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International Journal of Chronic Obstructive Pulmonary Disease

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https://read.qxmd.com/read/30774329/evaluation-of-plasma-antimicrobial-peptide-ll-37-and-nuclear-factor-kappab-levels-in-stable-chronic-obstructive-pulmonary-disease
#1
Pelin Uysal, Gonul Simsek, Sinem Durmus, Volkan Sozer, Hulya Aksan, Sibel Yurt, Caglar Cuhadaroglu, Filiz Kosar, Remise Gelisgen, Hafize Uzun
Background: Antimicrobial peptides are effectors of host defence against infection and inflammation and can encourage wound repair. Objectives: The objectives of this study were to investigate the plasma antimicrobial peptide LL-37 and nuclear factor-kappaB (NF-κB) levels in patients with stable COPD compared with a control group and to highlight their importance in immune inflammation. Methods: One hundred and thirty-eight stable COPD patients and 33 control subjects were enrolled in the study...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30774328/phenotyping-and-outcomes-of-hospitalized-copd-patients-using-rapid-molecular-diagnostics-on-sputum-samples
#2
Nawaf M Alotaibi, Virginia Chen, Zsuzsanna Hollander, Jonathon A Leipsic, Cameron J Hague, Darra T Murphy, Mari L DeMarco, J M FitzGerald, Bruce M McManus, Raymond T Ng, Don D Sin
Background: Etiologies of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are heterogeneous. We phenotyped severe AECOPD based on molecular pathogen detection of sputum samples collected at hospitalization of COPD patients and determined their outcomes. Methods: We phenotyped 72 sputum samples of COPD patients who were hospitalized with a primary diagnosis of AECOPD using a molecular array that detected common bacterial and viral respiratory pathogens...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30774327/short-term-effects-of-ambient-air-pollution-on-chronic-obstructive-pulmonary-disease-admissions-in-beijing-china-2013-2017
#3
Nannan Gao, Chunhou Li, Jiadong Ji, Yanli Yang, Shaoting Wang, Xinlun Tian, Kai-Feng Xu
Purpose: Evidence between air pollution and COPD admissions is inconsistent and limited in China. In this study, we aimed to explore the effects of air pollutants on COPD admissions in Beijing, China. Patients and methods: Daily COPD hospital admission visits derived from tertiary and secondary hospitals in Beijing were retrieved from January 2013 to February 2017. Air pollutant levels and meteorological data over the same periods were also achieved. Generalized additive model was applied to estimate the percentage changes with 95% CIs in daily admissions corresponding to 10 µg/m3 increases in pollutants levels [1 mg/m3 in carbon monoxide (CO)], stratified by age, gender, and season...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30774326/efficacy-of-a-home-discharge-care-bundle-after-acute-exacerbation-of-copd
#4
Stéphanie Cousse, André Gillibert, Mathieu Salaün, Luc Thiberville, Antoine Cuvelier, Maxime Patout
Purpose: Acute exacerbations of COPD (AECOPD) are frequent and associated with a poor prognosis. A home discharge care bundle, the PRADO-BPCO program, has been set up by the French National Health System in order to reduce readmission rate after hospitalization for AECOPD. This program includes early consultations by the general practitioner, a nurse, and a physiotherapist after discharge. The aim of our study was to evaluate the effect of the PRADO-BPCO program on the 28-days readmission rate of COPD patients after hospitalization for AECOPD...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30774325/changes-in-copd-inhaler-prescriptions-in-the-united-kingdom-2000-to-2016
#5
Chloe I Bloom, S L Elkin, J K Quint
Background: Over the past two decades, there have been significant changes in the pharmacological management of COPD, due to an explosion of inhaler trials, and timely updation of national and international guidelines. We sought to describe temporal changes in prescribing practices in the United Kingdom, and some of the factors that may have influenced them. Patients and methods: COPD patients were identified from UK primary care nationally representative electronic healthcare records (Clinical Practice Research Datalink), between 2000 and 2016...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30774324/minimal-clinically-important-difference-of-3-minute-chair-rise-test-and-the-direct-questionnaire-after-pulmonary-rehabilitation-in-copd-patients
