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Journals International Journal of Strok...

International Journal of Stroke : Official Journal of the International Stroke Society

https://read.qxmd.com/read/38546177/baseline-clinical-and-neuroradiological-predictors-of-outcome-in-patients-with-large-ischemic-core-undergoing-mechanical-thrombectomy-a-retrospective-multicenter-study
#1
JOURNAL ARTICLE
Andrea Alexandre, Mauro Monforte, Valerio Brunetti, Luca Scarcia, Luigi Cirillo, Andrea Zini, Irene Scala, Vincenzo Nardelli, Francesco Arbia, Giuseppe Arbia, Giovanni Frisullo, Erwah Kalsoum, Arianna Camilli, Davide De Leoni, Colò Francesca, Serena Abruzzese, Mariangela Piano, Claudia Rollo, Antonio Macera, Maria Ruggiero, Elvis Lafe, Joseph Domenico Gabrieli, Giacomo Cester, Nicola Limbucci, Francesco Arba, Simone Ferretti, Valerio Da Ros, Luigi Bellini, Giancarlo Salsano, Nicola Mavilio, Riccardo Russo, Mauro Bergui, Antonio Armando Caragliano, Sergio Lucio Vinci, Daniele Giuseppe Romano, Giulia Frauenfelder, Vittorio Semeraro, Ganimede Maria Porzia, Emilio Lozupone, Andrea Romi, Anna Cavallini, Luca Milonia, Massimo Muto, Paolo Candelaresi, Paolo Calabresi, Alessandro Pedicelli, Aldobrando Broccolini
BACKGROUND: Recent randomized trials have shown the benefit of mechanical thrombectomy (MT) also in patients with an established large ischemic core. AIM: The purpose of this study was to define baseline predictors of clinical outcome in patients with large vessel occlusion (LVO) in the anterior circulation and an Alberta Stroke Program Early CT score (ASPECTS) ≤ 5, undergoing MT. MATERIAL AND METHODS: The databases of 16 comprehensive stroke centers were retrospectively screened for patients with LVO and ASPECTS ≤ 5 that received MT...
March 28, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38546172/an-automated-flowchart-for-the-modified-rankin-scale-assessment-a-multicenter-inter-rater-agreement-analysis
#2
JOURNAL ARTICLE
Joao Brainer Clares de Andrade, Terence Joseph Quinn, Leonardo Augusto Carbonera, Vinicius Montanaro, Alexandre Robles, Rafael Padua, Saulo Ribeiro, Gisele Sampaio Silva
BACKGROUND AND OBJECTIVE: The Modified Rankin Scale (mRS) is a widely adopted scale for assessing stroke recovery. Despite limitations, the mRS has been adopted as primary outcome in most recent clinical acute stroke trials. Designed to be used by multidisciplinary clinical staff, the congruency of this scale is not consistent, which may lead to mistakes in clinical or research application. We aimed to develop and validate an interactive and automated digital tool for assessing the mRS - the iRankin...
March 28, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38546170/predicting-post-stroke-cognitive-impairment-using-electronic-health-record-data
#3
JOURNAL ARTICLE
Jeffrey M Ashburner, Yuchiao Chang, Bianca Porneala, Sanjula D Singh, Nirupama Yechoor, Jonathan M Rosand, Daniel E Singer, Christopher D Anderson, Steven J Atlas
BACKGROUND: Secondary prevention interventions to reduce post-stroke cognitive impairment (PSCI) can be aided by the early identification of high-risk individuals who would benefit from risk factor modification. AIMS: To develop and evaluate a predictive model to identify patients at increased risk of PSCI over 5 years using data easily accessible from electronic health records. METHODS: Cohort study that included primary care patients from two academic medical centers...
March 28, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38533609/are-central-and-systemic-inflammation-associated-with-fatigue-in-cerebral-small-vessel-disease
#4
JOURNAL ARTICLE
Amy A Jolly, Robin B Brown, Daniel J Tozer, Young T Hong, Tim D Fryer, Franklin Aigbirhio, John O'brien, Hugh S Markus
BACKGROUND: Fatigue is a common symptom in cerebral small vessel disease (SVD), but its pathogenesis is poorly understood. It has been suggested that inflammation may play a role. We determined whether central (neuro) inflammation and peripheral inflammation were associated with fatigue in SVD. METHODS: 36 patients with moderate to severe SVD underwent neuropsychometric testing, combined PET-MRI and blood draw for analysis of inflammatory blood biomarkers. Microglial signal was taken as a proxy for neuroinflammation, assessed with radioligand 11C-PK11195...
