Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Roberta Galdiero, Nicola Maggialetti, Renato Patrone, Alessandro Ottaiano, Guglielmo Nasti, Lucrezia Silvestro, Antonio Cassata, Francesca Grassi, Antonio Avallone, Francesco Izzo, Antonella Petrillo
In this narrative review, we reported un up-to-date on the role of radiomics to assess prognostic features, which can impact on the liver metastases patient treatment choice. In the liver metastases patients, the possibility to assess mutational status (RAS or MSI), the tumor growth pattern and the histological subtype (NOS or mucinous) allows a better treatment selection to avoid unnecessary therapies. However, today, the detection of these features require an invasive approach. Recently, radiomics analysis application has improved rapidly, with a consequent growing interest in the oncological field...
March 16, 2023: Infectious Agents and Cancer
Sara Dadipoor, Azin Alavi, Zeinab Kader, Hadi Eshaghi Sani Kakhaki, Shokrollah Mohseni, Nahid Shahabi
BACKGROUND: Considering the high incidence rate of cervical cancer (CC) in Iran, screening is an effective way of reducing the impact of the disease due to early detection. Thus, the recognition of the factors affecting the use of cervical cancer screening (CCS) services is essential.The present study aimed to determine the associated factors of CCS in women living in the suburbs of Bandar Abbas in the south of Iran. METHODS: The present case-control study was conducted between January and March 2022 in the suburban areas of Bandar abbas...
March 11, 2023: Infectious Agents and Cancer
Pamela Moussavou-Boundzanga, Ismaël Hervé Koumakpayi, Corinne Engohan Aloghe, Junie K Chansi, Rose Revignet, Eric M Leroy, Nicolas Berthet
BACKGROUND: Cervical cancer is the third most common cancer among women worldwide, but particularly affects women living in sub-Saharan Africa. Screening and vaccination programs are two prevention approaches that can reduce cervical cancer incidence. However, effective vaccination campaigns require better knowledge of the prevalence of the main human papillomavirus (HPV) genotypes reported in high-grade neoplastic lesions and invasive carcinomas in women. METHODS: All samples collected in this study were processed using standard histopathological methods with haematoxylin and eosin staining of the sections...
March 8, 2023: Infectious Agents and Cancer
Zhenchao Zhang, Dongxian Li, Yuhua Li, Rui Zhang, Xianghuan Xie, Yi Yao, Linfei Zhao, Xiaowei Tian, Zhenke Yang, Shuai Wang, Xuejing Yue, Xuefang Mei
BACKGROUND: Trichomonas vaginalis (T. vaginalis) is a microaerophilic protozoan parasite which is responsible for trichomoniasis, the most common non-viral sexually transmitted infection in the world. The infection greatly damages the reproductive system. However, whether T. vaginalis infection can cause reproductive system cancer remains controversial. METHODS: This study systematically searched PubMed, EMBASE, Ovid and Google scholar, and 144 relevant articles were retrieved and classified into three categories: epidemiological investigations (68), reviews (30) and research articles (46)...
March 2, 2023: Infectious Agents and Cancer
Nazila Bostanshirin, Bahareh Hajikhani, Amir Abbas Vaezi, Fatemeh Kermanian, Fatemeh Sameni, Somayeh Yaslianifard, Mehdi Goudarzi, Masoud Dadashi
BACKGROUND: Colorectal cancer (CRC) is considered the second-deadliest and third-most common malignancy worldwide. Studying the carcinogenic mechanism of bacteria or their role in aggravating cancer can be precious. Fusobacterium nucleatum (F. nucleatum) is one of the important bacteria in the occurrence and spread of CRC. In this study, we investigated the expression levels of miR-21, miR-17-5P, miR-155, and the relative frequency of F. nucleatum in biopsy samples from patients with CRC...
March 1, 2023: Infectious Agents and Cancer
Vahideh Hamidi Sofiani, Parsa Veisi, Mohammad Rezaei Zadeh Rukerd, Reza Ghazi, Mohsen Nakhaie
Among human tumorigenic viruses, the role of Human papillomavirus (HPV) has been proven as one of the most important oncoviruses that are associated with a large number of cancers. Most cancers of the genital area such cervical and anal cancer as are caused by HPV, and in many other cancers, such as colorectal, gastric, liver, esophageal, urinary bladder, and head and neck cancers, it is considered as one of the important risk factors. Our search was conducted for published researches between 2000 and 2022 by using several international databases including Scopus, PubMed, and Web of Science as well as Google scholar...
