrics: WJP
Xiang Zhou, Wu-Sheng Lin, Feng-Yun Zou, Shuang-Shuang Zhong, Ya-Yin Deng, Xiao-Wen Luo, Li-Shan Shen, Shi-Huan Wang, Ruo-Mi Guo
BACKGROUND: Preschooling is a critical time for intervention in children with autism spectrum disorder (ASD); thus, we analyzed brain tissue component volumes (BTCVs) and clinical indicators in preschool children with ASD to identify new biomarkers for early screening. METHODS: Eighty preschool children (3-6 years) with ASD were retrospectively included. The whole-brain myelin content (MyC), white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), and non-WM/GM/MyC/CSF brain component volumes were obtained using synthetic magnetic resonance imaging (SyMRI)...
March 25, 2024: World Journal of Pediatrics: WJP
Tong Tong, Yi-Hua Jin, Min Wang, Fang-Qi Gong
BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), a relatively uncommon but severe pediatric complication, is associated with coronavirus disease 2019 (COVID-19). A variety of treatment approaches, including intravenous immunoglobulins (IVIGs), glucocorticoids (GCs) and biologic agents, such as anakinra and infliximab, have been described for the management of COVID-19-related MIS-C. Anticoagulant therapy is also important. However, a well-developed treatment system has not been established, and many issues remain controversial...
March 21, 2024: World Journal of Pediatrics: WJP
Marguerite Lockhart-Bouron, Noémie Vanel, Michael Levy, Anaïs R Briant, Etienne Javouhey, Sophie Breinig, Julia Dina, Marion Caseris, François Angoulvant, Stéphane Leteurtre, Morgan Recher, David W Brossier
BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for an important mortality rate worldwide. We aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the pediatric intensive care unit (PICU). Secondary objectives were to identify risk factors for death. METHODS: This national multicenter comparative study comprised all patients under 18 years old with positive SARS-CoV-2 polymerase chain reactions (PCRs) [acute corona virus disease 2019 (COVID-19) or incidental SARS-CoV-2 infection] and/or pediatric inflammatory multisystem syndrome (PIMS) recorded in the French PICU registry (PICURe) between September 1, 2021, and August 31, 2022...
March 20, 2024: World Journal of Pediatrics: WJP
(no author information available yet)
No abstract text is available yet for this article.
February 28, 2024: World Journal of Pediatrics: WJP
Xian-Li Zhang, Xi Zhang, Wang Hua, Zheng-De Xie, Han-Min Liu, Hai-Lin Zhang, Bi-Quan Chen, Yuan Chen, Xin Sun, Yi Xu, Sai-Nan Shu, Shun-Ying Zhao, Yun-Xiao Shang, Ling Cao, Yan-Hui Jia, Luo-Na Lin, Jiong Li, Chuang-Li Hao, Xiao-Yan Dong, Dao-Jiong Lin, Hong-Mei Xu, De-Yu Zhao, Mei Zeng, Zhi-Min Chen, Li-Su Huang
No abstract text is available yet for this article.
February 25, 2024: World Journal of Pediatrics: WJP
Zhi-Xing Zhu, Georgi Z Genchev, Yan-Min Wang, Wei Ji, Yong-Yong Ren, Guo-Li Tian, Sira Sriswasdi, Hui Lu
INTRODUCTION: Methylmalonic acidemia (MMA) is a disorder of autosomal recessive inheritance, with an estimated prevalence of 1:50,000. First-tier clinical diagnostic tests often return many false positives [five false positive (FP): one true positive (TP)]. In this work, our goal was to refine a classification model that can minimize the number of false positives, currently an unmet need in the upstream diagnostics of MMA. METHODS: We developed machine learning multivariable screening models for MMA with utility as a secondary-tier tool for false positives reduction...
February 24, 2024: World Journal of Pediatrics: WJP
Zhao-Yuan Wu, Si-Wei Chi, Liu-Jian Ouyang, Xiao-Qin Xu, Jing-Nan Chen, Bing-Han Jin, Rahim Ullah, Xue-Lian Zhou, Ke Huang, Guan-Ping Dong, Zhe-Ming Li, Ying Shen, Jie Shao, Yan Ni, Jun-Fen Fu, Qiang Shu, Wei Wu
BACKGROUND: Alanine aminotransferase (ALT) is widely used to screen patients with hepatic diseases. However, the current reference ranges (< 50 U/L) were developed by laboratories and have not been validated in populations with a large number of healthy individuals. METHODS: This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric Healthcare...
February 22, 2024: World Journal of Pediatrics: WJP
Yue Tao, Cheng-Juan Luo, Bing-Hua Zhang, Xin-Yan Shen, Rui-Ke Zhao, Bei-Ying Ma, Nan Shen, Chang-Ying Luo, Jian-Min Wang, Yi-Jun Xia, Li Xie, Jing Chen, Xi Mo
BACKGROUND: Diarrhea is a common complication of hematopoietic stem cell transplantation (HSCT) and is associated with substantial morbidity, but its etiology is often unknown. Etiologies of diarrhea in this population include infectious causes, chemotherapy- or medication-induced mucosal injury and graft-versus-host disease (GVHD). Distinguishing these potential causes of diarrhea is challenging since diarrheal symptoms are often multifactorial, and the etiologies often overlap in transplant patients...
