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International Journal of Chronic Obstructive Pulmonary Disease

https://read.qxmd.com/read/38646606/characteristics-of-users-and-new-initiators-of-single-and-multiple-inhaler-triple-therapy-for-chronic-obstructive-pulmonary-disease-in-germany
#1
JOURNAL ARTICLE
Kai-Michael Beeh, Kieran J Rothnie, Jing Claussen, Fränce Hardtstock, Rachel K Knapp, Thomas Wilke, Alexandrosz Czira, Chris Compton, Afisi S Ismaila
PURPOSE: To assess patient characteristics of users and new initiators of triple therapy for chronic obstructive pulmonary disease (COPD) in Germany. PATIENTS AND METHODS: Retrospective cohort study of patients with COPD and ≥1 prescription for single-inhaler triple therapy (SITT; fluticasone furoate/umeclidinium/vilanterol [FF/UMEC/VI] or beclomethasone dipropionate/glycopyrronium bromide/formoterol [BDP/GLY/FOR]) or multiple-inhaler triple therapy (MITT), using data from the AOK PLUS German sickness fund (1 January 2015-31 December 2019)...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38646605/neutrophil-to-lymphocyte-ratio-nlr-platelet-to-lymphocyte-ratio-plr-and-monocyte-to-lymphocyte-ratio-mlr-as-biomarkers-in-diagnosis-evaluation-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-a-retrospective-observational-study
#2
JOURNAL ARTICLE
Chuang Cai, Wentan Zeng, Hongwei Wang, Shuqi Ren
PURPOSE: Hierarchical management is advocated in China to effectively manage chronic obstructive pulmonary disease (COPD) patients and reduce the incidence and mortality of acute exacerbation of COPD (AE-COPD). However, primary and community hospitals often have limited access to advanced equipment and technology. Complete blood count (CBC), which is commonly used in these hospitals, offers the advantages of being cost-effective and easily accessible. This study aims to evaluate the significance of routine blood indicators in aiding of diagnosing AE-COPD...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38633565/correlation-between-hif1-a-expression-and-airway-remodeling-in-copd
#3
JOURNAL ARTICLE
Lingfang Tan, Xuefeng Yang, Jianxin Zhang, Kebing Zhou
BACKGROUND: Airway remodeling is a significant pathological characteristic of chronic obstructive pulmonary disease (COPD). In recent years, hypoxia-inducible factor 1-α (HIF-1α), a member of the hypoxia-inducible factor protein family, has gained attention. However, the potential correlation between HIF-1α and COPD airway remodeling remains unclear. OBJECTIVE: This study explored the expression patterns of HIF-1α in patients with COPD and its association with airway remodelling...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38628984/association-of-frailty-with-patient-report-outcomes-and-major-clinical-determinants-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#4
JOURNAL ARTICLE
Mengjiao Yang, Yang Liu, Yangyang Zhao, Ziwei Wang, Jie He, Yali Wang, Tokie Anme
PURPOSE: This study aimed to explore the correlation of frailty status with disease characteristics and patient-reported outcomes (PROs) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and determine the sensitivity and specificity of modified COPD PRO scale (mCOPD-PRO) for detecting frailty. PATIENTS AND METHODS: This cross-sectional study surveyed 315 inpatients with AECOPD from a tertiary hospital in China from August 2022 to June 2023...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38623318/neutrophil-lymphocyte-ratio-as-a-predictive-biomarker-of-niv-failure-in-aecopd-the-unveiled-facts-letter
#5
JOURNAL ARTICLE
Dipasri Bhattacharya, Antonio M Esquinas, Mohanchandra Mandal
No abstract text is available yet for this article.
