journal
https://read.qxmd.com/read/23197974/blockade-of-renin-angiotensin-system-increased-resistance-to-stz-induced-diabetes-in-rats-with-long-term-high-fat-diet
#21
JOURNAL ARTICLE
Xin Li, Li Yuan, Jin Li, Hailing Li, Suosuo Cheng
This study aimed to investigate whether rennin-angiotensin system (RAS) blockade through telmisartan would increase the resistance to streptozotocin- (STZ-) induced diabetes in insulin resistance rats. There were sixty Wistar rats that were divided into four groups: normal control (NC), high-fat diet (HF), high-fat diet plus STZ injection (HF+S), and high-fat diet plus STZ injection and telmisartan intervention (HF+S+T). Five rats were chosen randomly and respectively from groups NC and HF to undergo a hyperinsulinemic euglycemic clamp...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23193389/long-term-consequences-for-offspring-of-paternal-diabetes-and-metabolic-syndrome
#22
JOURNAL ARTICLE
Benigno Linares Segovia, Maximiliano Gutiérrez Tinoco, Angeles Izquierdo Arrizon, Juan Manuel Guízar Mendoza, Norma Amador Licona
BACKGROUND: Recent studies have reported an increase in the prevalence of obesity and metabolic syndrome in children and adolescents. However, few have focused how diabetes mellitus and metabolic syndrome together in parents can influence on obesity and metabolic disturbances in offspring. OBJECTIVE: To know the risk obesity and metabolic disturbance in children, adolescents, and young adults whose parents have diabetes mellitus and metabolic syndrome. METHODS: A comparative survey was made in healthy children of parents with diabetes mellitus and metabolic syndrome compared with offspring of healthy parents...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23133444/genetic-variation-in-cyp17a1-is-associated-with-arterial-stiffness-in-diabetic-subjects
#23
JOURNAL ARTICLE
Soo Jin Yang, Seung-Tae Lee, Won Jun Kim, Se Eun Park, Sung Woo Park, Jong-Won Kim, Cheol-Young Park
Hypertension and arterial stiffness are associated with an increasing risk of diabetes and cardiovascular diseases. This study aimed to identify genetic variants affecting hypertension and arterial stiffness in diabetic subjects and to compare genetic associations with hypertension between prediabetic and diabetic subjects. A total of 1,069 participants (326 prediabetic and 743 diabetic subjects) were assessed to determine the genetic variants affecting hypertension by analyzing 52 SNPs previously reported to be associated with hypertension...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23133443/cardiovascular-disease-risk-in-the-offspring-of-diabetic-women-the-impact-of-the-intrauterine-environment
#24
REVIEW
Laura J Marco, Kate McCloskey, Peter J Vuillermin, David Burgner, Joanne Said, Anne-Louise Ponsonby
The incidence of gestational diabetes is increasing worldwide, exposing large numbers of infants to hyperglycaemia whilst in utero. This exposure may have a long-term negative impact on the cardiovascular health of the offspring. Novel methods to assess cardiovascular status in the neonatal period are now available-including measuring arterial intima-media thickness and retinal photography. These measures will allow researchers to assess the relative impact of intrauterine exposures, distinguishing these from genetic or postnatal environmental factors...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23125848/influence-of-tumour-necrosis-factor-alpha-on-the-outcome-of-ischaemic-postconditioning-in-the-presence-of-obesity-and-diabetes
#25
JOURNAL ARTICLE
Lydia Lacerda, Lionel H Opie, Sandrine Lecour
Obesity and diabetes contribute to cardiovascular disease and alter cytokine profile. The cytokine, tumour necrosis factor alpha (TNFα), activates a protective signalling cascade during ischaemic postconditioning (IPostC). However, most successful clinical studies with IPostC have not included obese and/or diabetic patients. We aimed to investigate the influence of TNFα on the outcome of IPostC in obese or diabetic mice. TNF knockout or wildtype mice were fed for 11 weeks with a high carbohydrate diet (HCD) to induce modest obesity...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23118743/genetic-dissection-of-complex-genetic-factor-involved-in-niddm-of-oletf-rat
#26
REVIEW
Takahisa Yamada, Hiroyuki Kose, Takeshi Ohta, Kozo Matsumoto
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, noninsulin-dependent diabetes mellitus (NIDDM) in humans. NIDDM in this rat model was shown to be regulated by multiple genes. We have identified 14 quantitative trait loci (QTLs) responsible for NIDDM (Nidd1-14/of) on chromosomes 1, 5, 7, 8, 9, 11, 12, 14, 16, and 17 by a whole genome search in 160 F2 progenies obtained by mating the OLETF and the F344 rats. Among these loci, two QTLs, Nidd1 and 2/of, were declared significant loci at a genome-wide level...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23118742/metformin-stimulates-fgf21-expression-in-primary-hepatocytes
#27
JOURNAL ARTICLE
Eva B Nygaard, Sara G Vienberg, Cathrine Ørskov, Harald S Hansen, Birgitte Andersen
