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Journals International Journal of Strok...

International Journal of Stroke : Official Journal of the International Stroke Society

https://read.qxmd.com/read/38651759/the-aha-asa-and-dsm-v-diagnostic-criteria-for-vascular-cognitive-impairment-identify-cases-with-predominant-vascular-pathology
#21
JOURNAL ARTICLE
Melmar C Folloso, Steven G Villaraza, Lo Yi-Wen, Khong Pek-Lan, Tomotaka Tanaka, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen
BACKGROUND: There are major challenges in determining the etiology of vascular cognitive impairment (VCI) clinically, especially in the presence of mixed pathologies, such as vascular and amyloid. Most recently, two criteria (American Heart Association/American Stroke Association (AHA/ASA) and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)) have been proposed for the clinical diagnosis of VCI but have not as yet been validated using neuroimaging. AIMS: This study aims to determine whether the AHA/ASA and DSM-V criteria for VCI can distinguish between cases with predominantly vascular pathology and cases with mixed pathology...
May 16, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38751129/associated-demographic-factors-for-the-recurrence-and-prognosis-of-stroke-patients-within-a-multi-ethnic-asian-population
#22
JOURNAL ARTICLE
Keng Siang Lee, Isabel Siow, Tessa Riandini, Kaavya Narasimhalu, Kelvin Bryan Tan, Deidre Anne De Silva
OBJECTIVE: There is a paucity of studies investigating the outcomes amongst Asian stroke patients. Identifying subgroups of stroke patients at risk of poorer outcomes could identify patients who would benefit from targeted interventions. Therefore, the aim of this study was to identify which ischemic stroke patients at high risk of recurrent events and mortality. METHODS: This cohort study adhered to STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) guidelines...
May 15, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38708722/prevalence-and-prognostic-impact-of-stroke-in-a-national-cohort-of-infective-endocarditis
#23
JOURNAL ARTICLE
Sara Álvarez Zaballos, Pilar Vazquez Alen, Patricia Muñoz, Arístides de Alarcón, Encarnación Gutiérrez-Carretero, Ana Álvarez-Uría, Mª Carmen Fariñas, Raquel Rodríguez-García, Miguel Ángel Goenaga, Guillermo Cuervo, Antonio Plata-Ciezar, Carmen Hidalgo-Tenorio, Gonzalo Aldamiz-Echevarría, Manuel Martínez-Sellés
BACKGROUND: Stroke is a common complication of infective endocarditis (IE). Our aim was to describe the prevalence and prognostic impact of stroke in a national prospective cohort of IE. METHODS: Consecutive inclusion at 46 Spanish hospitals between 2008 and 2021. RESULTS: Out of 5667 IE cases, 1125 had acute stroke (19.8%): 811 ischemic strokes (618 cardioembolic strokes, 193 cardioembolic strokes with hemorrhagic transformation, 4 transient ischemic attacks, 3 lacunar infarctions), 125 intracranial hemorrhages, and 29 other neurological complications (cerebral abscesses, encephalitis, meningitis, seizures)...
May 6, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38703035/sex-differences-in-histopathological-markers-of-cerebral-amyloid-angiopathy-and-related-hemorrhage
#24
JOURNAL ARTICLE
Emma Koemans, Valentina Perosa, Whitney Freeze, Hang Lee, Mariel G Kozberg, Gillian Theresa Coughlan, Rachel F Buckley, Marieke Wermer, Steven M Greenberg, Susanne J van Veluw
BACKGROUND: Men with cerebral amyloid angiopathy (CAA) may have an earlier onset of intracerebral hemorrhage, and a more hemorrhagic disease course compared to women. In this cohort study we investigated sex differences in histopathological markers associated with amyloid-β burden and hemorrhage in cognitively impaired individuals and patients with CAA, using neuropathological data from two autopsy databases. METHODS: First, we investigated presence of parenchymal (Thal score) and vascular amyloid-β (CAA severity score) in cognitively impaired individuals from the National Alzheimer's Coordinating Center (NACC) neuropathology database...
