journal
https://read.qxmd.com/read/38411117/role-of-pd-1-and-immune-cells-in-hsv-infection-and-latency
#1
REVIEW
Liqiong Ding
A large proportion of the world's population is infected with HSV-1. Antiviral CD8+ T cells and CD8α+ dendritic cells are closely related to HSV-1 infection and latency. Latency-associated transcript of HSV-1 and PD-1 are involved in the regulation of latency and reactivation of HSV-1. Here, the role of latency-associated transcript, PD-1, CD8+ T cells and CD8α+ dendritic cells in HSV-1 infection, the interrelationships between them and how these interactions lead to latency are discussed, possibly providing new ideas for the treatment of HSV-1 infection...
February 27, 2024: Future Microbiology
https://read.qxmd.com/read/38411115/disinformation-and-trust-in-vaccines-in-the-era-of-artificial-intelligence-the-necessity-of-implementing-statistical-recommendations
#2
EDITORIAL
Michal Ordak
No abstract text is available yet for this article.
February 27, 2024: Future Microbiology
https://read.qxmd.com/read/38411103/ferroptosis-in-viral-infection-a-potential-therapeutic-target
#3
REVIEW
Liqiong Ding
Ferroptosis, known as a type of programmed cell death that is iron dependent, is characterized by intracellular iron accumulation, glutathione depletion, glutathione peroxidase inactivation and lipid peroxidation. More and more research in recent years has demonstrated the tight connection between viral infections and ferroptosis. This article reviews the potential role and mechanism of ferroptosis in viral infection, and these findings will help in the prevention and treatment of the virus.
February 27, 2024: Future Microbiology
https://read.qxmd.com/read/38381028/manganese-ii-copper-ii-and-silver-i-complexes-containing-1-10-phenanthroline-1-10-phenanthroline-5-6-dione-against-candida-species
#4
JOURNAL ARTICLE
Rafael M Gandra, Clarissa A Pacheco, Leandro S Sangenito, Lívia S Ramos, Lucieri Op Souza, Pauraic McCarron, Malachy McCann, Michael Devereux, Marta H Branquinha, André Ls Santos
Background: New chemotherapeutics are urgently required to treat Candida infections caused by drug-resistant strains. Methods: The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate complexed with Mn(II), Cu(II) and Ag(I) were evaluated against ten different Candida species. Results: Proliferation of Candida albicans , Candida dubliniensis , Candida famata , Candida glabrata , Candida guilliermondii , Candida kefyr , Candida krusei , Candida lusitaniae , Candida parapsilosis and Candida tropicalis was inhibited by three of six Cu(II) (MICs 1...
February 21, 2024: Future Microbiology
https://read.qxmd.com/read/38381027/nanomedicine-for-eradication-of-helicobacter-pylori-recent-advances-challenges-and-future-perspective
#5
REVIEW
Aakriti Garg, Sonali Karhana, Mohd A Khan
Helicobacter pylori infection is linked to gastritis, ulcers and gastric cancer. Nanomedicine offers a promising solution by utilizing nanoparticles for precise drug delivery, countering antibiotic resistance and delivery issues. Nanocarriers such as liposomes and nanoparticles enhance drug stability and circulation, targeting infection sites through gastric mucosa characteristics. Challenges include biocompatibility, stability, scalability and personalized therapies. Despite obstacles, nanomedicine's potential for reshaping H...
February 21, 2024: Future Microbiology
https://read.qxmd.com/read/38358357/proteomic-alterations-associated-with-the-formation-of-monocyte-extracellular-trap-induced-by-candida%C3%A2-albicans-hyphae
#6
JOURNAL ARTICLE
Xian Wu, Liying Sun, Lei Huang, Chenwei Huang, Kuixia Sun, Haixia Li
Background: The interaction between the host and Candida albicans is dynamic and intricate. We performed proteomic analysis to explore monocyte -C. albicans hyphae interaction. Materials & methods: Primary human monocytes were stimulated by heat-killed C. albicans hyphae and their proteins were profiled by tandem liquid chromatography with mass spectrometry (LC-MS/MS). Results: Based on the protein database of different species for analysis, we found that stimulation of monocytes by hyphae was accompanied by upregulation of histones and activation of extracellular traps (ETs) formation pathway...
