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Journals Expert Review of Respiratory M...

Expert Review of Respiratory Medicine

https://read.qxmd.com/read/38755109/unmet-challenges-in-cystic-fibrosis-treatment-with-modulators
#1
REVIEW
Federica Corrao, Mairead Kelly-Aubert, Isabelle Sermet-Gaudelus, Michaela Semeraro
INTRODUCTION: 'Highly effective' modulator therapies (HEMTs) have radically changed the Cystic Fibrosis (CF) therapeutic landscape. These novel therapeutic approaches have permitted unprecedented opportunities for quality-of-life improvement and for enhancing people with CF's (pwCF) life expectancy. AREAS COVERED: The aim of this review is to describe the current knowledge gaps. A comprehensive search strategy was undertaken to assess impact of HEMT in life of pwCF, treatment challenges in specific populations such as very young children, and research needs...
May 16, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38753449/nanofiberous-facemasks-as-protectives-against-pandemic-respiratory-viruses
#2
REVIEW
Merna H Emam, Reham S Elezaby, Shady A Swidan, Rania M Hathout
INTRODUCTION: Wearing protective face masks and respirators has been a necessity to reduce the transmission rate of respiratory viruses since the outbreak of the coronavirus (COVID-19) disease. Nevertheless, the outbreak has revealed the need to develop efficient air filter materials and innovative anti-microbial protectives. Nanofibrous facemasks, either loaded with antiviral nanoparticles or not, are very promising personal protective equipment (PPE) against pandemic respiratory viruses...
May 16, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38743428/targeting-respiratory-microbiomes-in-copd-and-bronchiectasis
#3
REVIEW
Sanjay H Chotirmall, Micheál Mac Aogáin, Pei Yee Tiew, Tavleen Kaur Jaggi, Jayanth Kumar Narayana, Shivani Singh, Philip M Hansbro, Leopoldo N Segal
INTRODUCTION: This review summarizes our current understanding of the respiratory microbiome in COPD and Bronchiectasis. We explore the interplay between microbial communities, host immune responses, disease pathology and treatment outcomes. AREAS COVERED: We detail the dynamics of the airway microbiome, its influence in chronic respiratory diseases, and analytical challenges. Relevant articles from PubMed and Medline searches between Jan 2010 and March 2024 were retrieved and summarized...
May 14, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38712558/prone-positioning-in-awake-patients-without-ventilatory-support-does-not-alter-major-clinical-outcomes-in-severe-covid-19-results-from-a-retrospective-observational-cohort-study-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Fernando Val, Raíssa S Freire, Camila M S S Barros, Jefferson Valente, Cássia da Luz Goulart, Anna G R Santos, Fernando H Fonseca, Sabrina T Saenz, Andiana S Dias, Maria G A Rodrigues, Bernardo Maia Silva, Eduardo Fernandes, Nadia Cubas-Vega, Vanderson Sampaio, Mariana Simão, Djane Baía-da-Silva, Richard Severin, Guilherme Peixoto Tinoco ArêArêAs, Roberta Lins Gonçalves, Renata Gonçalves Mendes, Flor E Martinez-Espinosa
OBJECTIVES: During the Coronavirus disease (COVID-19) pandemic, clinicians recommended awake-prone positioning (APP) to avoid the worst outcomes. The objectives of this study were to investigate if APP reduces intubation, death rates and hospital length of stay (HLOS) in acute COVID-19. METHODS: We performed a retrospective cohort with non-mechanically ventilated patients hospitalized in a reference center in Manaus, Brazil, 2020. Participants were stratified into APP and awake-not-prone positioning (ANPP) groups...
May 7, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38690646/preoperative-frailty-screening-in-elderly-patients-with-non-small-cell-lung-cancer-surgery-an-essential-step-for-a-good-surgical-outcome
#5
REVIEW
Sabina Antonela Antoniu, Radu Iacobescu, Alina Delia Popa, Mariana Pavel-Tanase, Teodora Alexa Stratulat
INTRODUCTION: Non-small cell lung cancer (NSCLC) is a disease commonly diagnosed in the elderly, often in advanced stages. However, elderly patients with lung cancer can benefit from surgery, provided that postoperative risks are assessed appropriately before surgery. Frailty is a measure of age-related impaired functional status and a predictor of mortality and morbidity. However, its importance as a preoperative marker is not well defined. AREAS COVERED: This systematic review discusses the importance of preoperative frailty screening in elderly patients with NSCLC...