May 4, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38676549/validation-of-a-simple-clinical-tool-for-screening-of-acute-lacunar-stroke-a-substudy-of-the-wake-up-trial
#25
JOURNAL ARTICLE
Francesco Arba, Chiara Rinaldi, Märit Jensen, Matthias Endres, Jochen Benedikt Fiebach, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Simonsen, Vincent Thijs, Christian Gerloff, Joanna Wardlaw, Götz Thomalla
INTRODUCTION: Lacunar stroke represents around a quarter of all ischemic strokes, however, their identification with Computed Tomography in the hyperacute setting is challenging. We aimed to validate a clinical score to identify lacunar stroke in the acute setting, independently, with data from the WAKE-UP trial using magnetic resonance imaging. METHODS: We analysed data from the WAKE-UP trial and extracted Oxfordshire Community Stroke Project (OCSP) classification...
April 27, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38666480/thrombectomy-in-ischemic-stroke-patients-with-large-core-but-minor-ischemic-changes-on-non-enhanced-computed-tomography
#26
JOURNAL ARTICLE
Gabriel Broocks, Helge Kniep, Rosalie McDonough, Matthias Bechstein, Christian Heitkamp, Laurens Winkelmeier, Susan Klapproth, Tobias Djamsched Faizy, Maximilian Schell, Gerhard Schön, Uta Hanning, Susanne Gellißen, André Kemmling, Panagiotis Papanagiotou, Jens Fiehler, Lukas Meyer
PURPOSE: The Alberta Stroke Program Early CT Score (ASPECTS) is regularly used to guide patient selection for mechanical thrombectomy (MT). Similarly, penumbral imaging based on computed tomography perfusion (CTP) may serve as neuroimaging tool to guide treatment. Yet, patients with a large ischemic core on CTP may show only minor ischemic changes resulting in a high ASPECTS. AIM: We hypothesized twofold: 1) the treatment effect of vessel recanalization in patients with core volume >50ml but ASPECTS≥6 is not different compared to high ASPECTS patients with core volume <50ml, and 2) recanalization is associated with core overestimation...
April 26, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38591740/comparative-study-of-venous-thromboembolic-prophylaxis-strategies-in-hemorrhagic-stroke-a-systematic-review-and-network-meta-analysis
#27
REVIEW
Giorgio Maraziti, Maria Giulia Mosconi, Maurizio Paciaroni
BACKGROUND: Venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are frequent complications in patients with intracerebral hemorrhage (ICH). Various prophylactic strategies have been employed to mitigate this risk, such as heparin, intermittent pneumatic compression (IPC), and graduated compression stockings (GCS). The optimal thromboembolic prophylaxis approach remains uncertain due to the lack of randomized controlled trials (RCTs) comparing all interventions...
April 24, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38651761/quality-of-life-and-quality-adjusted-life-years-after-stroke-in-sierra-leone
#28
JOURNAL ARTICLE
Daniel Youkee, Gibrilla Deen, Catherine Sackley, Durodamil Radcliffe Lisk, Iain Marshall, Marina Soley-Bori
BACKGROUND: Stroke is a leading cause of mortality and negatively affects health related quality of life (HRQoL). HRQoL after stroke is understudied in Africa and there are no reports of quality-adjusted life years after stroke (QALYs) in African countries. We determined the impact of stroke on HRQoL after stroke in Sierra Leone. We calculated QALYs at one year post stroke, and determined sociodemographic and clinical variables associated with HRQoL and QALYs in this population. METHODS: A prospective stroke register was established at the two principal adult tertiary government hospitals in Freetown, Sierra Leone...
