journal
https://read.qxmd.com/read/38096771/a-new-tidal-breathing-measurement-device-detects-bronchial-obstruction-during-methacholine-challenge-test
#21
JOURNAL ARTICLE
Andreas Zachariades, Nadav Bachar, Noy Danino, Inbal Shafran, Ronit Shtrichman, Gregory Shuster, Wieland Voigt
PURPOSE: Bronchial hyperresponsiveness (BHR), a hallmark of bronchial asthma, is typically diagnosed through a methacholine inhalation test followed by spirometry, known as the methacholine challenge test (MCT). While spirometry relies on proper patients' cooperation and precise execution of forced breathing maneuvers, we conducted a comparative analysis with the portable nanomaterial-based sensing device, SenseGuard™, to non-intrusively assess tidal breathing parameters. MATERIALS AND METHODS: In this prospective study, 37 adult participants with suspected asthma underwent sequential spirometry and SenseGuard™ measurements after inhaling increasing methacholine doses...
December 13, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37945441/may-noninvasive-mechanical-ventilation-and-or-continuous-positive-airway-pressure-increase-the-bronchoalveolar-lavage-salvage-in-patients-with-pulmonary-diseases-randomized-clinical-trial-study-protocol
#22
JOURNAL ARTICLE
Anna Danel, Ewelina Tobiczyk, Adam Warcholiński, Marzena Trzaska-Sobczak, Andrzej Swinarew, Grzegorz Brożek, Ewa Trejnowska, Halina Batura-Gabryel, Antonina Jedynak, Raffaele Scala, Adam Barczyk, Szczepan Cofta, Szymon Skoczyński
PURPOSE: Bronchoalveolar lavage (BAL) procedure is a useful tool in the diagnosis of patients with interstitial lung disease (ILD) and is helpful in clinical research of chronic obstructive pulmonary disease (COPD) patients. Still little is known about predictors of poor BAL salvage. The trial aims to find the most efficient way to improve BAL recovery. MATERIAL AND METHODS: Our study is a prospective, multicenter, international, two-arm randomized controlled trial...
November 7, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37945440/the-use-of-non-invasive-respiratory-assistance-to-facilitate-bronchofiberoscopy-performance-in-patients-with-hypoxemic-type-one-respiratory-failure-study-protocol
#23
JOURNAL ARTICLE
Aleksandra Oraczewska, Szczepan Cofta, Adam Warcholiński, Ewa Trejnowska, Grzegorz Brożek, Andrzej Swinarew, Daiana Stolz, Raffaele Scala, Adam Barczyk, Szymon Skoczyński
PURPOSE: Bronchofiberoscopy (FOB) is a procedure routinely performed for: lung cancer, obstruction, interstitial diseases, foreign bodies' removal, airway clearance, and hemoptysis. It causes acute airway narrowing leading to respiratory and cardiovascular stress. Due to increasing number of ill patients with respiratory failure (RF), conventional oxygen therapy (COT) is frequently insufficient to assure accurate oxygenation and prevent RF in patients requiring FOB. In this clinical scenario, patients may be intubated and supported with invasive mechanical ventilation (IMV) with the specific aim of allowing a safe FOB...
November 7, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37945439/coding-rna-expression-profile-and-transcription-factor-analysis-of-h-pylori-associated-chronic-atrophic-gastritis
#24
JOURNAL ARTICLE
Xinguo Wang, Juan Dong, Hao Sheng, Xingting Ma, Lazati Baheti, Jie Xu
PURPOSE: Atrophic gastritis, one of the processes leading to gastric cancer (GC), is closely related to Helicobacter pylori (HP) infection. This study aimed to understand how HP causes chronic inflammation that leads to ulcers and stomach problems. METHODS: Twenty-eight CAG patients were included in the study (9 HP-infected and 19 HP-uninfected). Endoscopy, histopathology, and high-throughput mRNA sequencing were performed. Differentially expressed genes (DEGs) were validated via qRT-PCR...