May 7, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38646681/relationship-between-obstructive-sleep-apnea-and-pulmonary-hypertension-past-present-and-future
#6
REVIEW
Jyotirmayee Lenka, Raymond Foley, Mark Metersky, Adrian Salmon
INTRODUCTION: Obstructive sleep apnea (OSA) is a widely prevalent condition with consequent multiple organ systems complications. There is consensus that OSA is associated with negative effects on pulmonary hemodynamics but whether it contributes to development of clinical pulmonary hypertension (PH) is unclear. AREAS COVERED: In this review, we (1) highlight previous studies looking into the possible bidirectional association of OSA and PH, focusing on those that explore clinical prognostic implications, (2) explore potential pathophysiology, (3) discuss the new metrics in OSA, (4) describe endo-phenotyping of OSA, (5) recommend possible risk assessment and screening pathways...
April 24, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38652642/the-influenza-landscape-and-vaccination-coverage-in-older-adults-during-the-sars-cov-2-pandemic-data-from-several-european-countries-and-israel
#7
REVIEW
George Kassianos, Jean-Marie Cohen, Rok Civljak, Nadav Davidovitch, Oana Falup Pecurariu, Filipe Froes, Andrei Galev, Inga Ivaskeviciene, Kadri Kõivumägi, Zuzana Kristufkova, Ernest Kuchar, Jan Kyncl, Helena C Maltezou, Miloš Marković, Aneta Nitsch-Osuch, Raul Ortiz de Lejarazu, Alessandro Rossi, Jörg Schelling, Gerrit A van Essen, Dace Zavadska
INTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel. AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza seasons...
April 23, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38489161/hypercapnia-and-its-relationship-with-respiratory-infections
#8
REVIEW
Elena Campaña-Duel, Adrian Ceccato, Luis Morales-Quinteros, Marta Camprubí-Rimblas, Antonio Artigas
INTRODUCTION: Hypercapnia is developed in patients with acute and/or chronic respiratory conditions. Clinical data concerning hypercapnia and respiratory infections interaction is limited. AREAS COVERED: Currently, the relationship between hypercapnia and respiratory infections remains unclear. In this review, we summarize studies on the effects of hypercapnia on models of pulmonary infections to clarify the role of elevated CO2 in these pulmonary pathologies. Hypercapnia affects different cell types in the alveoli, leading to changes in the immune response...
March 19, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38488035/do-all-patients-with-cancer-thrombosis-have-the-same-risk-of-bleeding-and-recurrence-particularities-of-lung-cancer
#9
EDITORIAL
Laurent Bertoletti, Ludovic Lafaie, Thibault LeConte, Anne-Laure Desage, Bastien Petit, Lutfi Ozturk, Sandrine Accassat, Pauline Corbaux, Géraldine Poenou
No abstract text is available yet for this article.
March 15, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38486441/so-we-now-have-rsv-vaccines-what-s-our-next-steps
#10
EDITORIAL
Joseph M Blondeau
No abstract text is available yet for this article.
March 14, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38486433/interstitial-lung-diseases-never-forget-to-think-about-it-in-primary-care
#11
EDITORIAL
Guadalupe Bermudo, Miguel Roman-Rodriguez, Maria Molina-Molina
No abstract text is available yet for this article.
March 14, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38457174/advances-in-lung-cancer-surgery-the-role-of-segmentectomy-in-early-stage-management
#12
REVIEW
Luca Bertolaccini, Monica Casiraghi, Clarissa Uslenghi, Cristina Diotti, Antonio Mazzella, Giovanni Caffarena, Lorenzo Spaggiari
INTRODUCTION: The evolving landscape of surgical interventions for early-stage non-small cell lung cancer (NSCLC) necessitates a reassessment of the traditional gold standard of lobectomy versus emerging sublobar resections, prompting this critical narrative review. AREAS COVERED: This review encompasses recent randomized controlled trials, notably JCOG0802/WJOG4607L and CALGB140503, comparing lobectomy and sublobar resections for early-stage NSCLC, focusing on tumor size and recurrence rates...
March 8, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38454777/factors-associated-with-anxiety-and-depression-among-patients-with-chronic-obstructive-pulmonary-disease
#13
JOURNAL ARTICLE
Anan S Jarab, Walid A AlQerem, Shrouq R Abu Heshmeh, Yazid N Al Hamarneh, Salah Aburuz, Judith Eberhardt
OBJECTIVES: This study investigated factors associated with anxiety and depression in COPD outpatients. METHODS: A cross-sectional study of 702 COPD outpatients from two major Jordanian hospitals using the Hospital Anxiety and Depression Scale (HADS) was conducted. RESULTS: Significant associations were found with gender (Anxiety OR: 5.29, 95%CI: 2.38-11.74; Depression OR: 0.20, 95%CI: 0.08-0.51), disease severity (Anxiety OR: 2.97, 95%CI: 1...
