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Cardiovascular & Hematological Disorders Drug Targets

Antonio Girolami, Elisabetta Cosi, Silvia Ferrari, Bruno Girolami, Maria Luigia Randi
OBJECTIVE: to investigate the prevalence of thrombotic events among patients with proven or highly probable homozygosis for the Arg304Gln (Factor VII Padua) defect or compound heterozygosis containing the Arg304Gln mutation. PATIENTS AND METHODS: Homozygotes and compound heterozygotes proven by molecular studies to have the Arg304Gln mutation were gathered from personal files and from two PubMed searches. In addition, patients with probable homozygosis on the basis of clotting tests (discrepancies among Factor VII activity levels according to the tissue thromboplastin used) were also gathered...
March 7, 2019: Cardiovascular & Hematological Disorders Drug Targets
Dimitris Kounatidis, Dimitra Rontogianni, Dimitrios Sampaziotis, Maria Vardaka, Chara Giatra, Christodoulos Dolapsakis, Evangelia Margellou, Natalia G Vallianou
Multicentric Castleman Disease (MCD) presents with enlarged lymph nodes in multiple regions and systemic inflammatory symptoms, due to the dysregulation of cytokines, most commonly interleukin-6 (IL-6). Human herpes virus-8 (HHV-8) is strongly related to MCD (HHV-8-associated MCD) and is being implicated in cytokine dysregulation in patients, the majority of whom are HIV positive or immunosuppressed. Preferred treatment of HHV-8-associated MCD depends on the presence or not of concurrent Kaposi sarcoma and on whether the patient has life-threatening organ failure or poor performance status thought to be related to HHV-8-associated MCD...
February 27, 2019: Cardiovascular & Hematological Disorders Drug Targets
Fadwa El-Ouady, Mohamed Eddouks
Ammodaucus leucotrichus (Apiaceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes. The aim of this study was to evaluate the antidiabetic effect of the aqueous extract prepared from the fruits of this medicinal plant. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of Ammodaucus leucotrichus (A. leucotrichus) at a dose of 10 mg/kg. The blood glucose levels were determined during 6 hours and 15 days during this treatment...
February 22, 2019: Cardiovascular & Hematological Disorders Drug Targets
Miriam Michel, Manuela Zlamy, Andreas Entenmann, Karin Pichler, Sabine Scholl-Bürgi, Daniela Karall, Ralf Geiger, Christina Salvador, Christian Niederwanger, Hideo Ohuchi
In patients having undergone the Fontan operation, besides the well discussed changes in the cardiac, pulmonary and gastrointestinal system, alterations of further organ systems including the hematologic, immunologic, endocrinological and metabolic are reported. As a medical adjunct to Fontan surgery, the systematic study of the central role of the liver as a metabolizing and synthesizing organ should allow for a better understanding of the pathomechanism underlying the typical problems in Fontan patients, and in this context the profiling of endocrinological and metabolic patterns might offer a tool for the optimization of Fontan follow-up, targeted monitoring and specific adjunct treatment...
February 11, 2019: Cardiovascular & Hematological Disorders Drug Targets
Estefanía Lozano-Velasco, Carlos Garcia-Padilla, Amelia E Aránega, Diego Franco
Atrial fibrillation (AF) is the most frequent arrhythmogenic disease in humans, ranging from 2% in the general population and raising up to 10-12% in 80+ years. Genetic analyses of AF familiar cases have identified a series of point mutations in distinct ion channels, supporting a causative link. However, these genetic defects only explain a minority of AF patients. Genome-wide association studies identified single nucleotide polymorphisms (SNPs), close to PITX2 on 4q25 chromosome, that are highly associated to AF...
February 6, 2019: Cardiovascular & Hematological Disorders Drug Targets
Shahrzad Souri, Ghazaleh Dadashizadeh, Akbar Dorgalaleh, Shadi Tabibian, Mohammad Reza Keramati, Shaban Alizadeh, Maryam Sadat Hosseini, Farhad Zaker, Mahmood Shams
BACKGROUND: About one-fourth of patients with hemophilia A (HA) develop alloantibodies against factor (F) VIII, as the main treatment challenge. Here, we assessed the relationship between interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α) and FII and FV polymorphisms and risk of inhibitor formation in patients with severe HA. METHODS: We divided 39 patients with severe HA in two groups of cases (n: 19) and control (n: 20). Genotyping was performed by multiplex amplification tetra arms refractory mutation system-polymerase chain reaction (ARMS-PCR) and PCR-restriction fragment-length polymorphism (PCR-RFLP)...
