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Journals
Clinical Journal of the Americ...
Clinical Journal of the American Society of Nephrology : CJASN
#41
JOURNAL ARTICLE
Sean J Barbour, Rosanna Coppo, Lee Er, Evangeline Pillebout, Maria Luisa Russo, Charles E Alpers, Agnes B Fogo, Franco Ferrario, J Charles Jennette, Ian S D Roberts, H Terence Cook, Jie Ding, Baige Su, Xuhui Zhong, Fernando C Fervenza, Ladan Zand, Licia Peruzzi, Laura Lucchetti, Ritsuko Katafuchi, Yuko Shima, Norishige Yoshikawa, Daisuke Ichikawa, Yusuke Suzuki, Luisa Murer, Robert J Wyatt, Catherine Park, Raoul D Nelson, JoAnn H Narus, Scott Wenderfer, Duvuru Geetha, Eric Daugas, Renato C Monteiro, Shinya Nakatani, Antonio Mastrangelo, Matti Nuutinen, Mikael Koskela, Lutz T Weber, Agnes Hackl, Martin Pohl, Carmine Pecoraro, Nobuo Tsuboi, Takashi Yokoo, Ito Takafumi, Shouichi Fujimoto, Giovanni Conti, Domenico Santoro, Marco Materassi, Hong Zhang, Sufang Shi, Zhi-Hong Liu, Vladimir Tesar, Dita Maixnerova, Carmen Avila-Casado, Ingeborg Bajema, Antonella Barreca, Jan U Becker, Jessica M Comstock, Virgilius Cornea, Karen Eldin, Loren Herrera Hernandez, Jean Hou, Kensuke Joh, Mercury Lin, Nidia Messias, Andrea Onetti Muda, Fabio Pagni, Francesca Diomedi-Camassei, Heikki Tokola, Maria D'Armiento, Maximilian Seidl, Avi Rosenberg, Aurélie Sannier, Maria Fernanda Soares, Suxia Wang, Caihong Zeng, Mark Haas
BACKGROUND: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. METHODS: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis ( N =361) from 23 centers in North America, Europe, and Asia were independently scored by three pathologists...
April 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#42
JOURNAL ARTICLE
Raad Chowdhury, Shruti Gupta
No abstract text is available yet for this article.
March 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#43
JOURNAL ARTICLE
Zhong Zheng, Krutika Pandit, Alex R Chang, Jung-Im Shin, David M Charytan, Morgan E Grams, Aditya Surapaneni
BACKGROUND: CKD has been implicated as a risk factor of venous thromboembolism, but the evidence is limited to relatively healthy populations. The objective of this study was to discern whether parameters of kidney function and damage are associated with the occurrence of venous thromboembolism after hospitalization. METHODS: We conducted a retrospective study including 23,899 and 11,552 adult individuals hospitalized within Geisinger Health System and New York University (NYU) Langone Health from 2004 to 2019 and 2012 to 2022, respectively...
March 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#44
JOURNAL ARTICLE
Janina Paula T Sy-Go, Simon Moubarak, Lisa E Vaughan, Nattawat Klomjit, Jason K Viehman, F C Fervenza, Ladan Zand
BACKGROUND: Little is known about the prognostic significance of monoclonal gammopathy of undetermined and renal significance (MGUS and MGRS) in patients with CKD. The objective of this study was to determine the clinical and kidney outcomes of patients with CKD with either MGUS or MGRS compared with those with CKD without MGUS or MGRS. METHODS: We conducted a retrospective cohort study from 2013 to 2018. Patients who had both CKD diagnosis and monoclonal testing were identified...
March 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#45
JOURNAL ARTICLE
Yan Lu, Javier A Neyra
No abstract text is available yet for this article.
