Journals Expert Review of Respiratory M...

Expert Review of Respiratory Medicine
Anan S Jarab, Walid A AlQerem, Shrouq R Abu Heshmeh, Yazid N Al Hamarneh, Salah Aburuz, Judith Eberhardt
OBJECTIVES: This study investigated factors associated with anxiety and depression in COPD outpatients. METHODS: A cross-sectional study of 702 COPD outpatients from two major Jordanian hospitals using the Hospital Anxiety and Depression Scale (HADS) was conducted. RESULTS: Significant associations were found with gender (Anxiety OR: 5.29, 95%CI: 2.38-11.74; Depression OR: 0.20, 95%CI: 0.08-0.51), disease severity (Anxiety OR: 2.97, 95%CI: 1...
March 7, 2024: Expert Review of Respiratory Medicine
Michelle Casey, Nicholas J Simmonds
No abstract text is available yet for this article.
February 22, 2024: Expert Review of Respiratory Medicine
Almudena Felipe Montiel, Antonio Álvarez Fernández, Letizia Traversi, Eva Polverino
No abstract text is available yet for this article.
February 12, 2024: Expert Review of Respiratory Medicine
Andrea Mogavero, Ornella Cantale, Veronica Mollica, Shobana Anpalakhan, Alfredo Addeo, Giannis Mountzios, Alex Friedlaender, Ravindran Kanesvaran, Silvia Novello, Giuseppe Luigi Banna
INTRODUCTION: Immunotherapy (IO) has established a new milestone in lung cancer treatment. Several registrational studies have approved immune checkpoint inhibitors (ICIs) in different settings, including the metastatic nonsmall cell lung cancer (NSCLC). As wellknown, responders are just a certain proportion of patients, therefore their selection by using predictive factors has stood out as a crucial issue to address in tailoring a patientcentered care. AREAS COVERED: In our review we propose a detailed yet handy cross section on ICIs as firstline treatment in metastatic NSCLC, regarding indications, histological, clinical and bloodbased biomarkers, other than their mechanisms of resistance and new immunological actionable targets...
January 31, 2024: Expert Review of Respiratory Medicine
Jie He, Jun Hu, Hairong Liu
BACKGROUND: The disorder of circadian rhythm could be a key factor mediating fibrotic lung disease Therefore, our study aims to determine the diagnostic value of circadian rhythm-related genes (CRRGs) in IPF. METHODS: We retrieved the data on CRRGs from previous studies and the GSE150910 dataset. The participants from the GSE150910 dataset were divided into training and internal validation sets. Next, we used several various bioinformatics methods and machine learning algorithms to screen genes...
January 29, 2024: Expert Review of Respiratory Medicine
Joana Antão, Jeroen de Mast, Alda Marques, Frits M E Franssen, Martijn A Spruit, Qichen Deng
INTRODUCTION: Asthma and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality worldwide. Despite all available diagnostics and treatments, these conditions pose a significant individual, economic and social burden. Artificial intelligence (AI) promises to support clinical decision-making processes by optimizing diagnosis and treatment strategies of these heterogeneous and complex chronic respiratory diseases. Its capabilities extend to predicting exacerbation risk, disease progression and mortality, providing healthcare professionals with valuable insights for more effective care...
January 25, 2024: Expert Review of Respiratory Medicine
Ryan J Fiter, Lila J Murphy, Michelle N Gong, Krystal L Cleven
INTRODUCTION: Air pollution has been shown to have a significant impact on morbidity and mortality of respiratory illnesses including asthma. AREAS COVERED: Outdoor air pollution consists of a mixture of individual pollutants including vehicle traffic and industrial pollution. Studies have implicated an array of individual components of air pollution, with PM2.5 , NO2 , SO2 , and ozone being the most classically described, and newer literature implicating other pollutants such as black carbon and volatile organic compounds...
