journal
https://read.qxmd.com/read/38644718/procalcitonin-and-qsofa-as-a-marker-of-mortality-in-sepsis
#1
JOURNAL ARTICLE
Ashaq Hussain Parrey, Manzoor Koka, Basharat Kasana, Mohd Ismail
BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The qSOFA and procalcitonin are currently used for both diagnostic as well as prognostic purposes. OBJECTIVE: To explore the combined use of day one procalcitonin level and qSOFA scores for prognostication of sepsis-related mortality Design: This was a prospective observational study. PARTICIPANTS: All patients who fulfilled the inclusion criteria for sepsis with an age of more than 16 years were enrolled in the study Results: In this study of 211 patients, 15 patients died (7...
April 19, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38561622/gender-differences-in-patients-with-prolactinoma-single-center-ukrainian-experience
#2
JOURNAL ARTICLE
Oleksandr Voznyak, Iaroslav Zinkevych, Andrii Lytvynenko, Nazarii Hryniv, Roman Ilyuk, Nazarii Kobyliak
INTRODUCTION: Prolactinomas are the most common type of pituitary gland tumors that secrete overly prolactin. They account for approximately 60% of all hormone-secreting hypophysis tumors. AIM: This study aims to analyze gender differences in patients with prolactinomas who were operated on transsphenoidal surgery and conduct a single-center retrospective analysis of patient data. MATERIAL AND METHODS: This study evaluated the medical records of 109 patients (61 females and 48 males) from 2009 to 2019 at Feofaniya Clinical Hospital of the State Administration of Affairs in Kyiv, Ukraine...
March 29, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38561621/a-single-group-clinical-interventional-study-on-the-effect-of-iron-deficiency-anemia-on-blood-glucose-and-insulin-resistance-in-women-with-type-ii-diabetes
#3
JOURNAL ARTICLE
Mahmoud Parham, Gholam Reza Tavasoli, Shahram Arsang-Jang, Mohamad Amin Habibi, Davood Olad Dameshgi, Mohammad Reza Pashaei, Sajjad Ahmadpour, Jamshid Vafaeimanesh
AIMS: Iron deficiency anemia (IDA) is one of the disorders recently associated with an increase in insulin resistance (IR) and, consequently, diabetes mellitus (DM) affection by causing oxidative stress. In this study, we look at how IDA may contribute to developing type II diabetes mellitus (T2DM), controlling diabetes, and reducing IR in women with T2DM. METHODS: In this single group, clinical interventional study, we enrolled 40 women with T2DM and IDA. Before and after intervention with ferrous sulfate tablets, their blood glucose (BG) levels and IR levels were evaluated...
March 29, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38523517/comparison-of-the-efficacy-of-oral-magnesium-with-oral-ketorolac-for-postoperative-pain-management-in-anorectal-surgery-a-double-blinded-randomized-clinical-trial
#4
Seyed Jalal Eshagh Hoseini, Farzanesadat Ghazi, Mohsen Eshraghi, Mostafa Vahedian, Mohammad Reza Pashaei, Mohamad Amin Habibi, Sajjad Ahmadpour
BACKGROUND: Due to the presence of postoperative pain in patients undergoing anorectal surgery, and since the pain affects the quality of life of patients, we aimed to compare the analgesic effectiveness of oral magnesium with oral ketorolac to choose the right analgesic drug for these patients. METHODS: This study was a double-blind, randomized clinical trial performed on 104 candidates undergoing anorectal surgery. Patients were randomly divided into two groups...
March 21, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38409705/the-power-of-the-underutilized-and-neglected-medicinal-plants-and-herbs-of-the-middle-east
#5
JOURNAL ARTICLE
Mohamad Hesam Shahrajabian, Wenli Sun
The Middle east and North Africa harbour many native species with pharmaceutical and nutraceutical potential. Since the beginning of history, food and herbal medicinal plants have been an essential part of human lives and the traditional Middle Eastern healthcare system. The notable medicinal plants that have been mentioned in the Bible, which are common in West Asia and some regions of North Africa, are Aloe vera, anise, balm, cassia, cinnamon, cumin, flax, and fig. Chemical components of Aloe vera are aloin, sinapinic acid, catechin, chromone, myricetin, quercitrin and syringic acid...
