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Advances in Medical Sciences

Anna Lisowska, Przemysław Święcki, Małgorzata Knapp, Monika Gil, Włodzimierz J Musiał, Karol Kamiński, Tomasz Hirnle, Agnieszka Tycińska
PURPOSE: The role of insulin-like growth factor-binding protein-7 (IGFBP-7) in atherosclerosis is still not well-known. The objective of this study was to find out the following: 1) whether IGFBP-7 may act as a biomarker of coronary artery disease (CAD) occurrence and extent; 2) whether IGFBP-7 is potentially related to the classical and new markers of cardiovascular risk (carotid intima-media thickness - cIMT); 3) whether IGFBP-7 may be a marker of mortality in the group of patients with myocardial infarction (MI)...
February 12, 2019: Advances in Medical Sciences
Katarzyna Taranta-Janusz, Anna Moczulska, Hanna Nosek, Joanna Michaluk-Skutnik, Mark Klukowski, Anna Wasilewska
PURPOSE: We aimed at evaluating urinary levels of procollagen III aminoterminal propeptide (PIIINP) and β-catenin and the relationship between these markers and clinical and laboratory variables in children with a solitary functioning kidney (SFK). PATIENTS AND METHODS: The study group consisted of 98 (M/F: 62/36) children with an SFK with a median age of 8 years. An age-matched control group contained 54 healthy peers. Urinary levels of procollagen III aminoterminal propeptide and β-catenin were measured using a commercially available immunoassay kit...
February 6, 2019: Advances in Medical Sciences
Marcin Derlatka, Mikhail Ihnatouski, Marek Jałbrzykowski, Vladimir Lashkovski, Łukasz Minarowski
PURPOSE: This paper presents a method of ensembling rules obtained through induction of several basic types of decision trees. MATERIAL AND METHODS: The proposed method uses rules generated by means of well-known decision trees: CART, CHAID, exhaustive CHAID and C4.5. The method was tested on data describing pressure distribution under foot during gait in children with pes planovalgus (PV) and typical foot. Children with pes planovalgus underwent surgical intervention and were re-examined...
February 1, 2019: Advances in Medical Sciences
Ameneh Timar, Maryam Saberi-Karimian, Hamideh Ghazizadeh, Seyed Mohammad Reza Parizadeh, Reihaneh Sabbaghzadeh, Maryam Emadzadeh, Fatemeh Eshaghi, Shima Tavallaie, Gordon A Ferns, Majid Ghayour-Mobarhan
PURPOSE: Oxidative stress is caused by an imbalance between the antioxidant defenses and pro-oxidant production in favor of pro-oxidant production. Vitamin D has the potential for both pro- and anti-oxidative effects. The aim of this study was to assess the effect of high dose vitamin D supplementation on the prooxidant-antioxidant balance (PAB) in Iranian girls attending High School. MATERIALS AND METHODS: A total of 464 girls aged 12-18 years were asked to take vitamin D capsules containing 50000IU vitamin D3 once a week for a period of 9 weeks...
January 30, 2019: Advances in Medical Sciences
Andrei Kapitau, Inessa Goloenko, Victor Obyedkov, Kirill Pavlov, Sławomir Dariusz Szajda, Napoleon Waszkiewicz
PURPOSE: Allelic duality and functional impact of degenerate repeat at 5'- flanking promoter region in SLC6A4 gene of the serotonin transporter (5-HTTLPR), have been in the focus of investigations over the years. Various outcomes regarding an association of its polymorphism with risks of alcohol dependence syndrome (ADS) were presented. Such studies have not been conducted in the Eastern European population e.g. Belarus. We therefore checked: the association of 5-HTTLPR polymorphism with ADS, and functional impact of the polymorphism on progredience of ADS in Belarusian population...
January 28, 2019: Advances in Medical Sciences
Joanna Szklarczyk, Michalina Kot, Joanna Bonior, Zbigniew Śliwowski, Romana Tomaszewska, Jolanta Jaworek
PURPOSE: We aimed to evaluate the effects of unilateral vagotomy (right-VR or left-VL) on the severity of caerulein-induced acute pancreatitis (AP). MATERIAL AND METHODS: VR or VL was done in Wistar rats 4 days before AP, except in control, sham operated group. Following 5 h administration of subcutaneous injections of caerulein, the pancreatic blood flow (PBF), serum lipase and IL-10 in caval blood samples were measured. The pancreatic specimens were taken from sacrificed rats for the assessment of MDA-4-HNE and morphology...
