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Infectious Disorders Drug Targets

Ramadevi Mohan, Subhashree Venugopal
Superantigens of Staphylococcus aureus namely enterotoxin A, exfoliative toxin A, and Toxic shock syndrome toxin-1 cause detrimental effects on the cells of immune system. In this work, the toxins were downloaded from Protein DataBank database and energy minimized using KoBaMIN server. Forty flavonoids compounds were identified by pubchem compound database through extensive literature study and their 3D structures were obtained by submitting SMILES to CORINA tool. Based on Lipinski's rule of five the molecules were filtered resulting in 27 compounds...
February 6, 2019: Infectious Disorders Drug Targets
Azam Molapour, Amir Peymani, Parvaneh Saffarain, Narges Habibollah-Pourzereshki, Pooya Rashvand
INTRODUCTION: Plasmid-induced quinolone resistance has raised a great concern in the treatment of serious infections worldwide. The aims of this study were to determine the antibiotic susceptibility, the frequency of qepA, aac(6')-Ib, and qnr genes by PCR and sequencing, and typing of the resistant isolates using repetitive extragenic palindromic sequence-based PCR (REP-PCR) in Pseudomonas aeruginosa isolated from burn wound infections. MATERIAL AND METHODS: In the current cross-sectional study, 149 P...
February 6, 2019: Infectious Disorders Drug Targets
Ilo Dicko, Yaya Ibrahim Coulibaly, Modibo Sangaré, Bismark Sarfo, Priscillia Awo Nortey
BACKGROUND: Lymphatic filariasis (LF) is a parasitic disease that has been targeted for elimination through the Mass Drug Administration (MDA.) Although the MDA started in the Ankobra community in Ghana in 2000, LF prevalence as reported in 2014 was relatively high (4.5%). Non-compliance to the MDA has been associated with the persistent LF prevalence in endemic regions. OBJECTIVE: This study determined the factors associated with the non-compliance to the MDA among patients living in the Ankobra community, Ghana...
February 6, 2019: Infectious Disorders Drug Targets
Seyedeh Hanieh Eshaghi Zadeh, Hossein Fahimi, Fatemeh Fardsanei, Mohammad Mehdi Soltan Dallal
BACKGROUND: Salmonellosis is a major food-borne disease worldwide. The increasing prevalence of antimicrobial resistance among food-borne pathogens such as Salmonella spp. is concerning. OBJECTIVE: The main objective of this study is to identify class 1 integron genes and to determine antibiotic resistance patterns among Salmonella isolates from children with diarrhea. METHODS: A total of 30 Salmonella isolates were recovered from children with diarrhea...
January 30, 2019: Infectious Disorders Drug Targets
Mahnaz Arian, Mina Akbari Rad, Ahmad Bagheri Moghaddam, Abdollah Firoozi, Mohammad Jami
Allopurinol is an FDA-Approved xanthine oxidase inhibitor that uses in the treatment of gout, hyperuricemia and uremic kidney stones in the patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine to uric acid, and therefore its inhibition will result in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction...
January 27, 2019: Infectious Disorders Drug Targets
Priya Datta, Menal Gupta, Pooja Kumari, Varsha Gupta, Subina Narang, Jagdish Chander
Acinetobacter species are widely distributed in soil, water and hospital environment. In addition to A. calcoaceticus-baumannii complex, the clinically most relevant species, there are other genomospecies which are less frequently identified, mostly due to lack of accurate methods for routine identification. We describe the first case of post-traumatic endophthalmitis caused by otherwise non-pathogenic A. radioresistens, in India. Gram-negative coccobacilli were observed on Gram stain and culture of vitreous fluid specimen, and identified biochemically as Acinetobacter spp...
January 23, 2019: Infectious Disorders Drug Targets
Amal Ahmed Mohamed, Naglaa El-Toukhy Ramadan El-Toukhy, Ebada Mohamed Said, Hoda Mohamed Rabie Gabal, Hossameldin AbdelAziz, Wahid Doss, Hadeel El-Hanafi, Hala H El Deeb, Seham Mahmoud, Mahmoud Elkadeem, Hassan Salama Shalby, Sherief Abd-Elsalam
BACKGROUND: HCV treatment showed dramatical change due to the introduction of potent strong direct antiviral drugs. Before the appearance of Direct-acting antivirals, multiple therapeutic interventions were used for hepatitis C, but none of these interventions were effective on patient-centered outcomes. Direct-acting antivirals cause disruption of viral replication because they target specific nonstructural viral proteins. AIM: To review the advantages of efficient HCV therapy and its long term drawbacks...