February 6, 2019: Cardiovascular & Hematological Disorders Drug Targets
Mina Mohammadzadeh, Habib Haybar, Ahmad Reza Assare, Zeinab Deris Zayeri, Shahla Assadi Hoveyzian
BACKGROUND & OBJECTIVE: Acute renal failure (AKI) is one of the most important complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI earlier. The aim of this study is to evaluate the valuable factors with a focus on (HFAB-P) that can be predictive for AKI after Percutaneous Coronary Intervention (PCI). METHODS: This prospective study was performed on 95 patients (55 males and 44 females aged between 49-78 years) under PCI in Golestan and Imam Khomeini hospitals in Ahvaz...
February 6, 2019: Cardiovascular & Hematological Disorders Drug Targets
Durgarao Y, Poornima A Manjrekar, Prabha Adhikari, Chakrapani M, Rukmini Ms
Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. The vitamin D deficiency (VDD) pandemic was globally reported with increasing evidence and paralleled the prevalence of diabetes, obesity and cardiovascular diseases (CVDs)...
January 14, 2019: Cardiovascular & Hematological Disorders Drug Targets
Rahul Mittal, Rahul Dev Jayant
No abstract text is available yet for this article.
2019: Cardiovascular & Hematological Disorders Drug Targets
Garry Shen
No abstract text is available yet for this article.
2019: Cardiovascular & Hematological Disorders Drug Targets
Antonio Girolami, Diana Noemi Garcia de Paoletti, Marcelo Leonardo Nenkies, Silvia Ferrari, Hugo Guglielmone
A compound heterozygote due to the association of a new mutation (Gla72Asp) with an already known mutation (Gly154Arg) of the FX gene is reported. The proposita is a 38 year old female who had a moderate bleeding tendency (menorrhagia, epistaxis, easy bruising). The proposita has never received substitution therapy but in the occasion of a uterine biopsy. The mother was asymptomatic but was a heterozygote for the new mutation. The father was asymptomatic but had deserted the family and could not be investigated...
December 11, 2018: Cardiovascular & Hematological Disorders Drug Targets
Habib Haybar, Saeid Shahrabi, Mohammad Shahjahani, Hadi Rezaeeyan
Development of cardiomyopathy (CM) is dependent upon several factors. However, reaction of immune response against myocardial tissue due to microbial and viral infections plays an important role in this disease. Therefore, the purpose of this study is to investigate the relationship between HLAs and their pathogenic mechanisms in the incidence of CM. Relevant literature was identified by a PubMed search (1989-2017) of English-language papers using the terms "Cardiomyopathy", "Human leukocyte antigen or HLA", "immune response", and "polymorphism"...
December 5, 2018: Cardiovascular & Hematological Disorders Drug Targets
W Serra, A Fantin, C Longo, G Rabia, F De Rosa, C Plenteda, F Re, E Crisafulli, A Chetta
Carfilzomib, a proteasome inhibitor, known as a therapeutical option for people who have already received one or more previous treatments for multiple myeloma, has well known cardiac and systemic adverse effects. There is evidence supporting that adverse effects are dose-dependent, yet there is no known patient phenotype characterized by worse associated consequences, nor are there widely accepted monitoring protocols. In this article we describe two patients with cardiovascular adverse events related to carfilzomib treatment and their clinical course...
December 4, 2018: Cardiovascular & Hematological Disorders Drug Targets
Habib Haybar, Saeed Alipour Parsa, Isa Khaheshi, Zeinab Deris Zayeri
AIM: To examine if pentraxin can help identifying patients benefitting most from primary Percutaneous Coronary Intervention (PCI) vs. fibrinolysis. METHODS: Patients with acute ST-Elevation Myocardial Infarction (STEMI) were consecutively recruited from a community center without PCI and a tertiary center with PCI facilities.Left ventricular ejection fraction (LVEF) was determined echocardiographically at baseline and 5 day after the index admission; the difference between two measurements was considered as the magnitude of improvement...