January 25, 2019: Advances in Medical Sciences
Paulina Wejner-Mik, Jarosław D Kasprzak, Dominika Filipiak-Strzecka, Dawid Miśkowiec, Adrianna Lorens, Piotr Lipiec
PURPOSE: A microUSB ultrasound probe, which can be connected to a personal mobile device constitutes a new class of diagnostic pocket-size imaging devices (PSID). The aim of this study was to assess the feasibility and diagnostic value of brief transthoracic echocardiographic examination (bTTE) performed with the use of such equipment. MATERIAL AND METHODS: The study population comprised 87 consecutive patients (58 men, mean age 61 ± 16 years), 53 of whom were admitted to intensive cardiac care unit and 34 patients, who were referred for transthoracic echocardiography from outpatient clinic...
January 24, 2019: Advances in Medical Sciences
Vinay Chandrasekhara, Daniel Rhoades, Pavlos Z Kaimakliotis, Sun-Chuan Dai, Michael L Kochman
PURPOSE: Argon plasma coagulation (APC) is a standard modality for the treatment of gastrointestinal bleeding. However, there are no metrics to assess technical proficiency. We aimed to determine if a Quick APC Training Test (QAPCTT) can improve performance and assess proficiency with this modality. MATERIALS AND METHODS: Endoscopy trainees at various levels of training were asked to perform the QAPCTT with an in vivo model before and after an APC curriculum with didactic lectures and additional hands-on experience...
January 19, 2019: Advances in Medical Sciences
Francesco Copes, Martina Ramella, Luca Fusaro, Diego Mantovani, Mario Cannas, Francesca Boccafoschi
PURPOSE: Endothelialisation of vascular substitutes, in fact, remains one of the most unsolved problems in cardiovascular diseases treatment. Stromal Derived Factor 1 (SDF-1) has been largely investigated as an endothelialisation promoter and Pleiotrophin is a promising alternative. Although it has been known to exert beneficial effects on different cell types, its potential as an inducer of proliferation and migration of endothelial cells was not investigated. Therefore, this work is aimed to compare the effects of Pleiotrophin on proliferation and migration of endothelial cells with respect to SDF-1...
January 17, 2019: Advances in Medical Sciences
Agnieszka Gala-Błądzińska, Joanna Czech, Marcin Braun, Marzena Skrzypa, Krzysztof Gargasz, Artur Mazur, Izabela Zawlik
PURPOSE: Diabetes mellitus type 2 (T2DM) and its vascular complications are a serious world health problem. For this reason it is important to look for new diabetes complication risk factors. The aim of this study was to determine whether 18-bp insertion/deletion (I/D) polymorphism at -2549 position of the vascular endothelial growth factor (VEGF) gene is associated with diabetic vascular complications (DVC). MATERIAL AND METHODS: Caucasian subjects (n = 100) with T2DM were recruited for this study...
January 14, 2019: Advances in Medical Sciences
Joanna Szczykowska, Tomasz Hryszko, Beata Naumnik
Troponin measurement is one of crucial assessments facilitating diagnosis of acute coronary syndrome. Patients with chronic kidney disease are decimated by cardiovascular disease. Unfortunately, elevated concentration of serum troponin is commonly faced in clinical practice creating a challenge to rule out acute cardiac ischaemia in this vulnerable population. This review presents current knowlegde on analytical differences in troponin T and I measurements, their prognostic significance and their application in diagnosing acute coronary syndrome in chronic kidney disease patients...
January 11, 2019: Advances in Medical Sciences
Joanna Renke, Sabina Kędzierska-Mieszkowska, Magdalena Lange, Bogusław Nedoszytko, Eliza Wasilewska, Anna Liberek, Marcin Renke, Marek Niedoszytko, Jacek Witkowski, Joanna Skórko-Glonek, Barbara Lipińska
The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Mastocytosis is a heterogeneous group of disorders characterized by accumulation of MC in one or more organs...
January 11, 2019: Advances in Medical Sciences
Mahtab Farrokhi, Mehdi Zekriyapanah Gashti, Mahmood Hoormand, Azam Bakhtiarian, Rohalah Habibi
PURPOSE: A potential therapeutic approach on skin flap necrosis is to target parallel pathways involved in necrosis. Azelaic Acid, Minoxidil and Caffeine combination was tried on skin flap survival by their possible interaction with ATP sensitive potassium (KATP) channels and nitric oxide pathway. MATERIAL AND METHODS: Sprauge-Dawley rats were divided into 8 groups for skin flap surgery. Azelaic acid, minoxidil, caffeine, or their combination were applied topically in different groups...
January 10, 2019: Advances in Medical Sciences
Edyta Andrulewicz-Botulińska, Iwona Kuźmicz, Jolanta Nazaruk, Joanna Wosek, Anna Galicka
PURPOSE: In aging skin and some skin disorders, components of skin extracellular matrix (ECM) are disturbed and therefore research to find skin drugs is important. Evaluation of anethole impact on collagen, GAGs and MMP-2 in human skin fibroblasts was the aim of this study. MATERIALS AND METHODS: For collagen assay the Sircol dye, 5-[3 H]proline and real time-PCR were used. MMP-2 activity was detected by zymography. GAG concentration was determined using 1,9-dimethylmethylene blue (DMMB)...