March 27, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38533606/a-randomised-controlled-trial-of-medication-adherence-and-management-of-risk-factors-for-secondary-prevention-of-stroke-mamors-using-a-smartphone-based-application
#5
JOURNAL ARTICLE
Veena Babu, P N Sylaja, Biju Soman, Ravi Prasad Varma, Manju M S, G L Geethu, Suresh Kumar
BACKGROUND: There is little data on the use of smartphone-based applications for medication adherence and risk-factor control for the secondary prevention of stroke in low-and-middle-income countries (LMIC). AIMS: To determine whether a smartphone-based app improved medication adherence, risk-factor control, and provided health education to stroke survivors for lifestyle and behavioural modifications. METHODS: An unblinded, single-centre randomized controlled double arm trial with 1:1 allocation among stroke survivors was performed in South India...
March 27, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38506406/large-vessel-occlusive-stroke-with-milder-baseline-severity-show-better-collaterals-and-reduced-harm-from-thrombectomy-transfer-delays
#6
JOURNAL ARTICLE
Hannah R Rowling, Dominic Italiano, Leonid Churilov, Logesh Palanikumar, Jackson Harvey, Timothy Kleinig, Mark Parsons, Peter Mitchell, Stephen M Davis, Nyika Kruyt, Bruce Campbell, Henry Zhao
BACKGROUND: Patients with large vessel occlusion (LVO) stroke presenting with milder baseline clinical severity are common and require endovascular thrombectomy. However, such patients are difficult to recognize using pre-hospital severity-based triage tools and therefore are likely to require a secondary inter-hospital transfer if transported to a non-thrombectomy center. Given the potential for milder severity to represent better underlying cerebrovascular collateral circulation, it is unknown whether transfer delays are still associated with poorer post-stroke outcomes in this patient group...
March 20, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38503711/post-stroke-emotionalism-diagnosis-pathophysiology-and-treatment
#7
JOURNAL ARTICLE
Niall Broomfield, Joshua Blake, Fergus Gracey, Tom Steverson
Post-stroke emotionalism affects 1 in 5 stroke sufferers 6 months after their stroke, but despite its frequency remains a poorly understood stroke symptom. The literature is limited, especially compared to other frequently observed neurological conditions such as aphasia and visual neglect. This narrative review presents a summary of this literature, to inform clinical practice and future research. We cover discussion of definitions, prevalence, neurobiology, predisposing and precipitating factors, and treatment...
March 19, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38497344/trigger-factors-in-patients-with-a-patent-foramen-ovale-associated-stroke-a-case-crossover-study
#8
JOURNAL ARTICLE
Maikel Immens, Merel Sanne Ekker, Esmee Verburgt, Jamie Verhoeven, Mijntje Schellekens, Nina Hilkens, Esther Boot, Mayte van Alebeek, Paul J A M Brouwers, Renate Arntz, Gert van Dijk, Rob Gons, Inge van Uden, Tom den Heijer, Paul L M de Kort, K de Laat, Anouk Gw van Norden, Sarah E Vermeer, Marian van Zagten, Robert J van Oostenbrugge, Marieke Wermer, Paul J Nederkoorn, Henk Kerkhoff, F Rooyer, Frank van Rooij, Ido van den Wijngaard, Catharina Klijn, Anil M Tuladhar, Tim Ten Cate, Frank-Erik de Leeuw
BACKGROUND: Patent foramen ovale (PFO) is a congenital anatomical variant which is associated with strokes in young adults. Contrary to vascular risk factors and atherosclerosis, a PFO is present from birth. However, it is completely unknown how an anatomical structure that is already present at birth in a large proportion of the population, can convert into a PFO that causes stroke in a few. Recent studies reported a significant association between certain trigger factors and ischemic stroke in young adults...