February 21, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38409704/characterization-of-intrinsically-disordered-proteins-in-healthy-and-diseased-states-by-nuclear-magnetic-resonance
#6
JOURNAL ARTICLE
Mohamad Hesam Shahrajabian, Wenli Sun
Intrinsically Disordered Proteins (IDPs) are active in different cellular procedures like ordered assembly of chromatin and ribosomes, interaction with membrane, protein, and ligand binding, molecular recognition, binding, and transportation via nuclear pores, microfilaments and microtubules process and disassembly, protein functions, RNA chaperone, and nucleic acid binding, modulation of the central dogma, cell cycle, and other cellular activities, post-translational qualification and substitute splicing, and flexible entropic linker and management of signaling pathways...
February 21, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38415449/evaluation-of-urolithin-a-efficacy-in-heart-failure-patients-with-reduced-ejection-fraction-a-randomized-double-blind-crossover-placebo-controlled-clinical-trial
#7
Tannaz Jamialahmadi, Maede Hasanpour, Farveh Vakilian, Peter E Penson, Milad Iranshahy, Amirhossein Sahebkar
BACKGROUND: Mitochondrial dysfunction and impaired mitophagy are integral to myocyte loss and the progression of heart failure. Urolithin A (UA), a microbiota-produced metabolite of ellagitannins and ellagic acid, is a known stimulator of mitophagy and mitochondrial biogenesis that has shown cardioprotective effects in experimental models. METHODS: A randomized, double-blind, placebo-controlled 2×2 crossover trial was conducted on 10 patients with HF with reduced ejection fraction (HFrEF)...
February 20, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38549519/primary-paraganglioma-of-the-prostate-a-systematic-review-of-the-literature-for-a-rare-entity
#8
JOURNAL ARTICLE
Ilias Giannakodimos, Afroditi Ziogou, Alexios Giannakodimos, Evangelia Mitakidi, Konstantinos Tzelepis, Evangelos Fragkiadis, Nikolaos Charalampakis
BACKGROUND: Paragangliomas of the urinary tract are exceptionally uncommon, and sporadic case reports of primary paraganglioma of the prostate have been reported in the literature. METHODS: Systematic research in PubMed/Medline and Scopus databases concerning primary prostatic paraganglioma was performed by two independent investigators. RESULTS: This analysis included 25 adult males, with a mean age of 49.8 ± 22.4 years. 32% of included patients had a history of hypertension...
February 16, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38288802/comparison-of-clinical-trial-results-of-the-recently-approved-immunotherapeutic-drugs-for-advanced-biliary-tract-cancers
#9
JOURNAL ARTICLE
Samayita Das
The recently approved immunotherapeutic drugs are Keytruda (pembrolizumab) and Imfinzi (durvalumab) for advanced biliary tract cancers that inhibit PD-1 receptor and PD-L1 ligand, respectively. In this perspective, the results of the two clinical trials, i.e., TOPAZ-1 (NCT03875235) and KEYNOTE-966 (NCT04003636), are critically appraised, compared, and discussed to assess the benefits of these two drugs in the context of the treatment of advanced biliary tract cancers with a focus on PD-L1 status and MIS (microsatellite instability) status and therapy responsiveness in the subgroups...
January 29, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38288801/carob-ceratonia-siliqua-l-pharmacological-and-phytochemical-activities-of-neglected-legume-of-the-mediterranean-basin-as-functional-food
#10
JOURNAL ARTICLE
Mohamad Hesam Shahrajabian, Wenli Sun
Carob (Ceratonia siliqua L.) has been widely cultivated in different parts of the world, particularly in the Mediterranean region, and the tree belongs to the family Leguminosae. Several studies have indicated that carobs and their products can improve human health and help prevent different specific chronic diseases. Carob can considered as functional food due to its high content in dietary fibers, low-fat content, and high content of minerals. Its fruit is a pod containing 10%-20% seeds, and the pods consist of sugars, proteins, crude fibers, minerals, vitamins, polyphenols, vitamins, and lipids...