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38617018/long-term-sgrq-stability-in-a-cohort-of-individuals-with-alpha-1-antitrypsin-deficiency-associated-lung-disease
#6
JOURNAL ARTICLE
Radmila Choate, Kristen E Holm, Robert A Sandhaus, David M Mannino, Charlie Strange
BACKGROUND: Health-related quality of life (HRQoL) assessments such as St. George's Respiratory Questionnaire (SGRQ) are often used as outcome measures to evaluate patient-perceived changes in health status among individuals with lung disease. Several factors have been linked to deterioration in SGRQ, including symptoms (dyspnea, wheezing) and exercise intolerance. Whether these findings apply to individuals with alpha-1 antitrypsin deficiency (AATD) remains incompletely studied. This longitudinal study examines the trajectory of SGRQ scores in a cohort of United States individuals with AATD-associated lung disease and defines factors associated with longitudinal change...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38617017/prevalence-and-risk-factors-of-chronic-obstructive-pulmonary-disease-among-users-of-primary-health-care-facilities-in-morocco-letter
#7
JOURNAL ARTICLE
Song Wang, Jing Song, Xiaolian Jiang
No abstract text is available yet for this article.
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38606168/prevalence-and-associated-factors-of-chronic-obstructive-pulmonary-disease-among-adults-in-neno-district-malawi-a-cross-sectional-analytical-study-response-to-letter
#8
COMMENT
Haules Robbins Zaniku, Emilia Connolly, Moses Banda Aron, Beatrice Matanje, Myness Kasanda Ndambo, George Talama, Fabien Munyaneza, Todd Ruderman, Jamie Rylance, Luckson Dullie, Rejani Lalitha, Ndaziona Peter Kwanjo Banda, Adamson S Muula
No abstract text is available yet for this article.
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38596204/multidimensional-frailty-instruments-can-predict-acute-exacerbations-within-one-year-in-patients-with-stable-chronic-obstructive-pulmonary-disease-a-retrospective-longitudinal-study
#9
JOURNAL ARTICLE
Lujie Wei, Pingyang Li, Xiaofeng Liu, Yuxia Wang, Zhengping Tang, Hang Zhao, Lu Yu, Kaixiu Li, Jianping Li, Min Du, Xinzhu Chen, Xin Zheng, Yixiong Zheng, Yao Luo, Jing Chen, Xiamin Jiang, Xiaobing Chen, Huaicong Long
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is closely associated with frailty, and prevention of acute exacerbations is important for disease management. Moreover, COPD patients with frailty experience a higher risk of acute exacerbations. However, the frailty instruments that can better predict acute exacerbations remain unclear. PURPOSE: (1) To explore the factors influencing frailty and acute exacerbations in stable COPD patients, and (2) quantify the ability of multidimensional frailty instruments to predict acute exacerbations within 1 year...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38596203/promising-intestinal-microbiota-associated-with-clinical-characteristics-of-copd-through-integrated-bioinformatics-analysis
#10
JOURNAL ARTICLE
Tianwen Lai, Chaole Luo, Yalian Yuan, Jia Fang, Yun Wang, Xiantong Tang, Lihuan Ouyang, Keyan Lin, Bin Wu, Weimin Yao, Ruina Huang
INTRODUCTION: Chronic obstructive pulmonary disease (COPD), an incurable chronic respiratory disease, has become a major public health problem. The relationship between the composition of intestinal microbiota and the important clinical factors affecting COPD remains unclear. This study aimed to identify specific intestinal microbiota with high clinical diagnostic value for COPD. METHODS: The fecal microbiota of patients with COPD and healthy individuals were analyzed by 16S rDNA sequencing...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38596202/can-the-ado-index-be-used-as-a-predictor-of-mortality-from-covid-19-in-patients-with-copd
#11
MULTICENTER STUDY
Esra Ertan Yazar, Gulsah Gunluoglu, Burcu Arpinar Yigitbas, Mukadder Calikoglu, Gazi Gulbas, Nilgün Yılmaz Demirci, Nurhan Sarioglu, Fulsen Bozkus, Nevin Taci Hoca, Nalan Ogan, Seda Tural Onur, Muzaffer Onur Turan, Filiz Kosar, Evrim Eylem Akpinar, Burak Mete, Can Ozturk