February 15, 2024: Future Microbiology
https://read.qxmd.com/read/38329374/synergistic-interaction-of-polymyxin-b-with-carvacrol-antimicrobial-strategy-against-polymyxin-resistant-klebsiella-pneumoniae
#7
JOURNAL ARTICLE
Gleyce Ha de Souza, Marcia Sm Vaz, Joyce A Dos Santos Radai, Thiago L Fraga, Luana Rossato, Simone Simionatto
Objective: The antimicrobial activities of the synergistic combination of carvacrol and polymyxin B against polymyxin-resistant Klebsiella pneumoniae were evaluated. Methods: The methods employed checkerboard assays to investigate synergism, biofilm inhibition assessment and membrane integrity assay. In addition, the study included in vivo evaluation using a mouse infection model. Results: The checkerboard method evaluated 48 combinations, with 23 indicating synergistic action. Among these, carvacrol 10 mg/kg plus polymyxin B 2 mg/kg exhibited in vivo antimicrobial activity in a mouse model of infection, resulting in increased survival and a significant decrease in bacterial load in the blood...
February 8, 2024: Future Microbiology
https://read.qxmd.com/read/38305241/biosensors-for-the-detection-of-pathogenic-bacteria-current-status-and-future-perspectives
#8
REVIEW
Yalcin Dicle, Murat Karamese
Pathogenic microorganisms pose significant threats to human health, food safety and environmental integrity. Rapid and accurate detection of these pathogens is essential to mitigate their impact. Fast, sensitive detection methods such as biosensors also play a critical role in preventing outbreaks and controlling their spread. In recent years, biosensors have emerged as a revolutionary technology for pathogen detection. This review aims to present the current developments in biosensor technology, investigate the methods by which these developments are used in the detection of pathogenic bacteria and highlight future perspectives on the subject...
February 2, 2024: Future Microbiology
https://read.qxmd.com/read/38305237/detection-of-yersinia-enterocolitica-shigella-spp-and-salmonella-spp-in-rattus-norvegicus-captured-from-tehran-iran
#9
JOURNAL ARTICLE
Taher Azimi, Sina Nasrollahian, Sahar Sabour, Nahal Hadi, Leila Azimi, Fatemeh Fallah, Mohammed Reza Pourmand
Background: The present study aims to determine the presence of Yersinia spp., Yersinia pestis , Yersinia enterocolitica pathogen, Listeria monocytogenes , Salmonella spp., Shigella spp., Francisella tularensis and Borrelia spp. in brown rats of Tehran, Iran. Methods: PCR was used to detect various bacteria in 100 brown rats, Also, ELISA was used to detect antibodies against the F. tularensis and Borrelia spp. Results: A total of 16% and 13% of fecal samples were positive for Yersinia spp. and Y. enterocolitica pathogen...
February 2, 2024: Future Microbiology
https://read.qxmd.com/read/38305226/transposon-library-screening-to-identify-genes-with-a-potential-role-in-streptococcus-suis-biofilm-formation
#10
JOURNAL ARTICLE
Haikun Wang, Qingying Fan, Shuji Gao, Li Yi, Yuxin Wang, Yang Wang
Background: Biofilm formation is considered to be one of reasons for difficulty in the prevention and control of Streptococcus suis . Aims: To explore the potential genes involved in the biofilm formation of S. suis . Methods: Transposon mutagenesis technology was used to screen biofilm-defective strains of S. suis , and the potential genes related to biofilm were identified. Results: A total of 19 genes were identified that were involved in bacterial metabolism, peptidoglycan-binding protein, cell wall synthesis, ABC transporters, and so on...
February 2, 2024: Future Microbiology
https://read.qxmd.com/read/38305223/polyphenols-and-their-nanoformulations-as-potential-antibiofilm-agents-against-multidrug-resistant-pathogens
#11
REVIEW
Modawy Em Elkhalifa, Muhammad Ashraf, Alshebli Ahmed, Assad Usman, Alashary Ae Hamdoon, Mohammed A Elawad, Meshari G Almalki, Osama F Mosa, Laziz N Niyazov, Muhammad Ayaz
The emergence of multidrug-resistant (MDR) pathogens is a major problem in the therapeutic management of infectious diseases. Among the bacterial resistance mechanisms is the development of an enveloped protein and polysaccharide-hydrated matrix called a biofilm. Polyphenolics have demonstrated beneficial antibacterial effects. Phenolic compounds mediate their antibiofilm effects via disruption of the bacterial membrane, deprivation of substrate, protein binding, binding to adhesion complex, viral fusion blockage and interactions with eukaryotic DNA...