February 26, 2023: Infectious Agents and Cancer
Ali Shayeghpour, Mohammad-Moien Forghani-Ramandi, Setayesh Solouki, Amin Hosseini, Parastoo Hosseini, Sara Khodayar, Mahsa Hasani, Sepehr Aghajanian, Zeinab Siami, Mohadeseh Zarei Ghobadi, Sayed-Hamidreza Mozhgani
BACKGROUND: Adult T-cell Lymphoma/Leukemia (ATLL) is characterized by the malignant proliferation of T-cells in Human T-Lymphotropic Virus Type 1 and a high mortality rate. Considering the emerging roles of microRNAs (miRNAs) in various malignancies, the analysis of high-throughput miRNA data employing computational algorithms helps to identify potential biomarkers. METHODS: Weighted gene co-expression network analysis was utilized to analyze miRNA microarray data from ATLL and healthy uninfected samples...
February 25, 2023: Infectious Agents and Cancer
Guanghua Li, Zhihao Zhou, Zhixiong Wang, Zhao Wang
BACKGROUND: Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) was a unique molecular subtype of gastric cancer (GC). However, the clinicopathological characteristics and prognostic role of EBV infection remains unclear. We aimed to evaluate the clinicopathological features of EBVaGC and its role on prognosis. METHODS: EBV-encoded RNA (EBER) in situ hybridization method was used to evaluate the EBV status in GC. The serum tumor markers AFP, CEA, CA19-9 and CA125 of patients were detected before treatment...
February 19, 2023: Infectious Agents and Cancer
Coletha Yohana, Jared S Bakuza, Safari M Kinung'hi, Bruno A Nyundo, Peter F Rambau
INTRODUCTION: Bladder cancer is a possible outcome of chronic urinary schistosomiasis in many endemic countries. In Tanzania, the Lake Victoria area is one of the areas with the highest prevalence of urinary schistosomiasis and higher incidences of squamous cell carcinoma (SCC) of the urinary bladder. A previous study in the area over one decade (2001-2010) showed SCC to be common in patients aged below 50 years. With various prevention and intervention programs there are likely to be notable changes in schistosomiasis-related urinary bladder cancer, which is currently unknown...
February 19, 2023: Infectious Agents and Cancer
Maximilian J Mair, Agnieszka Maj-Hes, Alina Nussbaumer-Pröll, Rainer Puhr, Agnieszka Christenheit, Marlene Troch, Hannah C Puhr, Angelika M Starzer, Ariane Steindl, Sabine Eberl, Helmuth Haslacher, Thomas Perkmann, Christoph Minichsdorfer, Gerald W Prager, Wolfgang W Lamm, Anna S Berghoff, Barbara Kiesewetter, Markus Zeitlinger, Matthias Preusser, Markus Raderer
BACKGROUND: Patients with cancer are at high risk for severe courses of COVID-19. Based on (pre-)clinical data suggesting a potential protective effect due to the immunomodulating properties of azithromycin, we have initiated a prospective randomized trial. METHODS: This randomized, single-center, single-blinded, placebo-controlled phase 2 trial included adult patients with cancer undergoing systemic treatment. Patients were 1:1 randomized to oral azithromycin (1500 mg once weekly for 8 weeks) or placebo...
February 12, 2023: Infectious Agents and Cancer
Mayo Hirabayashi, Alexandra Traverse-Glehen, Jean-Damien Combes, Gary M Clifford, Catherine de Martel
The stomach is a common site for extranodal non-Hodgkin's lymphoma. While Helicobacter pylori (H. pylori) is the main established risk factor for primary gastric lymphoma, a fraction could be aetiologically associated with Epstein-Barr virus (EBV), a known haematolymphoid carcinogen. We systematically searched five databases from 1 January 1990 until 31 May 2022 for studies reporting EBV prevalence in gastric lymphoma tumour tissue by in-situ hybridisation (ISH) for EBV-encoded small RNA (PROSPERO CRD42020164473)...
February 10, 2023: Infectious Agents and Cancer
Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox, Avik Roy
Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze human civilization's economy and social growth, leaving an enduring damage that will take an exceptionally long time to repair. While a majority of infected patients survive after mild to moderate reactions after two to six weeks, a growing population of patients suffers for months with severe and prolonged symptoms of fatigue, depression, and anxiety...
February 7, 2023: Infectious Agents and Cancer
Saba Jalalifar, Hassan Morovati Khamsi, Seyed Reza Hosseini-Fard, Sajad Karampoor, Bahar Bajelan, Gholamreza Irajian, Rasoul Mirzaei
No abstract text is available yet for this article.
