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Current Stem Cell Research & Therapy

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https://read.qxmd.com/read/30868961/the-roles-of-different-stem-cells-on-premature-ovarian-failure
#1
Cheng Zhang
Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogenism before the age of 40, which affects 1% of women in the general population. POF is complex and heterogeneous due to the pathogenetic mechanisms. And it is one of the significant causes for female infertility. Although many treatments are available for POF, the therapies are lower efficient and cause many side effects. Therefore, it is still urgent to found the effective therapeutics for POF. Stem cells have self-renewal and regeneration potential, and are effective for the treatment of ovarian failure and consequently infertility...
March 14, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30868962/suppression-of-tgf-%C3%AE-and-erk-signaling-pathways-as-a-new-strategy-to-provide-rodent-and-non-rodent-pluripotent-stem-cells
#2
Maryam Farzaneh, Zahra Derakhshan, Jamal Hallajzadeh, Neda Hosseini Sarani, Armin Nejabatdoust, Seyed Esmaeil Khoshnam
Stem cells are unspecialized cells and excellent model in developmental biology and a promising approach to the treatment of disease and injury. In the last 30 years, pluripotent embryonic stem (ES) cells were established from murine and primate sources, and display indefinite replicative potential and the ability to differentiate to all three embryonic germ layers. Despite large efforts in many aspects of rodent and non-rodent pluripotent stem cell culture, a number of diverse challenges remain. Natural and synthetic small molecules (SMs) strategy has the potential to overcome these hurdles...
March 13, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30854976/effects-of-extracellular-vesicles-derived-from-mesenchymal-stem-stromal-cells-on-liver-diseases
#3
Wenjie Zheng, Yumin Yang, Russel Clive Sequeira, Colin E Bishop, Anthony Atala, Zhifeng Gu, Weixin Zhao
Therapeutic effects of mesenchymal stem/stromal cells (MSCs) transplantation have been observed in various disease models. However, it is thought that MSCs-mediated effects largely depend on the paracrine manner of secreting cytokines, growth factors, and extracellular vesicles (EVs). Similarly, MSCs-derived EVs also showed therapeutic benefits in various liver diseases through alleviating fibrosis, improving regeneration of hepatocytes, and regulating immune activity. This review provides an overview of the MSCs, their EVs, and their therapeutic potential in treating various liver diseases including liver fibrosis, acute and chronic liver injury, and hepatocellular carcinoma (HCC)...
March 8, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30843493/the-prognostic-value-of-circulating-tumor-cells-in-primary-breast-cancer-prior-to-any-systematic-therapy-a-systematic-review
#4
Sepideh Mansouri, Parisa Mokhtari Hesari, Fatemeh Naghavi-Al-Hosseini, Keivan Majidzadeh-A, Leila Farahmand
BACKGROUND: Numerous studies have inclined the upstanding role of circulating tumor cells (CTC) in management of cancer, particularly the ones in association with primary tumor metastases. OBJECTIVE: The overall aim of the present study was to investigate whether CTCs may serve as a clinical prognostic marker for survival in primary breast cancer. METHOD: Articles Published from June 2011 to July 2017 in PubMed, EMBase, and Cochrane library databases were thoroughly screened for selecting the ones mitting the inclusion criteria...
March 5, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30834841/the-study-of-cellular-mechanism-of-triptolide-in-the-treatment-of-cancer-bone-loss-and-cardiovascular-disease-and-triptolide-s-toxicity
#5
Youhan Wang, Biao Wang, Xiaobin Yang
Triptolide (TPL), the active component of Tripterygium wilfordii Hook F (Twhf) has been used to treat cancer and bone loss conditions for over two hundred years in traditional Chinese medicine (TCM). In this paper, we reviewed the specific molecular mechanisms in the treatment of cancer, bone loss and cardiovascular disease. In addition, we analyze the toxicity of TPL and collect some optimized derivatives extracted from TPL. Although positive results were obtained in most cell culture and animal studies, further studies are needed to substantiate the beneficial effects of TPL...
March 1, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30827260/harnessing-stem-cells-and-neurotrophic-factors-with-novel-technologies-in-the-treatment-of-parkinson-s-disease
#6
Massimo Conese, Roberta Cassano, Elisabetta Gavini, Giuseppe Trapani, Giovanna Rassu, Enrico Sanna, Sante Di Gioia, Adriana Trapani
Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, oxidative stress and neuroinflammation. The classical therapeutic approach with L-DOPA is not able to control motor symptoms in the long term, thus new disease-modifying or neuroprotective treatments are urgently required in order to match such yet unmet clinical need. Success in cell-based therapy has been accomplished at a clinical level with human fetal mesencephalic tissue, but ethical issues and shortage of organs clearly underline the need for novel sources of dopaminergic neurons...