#6
Jonathan Lévesque, Anestis Antoniadis, Pei Zhi Li, Frédéric Herengt, Christophe Brosson, Jean-Marie Grosbois, Alain Bernady, Anthony Bender, Murielle Favre, Antoine Guerder, Pascale Surpas, Thomas Similowski, Bernard Aguilaniu
Background: The 3-minute chair rise test (3-minute CRT) and the Disability Related to COPD Tool (DIRECT) are two reproducible and valid short tests that can assess the benefit of pulmonary rehabilitation (PR) in terms of functional capacity and dyspnea in everyday activities. Methods: We determined the minimal clinically important difference (MCID) of the DIRECT questionnaire and 3-minute CRT using distribution methods and anchor encroaches with a panel of eight standard tests in a cohort of 116 COPD patients who completed a PR program in real-life settings...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30718953/male-current-smokers-have-low-awareness-and-optimistic-bias-about-copd-field-survey-results-about-copd-in-korea
#7
Yong Il Hwang, Yong Bum Park, Hyoung Kyu Yoon, Tae-Hyung Kim, Kwang Ha Yoo, Chin Kook Rhee, Joo Hun Park, Seung Hun Jang, Sunghoon Park, Joo-Hee Kim, Jiyoung Park, Ki-Suck Jung
Background: Smoking is a major risk factor for COPD. However, there is low COPD awareness among smokers. We conducted a field survey to investigate COPD awareness, optimistic bias associated with COPD, and COPD prevalence (using handheld spirometry) among current male smokers. Subjects and methods: We enrolled currently smoking males aged over 40 years, who completed a self-administered questionnaire. The questionnaire consisted of six parts: 1) baseline demographics, 2) participants' awareness of COPD and pulmonary function tests, 3) presence of COPD-related respiratory symptoms and experience with pulmonary function testing, 4) optimistic bias about COPD, 5) willingness to change attitude toward respiratory health, and 6) preference of media for obtaining health-related information...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30718952/real-life-effectiveness-of-indacaterol-glycopyrronium-after-switching-from-tiotropium-or-salmeterol-fluticasone-therapy-in-patients-with-symptomatic-copd-the-power-study
#8
Alan Kaplan, Kenneth R Chapman, Syed M Anees, Irvin Mayers, Driss Rochdi, Michel Djandji, David Préfontaine, Andrew McIvor
Purpose: In contrast to randomized controlled trials (RCTs), changes in maintenance pharmacotherapy in clinical practice occur without a washout period. The Prospective cohort study for the real-life effectiveness evaluation of glycOpyrronium With indacatERol combination in the management of COPD in Canada (POWER) study evaluated the real-life effectiveness of indacaterol/glycopyrronium (IND/GLY) following a direct switch from a long-acting muscarinic antagonist (LAMA, tiotropium) or long-acting β2 -agonist (LABA)/inhaled corticosteroid (ICS) maintenance treatment (salmeterol/fluticasone [SFC])...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30718951/erratum-chronic-obstructive-pulmonary-disease-with-mild-airflow-limitation-current-knowledge-and-proposal-for-future-research-a-consensus-document-from-six-scientific-societies-corrigendum
#9
(no author information available yet)
[This corrects the article on p. 2593 in vol. 12, PMID: 28919728.].
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30718950/erratum-bronchiectasis-in-copd-patients-more-than-a-comorbidity-corrigendum
#10
(no author information available yet)
[This corrects the article on p. 1401 in vol. 12, PMID: 28546748.].
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30718949/erratum-russian-guidelines-for-the-management-of-copd-algorithm-of-pharmacologic-treatment-corrigendum
#11
(no author information available yet)
[This corrects the article on p. 183 in vol. 13, PMID: 29386887.].
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30718948/erratum-respiratory-medication-used-in-copd-patients-from-seven-latin-american-countries-the-lassyc-study-corrigendum
#12
(no author information available yet)
[This corrects the article on p. 1545 in vol. 13, PMID: 29785104.].
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30718947/erratum-joint-statement-for-the-diagnosis-management-and-prevention-of-chronic-obstructive-pulmonary-disease-for-gulf-cooperation-council-countries-and-middle-east-north-africa-region-2017-corrigendum
#13
(no author information available yet)
[This corrects the article on p. 2869 in vol. 12, PMID: 29070946.].