January 26, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38155467/introduction-of-various-models-of-palliative-oncology-care-a-systematic-review
#11
JOURNAL ARTICLE
Mahdieh Arian, Fatemeh Hajiabadi, Zakiyeh Amini, Mohammad Bagher Oghazian, Ali Valinejadi, Amirhossein Sahebkar
BACKGROUND: The aim of this study is to synthesize the existing evidence on various palliative care models for cancer patients. This effort seeks to discern which facets of PC models are suitable for various patient cohorts, elucidate their mechanisms, and clarify the circumstances in which these models operate. METHODS: A comprehensive search was performed using MeSH terms related to PC and cancer across various databases. The Preferred Reporting Items for Systematic Reviews and a comprehensive evidence map were also applied...
December 28, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38155466/role-of-complement-dependent-cytotoxicity-crossmatch-and-hla-typing-in-solid-organ-transplant
#12
JOURNAL ARTICLE
Arpit Tiwari, Sayali Mukherjee
BACKGROUND: Solid organ transplantation is a life-saving medical operation that has progressed greatly because of developments in diagnostic tools and histocompatibility tests. Crossmatching for complement-dependent cytotoxicity (CDC) and human leukocyte antigen (HLA) typing are two important methods for checking graft compatibility and reducing the risk of graft rejection. HLA typing and CDC crossmatching are critical in kidney, heart, lung, liver, pancreas, intestine, and multi-organ transplantation...
December 28, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38151848/multisystem-inflammatory-syndrome-in-children-mis-c-in-a-lowincome-country-what-treatment-should-be-adopted-in-case-of-a-lack-of-immunoglobulin
#13
JOURNAL ARTICLE
Babakhouya Abdeladim, Bouhmidi Massilia, Elouali Aziza, Elhaddar Zohair, Ghanam Ayad, Rkain Maria
INTRODUCTION: In multisystem inflammatory syndrome (MIS-C), children typically present high-grade fever, gastrointestinal symptoms, Kawasaki-like symptoms, and even a toxic shock-like syndrome days to weeks after recovering from SARS-CoV-2 infection. It is important to raise awareness of this condition in order to have early diagnosis and immediate treatment of patients. We have, herein, reported 44 cases of MIS-C with various risk factors and symptoms. Furthermore, we have emphasized the efficacy of experience in treating children with MIS-C with high-dose corticosteroids as an alternative to immunoglobulin in low-income countries...
December 26, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38141197/potential-indications-of-dupilumab-in-th-2-inflammatory-disease
#14
JOURNAL ARTICLE
Proietti Ilaria, Skroza Nevena, Tolino Ersilia, Bernardini Nicoletta, Federica Trovato, Marco Di Fraia, Dybala Agniezska, Potenza Concetta
Dupilumab is a fully humanized IgG4 monoclonal antibody, inhibiting IL-4 and IL-13 signaling, which are the main cytokines involved in type 2 inflammatory diseases. Its introduction was a breakthrough in the treatment of moderate-to-severe atopic dermatitis, but it is also used in other inflammatory diseases, including asthma, eosinophilic esophagitis and chronic rhinosinusitis with nasal polyposis. Recent advances in the understanding of inflammatory pathways have revealed that Th2-type inflammation is involved in a wider range of diseases than previously thought...
December 20, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38058097/parp-inhibitors-in-colorectal-malignancies-a-2023-update
#15
JOURNAL ARTICLE
Nikolaos Skouteris, Georgios Papageorgiou
BACKGROUND: Colorectal carcinoma (CRC) is one of the most common malignancies in the Western world, and metastatic disease is associated with a dismal prognosis. Poly-ADpribose polymerase (PARP) inhibitors gain increasing attention in the field of medical oncology, as they lead to synthetic lethality in malignancies with preexisting alterations in the DNA damage repair (DDR) pathway. As those alterations are frequently seen in CRC, a targeted approach through PARP inhibitors is expected to benefit these patients, both alone and in combination with other agents like chemotherapy, immunotherapy, antiangiogenics, and radiation...