March 1, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30819086/emerging-role-of-mesenchymal-stem-cell-derived-exosomes-in-regenerative-medicine
#7
Ting Zhao, Feng Sun, Jinwen Liu, Tianyan Ding, Jie She, Fei Mao, Wenrong Xu, Hui Qian, Yongmin Yan
BACKGROUND: The recent studies have shown the great value of cell therapy over the past few decades. Mesenchymal stem cells (MSCs) have been reported to treat various degenerative diseases not through their differentiation potential but through their paracrine factors of extracellular vesicle (EV) including exosomes. Exosomes are nanosized (70~150 nm) membrane-bound extracellular vesicles, not only involved in cell-to-cell communication but also in the development of tissue injury repair...
February 27, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30806326/what-will-become-of-the-taxpayer-investment-in-public-cord-blood-stem-cell-banking
#8
David T Harris, Scott Israel
Cord blood (CB) is a unique and readily available source of hematopoietic stem cells for transplantation. CB also contains other types of stem cells, including endothelial stem cells and mesenchymal stem cells, that may prove useful in non-traditional clinical uses. Genetic and molecular analyses have demonstrated that CB stem cells lie somewhere between mature stem cells like those found in bone marrow (BM), and fetal stem cells. After 25 years of clinical experience CB is now used in the same fashion as BM for all typical malignant and genetic diseases treated by bone marrow transplant...
February 22, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30806325/therapeutic-potential-of-amniotic-fluid-derived-mesenchymal-stem-cells-based-on-their-differentiation-capacity-and-immunomodulatory-properties
#9
C Randall Harrell, Marina Gazdic, Crissy Fellabaum, Nemanja Jovicic, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic
BACKGROUND: Amniotic fluid derived mesenchymal stem cells (AF-MSCs) are adult, fibroblast-like, self-renewable, multipotent stem cells. During the last decade, therapeutic potential of AF-MSCs, based on their huge differentiation capacity and immunomodulatory characteristics, have been extensively explored in animal models of degenerative and inflammatory diseases. OBJECTIVE: In order to describe molecular mechanisms responsible for therapeutic effects of AF-MSCs, we summarized current knowledge about phenotype, differentiation potential and immunosuppressive properties of AF-MSCs...
February 22, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30806324/approaches-to-targeting-cancer-stem-cells-in-solid-tumors
#10
Eloisi Caldas-Lopes, Alexandra Gomez-Arteaga, Monica L Guzman
CSCs are a population of self-renewing and tumor repopulating cells that have been observed in hematologic and solid tumors and their presence contributes to the development of drug resistance. The failure to eliminate CSCs with conventional therapy is one of major obstacles in the successful treatment of cancer. Several mechanisms have been described to contribute to CSCs chemoresistance properties that include the adoption of drug-efflux pumps, drug detoxification pathways, changes in metabolism, improved DNA repair mechanisms, and deregulated survival and pro-apoptotic pathways...
February 22, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30767753/macrophages-on-bone-homeostasis
#11
Lingbo Kong, Youhan Wang, Wanli Smith, Dingjun Hao
Aberrant or prolonged immune responding has been proved involved in bone homeostasis. As a component of the innate immune system, macrophages play a critical role in bone homeostasis. Conventionally, according to response to various panel of stimuli, macrophages can be plastically classified as two major phenotypes: M1 and M2. M1 macrophages are generally pro-inflammatory, whereas M2 are anti-inflammatory. Although studies demonstrated both M1 and M2 phenotypes have been implicated in various inflammatory bone diseases, their direct role in bone homeostasis remains exploring...
February 14, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30767752/therapeutic-potential-of-endothelial-colony-forming-cells-derived-from-human-umbilical-cord-blood
#12
Jing Jia, Baitao Ma, Shaoshuai Wang, Ling Feng
Endothelial progenitor cells (EPCs) are implicated in mutiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs' characteristics, classification and origins, a summary of the progress in preclinical studies as regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-ECFCs) for ischemia repair, tissue engineering and tumor, and highlight the necessity to select high proliferative CB-ECFCs and to optimize their recovery and expansion conditions...
February 14, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30760192/endometrial-regeneration-in-asherman-s-syndrome-clinical-and-translational-evidence-of-stem-cell-therapies
#13
Xuejing Hou, Ying Liu, Isabelle Streuli, Patrick Dallenback, Jean Dubuisson, Yveline Ansaldi, Nicola Pluchino
Asherman's Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman's syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman's Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality...