March 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#46
JOURNAL ARTICLE
Jonathan Barratt, Adrian Liew, See Cheng Yeo, Anders Fernström, Sean J Barbour, C John Sperati, Russell Villanueva, Ming-Ju Wu, Dazhe Wang, Anna Borodovsky, Prajakta Badri, Elena Yureneva, Ishir Bhan, Daniel Cattran
BACKGROUND: IgA nephropathy is the most common primary GN. Clinical features of IgA nephropathy include proteinuria, which is the strongest known surrogate of progression to kidney failure. Complement pathway activation is a critical driver of inflammation and tissue injury in IgA nephropathy. Cemdisiran is an investigational RNA interference therapeutic that suppresses hepatic production of complement component 5 (C5), thereby potentially reducing proteinuria in IgA nephropathy. We evaluated the efficacy and safety of cemdisiran in adult patients with IgA nephropathy at high risk of kidney disease progression...
January 15, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#47
JOURNAL ARTICLE
Wendy Rodgers
No abstract text is available yet for this article.
January 12, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#48
JOURNAL ARTICLE
Rinaldo Bellomo, Ravindra L Mehta, Lui G Forni, Alexander Zarbock, Marlies Ostermann, Claudio Ronco
No abstract text is available yet for this article.
January 12, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#49
JOURNAL ARTICLE
Xin Bo Justin Cheng, Joanne Bargman
Peritoneal dialysis (PD) is a form of KRT that offers flexibility and autonomy to patients with ESKD. It is associated with lower costs compared with hemodialysis in many countries. However, it can be associated with unexpected interruptions to or discontinuation of therapy. Timely diagnosis and resolution are required to minimize preventable modality change to hemodialysis. This review covers mechanical complications, including leaks, PD hydrothorax, hernias, dialysate flow problems, PD-related pain, and changes in respiratory mechanics...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#50
JOURNAL ARTICLE
Emilie Trinh, Karine Manera, Nicole Scholes-Robertson, Jenny I Shen
Home dialysis offers several clinical and quality-of-life benefits for patients with kidney failure. However, it is important to recognize that home dialysis may place an increased burden on patients and their care partners. Sources of burden may include concerns about the ability to adequately and safely perform dialysis at home, physical symptoms, impairment of life participation, psychosocial challenges, and care partner burnout. Overlooking or failing to address these issues may lead to adverse events that negatively affect health and quality of life and reduce longevity of home dialysis...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#51
JOURNAL ARTICLE
Mohammad Azfar Qureshi, Serban Maierean, John H Crabtree, Alix Clarke, Sean Armstrong, Rachel Fissell, Arsh K Jain, Sarbjit V Jassal, Susie L Hu, Peter Kennealey, Scott Liebman, Brendan McCormick, Bogdan Momciu, Robert P Pauly, Beth Pellegrino, Jeffrey Perl, James L Pirkle, Troy J Plumb, Rebecca Seshasai, Ankur Shah, Nikhil Shah, Jenny Shen, Gurmukteshwar Singh, Karthik Tennankore, Jaime Uribarri, Murray Vasilevsky, Robert Yang, Robert R Quinn, Ashlie Nadler, Matthew J Oliver
BACKGROUND: This study investigated the association of intra-abdominal adhesions with the risk of peritoneal dialysis (PD) catheter complications. METHODS: Individuals undergoing laparoscopic PD catheter insertion were prospectively enrolled from eight centers in Canada and the United States. Patients were grouped based on the presence of adhesions observed during catheter insertion. The primary outcome was the composite of PD never starting, termination of PD, or the need for an invasive procedure caused by flow restriction or abdominal pain...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#52
JOURNAL ARTICLE
Christina M Yuan, Brian Y Young, Maura A Watson, Amy N Sussman
BACKGROUND: In 2022, the Accreditation Council for Graduate Medical Education (ACGME) reduced minimum program director protected time for program administration from 10 to 8 hours/week, with no core faculty requirement. We surveyed program leaders regarding the impact of these changes. METHODS: Anonymous, on-line survey of all US adult nephrology program directors (March 2023), who forwarded core faculty/associate program director surveys. Questions included protected time in 2022-23 and 2021-22, whether it was sufficient, estimated time needed, and two validated single-item burnout measures (emotional exhaustion and depersonalization)...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#53
JOURNAL ARTICLE
Xin Bo Justin Cheng, Joanne Bargman