January 22, 2024: Expert Review of Respiratory Medicine
Jared Murphy, Ramiyya Tharumakunarajah, Karl A Holden, Charlotte King, Alice R Lee, Katie Rose, Daniel B Hawcutt, Ian P Sinha
INTRODUCTION: A child's living environment has a significant impact on their respiratory health, with exposure to poor indoor air quality (IAQ) contributing to potentially lifelong respiratory morbidity. These effects occur throughout childhood, from the antenatal period through to adolescence. Children are particularly susceptible to the effects of environmental insults, and children living in socioeconomic deprivation globally are more likely to breathe air both indoors and outdoors which poses an acute and long-term risk to their health...
January 19, 2024: Expert Review of Respiratory Medicine
S E Schiza, Esther I Schwarz, Maria R Bonsignore, Walter T McNicholas, Athanasia Pataka, Izolde Bouloukaki
INTRODUCTION: Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), is commonly associated with respiratory diseases, such as COPD, asthma and interstitial lung disease. AREAS COVERED: This narrative review aims to comprehensively synthesize the existing information on SDB in respiratory diseases, investigate the role of gender in this association, and highlight the importance of OSA management in improving sleep, quality of life, and disease prognosis in these specific patient populations...
January 10, 2024: Expert Review of Respiratory Medicine
Xiaoya Ma, Xufeng Zang, Leteng Yang, Wenqian Zhou, Yujie Li, Jie Wei, Jinping Guo, Junhui Han, Jing Liang, Tianbo Jin
BACKGROUND: Our study aimed to elucidate the association between single nucleotide polymorphisms (SNPs) in CYP2B6 gene and susceptibility to lung cancer (LC). METHODS: Five SNPs in CYP2B6 were genotyped in Chinese Han population (507 cases and 505 controls) utilizing Agena MassARRAY. The relationship between these SNPs and LC susceptibility was assessed using odds ratios, 95% confidence intervals, and χ2 tests. Additionally, multifactor dimensionality reduction was employed to analyze SNP-SNP interactions...
January 3, 2024: Expert Review of Respiratory Medicine
Megan Harrison, Grace Kavanagh, Tamera J Corte, Lauren K Troy
INTRODUCTION: Drug-induced interstitial lung disease (DI-ILD) is increasing in incidence, due to the use of many new drugs across a broad range of cancers and chronic inflammatory diseases. The presentation and onset of DI-ILD are variable even for the same drug across different individuals. Clinical suspicion is essential for identifying these conditions, with timely drug cessation an important determinant of outcomes. AREAS COVERED: This review provides a comprehensive and up-to-date summary of epidemiology, risk factors, pathogenesis, diagnosis, treatment, and prognosis of DI-ILD...
2024: Expert Review of Respiratory Medicine
Sunaina Chopra, Shivani Rana, Reenal Patel, Tessa Hamilton, Alyssa Dalip, Paramvir Malhi, Pat G Camp
BACKGROUND: Underrepresentation of minority groups in clinical trials may hinder the potential benefits of pulmonary rehabilitation (PR) programs for individuals with chronic obstructive pulmonary disease (COPD). The aim of this work was to determine whether participants in PR randomized control trials (RCTs) conducted in the U.S.A., Canada, the UK, and Australia are representative of ethnicity, sex, gender, and sociodemographic characteristics. RESEARCH DESIGN: A systematic search was performed for relevant literature from inception to December 2022...
2024: Expert Review of Respiratory Medicine
María Barca-Hernando, Luis Jara-Palomares
INTRODUCTION: Pulmonary embolism (PE) is a prevalent condition with a substantial morbi-mortality worldwide. Proper risk stratification of PE is essential for identifying the most suitable therapeutic strategy and the optimal care setting for the patient. This process entails evaluating various factors, including symptoms, comorbidities, and right heart dysfunction. AREAS COVERED: This review assesses the tools and methods utilized to identify and stratify individuals based on the probability of developing deterioration or death related to PE...
December 22, 2023: Expert Review of Respiratory Medicine
(no author information available yet)
No abstract text is available yet for this article.