January 20, 2019: Infectious Disorders Drug Targets
Hassan Mahmoudi, Hadi Hossainpour, Mohammad Moradi, Mohammad Yousef Alikhani
INTRODUCTION: Bacteria are requiring iron ions to grow and infect the host, which, by using iron uptake systems, acquire free iron from their host cell. Escherichia coli is one of the most important pathogens causing food poisoning and clinical infections. The aim of this study was to assess the genes encoding iron uptake systems in food samples compared to clinical specimens. MATERIALS AND METHODS: This investigation was conducted to determine the prevalence of E...
January 18, 2019: Infectious Disorders Drug Targets
Katherine A Kleinberg, Suresh J Antony
L. pneumophila is an unusual cause of pneumonia with a prevalence of 2.7%, and it is even more uncommon in pregnancy [1]. To date, only 11 cases of Legionnaire's Disease in pregnancy have been reported [2-11], though this small number could possibly be attributed to underdiagnoses and underdocumentation. In this paper, we present a 31-year-old Hispanic female, gravida 4, para 1 from the southwest United States who presented with a 3 week history of fever, worsening cough, dyspnea on exertion, and hypoxemia...
January 18, 2019: Infectious Disorders Drug Targets
Samaneh Rouhi, Rashid Ramazanzadeh
BACKGROUND: Resistance to antimicrobial agents in Pseudomonas aeruginosa (P. aeruginosa) including carbapenems is a prominent problem in patients. Aim of this study is surveying metallo-beta-lactamase (MBL)-producing P. aeruginosa isolated from patient specimens with nosocomial and non-nosocomial infections in Kurdistan province, Iran. MATERIALS AND METHODS: In total, 146 Pseudomonas spp. were collected (December 2015 to August 2017). P. aeruginosa isolates were detected by phenotypic and polymerase chain reactions (PCR) of gyrB gene...
January 18, 2019: Infectious Disorders Drug Targets
Sasan Nikpay, Masoumeh Otaghi, Milad Azami, Marzieh Karimi, Jahangir Abdi
Trichomoniasis is known as a common venereal disease. It is estimated that 180 million people in the world are infected with this disease. The present study was conducted to estimate the prevalence of (Trichomonas vaginalis) T. vaginalis among women who were referred to the central laboratory in Ilam. In this cross-sectional study, 481 women with suspicious symptoms of trichomoniasis were selected during the first six months of 2015 in the central laboratory and Shahid Mostafa laboratory in Ilam, Iran. All patients were referred to the labs by gynecologists...
January 17, 2019: Infectious Disorders Drug Targets
Aarti Dalal, Parvin Kumar, Radhika Khanna, Dinesh Kumar, Deepika Paliwal, Ramesh C Kamboj
A series of 1-{2-(prop-2-ynyloxy)aryl}-3-hydroxy-3-(4'-trifluoromethyl-phenyl)prop-2-en-1-ones obtained by photo-irradiation of 2-{2-(prop-2-ynyloxy)benzoyl}-3-(4-trifluoromethyl-phenyl)oxiranes (that were characterized by spectral studies: FT-IR, 1H NMR, 13C NMR and Mass analysis) was screened for the anti-malarial activity by evaluating against chloroquine-sensitive P. falciparum (CD7). The molecular docking studies using AutoDock Vina were also performed to further ascertain the efficacy of these compounds with PDB:4ORM...
January 15, 2019: Infectious Disorders Drug Targets
Raphael Taiwo Aruleba, Tayo Alex Adekiya, Babatunji Emmanuel Oyinloye, Priscilla Masamba, Londiwe Simphiwe Mbatha, Ashley Pretorius, Abidemi Paul Kappo
Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a rapid and swift rise globally, claiming thousands of lives every year and leaving 800 million people at the risk of infection. Due to the high prevalence of this disease and the steady increase in infection rates, praziquantel (PZQ) remains the only effective drug against this acute disease although it has no effect on the juvenile schistosome parasite...
December 31, 2018: Infectious Disorders Drug Targets
Manouchehr Fadaee, Jalil Rashedi, Sepideh Arabi, Behroz Mahdavi Poor, Hossein Samadi Kafil, Mahya Pourostadi, Abdolhassan Kazemi, Mohammad Asgharzadeh
Tuberculosis (TB) is a public health problem in developing countries. In recent decades, the incidence of the disease has been gradually reducing in Iran. However, the reducing incidence of the disease has stopped in the country during recent years. It could be due to increase of immigration, diabetes, HIV/AIDS, and the prevalence of drug-resistant strains. In order to prevent the spread of TB cases and control this disease, it is essential to identify the predisposing factors, which may be related to bacteria, host and environment...
