journal
https://read.qxmd.com/read/38530362/staining-blindly-%C3%A2-an-update-on-coloring-techniques-for-fecal-smears-in-parasitology-a-scoping-review
#1
REVIEW
Saulo Hudson Nery Loiola, Vitória Castilho Stéfano, Stefany Laryssa Rosa, Letícia Rodrigues Proença, Bianca Martins Dos Santos, Felipe Augusto Soares, Katia Denise Saraiva Bresciani, Alexandre Xavier Falcão, Jancarlo Ferreira Gomes
Dye application for parasite highlighting in the Ova and Parasite exam is a common practice in parasitology diagnosis. Methods: A scoping review investigated how staining solutions interact with parasite structures. After screening 1334 papers, 35 met eligibility criteria. Results: Differentiating background from foreground in the fecal smear under light microscopy is the core of the research on this topic. Refractivity, unevenness of staining, size and temperature were explored to enhance staining protocols...
March 26, 2024: Future Microbiology
https://read.qxmd.com/read/38530361/plant-based-compositions-for-the-treatment-of-local-and-topical-bacterial-infections-a-patent-review
#2
REVIEW
Sergio Cantor-Vásquez, Camila da Silva Lima, Izabel Almeida Alves, Diana Marcela Aragón
Aim: To examine recent patents related to plants with antimicrobial effects. Methods: Our investigation was carried out using the Espacenet database, searching patents related to International Patent Classification (IPC) codes A61P31/04, and A61K36/00 between 2008 and 2023. Results: The study began with 360 patents, of which 15 were found to be duplicates; 144 were not related to the research topic and six were not available. Then, 48 patents were related to other administration routes...
March 26, 2024: Future Microbiology
https://read.qxmd.com/read/38512111/current-alternative-therapies-for-treating-drug-resistant-neisseria-gonorrhoeae-causing-ophthalmia-neonatorum
#3
REVIEW
Praveen Belagal
Ophthalmia neonatorum is a microbial contraction, damaging eyesight, occurring largely among neonates. Infants are particularly vulnerable to bacterial infections acquired during birth from infected mothers, especially from Neisseria gonorrhoeae and Chlamydia trachomatis . Over the decades, N. gonorrhoeae is alarmingly developing a resistance to most antibiotics currently prescribed. To counter this challenge, it is imperative to find potent and cost-effective therapeutic agents for prophylaxis and treatment, to which the N...
March 21, 2024: Future Microbiology
https://read.qxmd.com/read/38507297/prevalence-of-ocular-toxoplasmosis-among-people-living-with-hiv-a-systematic-review-and-meta-analysis
#4
REVIEW
Maria Kantzanou, Evangelos Kostares, Georgia Kostare, Fotini Boufidou, Antzela Tzanai, Michael Kostares, Athanasios Tsakris
Aim: To determine the prevalence of ocular toxoplasmosis among people living with HIV through a systematic review and meta-analysis. Materials & methods: A literature search was conducted, estimating pooled prevalence and performing quality assessment, outlier, influential and meta-regression analyses. Results: Twenty-nine studies were included in the analysis, revealing that the rate of ocular toxoplasmosis among people living with HIV was 0.37% (95% CI: 0.2-0.6). Substantial heterogeneity was observed among the studies...
March 20, 2024: Future Microbiology
https://read.qxmd.com/read/38497914/common-sense-why-bacterial-sensing-systems-are-an-important-target-for-new-antibiotics
#5
EDITORIAL
Pedro Fn Souza
No abstract text is available yet for this article.
March 18, 2024: Future Microbiology
https://read.qxmd.com/read/38497913/-trichosporon-spp-what-s-new
#6
EDITORIAL
Yasmim Passos Lima, Vanessa Cordeiro Dias
No abstract text is available yet for this article.
March 18, 2024: Future Microbiology
https://read.qxmd.com/read/38497912/prevalence-of-linezolid-resistance-in-streptococcus-pneumoniae-isolates-a-systematic-review-and-meta-analysis
#7
REVIEW
Mohsen Heidari, Shirin Dashtbin, Arezoo Asadi, Parisa Asadollahi, Ali Khatib, Mohammad Amin Ebrahimi, Zahra Ghanbari, Atieh Darbandi, Roya Ghanavati, Reza Pakzad
Aim: This study aimed to understand the current level of linezolid (LNZ) resistance in Streptococcus pneumoniae isolates reported over the past 10 years. Material & methods: An electronic search was conducted for the following keywords: (( Streptococcus pneumoniae [title/abstract]) OR ( Pneumococcus [title/abstract]) OR (Pneumococci [title/abstract]) AND (linezolid [title/abstract]) OR (Zyvox [title/abstract])) OR (Zyvoxid [title/abstract])). Result: Out of all the studies, 80 had a cross-sectional design, while 11 followed a cohort approach...
