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Reviews on Recent Clinical Trials

Safinaz Abdelrahman, Nooraldaem Yousif
BACKGROUND: Mitral stenosis is one of the most commonly encountered valvular heart diseases during pregnancy, the majority are rheumatic in origin and poorly tolerated due to cardio circulatory changes that occur during pregnancy, labor and postpartum. OBJECTIVE: The distinctive physiological events that arise during pregnancy and labor and the influence of mitral stenosis are tackled in this article. METHOD: Through PUBMED and MEDLINE searches, we reviewed the literature of the last decade as well as the recommendations from guidelines of high-impact worldwide...
February 7, 2019: Reviews on Recent Clinical Trials
Aynaz Nourani, Haleh Ayatollahi, Masoud Solaymani Dodaran
BACKGROUND: Data management is an important, complex and multidimensional process in clinical trials. The execution of this process is very difficult and expensive without the use of information technology. A clinical data management system is software that is vastly used for managing the data generated in clinical trials. The objective of this study was to review the technical features of clinical trial data management systems. METHODS: Related articles were identified by searching databases, such as Web of Science, Scopus, Science Direct, ProQuest, Ovid and PubMed...
February 7, 2019: Reviews on Recent Clinical Trials
Seyedeh Ameneh Motallebi, Jamileh Amirzadeh Iranagh, Fatemeh Mohammadi
BACKGROUND: The present study examined the efficacy of walking program on biochemical parameters among elderly women. METHODS: A total of one hundred elderly women participated in this randomized clinical trial study. The intervention group attended a 24-week walking exercise meeting five times per week. The control group continued with their routine activities. The subjects were assessed in Fasting blood glucose (FBS) and lipid profile before and after 12th and 24th weeks of the program...
January 31, 2019: Reviews on Recent Clinical Trials
Simone Zanella, Lauro Enrico, Francesco Franceschi, Francesco Buccelletti, Annalisa Potenza, Andrea Zanoni, Giovanni Scudo, Enzo Bonadies, Mario De Bellis, Francesco Ricci, Antonios Vassiliadis
BACKGROUND: Laparoscopic incisional and ventral hernia repair (LIVHR) is a safety and worldwide accepted procedure performed using also absorbable tacks. The aim of the study was to evaluate recurrence rate in a long term follow-up and whether the results of laparoscopic IVH repair in the elderly (≥65 years old) are different with respect to results obtained in younger patients. PATIENTS AND METHODS: One hundred and twenty-nine consecutive patients (74 women and 55 men, median age 67 years, range=30-87years) with ventral (N=42, 32...
January 31, 2019: Reviews on Recent Clinical Trials
Guglielmo Actis Dato, Marco Picichè
BACKGROUND: Before the advent of CABG, standardized in the late '60s by Favaloro and Effler, patients with myocardial ischemia were treated with indirect methods and Off--pump procedures to achieve myocardial revascularization have been quite heterogeneous in the past. METHODS & RESULTS: Indirect revascularization such as Periaortic nerve plexus interruption, Vineberg operation, Sen procedure, TMR Laser and stem cell transplantation represented some of the way to obtain a revascularization in the past period...
January 31, 2019: Reviews on Recent Clinical Trials
Micaela De Palo, Teresa Quagliara, Annamaria Dachille, Alessandro Carrozzo, Francesco Giardinelli, Simone Mureddu, Florinda Mastro, Crescenzia Rotunno, Domenico Paparella
INTRODUCTION: Ischemic heart diseases are the major leading cause of death worldwide. Revascularization procedures dramatically reduced the overall risk for death related to acute coronary syndromes. Two kind of myocardial revascularization can grossly be outlined: percutaneous coronary intervention (PCI) and surgical coronary artery bypass graft intervention (CABG). The net clinical benefit coming from these two kinds of procedures is still under debate. METHODS: We have traced the state-of-art background about myocardial revascularization procedures by comparing the most important trials dealing with the evaluation of percutaneous interventions versus surgical approach to coronary artery diseases...