November 7, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37926002/heat-shock-proteins-in-cancer-known-but-always-being-rediscovered-their-perspectives-in-cancer-immunotherapy
#25
REVIEW
Alena Mazurakova, Zuzana Solarova, Lenka Koklesova, Martin Caprnda, Robert Prosecky, Artur Khakymov, Denis Baranenko, Peter Kubatka, Ladislav Mirossay, Peter Kruzliak, Peter Solar
Heat shock proteins (HSPs) represent cellular chaperones that are classified into several families, including HSP27, HSP40, HSP60, HSP70, and HSP90. The role of HSPs in the cell includes the facilitation of protein folding and maintaining protein structure. Both processes play crucial roles during stress conditions in the cell such as heat shock, degradation, and hypoxia. Moreover, HSPs are important modulators of cellular proliferation and differentiation, and are strongly associated with the molecular orchestration of carcinogenesis...
November 3, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37926001/a-comprehensive-review-of-ace2-ace1-tmprss2-and-ifitm3-gene-polymorphisms-and-their-effect-on-the-severity-of-covid-19
#26
REVIEW
Parisa Sahranavard-Pirbazari, Azin Khoshghiafeh, Mohammad Javad Kamali, Hanieh Esfandiar, Marzieh Bakhtiari, Mohamadreza Ahmadifard
Recent events have raised concerns about the outbreak of a pandemic by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An infection caused by a virus can provoke an inflammatory reaction, which can result in severe lung damage, failure of several organs, and death. The unique genetic makeup of each individual may be a component in the development of each of these responses. In this context, genetic variants of the genes linked to the invasion of the virus into the host's body can be analyzed...
November 3, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37924749/combination-therapy-along-with-mesenchymal-stem-cells-in-wound-healing-the-state-of-the-art
#27
REVIEW
Hossein Daneste, Linda Mohammadzadeh Boukani, Narges Ramezani, Fatemeh Asadi, Haider Kamil Zaidan, Azita Sadeghzade, Maedeh Ehsannia, Ali Azarashk, Nasim Gholizadeh
Mesenchymal stem cells (MSCs) are being increasingly used in various therapeutic applications including skin tissue repair and wound healing. The positive effects of the MSCs therapy are largely elicited by immunomodulation, increasing angiogenesis, supporting extracellular matrix (ECM) and thus favoring skin structure. However, the therapeutic competences of MSC-based therapies are somewhat hindered by their apparent modest clinical merits, conferring the need for methods that would rise the efficacy of such therapies...
November 2, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37913738/investigation-of-the-effects-of-urotensin-ii-receptors-in-lps-induced-inflammatory-response-in-huvec-cell-line-through-calcineurin-nfatc-il-2-pathway
#28
JOURNAL ARTICLE
Zekai Halici, Vedat Bulut, Elif Cadirci, Muhammed Yayla
PURPOSE: The effect of urotensin II (U-II), a powerful endogenous vasoconstrictor substance, on the immune system and its mediators is very important. It was herein aimed to demonstrate the possible relationship between the calcineurin/nuclear factor of activated T-cells cytoplasmic 1/interleukin-2 (CaN/NFATc/IL-2) pathway and urotensin receptors (UTRs) in inflammatory response due to lipopolysaccharide (LPS). METHODS: An LPS-induced inflammation model was used on the human umbilical vein endothelial cells (HUVEC) cell line and drugs were applied accordingly, forming the following groups: Control Group, LPS Group, Agonist Group (10-8  ​M U-II), Antagonist Group (10-6  ​M palosuran), Tacrolimus (TAC) Group (10 ​ng/mL FK-506), Agonist ​+ ​TAC Group, and Antagonist ​+ ​TAC Group...
October 30, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37866205/extracellular-vesicle-derived-circhipk3-novel-diagnostic-biomarker-for-lung-cancer
#29
JOURNAL ARTICLE
Yingying Zhu, Li Shen, Qiuyan Xia, Heyun Tao, Zhanguo Liu, Mengdie Wang, Xiaomin Zhang, Jun Zhang, Jian Lv
PURPOSE: Lung cancer (LC) is a common malignancy worldwide. A great number of circular RNAs (circRNAs) have been identified that serve crucial roles in cancer development. Extracellular vesicles (EVs) and their contents have been shown to be biomarkers for the diagnosis and prognosis of LC. Thus, we intended to clarify the functional role of EVs-derived circRNA homology domain interacting protein kinase 3 (EVs-circHIPK3) and its underlying mechanism of action. MATERIAL AND METHODS: Bioinformatics analysis was performed to validate the potential of partially circulating HIPK3 in LC diagnosis...