April 23, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38651756/strategic-white-matter-hyperintensity-locations-associated-with-post-stroke-cognitive-impairment-a-multicenter-study-in-1568-stroke-patients
#29
JOURNAL ARTICLE
Mirthe Coenen, Floor A S de Kort, Nick A Weaver, Hugo J Kuijf, Hugo Paul Aben, Hee-Joon Bae, Régis Bordet, Christopher Lh Chen, Anna Dewenter, Thomas Doeven, Thibaut Dondaine, Marco Duering, Rong Fang, Ruben S van der Giessen, Jonguk Kim, Beom Joon Kim, Paul L M de Kort, Peter Koudstaal, Minwoo Lee, Jae-Sung Lim, Renaud Lopes, Robert J van Oostenbrugge, Julie Staals, Kyung-Ho Yu, Geert Jan Biessels, J Matthijs Biesbroek
BACKGROUND: Post-stroke cognitive impairment (PSCI) occurs in up to 50% of stroke survivors. Presence of pre-existing vascular brain injury, in particular the extent of white matter hyperintensities (WMH), is associated with worse cognitive outcome after stroke, but the role of WMH location in this association is unclear. AIM: We determined if WMH in strategic white matter tracts explain cognitive performance after stroke. METHODS: Individual patient data from 9 ischemic stroke cohorts with MRI were harmonized through the Meta VCI Map consortium...
April 23, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38651751/clinical-impact-of-body-mass-index-on-ischemic-and-hemorrhagic-stroke
#30
JOURNAL ARTICLE
Kaori Miwa, Michikazu Nakai, Sohei Yoshimura, Yusuke Sasahara, Shinichi Wada, Junpei Koge, Akiko Ishigami, Yoshiki Yagita, Kenji Kamiyama, Yoshihiro Miyamoto, Shotai Kobayashi, Kazuo Minematsu, Kazunori Toyoda, Masatoshi Koga
BACKGROUND AND AIM: To investigate the prognostic implication of body mass index (BMI) on clinical outcomes after acute ischemic and hemorrhagic stroke. METHODS: The subjects of the study included adult patients with available baseline body weight and height data who had suffered an acute stroke and were registered in the Japan Stroke Data Bank-a hospital-based, multicenter stroke registration database-between January 2006 and December 2020. The outcome measures included unfavorable outcomes defined as a modified Rankin Scale [mRS] score of 5-6 and favorable outcomes (mRS 0-2) at discharge, and in-hospital mortality...
April 23, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38803115/treatment-for-intracerebral-hemorrhage-dawn-of-a-new-era
#31
REVIEW
David J Seiffge, Craig S Anderson
Intracerebral hemorrhage (ICH) is a devastating disease, causing high rates of death, disability, and suffering across the world. For decades, its treatment has been shrouded by the lack of reliable evidence, and consequently, the presumption that an effective treatment is unlikely to be found. Neutral results arising from several major randomized controlled trials had established a negative spirit within and outside the stroke community. Frustration among researchers and a sense of nihilism in clinicians has created the general perception that patients presenting with ICH have a poor prognosis irrespective of them receiving any form of active management...
June 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38204182/variations-in-the-prevalence-of-atrial-fibrillation-and-in-the-strength-of-its-association-with-ischemic-stroke-in-countries-with-different-income-levels-interstroke-case-control-study
#32
JOURNAL ARTICLE
Robert Murphy, Albertino Damasceno, Catriona Reddin, Graeme J Hankey, Helle K Iversen, Shahram Oveisgharan, Fernando Lanas, Anna Czlonkowska, Peter Langhorne, Adesola Ogunniyi, Mohammad Wasay, Zvonko Rumboldt, Conor Judge, Aytekin Oguz, Charles Mondo, Yaroslav Winter, Annika Rosengren, Nana Pogosova, Alvaro Avezum, Yongchai Nilanont, Ernesto Penaherrera, Denis Xavier, Patricio Lopez-Jaramillo, Xingyu Wang, Salim Yusuf, Martin O'Donnell
BACKGROUND: The contribution of atrial fibrillation (AF) to the etiology and burden of stroke may vary by country income level. AIMS: We examined differences in the prevalence of AF and described variations in the magnitude of the association between AF and ischemic stroke by country income level. METHODS: In the INTERSTROKE case-control study, participants with acute first ischemic stroke were recruited across 32 countries. We included 10,363 ischemic stroke cases and 10,333 community or hospital controls who were matched for age, sex, and center...