November 20, 2018: Cardiovascular & Hematological Disorders Drug Targets
Parisa Sadighara, Atefeh Araghi, Behrouz Tajdar-Oranj, Leila Peivasteh Roudsari, Afsaneh Mohajer, Ramezan Behzadi
BACKGROUND: there has been considerable interest in the potential health benefits of borage. Little information is available regarding safety of this plant. The purpose of this study was to evaluate the impact of borage on the mouse heart. METHODS: Different amounts of borage extract were injected on mice. The mice randomly divided into 4 group including group1 (Control group without injection), group2, 3 and 4 that received 12.5 mg/kg, 25 mg/kg and 50 mg/kg respectively...
November 4, 2018: Cardiovascular & Hematological Disorders Drug Targets
Trevor Simard, Richard Jung, Alisha Labinaz, Mohammad Ali Faraz, F Daniel Ramirez, Pietro Di Santo, Ian Pitcher, Pouya Motazedian, Chantal Gaudet, Rebecca Rochman, Jeffrey Marbach, Paul Boland, Kiran Sarathy, Saleh Alghofaili, Juan J Russo, Etienne Couture, Robert S Beanlands, Benjamin Hibbert
Adenosine, a purine nucleoside, is produced broadly and implicated in the homeostasis of many cells and tissues. It signals predominantly via 4 purinergic adenosine receptors (ADORs) - ADORA1, ADORA2A, ADORA2B and ADORA3 in addition to non-ADOR mediated effects. Through these signaling mechanisms, adenosine exerts effects on numerous cell types crucial to maintaining vascular homeostasis, especially following vascular injury. Both in vitro and in vivo models have provided considerable insights into adenosine signaling and identified targets for therapeutic intervention...
October 10, 2018: Cardiovascular & Hematological Disorders Drug Targets
Tahereh Farkhondeh, Saeed Samarghandian, Mohsen Azimi-Nezhad, Ali Mohammad Pourbagher Shahri
Curcumin, is the major phenolic compound the rhizome of the Curcuma species that is used in herbal medicine. Several studies has showed the protective effects of curcumin against nephrotoxi agents such as gallic acid, glucose, tartrazine, streptozotocin, lead, maleate, malathion, nicotine, cisplatin, gentamicin and methotrexate. However, due to the lake of linical trial studies, more investigation are needed to determine the efficacy of curcumin as an antidote agent. The present study aimed to critically review the recent literature data from that regarding the protective effects of curcumin against nephrotoxin agents...
September 5, 2018: Cardiovascular & Hematological Disorders Drug Targets
Surya Prakash Pandey, Prasoon Madhukar, Priya Dev, Deepika Joshi, Vijay Nath Mishra, Rameshwar Nath Chaurasia, Abhishek Pathak
Background Blood biomarkers are a cost-effective and valid method to diagnose ischemic stroke and differentiate it's subtypes in countries with poor resources. Objective To perform a systematic review of published literature evaluating diagnostic utility of blood based biomarkers to diagnose and differentiate etiology of ischemic stroke. Methods A comprehensive literature search was carried out till December 2017 in major scientific and medical databases including PubMed, Cochrane, OVID and Google Scholar. Modified Quality Assessment of Diagnostic Accuracy Studies questionnaire was used to assess methodological quality of each study...
August 29, 2018: Cardiovascular & Hematological Disorders Drug Targets
Dimitris Kounatidis, Natalia Vallianou, Vasiliki Daskalaki, Christos Masaoutis, Evangelia Margellou, Nikos Harhalakis, Evangelos Kokkinakis
Pure red cell aplasia (PRCA) is a clinical entity comprising severe normochromic normocytic anemia, reticulocytopenia, erythroblastopenia in the bone marrow, with normal leukocyte and platelets count. PRCA can be classified into congenital and acquired, with the latter characterized as idiopathic or secondary to various infections, hematological malignancies, collagen vascular diseases, thymoma, and exposure to a variety of drugs and other chemical substances. Herein, we present a female patient, who presented with PRCA due to azathioprine treatment...
August 28, 2018: Cardiovascular & Hematological Disorders Drug Targets
Bashir M Matata, Maqsood M Elahi
BACKGROUND: Left ventricular hypertrophy and myocardial remodelling occur with aortic valve disease and may lead to heart failure. Although increased oxidative stress and inflammatory factors have been implicated in heart failure, their role in the progression of valve disease remains unclear. OBJECTIVES: We investigated the role of oxidative stress and inflammatory factors in valve disease whether this relates to cell death. METHODS: Blood samples were taken from 24 patients with valve disease before surgery and the results were compared with those from blood samples from 30 control healthy subjects...
July 22, 2018: Cardiovascular & Hematological Disorders Drug Targets
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