March 18, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38497332/individual-patient-data-meta-analysis-of-the-effects-of-fluoxetine-on-functional-outcomes-after-acute-stroke
#9
JOURNAL ARTICLE
Gillian Elizabeth Mead, Catriona Graham, Erik Lundström, Graeme J Hankey, Maree L Hackett, Laurent Billot, Per Näsman, John Forbes, Martin Dennis
BACKGROUND: Three large randomised controlled trials of fluoxetine for stroke recovery have been performed. We perfomed an individual patient data meta-analysis (IPDM) on the combined data. METHODS: Fixed effects meta-analyses was performed on the combined data set, for the primary outcome (modified Rankin scale (mRS) at 6 months), and secondary outcomes common to the individual trials. As a sensitivity analysis, summary statistics from each trial were created and combined...
March 18, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38494462/reducing-the-global-burden-of-cerebral-venous-thrombosis-an-international-research-agenda
#10
JOURNAL ARTICLE
Jonathan M Coutinho, Anita van de Munckhof, Diana Aguiar de Sousa, Sven Poli, Sanjith Aaron, Antonio Arauz-Góngora, Adriana Conforto, Katarzyna Krzywicka, Sini Hiltunen, Erik Lindgren, Mayte Sanchez van Kammen, Liqi Shu, Tamam Bakchoul, Rosalie Belder, Rene van den Berg, Elisheva Boumans, Suzanne Cannegieter, Vanessa Cano-Nigenda, Thalia Shoshana Field, Isabel Fragata, Mirjam R Heldner, María Hernández-Pérez, Frederikus A Klok, Ronen R Leker, Lia Lucas Neto, Jeremy Molad, Thanh N Nguyen, Dirk-Jan Saaltink, Gustavo Saposnik, Pankaj Sharma, Jan Stam, Vincent Thijs, Michiel van der Vaart, David Werring, Diana Wong Ramos, Shadi Yaghi, Nilufer Yesilot, Turgut Tatlisumak, Jukka Putaala, Katarina Jood, Marcel Arnold, Jose M Ferro
BACKGROUND: Due to the rarity of cerebral venous thrombosis (CVT), performing high-quality scientific research in this field is challenging. Providing answers to unresolved research questions will improve prevention, diagnosis, and treatment, and ultimately translate to a better outcome of patients with CVT. We present an international research agenda, in which the most important research questions in the field of CVT are prioritized. AIMS: This research agenda has three distinct goals: (1) To provide inspiration and focus to research on CVT for the coming years; (2) To reinforce international collaboration; and (3) To facilitate the acquisition of research funding...
March 17, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38395748/stroke-and-high-risk-tia-outcomes-with-reduction-of-treatment-duration-when-treatment-initiated-in-emergency-rooms-shorter-study
#11
JOURNAL ARTICLE
Adel Alhazzani, Fahad S Alajlan, Ali M Alkhathaami, Fahmi Mohammed Al-Senani, Taim A Muayqil, Saeed A Alghamdi, Ammar AlKawi, Saeed AlZahrani, Majid Bakheet, Mohammed Aljohani, Nouran Taher, Abdulkarim Almutairi, Mustafa AlQarni, Sadiq Alsalman, Saeed A Alqahtani, Nouf Almansour, Laila Abukhamsin, Amr Mouminah, Nehal Almodarra, Gamal Mohamed, Meshal Almodhy, Eid Albogumi, Mohamad Alzawahmah, Abdulrahman Alreshaid, Naveed Akhtar, Muhammad Shazam Hussain, Gregory W Albers, Ashfaq Shuaib
BACKGROUND: Following transient ischemic attack (TIA) and minor stroke, the risk of recurrent stroke can be significantly reduced with short-duration dual antiplatelet therapy (DAPT). We wish to investigate whether 10 days of DAPT is as effective as 21 days' treatment. STUDY DESIGN: This is an open-label, randomized, parallel-group study comparing whether 10 days of DAPT treatment (ASA + clopidogrel) is non-inferior to 21 days of DAPT in patients with acute ischemic stroke (AIS) or high-risk TIA...