BACKGROUND: Several studies have shown that the risk of mortality due to COVID-19 is high in patients with COPD. However, evidence on factors predicting mortality is limited. RESEARCH QUESTION: Are there any useful markers to predict mortality in COVID-19 patients with COPD?. STUDY DESIGN AND METHODS: A total of 689 patients were included in this study from the COPET study, a national multicenter observational study investigating COPD phenotypes consisting of patients who were followed up with a spirometry-confirmed COPD diagnosis...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38566847/use-of-ecological-momentary-assessment-to-measure-dyspnea-in-copd
#12
JOURNAL ARTICLE
Sarah N Miller, Michelle Nichols, Ronald J Teufel Ii, Erin P Silverman, Marta Walentynowicz
Dyspnea is an unpredictable and distressing symptom of chronic obstructive pulmonary disease (COPD). Dyspnea is challenging to measure due to the heterogeneity of COPD and recall bias associated with retrospective reports. Ecological Momentary Assessment (EMA) is a technique used to collect symptoms in real-time within a natural environment, useful for monitoring symptom trends and risks of exacerbation in COPD. EMA can be integrated into mobile health (mHealth) platforms for repeated data collection and used alongside physiological measures and behavioral activity monitors...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38562440/comparison-of-the-application-of-vibrating-mesh-nebulizer-and-jet-nebulizer-in-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Zhouzhou Feng, Zhengcai Han, Yaqin Wang, Hong Guo, Jian Liu
OBJECTIVE: To comparison of the application of Vibrating Mesh Nebulizer and Jet Nebulizer in chronic obstructive pulmonary disease (COPD). RESEARCH METHODS: This systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statements. The primary outcome measures analyzed included: The amount of inhaler in the urine sample at 30 minutes after inhalation therapy (USAL0.5), The total amount of inhaler in urine sample within 24 hours (USAL24), Aerosol emitted, Forced expiratory volume in 1 second (FEV1 ), Forced vital capacity (FVC)...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38544929/silencing-klf6-alleviates-cigarette-smoke-extract-induced-mitochondrial-dysfunction-in-bronchial-epithelial-cells-by-sirt4-upregulation
#14
JOURNAL ARTICLE
Menghong Wan, Chen Wang, Jiamin Cui, Qing Xia, Lei Zhang
BACKGROUND: The incidence of chronic obstructive pulmonary disease (COPD) is increasing year by year. Kruppel-like factor 6 (KLF6) plays an important role in inflammatory diseases. However, the regulatory role of KLF6 in COPD has not been reported so far. METHODS: The viability of human bronchial epithelial cells BEAS-2B induced by cigarette smoke extract (CSE) was detected by CCK-8 assay. The protein expression of KLF6 and sirtuin 4 (SIRT4) was appraised with Western blot...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38529479/inhibitory-effect-of-p22077-on-airway-inflammation-in-rats-with-copd-and-its-mechanism
#15
JOURNAL ARTICLE
Di Zeng, Wenbo Zhang, Xiaoju Chen, Guochun Ou, Yuewei Huang, Chengxiu Yu
PURPOSE: Here, we studied the pharmacological effect of P22077 on airway inflammation induced by lipopolysaccharide and cigarette smoke and explored the therapeutic mechanism of P22077 in COPD model RAT. PATIENTS AND METHODS: The COPD model was established by lipopolysaccharide combined with fumigation; animals were treated with vehicle or P22077. Serum, bronchoalveolar lavage fluid (BALF), and lung tissues were collected for analysis. RESULTS: Our results showed that P22077 treatment significantly improved the airway inflammation of COPD model RAT and reduced the recruitment of leukocytes in BALF, and hypersecretion of interleukin-18 (IL-18), interleukin-1β (IL-1β) in BALF and serum...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38529478/network-pharmacology-and-experimental-verification-reveal-the-regulatory-mechanism-of-chuanbeimu-in-treating-chronic-obstructive-pulmonary-disease
#16
JOURNAL ARTICLE
Meilan Xian, Jiaoyuan Xu, Yamei Zheng, Lei Zhang, Jie Zhao, Jie Chen, Siguang Li, Lingsang Lin, Yi Zhong, Zehua Yang, Tian Xie, Linhui Huang, Yipeng Ding
