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Current Drug Safety

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https://read.qxmd.com/read/30767751/drug-induced-idiosyncratic-acute-liver-failure-a-challenging-and-distressing-scenario
#1
Carla Stefania Colaci, Manuel Mendizabal, Fernando Bessone
Idiosyncratic drug induced liver injury (DILI) is a rare adverse event to drugs that occasionally leads to severe liver damage, being one of the leading causes of acute liver failure (ALF) in developed countries. DILI is largely a diagnosis of exclusion. Thus, careful history of drug taking and ruling out other competing etiologies is mandatory given that DILI can present with an extremely variable phenotype. Several prognostic scores have been developed to promptly identify patients with potential risk of developing ALF...
February 14, 2019: Current Drug Safety
https://read.qxmd.com/read/30767750/citalopram-associated-alopecia-a-case-report-and-brief-literature-review
#2
Joshua Hekmatjah, Kinza Tareen, Ruqiya Shama Tareen
BACKGROUND: Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer improved side effect profile compared to older treatments, which improve patient adherence and quality of life. CASE REPORT: Here we discuss a case of an uncommon, but distressing side effect of citalopram. A 76-year old woman was referred to the psychiatry clinic for bizarre behavior. Patient was diagnosed with behavioral variant frontotemporal dementia, and was started on citalopram 20 mg and aripiprazole 5 mg daily...
February 14, 2019: Current Drug Safety
https://read.qxmd.com/read/30727914/metronidazole-induced-cerebellar-dysfunction-a-dose-related-phenomenon-or-a-pharmacogenetic-outcome
#3
Upinder Kaur, Ishan Kumar, Anup Singh, Mukesh Kumar, Sankha Shubhra Chakrabarti
Metronidazole, a widely used antibacterial and antiprotozoal drug, is often the drug of choice in amoebic liver abscess. The drug, otherwise safe, can cause serious central nervous disturbances in rare circumstances. Here we report a case of cerebellar dysfunction in the form of slurring of speech and episodes of falls, in an elderly male following a three-week course of metronidazole therapy. The patient manifested classic radiologic features of metronidazole neurotoxicity. Marked improvement in clinical symptoms were seen following drug discontinuation...
February 6, 2019: Current Drug Safety
https://read.qxmd.com/read/30727913/new-indices-for-ethnotoxicological-assessment-of-medicinal-plants-example-of-tafilalet-region-morocco
#4
Mohamed Eddouks, Mohammed Ajebli, Morad Hebi
BACKGROUND: several botanical species are poisonous and are used for medicinal purposes in traditional medicine. In fact, a relationship between toxicity and phytotherapeutic potent of medicinal plants exists. INTRODUCTION: Until now, there is no ethnopharmacological indices evaluating mathematically the toxic property of any medicinal plant used traditionally. Consequently, it is important to find this link trough the establishment and development of novel indices that put into consideration the relationship between toxicity and phytotherapy...
February 6, 2019: Current Drug Safety
https://read.qxmd.com/read/30727912/safety-of-sglt2-inhibitors-in-patients-with-diabetes-mellitus
#5
Mahakpreet Singh, Ruchika Sharma, Anoop Kumar
BACKGROUND: Recently, Food and Drug Administration (FDA) has approved sodium/glucose co-transporter 2 (SGLT2) inhibitors for the treatment of diabetes mellitus. However, regarding adverse drug reactions (ADRs) of SGLT2 inhibitors in large group of population, very less information is available. Thus, we have tried to find out the risk profile of SGLT 2 inhibitors. MATERIAL & METHODS: A total of 1,042 studies have been published from Nov. 2012-Nov.2017 regarding SGLT2 inhibitors...
February 6, 2019: Current Drug Safety
https://read.qxmd.com/read/30706827/drug-rash-with-eosinophilia-and-systemic-symptoms-dress-syndrome-induced-by-imatinib
#6
F Zgolli, I Aouinti, O Charfi, T Badri, S Elaidli, G Lakhoua, S Kastalli, A Zaïem
Imatinib is the treatment of choice in patients with locally advanced or metastatic gastrointestinal stromal tumours (GIST). Clinical tolerance of imatinib is excellent except the common adverse drug reaction (ADR). Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a severe, potentially life-threatening drug-induced hypersensitivity reaction, characterized by cutaneous eruptions, fever, diffuse lymphadenopathy, along with eosinophilia, and elevated liver function tests. This ADR is rarely reported with imatinib...
January 30, 2019: Current Drug Safety
https://read.qxmd.com/read/30666916/depression-antidepressants-and-hypertensive-disorders-of-pregnancy-a-systematic-review
#7
Sabrina Youash, Verinder Sharma
BACKGROUND: Hypertensive disorders of pregnancy including gestational hypertension, preeclampsia and eclampsia are conditions that cause significant perinatal and maternal morbidity and mortality. OBJECTIVE: This is a systematic review of the current evidence examining the relationship between both depression and antidepressants on pregnancy-related hypertensive conditions. METHOD: In accordance with Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) protocol, six databases were searched for articles published between January 1990 and December 2017 (PubMed, Embase, PsycINFO, Cochrane Database of Systematic Reviews, MEDLINE and ClinicalTrials...