December 6, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38099534/comparison-of-the-effects-of-govarcin-herbal-capsule-and-metoclopramide-for-alleviating-gastrointestinal-symptoms-in-patients-with-functional-dyspepsia-a-randomized-double-blind-clinical-trial
#16
Majid Asghari, Sajjad Ahmadpour, Mikaeil Molazadeh, Mohammad Mehdi Jafari, Ahmad Hormati, Mohammad Reza Pashaei, Yousef Mohammadpour, Mohamad Amin Habibi, Abolfazl Mohammadbeigi, Seyed Mahmoud Eshagh Hoseini
BACKGROUND: Functional dyspepsia (FD) is felt as a discomfort or pain on the center line or upper abdomen. In this study, we investigated the effect of Govarcin herbal capsule on FD so that if it is effective, it can be used in the treatment of patients with this disease. METHODS: Totally, 106 patients enrolled in a double-blind, clinical trial study. The participants had FD and were divided into two groups receiving Govarcin and Metoclopramide by block randomization...
December 1, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38099533/confidence-interval-advantages-disadvantages-and-the-dilemma-of-interpretation
#17
JOURNAL ARTICLE
Pramod K Sharma, Mamta Yadav
Confidence interval (CI) is one of the important reporting tools for research data as it not only provides valuable information about the effect size along with its width but also possible clinical significance. Unfortunately, this approach is not being utilized to its fullest extent. Determining point estimate always includes an element of uncertainty due to associated sampling error. A confidence interval may be an appropriate tool to measure this uncertainty. Further, the P value does not convey information about the magnitude of an effect and the error associated with it...
December 1, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38047364/iranian-traditional-medicine-itm-and-natural-remedies-for-treatment-of-the-common-cold-and-flu
#18
JOURNAL ARTICLE
Mohamad Hesam Shahrajabian, Wenli Sun
Traditional Iranian medicine is usually used for both prevention and relief of cold and flu symptoms in China, Iran, and many other Asian countries all over the world. There are 4 kinds of influenza viruses. Unlike type B, which may cause seasonal epidemics, type A viruses can cause pandemics, and influenza C may lead to mild human infection with little public health effects. A literature review was done by using multiple databases such as ISI Web of knowledge, PubMed, Science Direct and Google Scholar. The most notable antiviral medicinal plants for flu and cold are honeysuckle flowers, thyme leaf, green chiretta, andrographis, peppermint oil and leaf and calendula...
December 1, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/37953617/a-review-of-clinical-trials-of-cancer-and-its-treatment-as-a-vaccine
#19
JOURNAL ARTICLE
Chandani Chanarana, Anuradha Tiwari
BACKGROUND: Cancer and infectious diseases are one of the greatest challenges of modern medicine. An unhealthy lifestyle, poor drug use, or drug misuse contribute to the rise in morbidity and mortality brought on by these illnesses. The inadequacies of the medications now being used to treat these disorders, along with the growing issue of drug resistance, have compelled researchers to look for novel compounds with therapeutic promise. The number of infections and diseases has significantly abated due to vaccine development and use over time, which is described in detail...
November 10, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/37937577/cancer-patients-attitudes-towards-the-anti-covid-19-vaccine-a-collective-case-study
#20
JOURNAL ARTICLE
Mara Mirandola, Federica Andreis, Chiara Deori, Sonia Abdel Kader, Anna Chiara Wedenissow, Clelia Malighetti, Fausto Meriggi, Alberto Zaniboni
AIM: The purpose of the present study was to determine cancer patients' attitudes toward the anti-COVID-19 vaccine. BACKGROUND: Historically, the scientific community's responsibility was to investigate attitudes about vaccination. The course of COVID-19 in cancer patients makes them a high priority for vaccination. Cancer patients are at greater risk of serious complications and death because of COVID-19 infection. OBJECTIVE: The purpose of the present study was to determine cancer patients' attitudes toward the anti-COVID-19 vaccine...
November 6, 2023: Reviews on Recent Clinical Trials
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