January 31, 2019: Reviews on Recent Clinical Trials
Silvia Cardone, Carmine Petruzziello, Barbara Fiori, Teresa Spanu, Tiziana D'Inzeo, Francesco Franceschi, Veronica Ojetti
INTRODUCTION: Urinary tract infections (UTIs) are among the most common bacterial infections, affecting 150 million people worldwide each year. Importantly, the incidence of UTI increases markedly with age. The increasing resistance to empirically prescribed antimicrobial agents complicates the management of this disease. This makes UTI an important issue in increasingly aging population and updated epidemiological investigation is advisable. To understand the epidemiological variation in UTI resistance patterns among differently aged populations, we conducted a retrospective study among patients presenting to the emergency department (ED) of a large tertiary-care hospital in Italy during January 2013 and June 2017...
December 26, 2018: Reviews on Recent Clinical Trials
Danilo Rocco, Ciro Battiloro, Luigi Della Gravara, Cesare Gridelli
BACKGROUND: Lung cancer is the leading cause of cancer mortality, being responsible for more than 1.6 million deaths each year worldwide and non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers; moreover, 10 to 15% of all NSCLCs harbors EGFR (epidermal growth factor receptor) activating mutations, being suitable for EGFR-Tyrosine Kinase Inhibitors (TKI) molecular targeted therapy. However, EGFR+ NSCLCs gain acquired resistance to these agents, representing one of the key challenges for modern precision oncology...
December 5, 2018: Reviews on Recent Clinical Trials
Alberto Enrico Maraolo, Antonio Riccardo Buonomo, Emanuela Zappulo, Riccardo Scotto, Biagio Pinchera, Ivan Gentile
INTRODUCTION: Historically, spontaneous bacterial peritonitis (SBP) has represented one of the most frequent and relevant infectious complications of advanced liver disease, and this is still valid today. Nevertheless, in recent years the role of fungi as causative pathogens of primary peritonitis in patients with cirrhosis has become not negligible. Another issue is linked with the traditional distinction, instrumental in therapeutic choice, between community-acquired and nosocomial forms, according to the onset...
December 3, 2018: Reviews on Recent Clinical Trials
Fausto Meriggi
BACKGROUND: Malignant pleural effusion, which is a common clinical problem in patients with cancer, may be due to both primary thoracic tumours or to a metastatic spread in the chest and constitutes the first sign of disease in approximately 10% of patients. Almost all cancers can potentially produce a pleural effusion. The presence of malignant tumour cells in the pleural fluid is generally indicative of advanced disease and is associated with high morbidity and mortality with reduced therapeutic options...
December 3, 2018: Reviews on Recent Clinical Trials
Tiziana Prochilo, Alessandra Huscher, Federica Andreis, Mara Mirandola, Elisabetta Zaina, Barbara Pomentale, Chiara Pedrali, Laura Zanotti, Stefano Mutti, Alberto Zaniboni
BACKGROUND: The most effective agents in the treatment of breast cancer have as common side effect the hair loss. Some studies reported a reduction of hair loss with the use of the scalp cooling device. Indeed, it decreases the drug accumulation in the hair follicles. We report our preliminary experience with a scalp cooling device in reducing chemotherapy-induced alopecia and related distress in breast cancer patients undergoing adjuvant chemotherapy. METHODS: Hair loss grading and treatment tolerability were evaluated during chemotherapy every 21 days and 3 weeks after the last cycle of chemotherapy via Dean's scale by patients and operators and a comfort analogic scale by patients...
November 19, 2018: Reviews on Recent Clinical Trials
Dominika M Zoltowska, Yashwant Agrawal, Nilesh Patel, Nishta Sareen, Jagadeesh K Kalavakunta, Vishal Gupta, Abdul Halabi
INTRODUCTION: This study was done to review the association of pulmonary hypertension (PH) with Transcatheter Aortic Valve Replacement (TAVR) procedures done in the US for years 2010 to 2012. METHODS: We used Nationwide Inpatient Sample (NIS) data to extract data for patients who were hospitalized with a primary/secondary diagnosis of TAVR as specified by International Classification of Disease (ICD-9) codes 35.05 and 35.06. PH was identified with ICD-9 codes 416...
November 19, 2018: Reviews on Recent Clinical Trials
Ludovico Abenavoli
No abstract text is available yet for this article.