March 7, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38386416/why-don-t-anti-inflammatories-work-in-cystic-fibrosis
#14
EDITORIAL
Michelle Casey, Nicholas J Simmonds
No abstract text is available yet for this article.
February 22, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38347811/the-ageing-of-cystic-fibrosis-patients-with-new-modulators-current-gaps-and-challenges
#15
EDITORIAL
Almudena Felipe Montiel, Antonio Álvarez Fernández, Letizia Traversi, Eva Polverino
No abstract text is available yet for this article.
February 12, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38294292/first-line-immunotherapy-in-non-small-cell-lung-cancer-how-to-select-and-where-to-go
#16
REVIEW
Andrea Mogavero, Ornella Cantale, Veronica Mollica, Shobana Anpalakhan, Alfredo Addeo, Giannis Mountzios, Alex Friedlaender, Ravindran Kanesvaran, Silvia Novello, Giuseppe Luigi Banna
INTRODUCTION: Immunotherapy (IO) has established a new milestone in lung cancer treatment. Several registrational studies have approved immune checkpoint inhibitors (ICIs) in different settings, including the metastatic nonsmall cell lung cancer (NSCLC). As wellknown, responders are just a certain proportion of patients, therefore their selection by using predictive factors has stood out as a crucial issue to address in tailoring a patientcentered care. AREAS COVERED: In our review we propose a detailed yet handy cross section on ICIs as firstline treatment in metastatic NSCLC, regarding indications, histological, clinical and bloodbased biomarkers, other than their mechanisms of resistance and new immunological actionable targets...
January 31, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38285622/a-three-gene-random-forest-model-for-diagnosing-idiopathic-pulmonary-fibrosis-based-on-circadian-rhythm-related-genes-in-lung-tissue
#17
JOURNAL ARTICLE
Jie He, Jun Hu, Hairong Liu
BACKGROUND: The disorder of circadian rhythm could be a key factor mediating fibrotic lung disease Therefore, our study aims to determine the diagnostic value of circadian rhythm-related genes (CRRGs) in IPF. METHODS: We retrieved the data on CRRGs from previous studies and the GSE150910 dataset. The participants from the GSE150910 dataset were divided into training and internal validation sets. Next, we used several various bioinformatics methods and machine learning algorithms to screen genes...
January 29, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38270524/demystification-of-artificial-intelligence-for-respiratory-clinicians-managing-patients-with-obstructive-lung-diseases
#18
REVIEW
Joana Antão, Jeroen de Mast, Alda Marques, Frits M E Franssen, Martijn A Spruit, Qichen Deng
INTRODUCTION: Asthma and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality worldwide. Despite all available diagnostics and treatments, these conditions pose a significant individual, economic and social burden. Artificial intelligence (AI) promises to support clinical decision-making processes by optimizing diagnosis and treatment strategies of these heterogeneous and complex chronic respiratory diseases. Its capabilities extend to predicting exacerbation risk, disease progression and mortality, providing healthcare professionals with valuable insights for more effective care...
January 25, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38247719/the-impact-of-air-pollution-on-asthma-clinical-outcomes-current-epidemiology-and-health-disparities
#19
REVIEW
Ryan J Fiter, Lila J Murphy, Michelle N Gong, Krystal L Cleven
INTRODUCTION: Air pollution has been shown to have a significant impact on morbidity and mortality of respiratory illnesses including asthma. AREAS COVERED: Outdoor air pollution consists of a mixture of individual pollutants including vehicle traffic and industrial pollution. Studies have implicated an array of individual components of air pollution, with PM2.5 , NO2 , SO2 , and ozone being the most classically described, and newer literature implicating other pollutants such as black carbon and volatile organic compounds...
January 22, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38240133/impact-of-indoor-environment-on-children-s-pulmonary-health
#20
REVIEW
Jared Murphy, Ramiyya Tharumakunarajah, Karl A Holden, Charlotte King, Alice R Lee, Katie Rose, Daniel B Hawcutt, Ian P Sinha
INTRODUCTION: A child's living environment has a significant impact on their respiratory health, with exposure to poor indoor air quality (IAQ) contributing to potentially lifelong respiratory morbidity. These effects occur throughout childhood, from the antenatal period through to adolescence. Children are particularly susceptible to the effects of environmental insults, and children living in socioeconomic deprivation globally are more likely to breathe air both indoors and outdoors which poses an acute and long-term risk to their health...
January 19, 2024: Expert Review of Respiratory Medicine
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