February 2, 2024: Future Microbiology
https://read.qxmd.com/read/38305222/ferrostatin-1-improves-prognosis-and-regulates-gut-microbiota-of-steatotic-liver-transplantation-recipients-in-rats
#12
JOURNAL ARTICLE
Mengshu Yuan, Yuxin Wang, Xiaorong Tian, Weiping Zheng, Huaiwen Zuo, Xinru Zhang, Hongli Song
Aims: To investigate the effects of Ferrostatin-1 (Fer-1) on improving the prognosis of liver transplant recipients with steatotic liver grafts and regulating gut microbiota in rats. Methods: We obtained steatotic liver grafts and established a liver transplantation model. Recipients were divided into sham, liver transplantation and Fer-1 treatment groups, which were assessed 1 and 7 days after surgery (n = 6). Results & conclusion: Fer-1 promotes recovery of the histological structure and function of steatotic liver grafts and the intestinal tract, and improves inflammatory responses of recipients following liver transplantation...
February 2, 2024: Future Microbiology
https://read.qxmd.com/read/38294306/development-of-a-machine-learning-model-to-predict-risk-of-development-of-covid-19-associated-mucormycosis
#13
JOURNAL ARTICLE
Rajashri Patil, Sahjid Mukhida, Jyoti Ajagunde, Uzair Khan, Sameena Khan, Nageswari Gandham, Chanda Vyawhare, Nikunja K Das, Shahzad Mirza
Aim: The study aimed to identify quantitative parameters that increase the risk of rhino-orbito-cerebral mucormycosis, and subsequently developed a machine learning model that can anticipate susceptibility to developing this condition. Methods: Clinicopathological data from 124 patients were used to quantify their association with COVID-19-associated mucormycosis (CAM) and subsequently develop a machine learning model to predict its likelihood. Results: Diabetes mellitus, noninvasive ventilation and hypertension were found to have statistically significant associations with radiologically confirmed CAM cases...
January 31, 2024: Future Microbiology
https://read.qxmd.com/read/38294294/gnat-toxin-may-have-a-potential-role-in-pseudomonas-aeruginosa-persistence-an-in-vitro-and-in-silico-study
#14
JOURNAL ARTICLE
Anahita Etemad, Behrooz Sadeghi Kalani, Sobhan Ghafourian, Niloofar Khodaei, Maryam Davari, Nourkhoda Sadeghifard
Aims: Persistent cells are primarily responsible for developing antibiotic resistance and the recurrence of Pseudomonas aeruginosa . This study investigated the possible role of GNAT toxin in persistence. Materials & methods: P. aeruginosa was exposed to five MIC concentrations of ciprofloxacin. The expression levels of target genes were assessed. The GNAT/HTH system was bioinformatically studied, and an inhibitory peptide was designed to disrupt this system. Results: Ciprofloxacin can induce bacterial persistence...
January 31, 2024: Future Microbiology
https://read.qxmd.com/read/38294293/antimicrobial-activity-of-hydralazine-against-methicillin-resistant-and-methicillin-susceptible-staphylococcus-aureus
#15
JOURNAL ARTICLE
Francisca B Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, João B de Andrade Neto, Lisandra Juvêncio da Silva, Daniel Sampaio Rodrigues, Vitória P de Farias Cabral, Amanda Dias Barbosa, Lara E Almeida Moreira, Camille R Braga Vasconcelos, Bruno Coêlho Cavalcanti, Maria E França Rios, Jacilene Silva, Emmanuel Silva Marinho, Helcio Silva Dos Santos, Jacó Rl de Mesquita, Marina Duarte Pinto Lobo, Manoel Odorico de Moraes, Hélio V Nobre Júnior, Cecília Rocha da Silva
Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. Materials & methods: The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms. With regard to action mechanisms, the authors evaluated cell viability, DNA damage and molecular docking. Results: MIC and minimum bactericidal concentration values ranged from 128 to 2048 μg/ml. There was synergism with oxacillin (50%) and vancomycin (25%)...
