journal
https://read.qxmd.com/read/37254553/osimertinib-induced-keratitis-and-secondary-toxic-epidermal-necrotic-drug-eruption-a-case-report-and-literature-review
#1
Yunhua Xu, Yong Li, Jie Luo, Rong Tang
BACKGROUND: Osimertinib is a third-generation Tyrosine Kinase inhibitor, mainly used in non-small cell lung cancer with EGFR mutation. Its efficacy and safety have been confirmed by clinical practice. Toxic epidermolysis necrotizing disease (TEN) is a severe drug eruption that is rare in clinics and has a high mortality rate. Toxic epidermal necrotic drug rash caused by Osimeritinib is even rarer. OBJECTIVE: To investigate the rare side effects of Osimertinib through a case of toxic Epidermal necrosis Case presentation: A 63-year-old female patient was diagnosed with lung adenocarcinoma with brain metastases, and genetic testing revealed an EGFR21 exon mutation...
May 29, 2023: Current Drug Safety
https://read.qxmd.com/read/37231751/adverse-effects-post-covid-19-vaccination-and-its-association-with-age-gender-and-comorbid-disease-in-basrah-city-southern-of-iraq
#2
JOURNAL ARTICLE
Zainab Najim Abdul-Nabi, Noor Kadhim Mohamed-Jawad, Noor Yousif Fareed, Nadheerah Falih Neama, Falah Hassan Shari
BACKGROUND: Vaccination against COVID-19 virus is the most valuable tool available for protection during the pandemic of coronavirus. The clinical manifestation post-vaccination is a barrier to vaccination for many people in Iraq and worldwide. OBJECTIVE: The objective of this study is identifying various clinical manifestations occurring after receiving vaccines among individuals in Basrah Governorate. Moreover, we examine its association with respondents' demographics and the type of vaccine they received...
May 25, 2023: Current Drug Safety
https://read.qxmd.com/read/37231731/penicillamine-induced-stevensjohnson-syndrome-toxic-epidermal-necrolysis-sjs-ten-overlap-in-an-hiv-infected-patient-with-wilson-s-disease-and-hepatitis-b
#3
Namrata Chhabra, P S Meghana Reddy, Ayush Bhatnagar, Satyaki Ganguly
INTRODUCTION: Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) are severe adverse drug reactions characterized by widespread blistering and mucositis. Wilson's disease is a rare, autosomal recessive disorder that results in excessive copper accumulation in the body, where penicillamine is an effective treatment option for copper chelation. Penicillamine-induced SJS-TEN is a rare but potentially fatal adverse effect. There is increased susceptibility to SJS/TEN in HIV infection due to immunosuppression and chronic liver disease due to impaired hepatic function...
May 25, 2023: Current Drug Safety
https://read.qxmd.com/read/37198992/remimazolam-and-remifentanil-use-induced-severe-respiratory-depression-and-laryngeal-spasm-during-intravenous-sedation-and-analgesia-a-case-report
#4
Zhijun Xin, Ning Wang, Huaizhou Wang
INTRODUCTION: Intravenous sedation and analgesia are widely used in minor surgeries. Remifentanil and remimazolam are advantageous in this setting because of their rapid onset of action, and short duration of action leading to a rapid recovery. However, the two drugs combined need to be titrated to avoid airway-related adverse events. CASE PRESENTATION: This article reports a case of severe respiratory depression and severe laryngeal spasm induced by remifentanil and remimazolam when they were used for analgesia and sedation in a patient undergoing oral biopsy...
May 17, 2023: Current Drug Safety
https://read.qxmd.com/read/37194235/methotrexate-induced-severe-pancytopenia-in-a-patient-with-rheumatoid-arthritis-a-case-report-and-review-of-literature
#5
JOURNAL ARTICLE
Elham Hosseini, Foroud Shahbazi
Toxicity associated with low doses of methotrexate (MTX) is low, but it may be fatal. Bone marrow suppression and mucositis are among the common side effects of low dose MTX toxicity. Different risk factors have been reported for toxicities associated with low doses of MTX, including accidental use of higher doses, renal dysfunction, hypoalbuminemia, and polypharmacy. In this paper, we present a female patient who had mistakenly used 7.5 mg of MTX daily instead of the same dose of MTX on Thursday and Friday...