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30697043/cost-effectiveness-of-physical-activity-in-the-management-of-copd-patients-in-the-uk
#14
Mafalda Ramos, Mark Lamotte, Laetitia Gerlier, Per Svangren, Anna Miquel-Cases, John Haughney
Background: While the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines advise exercise to reduce disease progression, little investment in promoting physical activity (PA) is made by health care authorities. The purpose of this study was to estimate the cost-effectiveness of regular PA vs sedentary lifestyle in people with COPD in the UK. Methods: Efficacy, quality of life, and economic evidence on the PA effects in COPD patients were retrieved from literature to serve as input for a Markov microsimulation model comparing a COPD population performing PA vs a COPD population with sedentary lifestyle...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30666102/nutritional-status-dietary-intake-and-health-related-quality-of-life-in-outpatients-with-copd
#15
Ha Thanh Nguyen, Peter F Collins, Toby G Pavey, Nhung Viet Nguyen, Tuong Duy Pham, Danielle L Gallegos
Background: Malnutrition is common in patients with COPD; however, little is known about its impacts on health-related quality of life (QoL) among patients with COPD. This study aimed to explore the nutritional status and dietary intake among outpatients with COPD in Vietnam and its possible associations with QoL. Methods: A cross-sectional study was carried out in COPD outpatients visiting the COPD management unit at the National Lung Hospital, Hanoi, Vietnam between May 2017 and July 2017...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30666101/is-iron-deficiency-modulating-physical-activity-in-copd
#16
Clara Martín-Ontiyuelo, Anna Rodó-Pin, Antonio Sancho-Muñoz, Juana María Martinez-Llorens, Mireia Admetlló, Lluis Molina, Joaquim Gea, Esther Barreiro, Diego A Rodríguez Chiaradía
There is evidence that iron plays a key role in the adequate functioning of skeletal muscle. While it has been demonstrated that nonanemic iron deficiency (NAID) affects exercise tolerance and response to exercise training in patients with COPD, the impact on daily physical activities (DPAs) remains unknown. Eighteen COPD patients with NAID (ferritin <100 ng/mL or ferritin 100-299 ng/mL with a transferrin saturation <20%) and 18 COPD patients without this abnormality, matched for age, gender, and the degree of airflow limitation (control group), were enrolled to the study...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30666100/a-randomized-trial-to-determine-the-impact-of-indacaterol-glycopyrronium-on-nighttime-oxygenation-and-symptoms-in-patients-with-moderate-to-severe-copd-the-duosleep-study
#17
Sverre Lehmann, Thomas Ringbæk, Anders Løkke, Ludger Grote, Jan Hedner, Eva Lindberg
Purpose: This study investigated the effect of dual bronchodilation with the long-acting β-receptor agonist/long-acting muscarinic antagonist combination, indacaterol/glycopyrronium (IND/GLY), on nighttime oxygenation, lung function, sleep quality, and symptoms in patients with moderate-to-severe COPD. Patients and methods: This was a 4-week, double-blind, multicenter, placebo-controlled, two-period crossover study. Patients were randomized in a 1:1 ratio to receive IND/GLY 110/50 µg once daily or matching placebo...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30662260/rating-sputum-cell-quality-in-clinical-trials-for-asthma-and-copd-treatment
#18
Frauke Pedersen, Ulrich M Zissler, Henrik Watz, Klaus F Rabe, Jens M Hohlfeld, Olaf Holz
No abstract text is available yet for this article.
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30655665/effects-of-baseline-symptom-burden-on-treatment-response-in-copd
#19
Fernando J Martinez, Roger A Abrahams, Gary T Ferguson, Leif Bjermer, Lars Grönke, Florian Voß, Dave Singh
Rationale: In symptomatic patients with COPD, the decision whether to initiate maintenance treatment with a single agent or a combination of long-acting bronchodilators remains unclear. Objective: To investigate whether baseline symptomatic status influences response to tiotropium/olodaterol treatment. Materials and methods: Post hoc analysis of the randomized OTEMTO® studies (NCT01964352; NCT02006732), in which patients with moderate-to-severe COPD received placebo, tiotropium 5 µg, tiotropium/olodaterol 2...
2019: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/30655664/the-association-between-recent-hospitalized-copd-exacerbations-and-adverse-outcomes-after-percutaneous-coronary-intervention-a-nationwide-cohort-study
#20
Wei-Chieh Lin, Chang-Wen Chen, Chin-Li Lu, Wu-Wei Lai, Min-Hsin Huang, Liang-Miin Tsai, Chung-Yi Li, Chao-Han Lai
Purpose: COPD is associated with coronary artery disease, and exacerbations are major events in COPD. However, the impact of recent hospitalized exacerbations on outcomes of percutaneous coronary intervention (PCI) remains underdetermined. Patients and methods: Using the National Health Insurance Research Database of Taiwan, we identified 215,275 adult patients who underwent first-time PCI between 2000 and 2012. Among these patients, 15,485 patients had COPD. The risks of hospital mortality, overall mortality, and adverse cardiovascular outcomes after PCI (ie, ischemic events, repeat revascularization, cerebrovascular events, and major adverse cardiac and cerebrovascular events [MACCEs]) in relation to COPD, and the frequency and timing of recent hospitalized exacerbations within 1 year before PCI were estimated...
2019: International Journal of Chronic Obstructive Pulmonary Disease
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