June 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/37950392/cerebral-microbleeds-and-asundexian-in-non-cardioembolic-ischemic-stroke-secondary-analyses-of-the-pacific-stroke-randomized-trial
#33
RANDOMIZED CONTROLLED TRIAL
Pargol Balali, Robert G Hart, Eric E Smith, Feryal Saad, Pablo Colorado, Robin Lemmens, Gian Marco De Marchis, Valeria Caso, Lizhen Xu, Laura Heenan, Stuart J Connolly, Hardi Mundl, Ashkan Shoamanesh
BACKGROUND AND AIMS: Cerebral microbleeds are magnetic imaging resonance (MRI) markers of hemorrhage-prone cerebral small vessel disease that predict future risk of ischemic stroke and intracranial hemorrhage (ICrH). There exist concerns about the net benefit of antithrombotic therapy in patients with microbleeds. We aimed to investigate the effects of an oral factor-XIa inhibitor (asundexian), that is hypothesized to inhibit thrombosis without compromising hemostasis, on the development of new microbleeds over time and interactions between microbleeds and asundexian treatment on clinical outcomes...
June 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/37947341/identifying-the-optimal-time-period-for-detection-of-atrial-fibrillation-after-ischaemic-stroke-and-tia-an-updated-systematic-review-and-meta-analysis-of-randomized-control-trials
#34
JOURNAL ARTICLE
Mrinal Thakur, Ahmed Alsinbili, Rahul Chattopadhyay, Elizabeth A Warburton, Kayvan Khadjooi, Isuru Induruwa
BACKGROUND: Atrial fibrillation (AF) is a major risk factor for ischaemic stroke (IS) and transient ischaemic attack (TIA). The timely detection of first-diagnosed or "new" AF (nAF) would prompt a switch from antiplatelets to anticoagulation to reduce the risk of stroke recurrence; however, the optimal timing and duration of rhythm monitoring to detect nAF remains unclear. AIMS: We searched MEDLINE, PubMed, Cochrane database, and Google Scholar to undertake a systematic review and meta-analysis of randomized controlled trials (RCT) between 2012 and 2023 investigating nAF detection after IS and TIA...
June 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38546170/predicting-post-stroke-cognitive-impairment-using-electronic-health-record-data
#35
JOURNAL ARTICLE
Jeffrey M Ashburner, Yuchiao Chang, Bianca Porneala, Sanjula D Singh, Nirupama Yechoor, Jonathan M Rosand, Daniel E Singer, Christopher D Anderson, Steven J Atlas
BACKGROUND: Secondary prevention interventions to reduce post-stroke cognitive impairment (PSCI) can be aided by the early identification of high-risk individuals who would benefit from risk factor modification. AIMS: To develop and evaluate a predictive model to identify patients at increased risk of PSCI over 5 years using data easily accessible from electronic health records. METHODS: Cohort study that included primary care patients from two academic medical centers...
April 18, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38546177/baseline-clinical-and-neuroradiological-predictors-of-outcome-in-patients-with-large-ischemic-core-undergoing-mechanical-thrombectomy-a-retrospective-multicenter-study
#36
JOURNAL ARTICLE
Andrea M Alexandre, Mauro Monforte, Valerio Brunetti, Luca Scarcia, Luigi Cirillo, Andrea Zini, Irene Scala, Vincenzo Nardelli, Francesco Arbia, Giuseppe Arbia, Giovanni Frisullo, Erwah Kalsoum, Arianna Camilli, Davide De Leoni, Francesca Colò, Serena Abruzzese, Mariangela Piano, Claudia Rollo, Antonio Macera, Maria Ruggiero, Elvis Lafe, Joseph D Gabrieli, Giacomo Cester, Nicola Limbucci, Francesco Arba, Simone Ferretti, Valerio Da Ros, Luigi Bellini, Giancarlo Salsano, Nicola Mavilio, Riccardo Russo, Mauro Bergui, Antonio A Caragliano, Sergio L Vinci, Daniele G Romano, Giulia Frauenfelder, Vittorio Semeraro, Maria P Ganimede, Emilio Lozupone, Andrea Romi, Anna Cavallini, Luca Milonia, Massimo Muto, Paolo Candelaresi, Paolo Calabresi, Alessandro Pedicelli, Aldobrando Broccolini
BACKGROUND: Recent randomized trials have shown the benefit of mechanical thrombectomy (MT) also in patients with an established large ischemic core. AIMS: The purpose of this study was to define baseline predictors of clinical outcome in patients with large vessel occlusion (LVO) in the anterior circulation and an Alberta Stroke Program Early CT score (ASPECTS) ⩽ 5, undergoing MT. MATERIAL AND METHODS: The databases of 16 comprehensive stroke centers were retrospectively screened for patients with LVO and ASPECTS ⩽5 that received MT...