January 21, 2019: Current Drug Safety
https://read.qxmd.com/read/30666915/adverse-drug-reactions-to-radiographic-contrast-media-in-a-teaching-hospital-in-north-india-an-observational-study
#8
Deepti Chopra, Abhinav Jain, Richa Garg, Shreya Dhingra
BACKGROUND: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. METHODS: An observational study carried out for a period of six months in a teaching hospital...
January 21, 2019: Current Drug Safety
https://read.qxmd.com/read/30659549/aripiprazole-overdose-and-transient-2-1-second-degree-atrioventricular-block-only-a-coincidence
#9
Russo Lucia, Angelo Di Vincenzo, Rizzo Alessandro, Rossato Marco, Vettor Roberto
Atypical antipsychotics, unlike traditional antipsychotics, are considered to have limited cardiovascular side effects, but recent evidence drew attention to potential cardiac rhythm disturbances during aripiprazole therapy. Prolonged QT-interval and increased heart rate were described during treatment with therapeutic doses of aripiprazole, and some reports have even shown relevant arrhythmias, such as ventricular trigeminy and supraventricular tachycardia, in patients treated with this drug. Here we report a case of a young female who attempted suicide with aripiprazole overdose presenting with a concomitant 2:1 second degree atrioventricular block...
January 19, 2019: Current Drug Safety
https://read.qxmd.com/read/30659548/a-novel-desensitization-protocol-for-infliximab-hypersensitivity-in-a-13-year-old-patient-with-pustular-psoriasis
#10
Sapan Kumar Behera, Sandhiya Selvarajan, Jerene Mathews, Chandana Shajil, Saibal Das, Malathi Munisamy, Alphienes Stanley Xavier
BACKGROUND: Drug hypersensitivity reactions to infliximab have been reported in pediatric patients. At times, these patients may need infliximab administration in spite of hypersensitivity. However, only a few reports of desensitization protocols are available in the literature in pediatric patients. CASE REPORT: We report a case of immediate hypersensitivity reaction to intravenous infliximab in a 13-year-old child suffering from pustular psoriasis who eventually underwent a 14 step desensitization protocol for the administration of infliximab in a pediatric intensive care unit...
January 18, 2019: Current Drug Safety
https://read.qxmd.com/read/30648521/double-infection-in-a-patient-with-psoriatic-arthritis-under-tnf-alpha-blockers-therapy-a-case-report
#11
Benedetto Caroleo, Alberto Migliore, Erika Cione, Stefania Zampogna, Francesco Perticone, Giovambattista De Sarro, Luca Gallelli
BACKGROUND: Either direct or indirect tumor necrosis factor (TNF)-alpha blockers, are usually used to treat psoriatic arthritis (PA), but their use can increase susceptibility to infectious diseases. CASE PRESENTATION: We report a rare case of double skin-knee wound and lung non-tubercular infection in a patient with PA under TNF-alpha blockers therapy. About 1 year after the beginning of adalimumab, a 48-year-old smoker suffering of PA was hospitalized for skin-knee wound...
January 14, 2019: Current Drug Safety
https://read.qxmd.com/read/30523768/evaluation-of-hospital-discharge-prescriptions-in-the-elderly-and-younger-adults-using-the-medication-regimen-complexity-index
#12
Sujit Balodiya, Ashwin Kamath
BACKGROUND: Advances in the clinical management of diseases have been accompanied by increasing complexity of treatment regimens. The complexity of medication regimen is of concern for patients as well as doctors as it may adversely affect patient compliance and treatment outcomes. It may result in medication errors, increased utilization of health resources owing to a reduction in treatment effectiveness, and increased risk of therapeutic failure. OBJECTIVE: To assess the complexity of medication regimen prescribed to patients on hospital discharge using the medication regimen complexity index (MRCI)...
December 6, 2018: Current Drug Safety
https://read.qxmd.com/read/30698108/preface
#13
Seetal Dodd
No abstract text is available yet for this article.
2019: Current Drug Safety
https://read.qxmd.com/read/30444202/pibrentasvir-glecaprevir-induced-cholestatic-jaundice-in-a-hcv-patient-with-renal-failure-a-case-presentation
#14
Benedetto Caroleo, Maria Cristina Caroleo, Antonio Cimellaro, Lidia Colangelo, Maria Perticone, Giulio Di Mizio, Giovambattista De Sarro, Luca Gallelli
Direct-acting a antiviral (DAA) are currently used in the treatment of chronic HCV infection. In patients with renal failure with Elbasvir/Grazoprevir (genotype 1 and 4) or Pibrentasvir/Glecaprevir (genotype 1-6) is advised and these documented both good safety and efficacy. In this manuscript we reported the development of cholestatic jaundice, during Pibrentasvir/Glecaprevir treatment, in a 86-year-old male with chronic HCV (genotype 2) infection and renal failure. At examination patient was jaundiced and suffered of a severe itch...