December 20, 2023: Expert Review of Respiratory Medicine
Anita Saigal, Amar J Shah, Swapna Mandal
INTRODUCTION: Home noninvasive ventilation (HNIV) has expanded globally, with a greater evidence base for its use. HNIV improves multiple patient related outcomes in patients with chronic hypercapnic respiratory failure. Obesity hypoventilation syndrome (OHS) is rapidly taking over as the primary indication for HNIV and COPD patients who overlap with obstructive sleep apnea hypoventilation syndromes (OSAHS) and are increasingly recognized but add to the complexity of HNIV prescribing...
December 19, 2023: Expert Review of Respiratory Medicine
Xiaohua Li, Bin Dai, Qingbing Han, Yanqiu Wu, Bi Ran, Tao Wang, Fuqiang Wen, Jun Chen
BACKGROUND: Despite potential benefits and widespread prescription of aspirin among chronic obstructive pulmonary disease (COPD) patients, limited research has investigated its adverse effects in COPD population. METHODS: We conducted a retrospective analysis of adverse drug events (ADEs) reported in the US Food and Drug Administration Adverse Event Reporting System (FAERS) between Q1 2013 and Q2 2022. COPD patients were categorized into two groups based on aspirin use...
December 12, 2023: Expert Review of Respiratory Medicine
Bi Ran, Yutian Zhang, Yanqiu Wu, Fuqiang Wen
BACKGROUND: Observational studies showed a bidirectional association between depression and chronic obstructive pulmonary disease (COPD). However, it is unclear whether the observed association is causal. Thus we estimated the relationship using observational studies combined with bidirectional Mendelian randomization [MR]. MATERIALS AND METHODS: The study included 9977 participants from the 2013-2018 National Health and Nutrition Examination Survey and used weighted logistic regression analysis to assess the association between depression and COPD, followed by a bidirectional Mendelian randomization analysis to verify their causality...
December 12, 2023: Expert Review of Respiratory Medicine
Amine Ghram, Imed Latiri, Jabeur Methnani, Amine Souissi, Wafa Benzarti, Emna Toulgui, Helmi Ben Saad
INTRODUCTION: Long-COVID-19 patients (LC19Ps) often experience cardiovascular and respiratory complications. Cardiorespiratory rehabilitation programs (CRRPs) have emerged as promising interventions to enhance exercise capacity in this population. This systematic review aimed to assess the impact of CRRPs on submaximal exercise performance, specifically the 6-minute walk test (6MWT) outcomes, in LC19Ps through an analysis of available randomized controlled trials (RCTs). METHODS: A systematic search was conducted in PubMed/Medline and Scopus to identify relevant RCTs...
December 8, 2023: Expert Review of Respiratory Medicine
Aishwarya Soni, Bhawna Dahiya, Abhishek Sheoran, Vipul Kumar, Astha Guliani, Nitin Kumar, Vikas Hooda, Aparna Yadav, Kiran Nehra, Promod K Mehta
BACKGROUND: Diagnosis of pleural tuberculosis (TB) is tedious owing to its close resemblance with malignant pleural effusion and sparse bacterial load in clinical specimens. There is an immediate need to design a rapid and dependable diagnostic test to prevent unnecessary morbidity/mortality. RESEARCH DESIGN AND METHODS: A multi-targeted loop-mediated isothermal amplification (MT-LAMP) was deliberated using mpt64 and IS6110 to diagnose pleural TB within pleural fluids/biopsies...
December 7, 2023: Expert Review of Respiratory Medicine
Luigino Calzetta, Paola Rogliani
OBJECTIVES: Single-inhaler triple therapies (SITTs) have never been directly compared in randomized controlled trials (RCTs) in chronic obstructive pulmonary disease (COPD). Cochrane recommends the Bayesian approach for indirect comparisons but a frequentist network meta-analysis (NMA) reported superiority of fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) over other SITT. We assessed the most appropriate inference method for NMA characterized by between-study heterogeneity on SITT in COPD...
December 2023: Expert Review of Respiratory Medicine
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