May 16, 2023: Current Drug Safety
https://read.qxmd.com/read/37165593/concise-review-on-scientific-approaches-to-burns-and-scars
#6
JOURNAL ARTICLE
Hitesh Malhotra, Prerna Sharma, Mohammad Amjad Kamal, Peeyush Kaushik, Nidhi Rani
Burns are large open surgical lesions bathed in virulent pus that result in rupturing of the cutaneous membrane, which has serious consequences such as an extensive loss of proteins, and body fluids, increased chances of infections, and sometimes death. These can be classified based on their penetration levels, i.e., first-degree burns penetrating the epidermis, second-degree burns including both epidermis and dermis, third-degree burns to both layers including the hair follicular cells, sweat glands and various core tissues, fourth-degree burns to adipose tissue, fifth stage burns to muscles, and sixth stage burns to bones...
May 9, 2023: Current Drug Safety
https://read.qxmd.com/read/37151075/paracetamol-acetaminophen-associated-sjs-ten-agep-and-dress-syndromes-a-narrative-review
#7
JOURNAL ARTICLE
Naina Mohamed Pakkir Maideen, Ibrahim Ramadan Barakat, AbduRazak Hassan Jumale
INTRODUCTION: Paracetamol (Acetaminophen) is a very common OTC drug that is found in more than 200 OTC products sold as pain, cough and cold remedies. Paracetamol is commonly used as an antipyretic to reduce fever and as an alternative to Non-steroidal anti-inflammatory drugs (NSAIDs) that are contraindicated in certain patients to relieve mild-moderate pain. OBJECTIVE: This review article focuses on SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes associated with the use of paracetamol or paracetamol-containing products...
May 5, 2023: Current Drug Safety
https://read.qxmd.com/read/37138485/side-effects-reported-by-moroccan-medical-students-who-received-covid-19-vaccines
#8
JOURNAL ARTICLE
Badreddine Moukafih, Leila Belaroussi, Sanae Achour, Abdeslam El Kartouti
BACKGROUND: Low confidence in the safety of COVID-19 vaccines was found to be a key promoter of vaccine reluctance especially among youth. Furthermore, young adults are an important demographic for building herd immunity through vaccination. As a result, their reactions to getting COVID-19 vaccines are crucial in our fight against SARS-CoV-2 Materials and Methods: A cross-sectional survey-based study to assess the COVID-19 vaccines' short-term AEFIs among Moroccan medical and pharmacy students...
May 3, 2023: Current Drug Safety
https://read.qxmd.com/read/37132145/current-scenario-and-future-prospects-of-adverse-drug-reactions-adrs-monitoring-and-reporting-mechanisms-in-the-rural-areas-of-india
#9
JOURNAL ARTICLE
Shalini Shukla, Priyanka Sharma, Priya Gupta, Shikha Pandey, Reshu Agrawal, Deepak Rathour, Dharmendra Kumar Kewat, Ramu Singh, Sunil Kumar Thakur, Rishi Paliwal, Kunjbihari Sulakhiya
BACKGROUND: Pharmacovigilance (PV) deals with the detection, collection, assessment, understanding, and prevention of adverse effects associated with drugs. The objective of PV is to ensure the safety of the medicines and patients by monitoring and reporting all adverse drug reactions (ADRs) associated with prescribed medicine usage. Findings have indicated that about 0.2-24% of hospitalization cases are due to ADRs, of which 3.7% of patients have lethal ADRs. The reasons include the number of prescribed drugs, an increased number of new medicines in the market, an inadequate PV system for ADR monitoring, and a need for more awareness and knowledge about ADR reporting...