February 2, 2023: Infectious Agents and Cancer
B Wan, L J Wei, T M Tan, L Qin, H Wang
OBJECTIVE: To study the potential mechanism of Lactobacillus crispatus inhibiting cervical squamous intraepithelial lesion (SIL) and screen the early warning factors of SIL. METHODS: The effects of Lactobacillus crispatus on the proliferation, apoptosis, cross pore migration and invasion and cytokines of cervical precancerous cells Ect1/E6E7 were detected respectively. The effect of Lactobacillus crispatus on the expression of differential proteins screened in Ect1/E6E7 cells were detected by Western blot...
February 1, 2023: Infectious Agents and Cancer
Awoke Derbie, Melanie Maier, Bereket Amare, Eyaya Misgan, Endalkachew Nibret, Uwe G Liebert, Yimtubezinash Woldeamanuel, Tamrat Abebe
BACKGROUND: Human papillomavirus (HPV) genotypes differ by geographic location. With the advent of HPV vaccination and HPV-based cervical screening tests in Ethiopia, a nationwide dataset on the genotype distribution of HPV among women has paramount importance in the fight against cervical cancer. However, there is limited data in this regard in the northwest part of the country. Therefore, this study aimed to identify the genotype distribution of high-risk HPVs among women presenting with cervical abnormalities...
January 27, 2023: Infectious Agents and Cancer
Saba Jalalifar, Hassan Morovati Khamsi, Seyed Reza Hosseini-Fard, Sajad Karampoor, Bahar Bajelan, Gholamreza Irajian, Rasoul Mirzaei
The role of gut microbiota and its products in human health and disease is profoundly investigated. The communication between gut microbiota and the host involves a complicated network of signaling pathways via biologically active molecules generated by intestinal microbiota. Some of these molecules could be assembled within nanoparticles known as outer membrane vesicles (OMVs). Recent studies propose that OMVs play a critical role in shaping immune responses, including homeostasis and acute inflammatory responses...
January 19, 2023: Infectious Agents and Cancer
Jianming Yang, Yewu Chen, Haobin Sun, Xijian Zhang, Jianfeng Wang, Zhixing Liang, Binsheng Fu, Tong Zhang, Shuhong Yi, Yinan Deng, Yang Yang
BACKGROUND: Recent studies have proved that tenofovir disoproxil fumarate (TDF) is associated with a lower risk of hepatocellular carcinoma (HCC) occurrence in chronic hepatitis B (CHB) patients and HCC recurrence in patients who underwent hepatectomy when compared to ETV. However, it is unclear whether TDF and ETV treatment, which are both recommended as first-line antiviral agents to prevent the hepatitis B (HBV) recurrence after liver transplantation (LT), are associated with equivalent prognosis...
January 17, 2023: Infectious Agents and Cancer
Zinaye Tekeste, Nega Berhe, Mahlet Arage, Abraham Degarege, Yohanns Melaku, Amy Reynolds
BACKGROUND: There is a paucity of data on public awareness of cancer in Ethiopia. This study assessed cancer signs, symptoms, and risk factors awareness among individuals aged 18 and older in Addis Ababa, Ethiopia. METHOD: A population-based face-to-face interview was conducted applying a validated cancer awareness measure (CAM) tool. A total of 600 adults (315 males and 285 females) were recruited using a multistage sampling technique...
January 4, 2023: Infectious Agents and Cancer
Huili Wu, Fang Xiong, Xuli Bao, Jun Lu
OBJECTIVES: To investigate the incidence and influencing factors of thyroid dysfunction (TD) in patients with primary liver cancer (PLC) induced by PD-1 monoclonal antibodies. METHODS: Clinical data were collected from 195 PLC patients treated with PD-1. They were divided into TD group and normal thyroid function (NTF) group, and further divided into TD subgroups, the differences between groups and subgroups were analyzed. RESULTS: A total of 113 of 195 (57...
December 29, 2022: Infectious Agents and Cancer
Francesca Pagliuca, Andrea Ronchi, Annamaria Auricchio, Eva Lieto, Renato Franco
Inflammatory pseudotumour-like follicular/fibroblastic dendritic cell sarcoma (IPT-like FDCS) is a rare EBV-associated variant of follicular dendritic cell sarcoma, usually arising in the liver or spleen and characterized by a favourable prognosis. The neoplastic cells show variable follicular dendritic cell or fibroblastic reticular cell differentiation and their immunoprofile is still poorly characterized. We describe a case of splenic IPT-like FDCS with unexpected CD31 expression and provide a concise review of English literature on the topic...
December 24, 2022: Infectious Agents and Cancer
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