December 28, 2018: Infectious Disorders Drug Targets
Rahmita Burhamzah, Gemini Alam, Herlina Rante
Endophytic fungi lives in plants tissue and can produce the same bioactive compounds as its host plant produces. Syzygiumpolyanthum leaves have known to be one of the antibacterial compound producer. This study aimed to characterize morphologically, microscopically, and molecularly the antibacterial-producing endophytic fungi of Syzygiumpolyanthum leaves.The isolation of endophytic fungi was done by fragment planting method on PDA medium. The antibacterial screening was using the antagonistic test as the first screening and followed by the disc diffusion test method...
December 26, 2018: Infectious Disorders Drug Targets
Evelyn Chokuda, Chrs Reynolds, Satyajit Das
With the advent of combination antiretroviral therapy (cART) the survival of HIV patients have improved dramatically, but the complications of the disease and treatment have become an important issue in the management of HIV patients. Vitamin-D deficiency is common in HIV patients. Low vitamin-D is associated with different comorbidities in the HIV uninfected general population. In this review, we first briefly describe vitamin D synthesis and mechanism of action and we focus on the epidemiological and clinical data dealing with the relationship between vitamin D deficiency in HIV infection with several comorbidities which has been found to be increasingly common in patients living with HIV infection...
December 21, 2018: Infectious Disorders Drug Targets
Saeed Ghodrati, Zahra Shahabinezhad, Seyed Ahmad Seyed Alinaghi
BACKGROUND: With recent progress in the treatment of people living with HIV (PLWH) and their increased rate of survival, health-related quality of life (HRQoL) has become an important issue. OBJECTIVE: In the present study, we aimed to investigate the association of current CD4 cell count, baseline CD4 cell count, nadir CD4 cell count, and plasma viral load with health-related quality of life in people living with HIV (PLWH). METHODS: Participants were 67 PLWH who were under the treatment of antiretroviral therapy in Imam Khomeini Hospital of Tehran, Iran in 2016...
December 21, 2018: Infectious Disorders Drug Targets
Ossama A Ahmed, Mohamed A Elsebaey, Mohamed Hassan A Fouad, Mahmoud Elkadeem, Rehab Badawi, Ahmed Khayyal, Shaimaa Soliman, Manal Saad Negm, Sherief Abd-Elsalam
BACKGROUND & AIMS: Treatment plan of chronic HCV infection has dramatically improved after the introduction of different groups of direct-acting antiviral (DAA) drugs. These drugs have been found to be safe and effective. Sofosbuvir (SOF) plus simeprevir (SMV) regimen has been shown to be tolerable and effective in treatment of patients with HCV genotype 1. The aim of the study was to evaluate the safety and the efficacy of combined sofosbuvir plus simeprevir treatment in genotype 4 chronic HCV patients...
December 17, 2018: Infectious Disorders Drug Targets
Bontha Venkata Subrahmanya Lokesh, Y Rajendra Prasad, Afzal Basha Shaik
A series of new pyrazolines containing 2,5-dichloro-3-acetylthiophene chalcone moiety (PZT1-PZT20) have been synthesized, characterized by 1HNMR and 13CNMR and evaluated for them in vitro antitubercular activity against M. tuberculosis H37Rv strain and in vitro anticancer activity against DU-145 prostate cancer cell lines. Majority of screened compounds have displayed potential activity against Mycobacterium tuberculosis H37Rv(MTB) strain and anticancer activity against DU-149 prostate cancer cell lines. Among the series, compound PZT5 with 2", 4"-dichlorophenyl group at 5-position on the pyrazoline ring exhibited the most potent antitubercular activity (MIC=1...
December 17, 2018: Infectious Disorders Drug Targets
Jalil Rajabi, Ramin Hamidi-Farahani, Feizollah Mansouri, Saeed Soleiman-Meigooni
INTRODUCTION: Incidence of brucellosis was growing up in Iran during the past years. Kermanshah province-west of Iran is one of the endemic regions of the disease. The aim of this study was to evaluate the incidence and risk factors of brucellosis in Kermanshah province during a recent five-year period. MATERIAL AND METHODS: This study was an observational cross-sectional study performed on registries of the patients with brucellosis at the center for the zoonotic disease of Kermanshah University of medical sciences during 2010-2014...
December 11, 2018: Infectious Disorders Drug Targets
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