April 28, 2023: Current Drug Safety
https://read.qxmd.com/read/37078347/association-between-glucose-lowering-treatments-and-risk-of-diabetic-retinopathy-in-people-with-type-2-diabetes-a-nationwide-cohort-study
#10
JOURNAL ARTICLE
Jakob Hasselstrøm Jensen, Peter Vestergaard, Morten Hasselstrøm Jensen
Introduction Glycaemic variability is possibly linked to the development of diabetic retinopathy, and newer second-line glucose-lowering treatments in type 2 diabetes might reduce glycaemic variability. Aim This study aimed to investigate whether newer second-line glucose-lowering treatments are associated with an alternative risk of developing diabetic retinopathy in people with type 2 diabetes. Methods A nationwide cohort of people with type 2 diabetes on second-line glucose-lowering treatment regimens in 2008-2018 was extracted from the Danish National Patient Registry...
April 20, 2023: Current Drug Safety
https://read.qxmd.com/read/37076467/a-case-report-of-cefixime-paracetamol-and-nimesulide-induced-toxic-epidermal-necrolysis-in-a-woman-with-dengue-infection-without-any-other-associated-comorbidities
#11
Renuka Munshi, Miteshkumar Maurya
BACKGROUND: Toxic Epidermal Necrolysis (TEN) is a rare, acute, and life-threatening mucocutaneous disease that occurs after the administration of certain drugs, resulting in extensive keratinocyte cell death, skin involvement at the dermal-epidermal junction, and extensive bullous skin eruptions and sloughing. Many published case reports have observed the presence of fever with a viral infection, drug, and/or genetic association as a possible trigger for TEN but associated with other comorbidities...
April 18, 2023: Current Drug Safety
https://read.qxmd.com/read/37073669/immediate-reaction-to-propranolol-an-extremely-rare-but-important-condition-a-case-report
#12
Lucía González-Bravo, María-José Sánchez-González, José Barbarroja-Escudero, Josefa Monjo-Paz, Dorotea Matas-Dominguez, Melchor Alvarez-Mon
INTRODUCTION: Beta-blockers involve a group of drugs widely used nowadays. Propranolol was the first beta-blocker available in the market. It is the most prescribed first-generation betablocker and is commonly used. Beta-blocker allergy is extremely unusual. Only an isolated case of an urticaria reaction to propranolol has been published in 1975. CASE PRESENTATION: We present a 44-year-old man. In 2016, he was treated with a daily dose of 5 mg of propranolol prescribed for a diagnosis of essential tremor...
April 17, 2023: Current Drug Safety
https://read.qxmd.com/read/37070438/oral-linezolid-induced-early-onset-hepatic-encephalopathy-a-case-report-of-65-year-old-diabetic-female
#13
M Upadhyay, B Purohit, P Pargi
INTRODUCTION/BACKGROUND: Linezolid is increasingly utilized to treat gram-positive bacteria that are resistant to other antibiotics like vancomycin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus aureus as well as drug-resistant tuberculosis. It acts by inhibiting protein synthesis in bacteria. Although it is a relatively safe medicine, many reports of hepatotoxicity and neurotoxicity linked to long-term usage have been received but patients with pre-existing risk factors, such as diabetes and alcoholism, may have toxicity even after short-term use of linezolid...
April 17, 2023: Current Drug Safety
https://read.qxmd.com/read/37031384/the-safety-and-effectiveness-of-antifungal-medications-in-the-management-of-mucormycosis-during-the-covid-19-pandemic
#14
EDITORIAL
Dhanya Jose, Krishna S Nair, Alagesan Murali, Joseph M Pappachan
No abstract text is available yet for this article.
April 9, 2023: Current Drug Safety
https://read.qxmd.com/read/37038681/non-anca-leucocytoclasic-vasculitis-induced-by-sofosbuvir-ledipasvir-treatment-a-case-report
#15
Yosra Zaimi, Myriam Ayari, Nadine Ghithia, Shema Ayadi
BACKGROUND: The development of direct-acting antivirals directed against the Hepatitis C Virus has dramatically modified the therapeutic approach to chronic hepatic viral disease. Larger use of such drugs has also led to increasing reports about their adverse effects. This report aimed to describe a case of leucocytoclasic vasculitis following treatment based on the sofosbuvir/ledipasvir regimen with complete disappearance shortly after withdrawal in a 61-year-old patient treated for genotype 1 hepatitis C...