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator of glucose and lipid metabolism; however, the exact mechanism of action and regulation of FGF21 is not fully understood. Metabolic status plays an important role in the regulation of FGF21, and we therefore examined whether metformin, an indirect AMPK-activator, regulates FGF21 expression in hepatocytes. FGF21 mRNA and protein expression were determined after incubation of primary cultured rat and human hepatocytes with metformin for 24 hours...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23118741/effect-of-ezetimibe-on-insulin-secretion-in-db-db-diabetic-mice
#28
JOURNAL ARTICLE
Yong Zhong, Jun Wang, Ping Gu, Jiaqing Shao, Bin Lu, Shisen Jiang
OBJECTIVE: To investigate the effect of ezetimibe on the insulin secretion in db/db mice. METHODS: The db/db diabetic mice aged 8 weeks were randomly assigned into 2 groups and intragastrically treated with ezetimibe or placebo for 6 weeks. The age matched db/m mice served as controls. At the end of experiment, glucose tolerance test was performed and then the pancreas was collected for immunohistochemistry. In addition, in vitro perfusion of pancreatic islets was employed for the detection of insulin secretion in the first phase...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23093954/impact-of-insulin-resistance-on-silent-and-ongoing-myocardial-damage-in-normal-subjects-the-takahata-study
#29
JOURNAL ARTICLE
Taro Narumi, Tetsuro Shishido, Nobuyuki Kiribayashi, Shinpei Kadowaki, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takehiko Miyashita, Takuya Miyamoto, Tetsu Watanabe, Yoko Shibata, Tsuneo Konta, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota
BACKGROUND: Insulin resistance (IR) is part of the metabolic syndrome (Mets) that develops after lifestyle changes and obesity. Although the association between Mets and myocardial injury is well known, the effect of IR on myocardial damage remains unclear. METHODS AND RESULTS: We studied 2200 normal subjects who participated in a community-based health check in the town of Takahata in northern Japan. The presence of IR was assessed by homeostasis model assessment ratio, and the serum level of heart-type fatty acid binding protein (H-FABP) was measured as a maker of silent and ongoing myocardial damage...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23093953/aspects-of-inflammation-and-oxidative-stress-in-pediatric-obesity-and-type-1-diabetes-an-overview-of-ten-years-of-studies
#30
REVIEW
Brian Tran, Stacy Oliver, Jaime Rosa, Pietro Galassetti
Obesity and type 1 diabetes (T1DM) are the two most common conditions of altered metabolism in children and adolescents. In both, similar long-term cardiovascular complications are known to occur, mediated in large part by underlying inflammatory and oxidative processes whose biochemical details remain relatively unclear. Through a series of experiments in these patient populations, over the last decade our laboratory has clarified a number of key issues in this field. Interestingly, while obese and type 1 diabetic children often differed in the specific type and magnitude of molecular alterations, in both groups a clear exaggeration of inflammatory and oxidative activation was detected when compared to healthy, age-matched controls...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23082075/diabetes-and-cancer-epidemiological-clinical-and-experimental-perspectives
#31
EDITORIAL
Chin-Hsiao Tseng, Chien-Jen Chen, Joseph R Landolph
No abstract text is available yet for this article.
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23056035/renal-podocyte-injury-in-a-rat-model-of-type-2-diabetes-is-prevented-by-metformin
#32
JOURNAL ARTICLE
Junghyun Kim, Eunjin Shon, Chan-Sik Kim, Jin Sook Kim
Hyperglycemia promotes oxidative stress and hence generation of reactive oxygen species (ROS), which is known to play a crucial role in the pathogenesis of diabetic nephropathy. Metformin, an oral hypoglycemic drug, possesses antioxidant effects. The aim of this paper is to investigate the protective effects of metformin on the injury of renal podocytes in spontaneously diabetic Torii (SDT) rats, a new model for nonobese type 2 diabetes. Metformin (350 mg/kg/day) was given to SDT rats for 17 weeks. Blood glucose, glycated haemoglobin (HbA1c), and albuminuria were examined...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23049543/haplotypes-in-the-crp-gene-associated-with-increased-bmi-and-levels-of-crp-in-subjects-with-type-2-diabetes-or-obesity-from-southwestern-mexico
#33
JOURNAL ARTICLE
América Martínez-Calleja, Irma Quiróz-Vargas, Isela Parra-Rojas, José Francisco Muñoz-Valle, Marco A Leyva-Vázquez, Gloria Fernández-Tilapa, Amalia Vences-Velázquez, Miguel Cruz, Eduardo Salazar-Martínez, Eugenia Flores-Alfaro
OBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease. METHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23049542/functional-expression-of-trpv4-channels-in-human-collecting-duct-cells-implications-for-secondary-hypertension-in-diabetic-nephropathy
#34
JOURNAL ARTICLE
Claire E Hills, Rosemary Bland, Paul E Squires