November 15, 2018: Current Drug Safety
https://read.qxmd.com/read/30411692/report-of-adverse-events-in-colombia-a-successful-case
#15
Ornella Moreno-Mattar, Rosana Ramírez, Andrés Alvarado, Francisco Sierra
The Colombian National Food and Drug Surveillance Institute (INVIMA) is responsible for monitoring the safety and efficacy of medicines circulating in the Colombian market. This article summarizes the strategies implemented by INVIMA to strengthen the National Pharmacovigilance Program, including the expansion of the National Pharmacovigilance Network and the implementation of the electronic submission of adverse events. Results: the number of adverse events reported in Colombia increased from 5,447 in 2013 to 95,658 in 2017, reaching a population-based reporting ratio within international standards...
November 9, 2018: Current Drug Safety
https://read.qxmd.com/read/30411691/delayed-hemolytic-anemia-after-treatment-with-artesunate-case-report-and-literature-review
#16
Mohammadreza Salehi, Hosein Masoumi-Asl, Mehrdad Assarian, Niloofar Khoshnam Rad, Afsaneh Motevalli Haghi, Mehran Nikbakht, Hossein Khalili
BACKGROUND: In recent years, few cases of post-artemisinin delayed hemolysis have been reported. OBJECTIVE: All cases of post-artemisinin delayed hemolysis were reported from non-middle east areas. No case of post-artemisinin delayed hemolysis has yet been reported from this region. In this paper, we describe a case of post-artemisinin delayed hemolysis in an Iranian female. Also previous reports have been reviewed. METHOD: Patient's data including demographic characteristics, past medical, drug and travelling history, present illness, vital signs, laboratory data, clinical course of current illness and follow-up findings were considered...
November 9, 2018: Current Drug Safety
https://read.qxmd.com/read/30394214/cardiotoxicity-associated-with-midazolam-in-a-patient-with-diphtheria
#17
Jayendra R Gohil, Sonal Jindal
Adverse cardiorespiratory events are associated with its continuous iv infusion used for sedation. Here we are reporting a case of 5 year old male child suffering from diphtheria, who received midazolam in the form of iv infusion for sedation. Six hours after starting midazolam infusion he started developing pulsus bigeminus and bradycardia and eventual death. Midazolam, although considered as one of the safest drugs, need to be used cautiously because of the possible cardiotoxic effect in an already affected heart...
November 5, 2018: Current Drug Safety
https://read.qxmd.com/read/30381086/phenytoin-induced-chorea-a-rare-adverse-effect-of-the-drug
#18
Dhruvkumar M Patel, Jayanti K Gurumukhani, Mukundkumar V Patel, Greshaben R Patel
BACKGROUND: Dyskinetic neurological diseases are common presentations of adverse reaction to many therapeutic agents. Phenytoin, a widely used age old antiepileptic drug has been reported to cause dyskinesias, a rare adverse drug reaction (ADR) in adults with toxic therapeutic serum level. When the drug is used in combination with other drugs which augments free drug level of phenytoin or in patients of organic brain lesion, this side effect is very occasionally reported with even normal therapeutic drug level...
October 31, 2018: Current Drug Safety
https://read.qxmd.com/read/30370856/comparison-of-the-effects-of-metoprolol-and-bisoprolol-on-lipid-and-glucose-profiles-in-cardiovascular-patients
#19
Ahmad Abdulrahman Almeman, Yasir Ahmed Beshir, Ahmad Hamad Aldosary
BACKGROUND: It is crucial to understand the pharmacological differences between the effects of beta blockers on the lipid and glucose profile. Moreover, the management of lipid and glucose profile is essential in cardiovascular patients. OBJECTIVE: We sought to compare two beta blockers, metoprolol and bisoprolol, as the most commonly used drugs in cardiology in terms of their effects on glucose and lipid profiles in patients with cardiovascular diseases. METHODS: We conducted a retrospective cross-sectional matched study at Prince Sultan Cardiac Center in Burydah in May 2018...
October 28, 2018: Current Drug Safety
https://read.qxmd.com/read/30370855/biperiden-induced-delirium-in-a-five-years-old-child
#20
Duygu Kınay, Ahmet Zihni Soyata
OBJECTIVE: Extrapyramidal adverse effects of antipsychotic drugs are more reported in children. Biperiden is an anticholinergic agent to treat the adverse effects of antipsychotic drugs. The drug has the potential to induce delirium at toxic doses. However, data are scarce about delirium associated with biperiden in children. Thus far, a case of delirium has been associated with biperiden in an adolescent patient. We report the first case of delirium associated with use of biperiden in a preadolescent patient...
October 28, 2018: Current Drug Safety
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