April 16, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38591748/early-reperfusion-therapy-with-intravenous-alteplase-for-recovery-of-vision-in-acute-central-retinal-artery-occlusion-revision-study-protocol-of-a-phase-iii-trial
#37
JOURNAL ARTICLE
Sven Poli, Carsten Grohmann, Daniel A Wenzel, Khouloud Poli, Johannes Tuennerhoff, Max Nedelmann, Jens Fiehler, Hansjürgen Agostini, Bruce Campbell, Dominik M Fischer, Marek Sykora, Brian Mac Grory, Nicolas Feltgen, David J Seiffge, Daniel Strbian, Maximilian Schultheiß, Martin S Spitzer
RATIONALE: Meta-analyses of case series of non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects of intravenous thrombolysis when initiated early after symptom onset. Randomized data is lacking to address this question. AIMS: REVISION investigates intravenous alteplase within 4.5 hours of monocular vision loss due to acute CRAO. METHODS: Randomized (1:1), double-blind, placebo-controlled, multicenter adaptive phase III trial...
April 9, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38497332/individual-patient-data-meta-analysis-of-the-effects-of-fluoxetine-on-functional-outcomes-after-acute-stroke
#38
JOURNAL ARTICLE
Gillian Mead, Catriona Graham, Erik Lundström, Graeme J Hankey, Maree L Hackett, Laurent Billot, Per Näsman, John Forbes, Martin Dennis
BACKGROUND: Three large randomized controlled trials of fluoxetine for stroke recovery have been performed. We performed an individual patient data meta-analysis (IPDM) on the combined data. METHODS: Fixed effects meta-analyses were performed on the combined data set, for the primary outcome (modified Rankin scale (mRS) at 6 months), and secondary outcomes common to the individual trials. As a sensitivity analysis, summary statistics from each trial were created and combined...
April 8, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38576067/clinical-change-during-inter-hospital-transfer-for-thrombectomy-incidence-associated-factors-and-relationship-with-outcome
#39
JOURNAL ARTICLE
Pierre Seners, Adrien Ter Schiphorst, Anke Wouters, Nicole Yuen, Michael Mlynash, Caroline Arquizan, Jeremy J Heit, Stephanie Kemp, Soren Christensen, Denis Sablot, Anne Wacongne, Thibault Lalu, Vincent Costalat, Gregory W Albers, Maarten G Lansberg
BACKGROUND: Patients with acute ischemic stroke with a large vessel occlusion (LVO) admitted to non endovascular-capable centers often require inter-hospital transfer for thrombectomy. We aimed to describe the incidence of substantial clinical change during transfer, the factors associated with clinical change, and its relationship with 3-month outcome. METHODS: We analyzed data from two cohorts of acute stroke patients transferred for thrombectomy to a comprehensive center (Stanford, USA, Nov 2019 to Jan 2023; Montpellier, France, Jan 2015 to Jan 2017), regardless of whether thrombectomy was eventually attempted...
April 4, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38567822/global-regional-and-national-burden-of-stroke-from-1990-to-2019-a-temporal-trend-analysis-based-on-the-global-burden-of-disease-study-2019
#40
JOURNAL ARTICLE
Liwei Zhang, Hao Lu, Chunhua Yang
BACKGROUND: Stroke is the second leading cause of death and the leading cause of disability worldwide. However, how the the prevalence of stroke varies across the world is uncertain. AIMS: The aim of this study was to and analyze temporal trends of prevalence for Stroke, including Ischemic stroke (IS), Intracerebral hemorrhage (ICH), and Subarachnoid hemorrhage (SAH) at the global, regional, and national levels. METHODS: The age-standardized prevalence rates (ASPR) of stroke, IS, ICH, and SAH, along with their corresponding 95% uncertainty intervals (UI), were derived from data in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019...
April 3, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
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