Abigail Fraser, Scott M Nelson, Corrie Macdonald-Wallis, Debbie A Lawlor
INTRODUCTION: Results from studies examining associations of maternal diabetes in pregnancy with offspring cognitive outcomes have been inconclusive. METHODS: We used data from the Avon Longitudinal Study of Parents and Children, a UK prospective pregnancy cohort. Outcomes were School Entry Assessment (SEA) scores (age 4, N = 6, 032) and WISC-III IQ (age 8, N = 5, 282-5,307) and General Certificate of Secondary Education (GCSE) results (age 16, N = 7, 615). RESULTS: Existing diabetes, gestational diabetes, and, to a lesser extent, glycosuria were associated with lower offspring SEA scores (age 4), IQ (age 8), and GCSE results (age 16) even when adjusting for offspring sex, maternal age, prepregnancy BMI, smoking in pregnancy, parity, caesarean section, maternal education, and occupational social class...
2012: Experimental Diabetes Research