October 20, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37837800/crispr-cas9-mediated-high-mobility-group-a2-knockout-inhibits-cell-proliferation-and-invasion-in-papillary-thyroid-carcinoma-cells
#30
JOURNAL ARTICLE
Shan Jin, Hong Yong, Yousheng Liu, Wuyuntu Bao
PURPOSE: Metastasis and recurrence are the prognostic risk factor in patients with thyroid carcinoma. High-mobility group A2 (HMGA2) protein plays a crucial role in papillary thyroid carcinoma (PTC) metastasis. The aim of this study was to investigate the mechanisms underlying the HMGA2 effect on PTC cell proliferation and invasion. MATERIALS AND METHODS: We used the CRISPR/Cas9 system to perform knockout of the HMGA2 gene in the human PTC cell line TPC-1. The knockout monoclonal cells were screened and verified by PCR analysis and genomic sequencing...
October 12, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37837798/monocyte-to-lymphocyte-ratio-correlates-with-parathyroid-hormone-concentration-in-patients-with-severe-symptomatic-aortic-stenosis
#31
JOURNAL ARTICLE
Anna Olasińska-Wiśniewska, Tomasz Urbanowicz, Kajetan Grodecki, Piotr Kübler, Bartłomiej Perek, Marek Grygier, Marcin Misterski, Maciej Walczak, Mateusz Szot, Marek Jemielity
PURPOSE: The normal healthy valve is devoid of inflammatory cells, however background of aortic stenosis (AS) may include inflammatory processes. Moreover, the link between hyperparathyroidism and heart failure is postulated. Simple whole blood analysis with indices is a beneficial tool in cardiovascular diseases' assessment. The purpose of the study was to evaluate correlation between parathyroid hormone (PTH) and simple blood parameters in severe AS. MATERIAL AND METHODS: The study included 62 patients with severe AS...
October 12, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37813048/biological-genetic-and-epigenetic-markers-in-ulcerative-colitis
#32
REVIEW
Gemma Caliendo, Giovanna D'Elia, Jasmine Makker, Luana Passariello, Luisa Albanese, Anna Maria Molinari, Maria Teresa Vietri
In this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic methods in UC, including several laboratory markers which are employed in diagnosis and disease assessment; however, colonoscopy remains the most widely used method...
October 7, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37806183/the-tgfbi-gene-and-protein-expression-in-topotecan-resistant-ovarian-cancer-cell-lines
#33
JOURNAL ARTICLE
Karolina Wojtowicz, Monika Świerczewska, Michał Nowicki, Radosław Januchowski
PURPOSE: The primary limiting factor in achieving cures for patients with cancer, particularly ovarian cancer, is drug resistance. The mechanisms of drug resistance of cancer cells during chemotherapy may include compounds of the extracellular matrix, such as the transforming growth factor-beta-induced protein (TGFBI). In this study, we aimed to analyze the TGFBI gene and protein expression in different sensitive and drug-resistant ovarian cancer cell lines, as well as test if TGFBI can be involved in the response to topotecan (TOP) at the very early stages of treatment...
October 5, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37797366/a-mouse-model-of-food-allergy-permitting-skin-and-nasal-symptoms
#34
JOURNAL ARTICLE
Takafumi Morinaga, Takuya Yamamoto, Yukio Sugimoto
PURPOSE: Developing experimental animal models that show clinical symptoms and methods for quantitative and objective evaluation are important for understanding food allergies. Therefore, this study aimed to develop an ovalbumin (OVA)-induced mouse model of food allergy and a useful method to evaluate the symptoms of food allergy. MATERIAL/METHODS: Mice were sensitized via intraperitoneal injection of OVA. Subsequently, local sensitization was performed once weekly by oral administration of OVA...
October 3, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37757664/adjunctive-use-of-platelet-rich-fibrin-in-surgical-treatment-of-furcation-defects-a-systematic-review
#35
REVIEW
Anna Skurska, Marek Chwiedosik, Zuzanna Ślebioda
Periodontitis is an infectious disease characterized by the inflammatory destruction of the tooth supporting tissues. In multi-rooted teeth, this process leads to periodontal destruction within furcations creating defects demanding in terms of treatment. Regeneration of class II furcation involvement, although possible, is considered an unpredictable procedure, especially in terms of the bone fill. The interest in wound healing improvement by additional use of autologous concentrates of growth factors remains high in many fields of dentistry...