March 16, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38472157/safety-and-efficacy-of-tight-versus-loose-glycemic-control-in-acute-stroke-patients-a-meta-analysis-of-randomized-controlled-trials
#12
JOURNAL ARTICLE
Shuangzhe Wu, Yuke Mao, Sijia Chen, Peiyan Pan, Huiying Zhang, Siqi Chen, Jue Liu, Donghua Mi
BACKGROUND: Hyperglycemia is associated with worse stroke outcomes but it is uncertain whether tight glycaemic control during the acute stroke period is associated with a better outcome. We conducted a meta-analysis to compare the effect of tight glycemic control versus loose glycemic control in the acute phase of stroke patients. METHODS: A literature search was performed to identify randomized controlled trials (RCTs) comparing the safety and efficacy of tight glycemic control with a relatively loose control of blood glucose of acute stroke (ischemic or hemorrhagic) patients within 24 hours after stroke onset...
March 12, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38264861/andexanet-alfa-versus-non-specific-treatments-for-intracerebral-hemorrhage-in-patients-taking-factor-xa-inhibitors-individual-patient-data-analysis-of-annexa-4-and-tich-noac
#13
JOURNAL ARTICLE
Bernhard M Siepen, Alexandros Polymeris, Ashkan Shoamanesh, Stuart Connolly, Thorsten Steiner, Sven Poli, Robin Lemmens, Martina B Goeldlin, Madlaine Müller, Mattia Branca, Janis Rauch, Thomas Meinel, Johannes Kaesmacher, Werner Z'Graggen, Marcel Arnold, Urs Fischer, Nils Peters, Stefan T Engelter, Philippe Lyrer, David Seiffge
BACKGROUND: Data comparing the specific reversal agent andexanet alfa with non-specific treatments in patients with non-traumatic intracerebral hemorrhage (ICH) associated with factor-Xa inhibitor (FXaI) use are scarce. AIM: The study aimed to determine the association between the use of andexanet alfa compared with non-specific treatments with the rate of hematoma expansion and thromboembolic complications in patients with FXaI-associated ICH. METHODS: We performed an individual patient data analysis combining two independent, prospective studies: ANNEXA-4 (180 patients receiving andexanet alfa, NCT02329327) and TICH-NOAC (63 patients receiving tranexamic acid or placebo ± prothrombin complex concentrate, NCT02866838)...
March 8, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38444323/sensitivity-of-the-boston-criteria-version-2-0-in-dutch-type-hereditary-cerebral-amyloid-angiopathy
#14
JOURNAL ARTICLE
Reinier van der Zwet, Emma Koemans, Sabine Voigt, Rosemarie van Dort, Ingeborg Rasing, Kanishk Kaushik, Thijs van Harten, Manon Schipper, Gisela M Terwindt, Thijs van Osch, Marianne Aa van Walderveen, Ellis van Etten, Marieke Wermer
BACKGROUND AND AIM: The revised Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) add two radiological markers to the existing criteria: severe visible perivascular spaces in the centrum semiovale and white matter hyperintensities (WMH) in a multispot pattern. This study aims to determine the sensitivity of the updated criteria in mutation carriers with Dutch-type hereditary CAA (D-CAA) in an early and later disease stage. METHODS: In this cross-sectional study, we included presymptomatic and symptomatic D-CAA mutation carriers from our prospective natural history study (AURORA) at the Leiden University Medical Center between 2018 and 2021...
March 6, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38429253/edoxaban-for-the-treatment-of-hypercoagulability-and-cerebral-thromboembolism-associated-with-cancer-a-randomized-clinical-trial-of-biomarker-targets
#15
JOURNAL ARTICLE
Jong-Won Chung, Jaechun Hwang, Hyung Jun Kim, Woo-Keun Seo, Myung-Ju Ahn, Jeffrey L Saver, Oh Young Bang
BACKGROUND: This study aimed compare efficacy of edoxaban and enoxaparin upon biomarkers of hypercoagulability in patients with cancer-related embolic stroke of undetermined source (ESUS). METHODS: In this open-label, randomized, pilot trial, patients with cancer-related ESUS within 30 days of diagnosis were randomly assigned (1:1) to receive edoxaban (60mg once daily) or enoxaparin (1mg/kg twice daily) for 90 days. The primary endpoint was interval change of serum D-dimer level between day 0 and 7...