January 10, 2019: Advances in Medical Sciences
Jarosław Szefel, Aleksandra Danielak, Wiesław Janusz Kruszewski
Difference in the metabolism of normal and cancer cells inspires to search for new, more specific and less toxic therapies than those currently used. The development of tumors is conditioned by genetic changes in cancer-transformed cells, immunological tolerance and immunosuppression. At the initial stages of carcinogenesis, the immune system shows anti-tumor activity, however later, cancer disrupts the function of Th1/Th17/Th2 lymphocytes by regulatory T (Treg) cells, tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) and finally causes immunosuppression...
December 31, 2018: Advances in Medical Sciences
Dominika Adamczuk, Beata Leszczyńska, Piotr Skrzypczyk, Agnieszka Turczyn, Agnieszka Antonowicz, Anna Majcher, Maria Szczepańska, Piotr Adamczyk, Ilona Zagożdżon, Aleksandra Żurowska, Marcin Tkaczyk, Anna Jander, Przemysław Sikora, Anna Wasilewska, Alfred Warzywoda, Katarzyna Kiliś-Pstrusińska, Danuta Zwolińska, Katarzyna Zachwieja, Dorota Drożdż, Roman Stankiewicz, Ryszard Grenda, Małgorzata Pańczyk-Tomaszewska
PURPOSE: The aim of the study was to analyze the effect of recombinant human growth hormone (rhGH) therapy and to establish factors influencing growth rate in dialyzed children in Poland. METHODS: We retrospectively analyzed medical records of 81 children with end-stage renal disease (ESRD) on chronic dialysis treated with rhGH for ≥12 months between 1994 and 2014. The following data were recorded: cause of ESRD, dialysis modality, age at the dialysis and rhGH initiation [years]...
December 20, 2018: Advances in Medical Sciences
Ewa Wasiluk, Pawel Krasnicki, Diana A Dmuchowska, Ewa Proniewska-Skrętek, Zofia Mariak
PURPOSE: To analyze long-term visual outcomes and complications of the implantation of a scleralfixated posterior chamber intraocular lens (PC-IOL) in patients with the lack of adequate capsular support, and to verify if the procedure can be performed with 9-0 polypropylene sutures. METHODS: The study was designed as a long-term retrospective analysis. Patients after the implantation of a scleralfixated PC-IOL were evaluated for the best corrected visual acuity (BCVA), intraocular pressure and occurrence of postoperative complications...
December 20, 2018: Advances in Medical Sciences
Michał Poznański, Ewa Brzeziańska-Lasota, Justyna Kiszałkiewicz, Ilona Kurnatowska, Jadwiga Kroczyńska-Bednarek, Anna Pękala-Wojciechowska, Tadeusz Pietras, Adam Antczak
PURPOSE: Pentraxin 3 (PTX-3) is an acute phase protein that belongs to the pentraxin superfamily. It is synthesized locally at the site of inflammation and its levels are related to the damage of blood vessels. There are only a few studies examining the relationship between PTX-3 and chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the serum levels of PTX-3 and relative PTX-3 gene expression in COPD patients and their correlations with cigarette smoking history and lung function...
December 17, 2018: Advances in Medical Sciences
Andrzej Hnatyszyn, Marlena Szalata, Marzena Skrzypczak-Zielinska, Karolina Wielgus, Jerzy Stanczyk, Ireneusz Dziuba, Adam Mikstacki, Agnieszka Dobrowolska, Malgorzata Waszak, Piotr Tomasz Hnatyszyn, Ryszard Slomski
PURPOSE: The main scope of this study was to evaluate the importance of selected DNA variants for developing inflammation of gastric mucosa and carcinogenesis in gastrointestinal diseases in patients infected with Helicobacter pylori. PATIENTS AND METHODS: Patients subjected to analysis constituted a group of 131 consecutive cases, with control groups consisting of 100 healthy volunteers and 13 dyspeptic patients. Molecular analysis included the following genes: TP53 (c...
December 13, 2018: Advances in Medical Sciences
Wahid Ali Khan
PURPOSE: Increased 16 α-hydroxyestrone (16 α-OHE1 ) and autoantibodies against histone H1 (H1 ) have been well described in systemic lupus erythematosus (SLE), but the combination effects of 16 α-OHE1 and H1 remains unclear. Here, we tried to assess the affinity and binding specificity of SLE autoantibodies against the 16 α-OHE1 -H1 adduct. IgG was induced against this adduct and was also used as immunochemical probe for the estimation of 16 α-OHE1 in the serum of SLE patients. MATERIALS AND METHODS: The affinity and binding specificities of SLE autoantibodies against 16 α-OHE1 -H1 were determined by direct binding and inhibition ELISA as well as quantitative precipitation titration in 60 patients and 30 control subjects...
December 5, 2018: Advances in Medical Sciences
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