2019: Reviews on Recent Clinical Trials
O Korotkyi, A Vovk, O Blokhina, K Dvorshchenko, T Falalyeyeva, L Abenavoli, L Ostapchenko
Blood cytokines affect the development of inflammatory processes in both normal and pathological states. We have studied changes in the concentration of interleukins (ILs) -1β, IL-4, IL-10, IL-12B p40, transforming growth factor β (TGF β), tumor necrosis factor (TNF-α) in acute carrageenan-induced inflammation and degenerative-dystrophic changes of knee joint caused by monoiodoacetate-induced osteoarthritis (OA) in experimental models on rats. We also investigated the change in the cytokine profile during prophylactic and therapeutic administration of chondroitin sulfate to animals under experimental conditions...
November 2, 2018: Reviews on Recent Clinical Trials
Morteza Ghojazadeh, Sakineh Hajebrahimi, Fatemeh Pournaghi-Azar, Mohammad Mohseni, Naser Derakhshani, Saber Azami-Aghdash
BACKGROUND & AIMS: Evaluating the effect of Kangaroo Mother Care (KMC) on breastfeeding success shows conflicting results. Regarding the importance of breastfeeding and uncertainties about its effect, this study intended to conduct a systematic review and meta-analysis of randomised controlled trials on the effect of KMC on success of breastfeeding. METHODS: In this systematic review and meta-analysis study, required data were collected by searching the following key words: breastfeeding, Breast-Feeding, "skin-to-skin", "Kangaroo Mother Care", randomized clinical trial...
September 24, 2018: Reviews on Recent Clinical Trials
Aynaz Nourani, Haleh Ayatollahi, Masoud Solaymani Dodaran
BACKGROUND: Clinical data management system is a software supporting the data management process in clinical trials. In this system, the effective support of clinical data management dimensions leads to the increased accuracy of results and prevention of diversion in clinical trials. The objective of this review article is to investigate the dimensions of data management in clinical data management systems. METHODS: This study was conducted in 2017. The used databases included Web of Science, Scopus, Science Direct, ProQuest, Ovid Medline and PubMed...
September 24, 2018: Reviews on Recent Clinical Trials
Giovanni Clemente Actis, Rinaldo Pellicano, Davide Giuseppe Ribaldone
BACKGROUND: The need for immune suppressive strategies in the control of chronic inflammatory bowel diseases originated in the 1960s following the perception of a relative inefficacy of salazopyrin and its derivatives. In some 50 years upon an anecdotal claim, the indication for thiopurines in the management of inflammatory bowel diseases has come of age. OBJECTIVE: The aim of this minireview is to give an overview, after the historical premises, of the current use of thiopurines in the context of inflammatory bowel diseases...
September 10, 2018: Reviews on Recent Clinical Trials
Aven Sidhu, Rohan Kakkar, Osamah Alenezi
BACKGROUND: Human Immunodeficiency Virus (HIV) prevalence rates in refugee camps are inconclusive in current literature, with some studies highlighting the increased risk of transmission due to poor living conditions and lower levels of education. With the increasing number of refugees from HIV endemic countries, it is important to assess the programs established to support patients upon arrival. Refugees have been reported to have a lower health literacy and face disease-related stigmatization, which must be overcome for the lifelong treatment of HIV...
September 3, 2018: Reviews on Recent Clinical Trials
Nooraldaem Yousif, Mohammady Shahin, Thomas F Luscher, Slayman Obeid
BACKGROUND: Although not well established; gender may play a role in the incidence, clinical manifestations, and atherosclerotic burden of coronary artery anomalies (CAAS). Our aim is to investigate the impact of gender on coronary artery anomalies Methods: All coronary angiograms performed at the University Heart Center Zurich, Switzerland, between January 2000 and December 2016 were investigated. Those of anomalous origin, course and termination (fistula) were included in the analysis with the exclusion of coronary artery aneurysms and myocardial bridges...
August 19, 2018: Reviews on Recent Clinical Trials
Basant K Puri, Anne Derham, Jean A Monro
Background The use of indwelling central venous access devices (CVADs) is associated with the development of bloodstream infections. When CVADs are used to administer systemic antibiotics, particularly second- or higher-generation cephalosporins, there is a particular risk of developing Clostridium difficile infection. The overall bloodstream infection rate is estimated to be around 1.74 per 1000 central venous catheter (CVC)-days. Objective We hypothesised that daily oral administration of the anion-binding resin colestyramine (cholestyramine) would help prevent infections in those receiving intravenous antibiotic treatment via CVADs...
August 17, 2018: Reviews on Recent Clinical Trials
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