March 1, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38429252/association-of-ldl-cholesterol-1-8-mmol-l-and-statin-use-with-the-recurrence-of-intracerebral-hemorrhage
#16
JOURNAL ARTICLE
Tsz Ching Lee, William Cy Leung, Chun Ho, Megan Wl Chiu, Ian Yh Leung, Yuen Kwun Wong, Roxanna K C Liu, Christopher Hf Sum, David Tw Lui, Raymond Cheung, Gilberto Ka Kit Leung, Koon Ho Chan, Kay-Cheong Teo, G K K Lau
BACKGROUND: Recent intensive LDL-C lowering trials, including FOURIER, ODYSSEY OUTCOMES, and TST trials, have mostly refuted the concern surrounding statin use, low-density lipoprotein cholesterol (LDL-C) lowering, and intracerebral hemorrhage (ICH) risk. However, the results from these trials may not be fully applied to ICH survivors, as the populations studied were mainly patients without prior ICH, in whom the inherent ICH risk is more than ten times lower than that of ICH survivors...
March 1, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38425241/global-regional-and-national-burden-of-stroke-attributable-to-extreme-low-temperatures-1990-2019-a-global-analysis
#17
JOURNAL ARTICLE
Lue Zhou, Yujie Wei, Yahao Ge, Yapeng Li, Kai Liu, Yuan Gao, Bo Song, Yusheng Li, Daping Zhang, Yacong Bo, Junxi Zhang, Yuming Xu, Xiaoran Duan
BACKGROUND: Extreme ambient temperatures have been linked to increased risks of stroke morbidity and mortality. However, global estimates of the burden of stroke due to extreme low temperatures are not well-defined. AIMS: This study aimed to determine the global burden of stroke due to extreme low temperatures and its spatiotemporal trend from 1990 to 2019. METHODS: Based on the Global Burden of Disease Study 2019, we obtained global, regional, and national data on deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR), and age-standardized rate of DALYs (ASDR) of stroke attributed to extreme low temperatures, further stratified by age, sex, and sociodemographic index (SDI)...
March 1, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38425239/post-stroke-cognitive-impairment-remains-highly-prevalent-and-disabling-despite-state-of-the-art-stroke-treatment
#18
JOURNAL ARTICLE
Laura Gallucci, Christoph Sperber, Adrian G Guggisberg, Christoph P Kaller, Mirjam R Heldner, Andreas U Monsch, Arsany Hakim, Norbert Silimon, Urs Fischer, Marcel Arnold, Roza Umarova
BACKGROUND: State-of-the-art stroke treatment significantly reduces lesion size and stroke severity, but it remains unclear whether these therapeutic advances have diminished the burden of post-stroke cognitive impairment (PSCI). AIMS: In a cohort of patients receiving modern state-of-the-art stroke care including endovascular therapy, we assessed the frequency of PSCI and the pattern of domain-specific cognitive deficits, identified risk factors for PSCI, and determined the impact of acute PSCI on stroke outcome...
March 1, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38415357/global-regional-and-national-temporal-trends-of-diet-related-ischemic-stroke-mortality-and-disability-from-1990-to-2019
#19
JOURNAL ARTICLE
Rongguang Ge, Shoujiang You, Danni Zheng, Zengli Zhang, Yongjun Cao, Jie Chang
BACKGROUND: Stroke is the second-leading cause of death and the third-leading cause of disability in the general population worldwide. However, the changing trend of ischemic stroke burden attributable to various dietary risk factors has not been fully revealed and may contribute to a better understanding of stroke epidemiology. AIMS: Our paper aimed to evaluate the temporal trend of diet-related ischemic stroke burden to inform future research and policy-making...
February 28, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38353219/dabigatran-etexilate-versus-warfarin-in-cerebral-venous-thrombosis-in-chinese-patients-choice-cvt-an-open-label-randomized-controlled-trial
#20
JOURNAL ARTICLE
Hongrui Ma, Yaqin Gu, Tingting Bian, Haiqing Song, Zhi Liu, Xunming Ji, Jiangang Duan
BACKGROUND: The efficacy and safety of dabigatran etexilate for Chinese patients with cerebral venous thrombosis (CVT) has not been well established. METHODS: CHOICE-CVT was an exploratory, single-center, randomized, open-label study in the National Center for Neurological Disorders involving Chinese patients with CVT aged 18 to 80 years who were randomly assigned (1:1) to either dabigatran etexilate or warfarin. Oral anticoagulants were initiated after 10-15 days of LMWH...
February 26, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
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