April 6, 2023: Current Drug Safety
https://read.qxmd.com/read/36999719/vitamin-d-deficiency-in-advanced-laryngeal-cancer-and-its-association-with-pharyngocutaneous-fistula-following-total-laryngectomy
#16
JOURNAL ARTICLE
Kamyar Iravani, Yaaghoob Khosravi, Aida Doostkam, Amir Soltaniesmaeili
BACKGROUND: Nutritional factors in developing some malignancies have been investigated recently. In this study, we evaluated the role of vitamin D in advanced laryngeal cancer and its association with the development of pharyngocutaneous fistula (PCF) following total laryngectomy. STUDY DESIGN: A cross-sectional, case-control study was conducted. METHOD: Fifty-five patients with advanced laryngeal cancer referred for total laryngectomy were included...
March 31, 2023: Current Drug Safety
https://read.qxmd.com/read/36999718/current-landscape-on-development-of-phenylalanine-and-toxicity-of-its-metabolites-a-review
#17
JOURNAL ARTICLE
Samrat Bose, Shirsendu Mandal, Rajesh Khan, Himangshu Sekhar Maji, Sumel Ashique
Phenylalanine, an essential amino acid, is the "building block" of protein. It has a tremendous role in different aspects of metabolic events. The tyrosine pathway is the prime one and is typically used to degrade dietary phenylalanine. Phenylalanine exceeds its limit in bodily fluids and the brain when the enzyme, phenylalanine decarboxylase, phenylalanine transaminase, phenylalanine hydroxylase (PAH) or its cofactor tetrahydrobiopterin (BH4) is deficient causes phenylketonuria, schizophrenia, attention-deficit/hyperactivity disorder and another neuronal effect...
March 31, 2023: Current Drug Safety
https://read.qxmd.com/read/36999717/covid-19-vaccination-program-for-children-an-electronic-assessment-of-symptoms
#18
JOURNAL ARTICLE
Naman Kumar, Arjun Khora, Riya Loomba, Nikhil Sharma, Abhishek Kumar, Ajay Rana, Rohit Kamboj, Sweta Kamboj, Kumar Guarve, Surya Prakash Guatam
BACKGROUND: The evolution of COVID-19 vaccinations, which are mostly seen as crucial to curb the epidemic, is a result of remarkable and ground-breaking researches by scientists around the world. The main goal of this study was to identify the significant adverse reactions of these vaccines, specifically in Homo sapiens. METHODS: In this research, a trial version of Qualtrics CoreXM software was used, and 18 questionnaires were prototyped as part of an online survey that was done in the northern part of India...
March 31, 2023: Current Drug Safety
https://read.qxmd.com/read/36999413/myocarditis-and-pericarditis-related-to-mrna-covid-19-vaccination-a-case-report
#19
Elena María Pérez López, Diego Rangel Sousa, Jorge Navarro Roldán
INTRODUCTION: Reported cases after the post-commercialization phase of mRNA vaccines against COVID-19 have revealed that myocarditis and pericarditis may occur predominantly in male adolescents after the second dose of the vaccine. CASE PRESENTATION: We report two cases of cardiac disorders associated with mRNA COVID-19 vaccination, both of them in 15 year-old males. One of the patients presented acute pericarditis and the second one presented acute myocarditis with left ventricular dysfunction at hospital discharge...
March 29, 2023: Current Drug Safety
https://read.qxmd.com/read/36896908/bleeding-complications-in-a-patient-after-the-unexpected-interaction-between-valproic-acid-and-phenprocoumon
#20
André Wieringa, Helle-Brit Fiebrich, Fleur van Gelder, Abraham J Valkenburg, Jan Gerard Maring, Elise J Smolders
BACKGROUND: Phenprocoumon is a vitamin K antagonist that is widely prescribed in Europe and Latin America for the prophylaxis and treatment of thromboembolic events. CASE PRESENTATION: A 90-year-old female was admitted to our hospital with tonic-clonic seizures, possibly due to dementia syndrome. DISCUSSION: Valproic acid (VPA) was prescribed for the treatment of seizures. VPA is an inhibitor of cytochrome P450 (CYP) 2C9 enzymes. A pharmacokinetic interaction with phenprocoumon occurred, which is a substrate for CYP2C9 enzymes...
March 10, 2023: Current Drug Safety
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