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder in pulmonology. Chuanbeimu (CBM) is a traditional Chinese medicinal herb for treating COPD and has been widely utilized in clinical practice. However, the mechanism of CBM in the treatment of COPD remains incompletely understood. This study aims to investigate the underlying therapeutic mechanism of CBM for COPD using network pharmacology and experimental approaches. METHODS: Active ingredients and their targets were obtained from the Traditional Chinese Medicine Systems Pharmacology database...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38524399/a-cross-sectional-study-evaluating-the-association-of-brachial-artery-flow-mediated-vasodilation-with-physical-activity-measured-by-accelerometry-in-patients-with-the-overlap-of-obstructive-sleep-apnea-and-chronic-obstructive-pulmonary-disease
#17
JOURNAL ARTICLE
Madalina Macrea, Atul Malhotra, Richard ZuWallack, Krisann Oursler, Richard Casaburi
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Overlap Syndrome (OS), the co-occurrence of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease. Clustering of patients in subgroups with similar pre-clinical manifestations (ie, endothelial dysfunction) may identify relevant therapeutic phenotype categories for patients with OS who are at high risk of CVD. We therefore conducted a cross-sectional pilot study of endothelial function in 7 patients with OS (Forced Expiratory Volume in 1 second/Forced Vital Capacity < 0...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38524398/high-blood-eosinophil-count-at-stable-state-is-not-associated-with-airway-microbiota-distinct-profile-in-copd
#18
JOURNAL ARTICLE
Jeanne-Marie Perotin, Anaëlle Muggeo, Quentin Lecomte-Thenot, Audrey Brisebarre, Sandra Dury, Claire Launois, Julien Ancel, Valérian Dormoy, Thomas Guillard, Gaëtan Deslee
PURPOSE: The heterogeneity of clinical features in COPD at stable state has been associated with airway microbiota. Blood eosinophil count (BEC) represents a biomarker for a pejorative evolution of COPD, including exacerbations and accelerated FEV1 decline. We aimed to analyse the associations between BEC and airway microbiota in COPD at stable state. PATIENTS AND METHODS: Adult COPD patients at stable state (RINNOPARI cohort) were included and characterised for clinical, functional, biological and morphological features...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38524397/circular-rna-expression-of-peripheral-blood-mononuclear-cells-associated-with-risk-of-acute-exacerbation-in-smoking-chronic-obstructive-pulmonary-disease
#19
JOURNAL ARTICLE
Xu-Rui Shen, Ying-Ying Liu, Rui-Qi Qian, Wei-Yun Zhang, Jian-An Huang, Xiu-Qin Zhang, Da-Xiong Zeng
PURPOSE: Circular RNAs (circRNAs) are newly identified endogenous non-coding RNAs that function as crucial gene modulators in the development of several diseases. By assessing the expression levels of circRNAs in peripheral blood mononuclear cells (PBMCs) from patients with chronic obstructive pulmonary disease (COPD), this study attempted to find new biomarkers for COPD screening. PATIENTS AND METHODS: We confirmed altered circRNA expression in PBMCs of COPD (n=41) vs controls (n=29)...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38505581/preserved-ratio-impaired-spirometry-prism-a-global-epidemiological-overview-radiographic-characteristics-comorbid-associations-and-differentiation-from-chronic-obstructive-pulmonary-disease
#20
REVIEW
Jia Huang, Wenjun Li, Yecheng Sun, Zhutang Huang, Rong Cong, Chen Yu, Hongyan Tao
Preserved Ratio Impaired Spirometry (PRISm) manifests notable epidemiological disparities across the globe, with its prevalence and influential factors showcasing pronounced diversities among various geographical territories and demographics. The prevalence of PRISm fluctuates considerably among regions such as Latin America, the United States, and Asian nations, potentially correlating with a myriad of determinants, including socioeconomic status, environmental factors, and lifestyle modalities. Concurrently, the link between PRISm and health risks and other disorders, especially its distinction and interrelation with chronic obstructive pulmonary disease (COPD), has become a pivotal subject of scientific enquiry...
2024: International Journal of Chronic Obstructive Pulmonary Disease
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