March 18, 2024: Future Microbiology
https://read.qxmd.com/read/38497911/rise-and-fall-of-caspofungin-the-current-status-of-caspofungin-as-a-treatment-for-cryptococcus-neoformans-infection
#8
REVIEW
Tawanny Kb Aguiar, Ana Cm Costa, Nilton As Neto, Daiane Ms Brito, Cleverson Dt Freitas, João Mm Neto, Felipe P Mesquita, Pedro Fn Souza
Antifungal infections are becoming a major concern to human health due to antimicrobial resistance. Echinocandins have been promising agents against resistant fungal infections, primarily caspofungin, which has a more effective mechanism of action than azoles and polyenes. However, fungi such as Cryptococcus neoformans appear to be inheritably resistant to these drugs, which is concerning due to the high clinical importance of C. neoformans . In this review, we review the history of C. neoformans and the treatments used to treat antifungals over the years, focusing on caspofungin, while highlighting the C...
March 18, 2024: Future Microbiology
https://read.qxmd.com/read/38470403/-in-vitro-mucin-degradation-and-paracellular-permeability-by-fecal-water-from-crohn-s-disease-patients
#9
JOURNAL ARTICLE
Heike Ef Becker, Nader Kameli, Alice Rustichelli, Britt Am Heijnens, Frank Rm Stassen, John Penders, Daisy Mae Jonkers
Aim: This study aimed to examine the impact of fecal water (FW) of active and remissive Crohn's disease (CD) patients on mucin degradation and epithelial barrier function. Methods: FW and bacterial membrane vesicles (MVs) were isolated from fresh fecal samples of six healthy controls (HCs) and 12 CD patients. Bacterial composition was determined by 16S rRNA gene amplicon sequencing. Results: In vitro FW-induced mucin degradation was higher in CD samples versus HC (p < 0.01), but not associated with specific bacterial genera...
March 12, 2024: Future Microbiology
https://read.qxmd.com/read/38440893/zein-nanoparticles-containing-ceftazidime-and-tobramycin-antibacterial-activity-against-gram-negative-bacteria
#10
JOURNAL ARTICLE
Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães
Aims: This work describes the encapsulation of ceftazidime and tobramycin in zein nanoparticles (ZNPs) and the characterization of their antibacterial and antibiofilm activities against Gram-negative bacteria. Materials & methods: ZNPs were synthesized by nanoprecipitation. Cytotoxicity was assessed by MTT assay and antibacterial and antibiofilm assays were performed by broth microdilution and violet crystal techniques. Results: ZNPs containing ceftazidime (CAZ-ZNPs) and tobramycin (TOB-ZNPs) showed drug encapsulation and thermal stability...
March 5, 2024: Future Microbiology
https://read.qxmd.com/read/38440873/anti-staphylococcus-aureus-effects-of-natural-antimicrobial-peptides-and-the-underlying-mechanisms
#11
REVIEW
Xueqi Chen, Jiuli Yang, Chang Qu, Qian Zhang, Shujuan Sun, Lihong Liu
Staphylococcus aureus can cause localized infections such as abscesses and pneumonia, as well as systemic infections such as bacteremia and sepsis. Especially, methicillin-resistant S. aureus often presents multidrug resistance, which becomes a major clinical challenge. One of the most common reasons for methicillin-resistant S. aureus antibiotic resistance is the presence of biofilms. Natural antimicrobial peptides derived from different species have shown effectiveness in combating S. aureus biofilms. In this review, we summarize the inhibitory activity of antimicrobial peptides against S...
March 5, 2024: Future Microbiology
https://read.qxmd.com/read/38426849/sulbactam-durlobactam-a-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combination-targeting-acinetobacter-baumannii
#12
REVIEW
Sarah M McLeod, John P O'Donnell, Navaneeth Narayanan, John P Mills, Keith S Kaye
Sulbactam-durlobactam is a pathogen-targeted β-lactam/β-lactamase inhibitor combination that has been approved by the US FDA for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex (ABC) in patients 18 years of age and older. Sulbactam is a penicillin derivative with antibacterial activity against Acinetobacter but is prone to hydrolysis by β-lactamases encoded by contemporary isolates...
March 1, 2024: Future Microbiology
https://read.qxmd.com/read/38411117/role-of-pd-1-and-immune-cells-in-hsv-infection-and-latency
#13
REVIEW
Liqiong Ding
A large proportion of the world's population is infected with HSV-1. Antiviral CD8+ T cells and CD8α+ dendritic cells are closely related to HSV-1 infection and latency. Latency-associated transcript of HSV-1 and PD-1 are involved in the regulation of latency and reactivation of HSV-1. Here, the role of latency-associated transcript, PD-1, CD8+ T cells and CD8α+ dendritic cells in HSV-1 infection, the interrelationships between them and how these interactions lead to latency are discussed, possibly providing new ideas for the treatment of HSV-1 infection...
February 27, 2024: Future Microbiology
https://read.qxmd.com/read/38411115/disinformation-and-trust-in-vaccines-in-the-era-of-artificial-intelligence-the-necessity-of-implementing-statistical-recommendations
#14
EDITORIAL
Michal Ordak
No abstract text is available yet for this article.