February 17, 2024: World Journal of Pediatrics: WJP
Ya-Xi Cui, Jun-Bao Du, Hong-Fang Jin
No abstract text is available yet for this article.
February 16, 2024: World Journal of Pediatrics: WJP
Hye Mi Lee, Jeongmin Shin, Sae Yun Kim, So Young Kim
BACKGROUND: Longer hospitalizations for preterm infants with bronchopulmonary dysplasia (BPD) delay developmental outcomes, increase the risk for hospital-acquired complications, and exert a substantial socioeconomic burden. This study aimed to identify factors associated with an extended length of stay (LOS) at different levels of severity of BPD. METHODS: A cohort study was conducted using the Korean Neonatal Network registry of very low birth weight infants with BPD between 2013 and 2017 through retrospective analysis...
February 15, 2024: World Journal of Pediatrics: WJP
Liang-Yu Kang, Zi-Rui Guo, Wei-Jing Shang, Gui-Ying Cao, Yi-Ping Zhang, Qiao-Mei Wang, Hai-Ping Shen, Wan-Nian Liang, Min Liu
BACKGROUND: Although birth defects are of great concern globally, the latest national prevalence has not yet been quantified in China. We conducted a systematic review and meta-analysis to estimate the perinatal prevalence of birth defects in the Mainland of China between 2000 and 2021. METHODS: We performed a systematic literature search of six databases for relevant articles published between January 1, 2000, and March 1, 2023. We included published studies that reported data on the perinatal prevalence of birth defects in the Mainland of China...
February 10, 2024: World Journal of Pediatrics: WJP
Yi-Kan Sun, Can Wang, Pei-Quan Lin, Lei Hu, Jing Ye, Zhi-Gang Gao, Ru Lin, Hao-Min Li, Qiang Shu, Li-Su Huang, Lin-Hua Tan
BACKGROUND: Coronavirus disease 2019 (COVID-19) tends to have mild presentations in children. However, severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at times, meriting further attention from clinicians. Meanwhile, the intricate interactions between the pathogen virulence factors and host defense mechanisms are believed to play indispensable roles in severe COVID-19 pathophysiology but remain incompletely understood. DATA SOURCES: A comprehensive literature review was conducted for pertinent publications by reviewers independently using the PubMed, Embase, and Wanfang databases...
February 6, 2024: World Journal of Pediatrics: WJP
Dan Hu, Chun-Hui She, Hua-Fang Bao, Jun Zou, Jian-Fei Cai, Jing-Fen Ye, Yan Shen, Hai-Fen Ma, Dan Luo, Jian-Long Guan
OBJECTIVES: Behçet's syndrome (BS) is a rare disease of unknown etiology, with limited reports especially in pediatric BS. The clinical characteristics and phenotypes of pediatric BS as a highly heterogeneous variable vessel vasculitis were investigated in this study. METHODS: A cross-sectional study was conducted to compare clinical variables and descriptive characteristics of BS by age of onset and gender. Cluster analysis was then performed to identify the phenotypes of pediatric BS...
February 5, 2024: World Journal of Pediatrics: WJP
Dimitra E Zazara, Olympia Giannou, Steven Schepanski, Mirja Pagenkemper, Anastasios D Giannou, Maike Pincus, Ioannis Belios, Stefan Bonn, Ania C Muntau, Kurt Hecher, Anke Diemert, Petra Clara Arck
BACKGROUND: Early-life respiratory infections and asthma are major health burdens during childhood. Markers predicting an increased risk for early-life respiratory diseases are sparse. Here, we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and asthma. METHODS: Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy cohort...
January 23, 2024: World Journal of Pediatrics: WJP
Daniel G Rayner, Elaine Wang, Cloris Su, Om D Patel, Stephanie Aleluya, Alessandra Giglia, Evelyn Zhu, Maha Siddique
BACKGROUND: The long-term sequelae of COVID-19 in children and adolescents remain poorly understood and characterized. This systematic review and meta-analysis sought to summarize the risk factors for long COVID in the pediatric population. METHODS: We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVID or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression analyses...
February 2024: World Journal of Pediatrics: WJP
Wen-Li Lu, Xiao-Yu Ma, Jiao Zhang, Jun-Qi Wang, Ting-Ting Zhang, Lei Ye, Yuan Xiao, Zhi-Ya Dong, Wei Wang, Shou-Yue Sun, Chuan-Yin Li, Rong-Gui Hu, Guang Ning, Li-Dan Zhang
No abstract text is available yet for this article.
January 19, 2024: World Journal of Pediatrics: WJP
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