January 31, 2024: Future Microbiology
https://read.qxmd.com/read/38294280/antimicrobial-therapy-using-vis-plus-water-filtered-infrared-a-as-an-alternative-method-to-treat-oral-diseases
#16
REVIEW
Sara Bernardi, Davide Gerardi, Sibylle Bartsch, Guido Macchiarelli, Elmar Hellwig, Ali Al-Ahmad
Oral biofilm is the main cause of pathologies affecting the hard and soft oral tissues around teeth. Its main components are the periodontal pathogens and other bacteria of the supragingival and subgingival biofilm. Different alternative strategies that could be adjuvants to the usual periodontal treatments used to eliminate biofilms are available. One of these methods is antimicrobial photodynamic therapy using VIS and water-filtered infrared-A combined with a photosensitizer. In this review, different recent studies were collected to evaluate the antimicrobial effects of antimicrobial photodynamic therapy and the effectiveness of different types of photosensitizers...
January 31, 2024: Future Microbiology
https://read.qxmd.com/read/38294272/triple-in-silico-targeting-of-impdh-enzyme-and-rna-dependent-rna-polymerase-of-both-sars-cov-2-and-rhizopus-oryzae
#17
JOURNAL ARTICLE
Abdel-Moniem S Hassan, Abdo A Elfiky, Alaa M Elgohary
Aim: Mucormycosis has been associated with SARS-CoV-2 infections during the last year. The aim of this study was to triple-hit viral and fungal RNA-dependent RNA polymerases (RdRps) and human inosine monophosphate dehydrogenase (IMPDH). Materials & methods: Molecular docking and molecular dynamics simulation were used to test nucleotide inhibitors (NIs) against the RdRps of SARS-CoV-2 and Rhizopus oryzae RdRp. These same inhibitors targeted IMPDH. Results: Four NIs revealed a comparable binding affinity to the two drugs, remdesivir and sofosbuvir...
January 31, 2024: Future Microbiology
https://read.qxmd.com/read/38270125/extracellular-vesicles-from-lacticaseibacillus-paracasei-pc-h1-inhibit-hif-1%C3%AE-mediated-glycolysis-of-colon-cancer
#18
JOURNAL ARTICLE
Yangqian Shi, Chunliang Zhang, Wanyu Cao, Luyi Li, Kaili Liu, Hanyue Zhu, Fikadu Balcha, Yong Fang
Aims: Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 have antiproliferative activity of colon cells, but the effect on glycolytic metabolism of cancer cell remains enigmatic. The authors investigated how Lacticaseibacillus paracasei extracellular vesicles (LpEVs) inhibit the growth of colon cancer cells by affecting tumor metabolism. Materials & methods: HCT116 cells were treated with LpEVs and then differentially expressed genes were analyzed by transcriptome sequencing, the sequencing results were confirmed in vivo and in vitro ...
January 25, 2024: Future Microbiology
https://read.qxmd.com/read/38252038/perspectives-on-the-use-of-ceftolozane-tazobactam-a-review-of-clinical-trial-data-and-real-world-evidence
#19
REVIEW
Ignacio Martin-Loeches, Christopher J Bruno, C Andrew DeRyke
Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) are common healthcare-associated infections linked to high morbidity and mortality. Gram-negative pathogens, such as Pseudomonas aeruginosa , exhibit multidrug resistance and are recognized as major public health concerns, particularly among critically ill patients with HABP/VABP. Ceftolozane/tazobactam is a novel combination antibacterial agent comprising ceftolozane (a potent antipseudomonal cephalosporin) and tazobactam (a β-lactamase inhibitor)...
January 22, 2024: Future Microbiology
https://read.qxmd.com/read/38180334/molecular-antimicrobial-susceptibility-testing-in-sepsis
#20
REVIEW
Ignacio Martin-Loeches, João Gonçalves Pereira, Tee Keat Teoh, Gavin Barlow, Laurent Dortet, Enitan D Carrol, Ulrike Olgemöller, Sara E Boyd, Julien Textoris
Rapidly detecting and identifying pathogens is crucial for appropriate antimicrobial therapy in patients with sepsis. Conventional diagnostic methods have been a great asset to medicine, though they are time consuming and labor intensive. This work will enable healthcare professionals to understand the bacterial community better and enhance their diagnostic capacity by using novel molecular methods that make obtaining quicker, more precise results possible. The authors discuss and critically assess the merits and drawbacks of molecular testing and the added value of these tests, including the shift turnaround time, the implication for clinicians' decisions, gaps in knowledge, future research directions and novel insights or innovations...
January 5, 2024: Future Microbiology
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