Peritoneal dialysis (PD) is a form of KRT that offers flexibility and autonomy to patients with ESKD. It is associated with lower costs compared with hemodialysis in many countries. Unlike mechanical complications that typical arise early in the course of treatment, noninfectious, nonmechanical complications often present late in patients who are established on PD. In this review, we first discuss abnormal-appearing drained dialysate, including hemoperitoneum, chyloperitoneum, and noninfectious cloudy dialysate...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#54
JOURNAL ARTICLE
Tristan McIntosh, Heidi Walsh, Kari Baldwin, Ana Iltis, Sumit Mohan, Deirdre Sawinski, Melody Goodman, James M DuBois
BACKGROUND: Apolipoprotein L1 (ApoL1) variants G1 and G2 are associated with a higher risk of kidney disease. ApoL1 risk variants are predominantly seen in individuals with sub-Saharan African ancestry. In most transplant centers, potential organ donors are being selectively genetically tested for ApoL1 risk variants. Transplant programs have highly variable ApoL1 testing practices and need guidance on essential ApoL1 clinical policy questions. METHODS: We conducted a Delphi consensus panel focused on ApoL1 clinical policy questions, including who gets tested, who decides whether testing occurs, how test results are shared, who receives test results, and how test results are used...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#55
JOURNAL ARTICLE
Matthew B Rivara, Jonathan Himmelfarb
Although the past two decades have seen substantial proportional growth of home hemodialysis in the United States, the absolute number of patients treated with home hemodialysis remains small. Currently available stationary hemodialysis devices for use in the home have inherent limitations that represent barriers for more widespread adoption by a larger proportion of individuals with kidney failure. These limitations include device weight and bulk, ergonomics considerations, technical complexity, vascular access challenges, and limited remote patient monitoring...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#56
JOURNAL ARTICLE
Shailesh Agarwal, Laura Gillis, Martin Wilkie
People treated with peritoneal dialysis (PD) often have complicating conditions that require careful management. Three such conditions are reviewed in this article-diabetes mellitus, polycystic kidney disease, and chronic liver disease. Each of these conditions requires an understanding of both its effect on the delivery of the PD and the effect of the PD on the condition itself. In diabetes, glucose absorption from the dialysate complicates metabolic control and affects salt and water management and patient outcome...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#57
JOURNAL ARTICLE
Jaye M Platnich, Robert P Pauly
The success of a home hemodialysis program depends largely on a patient safety framework and the risk tolerance of a home dialysis program. Dialysis treatments require operators to perform dozens of steps repeatedly and reliably in a complex procedure. For home hemodialysis, those operators are patients themselves or their care partners, so attention to safety and risk mitigation is front of mind. While newer, smaller, and more user-friendly dialysis machines designed explicitly for home use are slowly entering the marketplace, teaching patients to perform their own treatments in an unsupervised setting hundreds of times remains a foundational programmatic obligation regardless of machine...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#58
JOURNAL ARTICLE
Lisa B Westenberg, Robert A Pol, Jessica van der Weijden, Martin H de Borst, Stephan J L Bakker, Marco van Londen
BACKGROUND: In most screening guidelines, high body mass index (BMI) is considered a contraindication for kidney donation. New insights suggest that central body fat distribution might provide greater power in assessing kidney risk. This study aimed to determine if BMI and central body fat distribution measures are associated with long-term kidney function after donor nephrectomy. We hypothesized that higher BMI, waist circumference, and waist-to-height ratio were associated with lower kidney function long-term after donation...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#59
JOURNAL ARTICLE
S Susan Hedayati
No abstract text is available yet for this article.
January 4, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#60
JOURNAL ARTICLE
Xin Bo Justin Cheng, Ibrahim Alrowiyti, Rose Faratro, Celine D'Gama, Christopher T Chan
No abstract text is available yet for this article.
January 3, 2024: Clinical Journal of the American Society of Nephrology: CJASN
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