February 27, 2024: Future Microbiology
https://read.qxmd.com/read/38411103/ferroptosis-in-viral-infection-a-potential-therapeutic-target
#15
REVIEW
Liqiong Ding
Ferroptosis, known as a type of programmed cell death that is iron dependent, is characterized by intracellular iron accumulation, glutathione depletion, glutathione peroxidase inactivation and lipid peroxidation. More and more research in recent years has demonstrated the tight connection between viral infections and ferroptosis. This article reviews the potential role and mechanism of ferroptosis in viral infection, and these findings will help in the prevention and treatment of the virus.
February 27, 2024: Future Microbiology
https://read.qxmd.com/read/38381028/manganese-ii-copper-ii-and-silver-i-complexes-containing-1-10-phenanthroline-1-10-phenanthroline-5-6-dione-against-candida-species
#16
JOURNAL ARTICLE
Rafael M Gandra, Clarissa A Pacheco, Leandro S Sangenito, Lívia S Ramos, Lucieri Op Souza, Pauraic McCarron, Malachy McCann, Michael Devereux, Marta H Branquinha, André Ls Santos
Background: New chemotherapeutics are urgently required to treat Candida infections caused by drug-resistant strains. Methods: The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate complexed with Mn(II), Cu(II) and Ag(I) were evaluated against ten different Candida species. Results: Proliferation of Candida albicans , Candida dubliniensis , Candida famata , Candida glabrata , Candida guilliermondii , Candida kefyr , Candida krusei , Candida lusitaniae , Candida parapsilosis and Candida tropicalis was inhibited by three of six Cu(II) (MICs 1...
February 21, 2024: Future Microbiology
https://read.qxmd.com/read/38381027/nanomedicine-for-eradication-of-helicobacter-pylori-recent-advances-challenges-and-future-perspective
#17
REVIEW
Aakriti Garg, Sonali Karhana, Mohd A Khan
Helicobacter pylori infection is linked to gastritis, ulcers and gastric cancer. Nanomedicine offers a promising solution by utilizing nanoparticles for precise drug delivery, countering antibiotic resistance and delivery issues. Nanocarriers such as liposomes and nanoparticles enhance drug stability and circulation, targeting infection sites through gastric mucosa characteristics. Challenges include biocompatibility, stability, scalability and personalized therapies. Despite obstacles, nanomedicine's potential for reshaping H...
February 21, 2024: Future Microbiology
https://read.qxmd.com/read/38358357/proteomic-alterations-associated-with-the-formation-of-monocyte-extracellular-trap-induced-by-candida%C3%A2-albicans-hyphae
#18
JOURNAL ARTICLE
Xian Wu, Liying Sun, Lei Huang, Chenwei Huang, Kuixia Sun, Haixia Li
Background: The interaction between the host and Candida albicans is dynamic and intricate. We performed proteomic analysis to explore monocyte -C. albicans hyphae interaction. Materials & methods: Primary human monocytes were stimulated by heat-killed C. albicans hyphae and their proteins were profiled by tandem liquid chromatography with mass spectrometry (LC-MS/MS). Results: Based on the protein database of different species for analysis, we found that stimulation of monocytes by hyphae was accompanied by upregulation of histones and activation of extracellular traps (ETs) formation pathway...
February 15, 2024: Future Microbiology
https://read.qxmd.com/read/38329374/synergistic-interaction-of-polymyxin-b-with-carvacrol-antimicrobial-strategy-against-polymyxin-resistant-klebsiella-pneumoniae
#19
JOURNAL ARTICLE
Gleyce Ha de Souza, Marcia Sm Vaz, Joyce A Dos Santos Radai, Thiago L Fraga, Luana Rossato, Simone Simionatto
Objective: The antimicrobial activities of the synergistic combination of carvacrol and polymyxin B against polymyxin-resistant Klebsiella pneumoniae were evaluated. Methods: The methods employed checkerboard assays to investigate synergism, biofilm inhibition assessment and membrane integrity assay. In addition, the study included in vivo evaluation using a mouse infection model. Results: The checkerboard method evaluated 48 combinations, with 23 indicating synergistic action. Among these, carvacrol 10 mg/kg plus polymyxin B 2 mg/kg exhibited in vivo antimicrobial activity in a mouse model of infection, resulting in increased survival and a significant decrease in bacterial load in the blood...
February 8, 2024: Future Microbiology
https://read.qxmd.com/read/38305241/biosensors-for-the-detection-of-pathogenic-bacteria-current-status-and-future-perspectives
#20
REVIEW
Yalcin Dicle, Murat Karamese
Pathogenic microorganisms pose significant threats to human health, food safety and environmental integrity. Rapid and accurate detection of these pathogens is essential to mitigate their impact. Fast, sensitive detection methods such as biosensors also play a critical role in preventing outbreaks and controlling their spread. In recent years, biosensors have emerged as a revolutionary technology for pathogen detection. This review aims to present the current developments in biosensor technology, investigate the methods by which these developments are used in the detection of pathogenic bacteria and highlight future perspectives on the subject...
February 2, 2024: Future Microbiology
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