September 25, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37757663/genetic-aberrations-of-homologous-recombination-repair-pathways-in-prostate-cancer-the-prognostic-and-therapeutic-implications
#36
REVIEW
Hamidreza Saeidi, Ikmal Hisyam Bakrin, Chandramathi Samudi Raju, Patimah Ismail, Mohsen Saraf, Mohd Ghani Khairul-Asri
Prostate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency (HRD) can cause cell death. This has been exploited for the targeted treatment of PC patients with HRD by PARP inhibitors...
September 25, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37757662/frontal-eeg-alterations-induced-by-hippocampal-amyloid-pathology-in-rats
#37
JOURNAL ARTICLE
Enis Hidisoglu, Giuseppe Chiantia
PURPOSE: In this study, it was aimed to determine the dose-dependent effects of hippocampal amyloid beta (Aβ) on frontal EEG activity and to elucidate the possible non-invasive biomarkers by recording spontaneous EEG in free-moving rats. MATERIAL AND METHODS: Male albino Wistar rats aged 3 months were randomly divided into 4 groups (n ​= ​8 for each group), obtained by intrahippocampal injection of saline or different doses of Aβ1-42 i...
September 25, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37742478/safety-and-efficacy-of-melatonin-as-an-adjuvant-therapy-in-covid-19-patients-systematic-review-and-meta-analysis
#38
REVIEW
Amira Mohamed Taha, Sara Adel Abdelkader Saed, Mostafa Hossam-Eldin Moawad, Wesam Abd El-Tawab Moawad, Tala Al-Hejazi, Yosra Mousa, Ramaswamy Sharma, Russel J Reiter
BACKGROUND: Melatonin might be beneficial to coronavirus disease 2019 (COVID-19) patients in terms of both prevention and treatment. We investigated how melatonin affected various clinical and laboratory results in COVID-19 patients. METHODS: PubMed, Scopus, Cochrane Library and Web of Science databases were utilized for searching eligible articles fulfilling our inclusion criteria up to December 2022. We used random effect model in case of significant heterogeneity; in other cases, a fixed model was applied...
September 22, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37741003/alternative-donor-strategy-in-unrelated-hematopoietic-stem-cell-transplantation-outcome-with-mismatched-donors
#39
JOURNAL ARTICLE
Zorana Grubic, Marija Maskalan, Marija Burek Kamenaric, Lana Desnica, Mirta Mikulic, Katarina Stingl Jankovic, Nadira Durakovic, Ranka Serventi Seiwerth, Radovan Vrhovac, Renata Zunec
PURPOSE: This study retrospectively investigated the association between the level of human leukocyte antigen (HLA) mismatches (MMs), direction of disparities and differences at particular HLA locus on clinical outcomes of hematopoietic stem cell transplantation (HSCT). Investigated outcomes were overall survival (OS) and disease-free survival (DFS), graft-versus-host disease (GvHD), relapse and non-relapse mortality (NRM). PATIENTS AND METHODS: Study cohort included 108 adult patients transplanted between 2011 and 2021 and their 9/10 mismatched unrelated donors (MMUD)...
September 21, 2023: Advances in Medical Sciences
https://read.qxmd.com/read/37716182/the-melatonin-agonist-ramelteon-attenuates-bleomycin-induced-lung-fibrosis-by-suppressing-the-nlrp3-tgf-%C3%AE-1-hmgb1-signaling-pathway
#40
JOURNAL ARTICLE
Pelin Aydin, Zeynep B Aksakalli-Magden, Maide S Civelek, Sevgi Karabulut-Uzuncakmak, Behzad Mokhtare, Mustafa Ozkaraca, Fatih Alper, Zekai Halici
PURPOSE: The possible effects of ramelteon, a melatonin receptor agonist on bleomycin-induced lung fibrosis were analyzed via transforming growth factor β1 (TGF-β1), the high mobility group box 1 (HMGB1) and Nod-like receptor pyrin domain-containing 3 (NLRP3) which are related to the fibrosis process. MATERIALS AND METHODS: Bleomycin (0.1 ​mL of 5 ​mg/kg) was administered by intratracheal instillation to induce pulmonary fibrosis (PF)...
September 14, 2023: Advances in Medical Sciences
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