February 12, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30674267/the-role-of-exosomes-in-diseases-related-to-infertility
#14
Jiayu Huang, Ying Gao
Exosomes, small extracellular vesicles with diameters of 40-100nm, are generated through the fusion of multivessel with plasma membrane and secreted by a variety of living cells. Exosomes contain lipid bilayer membrane and releasable functionally active proteins, mRNA and microRNAs (miRNAs). This article reviews the latest progress of researches on exosomes in diseases lead to infertility.
January 23, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30674266/bone-marrow-niches-for-skeletal-progenitor-cells-and-their-inhabitants-in-health-and-disease
#15
Marietta Herrmann, Franz Jakob
The bone marrow hosts skeletal progenitor cells which have most widely been referred to as mesenchymal stem or stromal cells (MSCs), a heterogeneous population of adult stem cells possessing potential for self-renewal and multilineage differentiation. A consensus agreement on minimal criteria has been suggested to define MSCs in vitro, including adhesion to plastic, expression of typical surface markers and the ability to differentiate towards the adipogenic, osteogenic and chondrogenic lineages but they are critically discussed since the differentiation capability of cells could not always be confirmed by stringent assays in vivo...
January 23, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30674265/the-expression-and-functional-roles-of-mirnas-in-embryonic-and-lineage-specific-stem-cells
#16
Maryam Farzaneh, Masoumeh Alishahi, Zahra Derakhshan, Neda Hosseini Sarani, Farnoosh Attari, Seyed Esmaeil Khoshnam
The discovery of small non-coding RNAs opened an interesting era in cellular and molecular biology. To date, miRNAs are the best recognized non-coding RNAs for maintenance and differentiation of pluripotent stem cells including embryonic stem cells (ES), induced pluripotent stem cells (iPSC), and cancer stem cells. ES cells are defined by their ability to self-renew, teratoma formation, and to produce numerous types of differentiated cells. Dual capacity of ES cells for self-renewal and differentiation is controlled by specific interaction with the neighboring cells and intrinsic signaling pathways from the level of transcription to translation...
January 23, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30636614/bioreactors-design-types-influencing-factors-and-potential-application-in-dentistry-a-literature-review
#17
Neeraj Malhotra
OBJECTIVES: A variety of bioreactors and related approaches have been applied to dental tissues as their use has become more essential in the field of regenerative dentistry and dental tissue engineering. The review discusses the various types of bioreactors and their potential application in dentistry. METHODS: Review of literature was conducting using keywords (and MeSH) like Bioreactor, Regenerative Dentistry, Fourth Factor, Stem Cells, etc., from the journals published in English...
January 10, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30608044/inflammatory-cytokines-and-biodegradable-scaffolds-in-dental-mesenchymal-stem-cells-priming
#18
Tatjana Kanjevac, Collin Gustafson, Ana Ivanovska, Francesca Ravanetti, Antonio Cacchioli, Darko Bosnakovski
Mesenchymal stem cells (MSC) are multipotent stem cells with wide-ranging clinical applications due to their ability to regenerate tissue from mesenchymal origin and their capability of suppressing immune responses, thus reducing the likelihood of graft versus host disease after transplantation. MSCs can be isolated from a variety of sources including bone marrow, adipose tissue, umbilical cord blood, and immature teeth. Dental stem cells (DSC) possess progenitor and immunomodulatory abilities as the other MSC types and because they can be easily isolated, are considered as attractive therapeutic agents in regenerative dentistry...
January 3, 2019: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30588888/the-effect-of-physical-cues-on-the-stem-cell-differentiation
#19
Mehrdad Moosazadeh Moghaddam, Shahin Bonakdar, Mona Rastegar Shariatpanahi, Mohammad Ali Shokrgozar, Shahab Faghihi
Development of multicellular organisms is a very complex and organized process during which cells respond to various factors and features in extracellular environments. It has been demonstrated that during embryonic evolvement, under certain physiological or experimental conditions, unspecialized cells or stem cells can be induced to become tissue or organ-specific cells with special functions. Considering the importance of physical cues in stem cell fate, the present study reviews the role of physical factors in stem cells differentiation and discusses the molecular mechanisms associated with these factors...
December 27, 2018: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/30684322/a-consideration-of-the-non-pregnant-human-uterus-as-a-stem-cell-source-for-medical-therapy
#20
Carol A Eisenberg, Leonard M Eisenberg
No abstract text is available yet for this article.
2019: Current Stem Cell Research & Therapy
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