BACKGROUND: The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress. In the current study, we examine the functional expression of TRPV4 channels in cell volume regulation in cells of the human collecting duct. METHODS: Western blot analysis, siRNA knockdown, and microfluorimetry were used to assess the expression and function of TRPV4 in mediating Ca²⁺-dependent mechanical stimulation within a novel system of the human collecting duct (HCD)...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23049541/circulating-tgf-%C3%AE-1-glycation-and-oxidation-in-children-with-diabetes-mellitus-type-1
#35
JOURNAL ARTICLE
Vladimír Jakuš, Michal Sapák, Jana Kostolanská
The present study investigates the relationship between diabetes metabolic control represented by levels of HbA1c, early glycation products-(fructosamine (FAM)), serum-advanced glycation end products (s-AGEs), lipoperoxidation products (LPO), advanced oxidation protein products (AOPP) and circulating TGF-β in young patients with DM1. The study group consisted of 79 patients with DM1 (8-18 years). 31 healthy children were used as control (1-16 years). Baseline characteristics of patients were compared by Student's t-test and nonparametric Mann-Whitney test (Statdirect), respectively...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23049540/nicotine-exposure-exacerbates-development-of-cataracts-in-a-type-1-diabetic-rat-model
#36
JOURNAL ARTICLE
Nima Tirgan, Gabriela A Kulp, Praveena Gupta, Adam Boretsky, Tomasz A Wiraszka, Bernard Godley, Ronald G Tilton, Massoud Motamedi
Diabetes and smoking are known risk factors for cataract development. In this study, we evaluated the effect of nicotine on the progression of cataracts in a type 1 diabetic rat model. Diabetes was induced in Sprague-Dawley rats by a single injection of 65 mg/kg streptozotocin. Daily nicotine injections were administered subcutaneously. Forty-five rats were divided into groups of diabetics with and without nicotine treatment and controls with and without nicotine treatment. Progression of lens opacity was monitored using a slit lamp biomicroscope and scores were assigned...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23008698/glibenclamide-induces-collagen-iv-catabolism-in-high-glucose-stimulated-mesangial-cells
#37
JOURNAL ARTICLE
Liping Zhu, Pedro Cortes, Clare Hassett, David W Taube, Jerry Yee
We have shown the full prevention of mesangial expansion in insulin-deficient diabetic rats by treatment with clinically-relevant dosages of glibenclamide (Glib). Studies in mesangial cells (MCs) also demonstrated reduction in the high glucose (HG)-induced accumulation of collagens, proposing that this was due to increased catabolism. In the present study, we investigated the signaling pathways that may be implicated in Glib action. Rat primary MCs were exposed to HG for 8 weeks with or without Glib in therapeutic (0...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/23008697/simple-cystatin-c-formula-for-estimation-of-glomerular-filtration-rate-in-overweight-patients-with-diabetes-mellitus-type-2-and-chronic-kidney-disease
#38
COMPARATIVE STUDY
Sebastjan Bevc, Radovan Hojs, Robert Ekart, Matej Završnik, Maksimiljan Gorenjak, Ludvik Puklavec
In clinical practice the glomerular filtration rate (GFR) is estimated from serum creatinine-based equations like the Cockcroft-Gault formula (C&G) and Modification of Diet in Renal Disease formula (MDRD). Recently, serum cystatin C-based equations, the newer creatinine formula (The Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI)), and equation that use both serum creatinine and cystatin C (CKD-EPI creatinine & cystatin formula) were proposed as new GFR markers. Present study compares serum creatinine-based equations, combined (including both serum creatinine and cystatin C) equation, and serum simple cystatin C formula (100/serum cystatin C) against 51CrEDTA clearance in 113 adult overweight Caucasians with diabetes mellitus type 2 (DM2) and chronic kidney disease (CKD)...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/22997507/oxytocin-and-psychological-factors-affecting-type-2-diabetes-mellitus
#39
JOURNAL ARTICLE
K Kontoangelos, A E Raptis, C C Papageorgiou, P C Tsiotra, G N Papadimitriou, A D Rabavilas, G Dimitriadis, S A Raptis
BACKGROUND: The aim of this study was to investigate the association of oxytocin with trait and state psychological factors in type 2 diabetic patients. METHODS: OXT and psychological variables were analyzed from 86 controlled diabetic patients (glycosylated haemoglobin A1c (HbA1c) < 7%) from 45 uncontrolled diabetic patients (HbA1c ≥ 7). Psychological characteristics were assessed with the Eysenck Personality Questionnaire (EPQ), while state psychological characteristics were measured with the Symptom Checklist 90-R (SCL 90-R)...
2012: Experimental Diabetes Research
https://read.qxmd.com/read/22991506/dysregulation-of-dicer1-in-beta-cells-impairs-islet-architecture-and-glucose-metabolism
#40
JOURNAL ARTICLE
Amitai D Mandelbaum, Tal Melkman-Zehavi, Roni Oren, Sharon Kredo-Russo, Tomer Nir, Yuval Dor, Eran Hornstein
microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially constitute a significant portion of the total beta-cell population. However, during postnatal development, Dicer1-null cells are depleted. Furthermore, wild-type beta cells are repopulating the islets in complex compensatory dynamics...
2012: Experimental Diabetes Research
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